Constant-temperature thermal therapy application instrument for atopic dermatitis skin barrier repair

Abstract

The invention discloses a constant-temperature thermal therapy application instrument for atopic dermatitis skin barrier repair. The constant-temperature thermal therapy application instrument comprises an application base body, a constant-temperature controller, a heating layer, a hydrogel layer, a medicine release layer, a temperature sensor, a safety alarm module, an electronic timer and a skin hydration degree monitoring module. The thermostatic controller adopts a PID algorithm to realize closed-loop temperature control of the heating layer, the temperature sensor monitors the skin temperature in real time, and the safety alarm module gives an alarm and reduces the power when the temperature exceeds 49 DEG C to prevent scalding. The thermal therapy method comprises the steps of applying, starting constant-temperature heating, performing closed-loop temperature control, performing overtemperature protection, ending tearing at regular time and the like. By combining constant-temperature thermal therapy, hydrogel moisturizing and medicine permeation promotion, the temperature is accurately controlled, safety and reliability are achieved, medicine transdermal absorption can be promoted, local circulation can be improved, and safe, comfortable and intelligent skin barrier repair treatment is provided for atopic dermatitis.

Description

Technical Field

[0001] This invention relates to the field of thermotherapy dressing technology, and in particular to a constant temperature thermotherapy dressing for skin barrier repair in atopic dermatitis. Background Technology

[0002] Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease characterized by impaired skin barrier function, immune dysregulation, and intense itching. Patients often experience dry, scaly, and erythematous skin, accompanied by unbearable itching, severely impacting their quality of life. Current treatment strategies for AD primarily include topical corticosteroids, calcineurin inhibitors, antihistamines, and systemic immunosuppressants or biologics. However, long-term drug use can lead to problems such as local skin atrophy, telangiectasia, systemic adverse reactions, or high treatment costs. Therefore, exploring safe, effective, and long-term management-friendly non-pharmacological treatments has become an important research direction in this field.

[0003] Hyperthermia, as a physical therapy, has gained attention in recent years for its application value in the management of Alzheimer's disease (AD) symptoms. Studies have shown that transient receptor potential (TRP) channels, particularly vanillic acid receptor subtype 1 (TRPV1), play a crucial role in sensory transmission in the skin, participating not only in the transmission of itch signals but also responding to thermal stimulation. Clinical studies have confirmed that short-term (e.g., 5 seconds) thermal stimulation at 49°C on the affected skin areas of AD patients can significantly and rapidly reduce itching, with the effect lasting for a certain period. Furthermore, repeated applications did not reveal rapid tolerance, suggesting its potential as a non-pharmacological method for relieving itching. However, this study also points out individual differences in treatment response, emphasizing the importance of personalized and precise hyperthermia.

[0004] Despite the promising prospects of thermotherapy, existing heat therapy devices have significant shortcomings in the management of atopic dermatitis (AD). Traditional heat therapy patches are mostly based on the oxidation of iron powder to generate heat, resulting in passive and imprecise temperature control. This poses a risk of burns due to excessively high temperatures and makes it difficult to maintain a constant treatment temperature. More importantly, these patches generally lack real-time temperature monitoring and feedback adjustment mechanisms, failing to dynamically adjust according to the actual skin temperature. This not only affects treatment efficacy but may also exacerbate skin barrier damage due to thermal injury. Therefore, we propose a constant-temperature thermotherapy patch for skin barrier repair in atopic dermatitis. Summary of the Invention

[0005] The purpose of this invention is to provide a constant temperature thermotherapy dressing for skin barrier repair in atopic dermatitis, so as to solve the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is: a constant temperature thermotherapy dressing for skin barrier repair in atopic dermatitis, comprising a dressing substrate, an installation groove on one side of the dressing substrate, an installation cavity inside the installation groove, a constant temperature controller inside the installation cavity, a heating layer, a hydrogel layer and a drug release layer arranged sequentially from the inside to the outside of the installation groove, the constant temperature controller controlling the connection of the heating layer, an adhesive and a temperature sensor arranged on the outside of the installation groove, and a safety alarm module arranged on the side wall of the dressing substrate away from the installation groove, with an electronic timer connected to the safety alarm module.

[0007] Preferably, the dressing substrate is made of a biocompatible flexible material, and a skin-friendly cotton layer is provided on the outer wall of the dressing substrate outside the mounting groove. The temperature sensor is located on the skin-friendly cotton layer and is a high-precision negative temperature coefficient thermistor.

[0008] Preferably, the adhesive is located at the edge of the substrate and is arranged in a ring around the edge of the substrate.

[0009] Preferably, a protruding piece is fixedly connected to the outer side of the adhesive substrate, and an anti-slip strip is provided on the surface of the protruding piece.

[0010] Preferably, the surface of the drug release layer is covered with a release paper, and a corner convex film is connected to one corner of the release paper.

[0011] Preferably, the thermostat has a built-in microcontroller unit, which performs closed-loop control of the heating layer using a proportional-integral-derivative control algorithm.

[0012] Preferably, it also includes a skin hydration monitoring module, which is connected to the constant temperature controller.

[0013] Preferably, the heating layer is a positive temperature coefficient thermistor element or a flexible printed heating circuit.

[0014] Preferably, the safety alarm module is set to a safety threshold of 49°C, and when the temperature of the skin contact surface reaches or exceeds 49°C, the safety alarm module issues an audible and visual alarm and automatically cuts off or reduces the power supply to the heating layer.

[0015] A constant-temperature thermotherapy method for skin barrier repair in atopic dermatitis, using the aforementioned dressing device, includes the following steps: Step 1: Remove the release paper from the surface of the drug release layer. Fix the applicator to the atopic dermatitis area using the adhesive on the edge of the applicator, so that the drug release layer and hydrogel layer adhere to the skin of the affected area, and the skin-friendly cotton layer adheres to the skin periphery. Step 2: Start the thermostat. Through its built-in microcontroller and proportional-integral-derivative control algorithm, the heating layer starts to heat up. At the same time, the temperature sensor, electronic timer and skin hydration monitoring module are turned on. Step 3: The thermostat uses the real-time temperature of the skin contact surface collected by the temperature sensor to perform closed-loop thermostat control on the heating layer, maintaining the temperature of the heating layer stable. At the same time, it dynamically adjusts the heating power based on the skin hydration data fed back by the skin hydration monitoring module. Step 4: Set the heat therapy time using an electronic timer. During the heat therapy process, if the temperature sensor detects that the temperature of the skin contact surface reaches or exceeds 49°C, the safety alarm module will immediately issue an audible and visual alarm and automatically cut off or reduce the power supply to the heating layer. Step 5: After the heat therapy time is over, the thermostat automatically shuts off the heating layer. The patch is then removed by peeling off the protruding piece on the substrate, completing one thermostat treatment for skin barrier repair in atopic dermatitis.

[0016] This invention provides a constant temperature thermotherapy dressing for skin barrier repair in atopic dermatitis, which has the following beneficial effects.

[0017] 1. This invention utilizes a high-precision temperature sensor located on the skin contact surface and a thermostat with a built-in PID algorithm to work in tandem. This real-time monitoring and precise adjustment of the heating power of the heating layer forms a closed-loop feedback control, rapidly and stably maintaining the treatment temperature of the affected area within the optimal physiological range. This effectively avoids the problems of large temperature fluctuations and inaccurate temperature control found in traditional hot compress devices. Simultaneously, the safety alarm module has an over-temperature protection threshold of 49°C. In the event of an abnormal temperature, an audible and visual alarm is immediately triggered, and the heating power is automatically cut off or reduced, fundamentally eliminating the risk of low-temperature burns. This provides a safe and drug-free physical method for relieving itching and as an adjunct treatment for patients with atopic dermatitis.

[0018] 2. The patch integrates a heating layer, a hydrogel layer, and a drug release layer. Utilizing a constant-temperature thermal effect, it promotes local blood circulation and softens the stratum corneum, significantly enhancing the transdermal absorption efficiency of active drug ingredients and achieving a synergistic effect between thermotherapy and drug therapy. Furthermore, the device's built-in skin hydration monitoring module can assess the barrier function of the stratum corneum in real time and intelligently trigger or adjust the thermotherapy program based on the monitoring results, enabling personalized treatment intervention. Through the organic combination of heat-promoted penetration and precise moisturizing, it not only instantly relieves itching symptoms but also creates a constant-temperature, humid, and drug-rich repair microenvironment for the damaged skin barrier, accelerating the recovery of barrier function. Attached Figure Description

[0019] The present invention will be further described below with reference to the accompanying drawings and embodiments: Figure 1This is a schematic diagram of the overall structure of the present invention.

[0020] Figure 2 This is a schematic diagram of the exploded structure of the present invention.

[0021] Figure 3 This is an enlarged structural diagram of point A in the present invention.

[0022] Figure 4 This is a schematic diagram of the structure of the adhesive substrate of the present invention.

[0023] Figure 5 This is a schematic diagram of the present invention.

[0024] In the diagram: 1. Adhesive substrate; 2. Mounting slot; 3. Thermostat; 4. Safety alarm module; 5. Skin-friendly cotton layer; 6. Adhesive; 7. Temperature sensor; 8. Mounting cavity; 9. Heating layer; 10. Hydrogel layer; 11. Drug release layer; 12. Release paper; 13. Protrusion sheet; 14. Electronic timer; 15. Corner protrusion film; 16. Skin hydration monitoring module. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0026] Please see Figure 1 , Figure 2 , Figure 3 and Figure 4 The present invention provides a technical solution: a constant temperature thermotherapy patch for repairing the skin barrier in atopic dermatitis, comprising a patch substrate 1, an installation groove 2 on one side of the patch substrate 1, and an installation cavity 8 in the installation groove 2, wherein a constant temperature controller 3 is provided in the installation cavity 8.

[0027] A heating layer 9 is provided inside the mounting groove 2 outside the mounting cavity 8. A hydrogel layer 10 is provided on the side of the heating layer 9 away from the mounting cavity 8. A drug release layer 11 is provided on the surface of the hydrogel layer 10. The side of the drug release layer 11 away from the hydrogel layer 10 passes through the mounting groove 2. A safety alarm module 4 is provided on the other side of the application substrate 1. An electronic timer 14 is detachably connected to the side of the application substrate 1 located on the side of the safety alarm module 4. A temperature sensor 7 is provided on the side of the application substrate 1 located on the side of the mounting groove 2.

[0028] It should be noted that in this embodiment, an inwardly recessed mounting groove 2 is provided on the skin contact surface of the application substrate 1, and a mounting cavity 8 is provided in the central area of ​​the mounting groove 2. A circuit board is fixedly installed in the mounting cavity 8, and the circuit board integrates a constant temperature controller 3 and related control circuits.

[0029] In the mounting groove 2, in the area outside the mounting cavity 8, a heating layer 9 is stacked in sequence. The heating layer 9 uses a positive temperature coefficient (PTC) thermistor ceramic element, which has temperature self-limiting property. When the temperature exceeds the Curie point, the resistance increases sharply, thereby automatically reducing the power as the first layer of physical safety protection. Below the heating layer 9 is a hydrogel layer 10, which not only conducts heat evenly but also provides some moisturizing effect to the skin. Below the hydrogel layer 10, a drug release layer 11 is tightly adhered. This drug release layer 11 is a non-woven fabric or polymer carrier membrane impregnated with anti-inflammatory and repairing drugs, with a portion of it extending and exposed to the outside of the mounting groove 2 so that it can directly contact the patient's skin lesion during use.

[0030] A safety alarm module 4 is provided on the top surface of the dressing substrate 1. Next to the safety alarm module 4, the dressing substrate 1 is provided with a slot for detachably installing an electronic timer 14, so that the patient can set the treatment duration according to the doctor's order.

[0031] Please see Figure 2 and Figure 3 The dressing substrate 1 is made of a biocompatible flexible material and is connected to a skin-friendly cotton layer 5 on one side of the mounting groove 2. The mounting groove 2 penetrates the skin-friendly cotton layer 5. The temperature sensor 7 is set on the skin contact surface of the skin-friendly cotton layer 5 and adopts a high-precision negative temperature coefficient thermistor for real-time monitoring of skin surface temperature.

[0032] It should be noted that, in this embodiment, when using the product, the release paper 12 is peeled off, the drug release layer 11 is aligned with the patient's affected skin, the release frame paper on the adhesive 6 of the adhesive substrate 1 is peeled off, and the adhesive 6 is applied to the patient's skin. The skin-friendly cotton layer 5 located outside the drug release layer 11 is in contact with the patient's non-affected skin, which is skin-friendly and breathable.

[0033] After the patch is applied to the skin, the temperature sensor 7 begins to monitor the actual temperature of the skin surface in real time and feeds the temperature signal back to the thermostat 3. The thermostat 3 is a built-in control unit (MCU) that receives the data collected by the temperature sensor 7. The system has a preset target treatment temperature. The thermostat 3 uses a proportional-integral-derivative (PID) control algorithm to compare the measured temperature with the preset temperature. Based on the temperature difference, it accurately calculates the required heating power and drives the heating layer 9 to heat or pause heating, forming a closed-loop feedback mechanism.

[0034] During the constant temperature heating process of the heating layer 9, the local skin temperature rises, and the thermal effect can dilate the skin capillaries, increase blood flow, soften the stratum corneum, and open the pathways of skin appendages (such as hair and sweat glands), thereby reducing the resistance of the skin barrier to transdermal drug absorption. Heat is transferred from the heating layer 9 to the hydrogel layer 10 and the drug release layer 11 in sequence. The hydrogel layer 10, as a good conductor of heat and a water storage medium, can maintain a moist environment after being heated, promoting the continuous and stable penetration of the active ingredients in the drug release layer 11 into the lesion site, realizing the synergistic effect of thermotherapy and drug therapy. The integrated skin hydration monitoring module 16 can detect the current hydration status of the stratum corneum. If the skin barrier is severely damaged (hydration is too low), the system can automatically adjust the treatment temperature range or add protective intervals in the heating program to ensure the comfort and safety of the treatment process.

[0035] Users or medical staff can preset the treatment duration via the detachable electronic timer 14. When the treatment reaches the set time, the electronic timer 14 will issue a prompt to remind the user to end the treatment, avoiding excessive heat exposure time due to forgetfulness. The safety alarm module 4 sets a strict safety threshold. Once the temperature sensor 7 detects that the skin contact surface temperature reaches or exceeds 49°C, the safety alarm module 4 will be triggered immediately, emitting a buzzer to remind the user. At the same time, the system will automatically cut off or significantly reduce the power supply to the heating layer 9 to force cooling, fundamentally eliminating the risk of low-temperature burns. If the temperature gets out of control due to a malfunction of the temperature sensor 7 or a circuit abnormality, the physical characteristics of the PTC heating element itself will automatically increase the resistance and limit the current when the Curie temperature is reached, forming a physical over-temperature protection.

[0036] Please see Figure 1 and Figure 2 The surface of the skin-friendly cotton layer 5 is provided with a ring of adhesive 6 along its edge, and the adhesive 6 is used to bond with the patient's skin.

[0037] It should be noted that, in order to further improve the comfort of skin contact and the accuracy of temperature measurement in this embodiment, a skin-friendly cotton layer 5 is also compositely connected to the bottom surface of the patch substrate 1. The mounting groove 2 penetrates the skin-friendly cotton layer 5, so that the drug release layer 11 can directly contact the skin. A temperature sensor 7 is embedded in the skin contact surface of the skin-friendly cotton layer 5. The temperature sensor 7 is a high-precision negative temperature coefficient thermistor. Its probe protrudes slightly or is flush with the skin-friendly cotton layer 5 to ensure that the true temperature of the skin surface can be accurately collected and the signal is transmitted to the constant temperature controller 3 in real time.

[0038] To prevent the dressing device from shifting during use, a ring of adhesive 6 is applied to the bottom edge of the skin-friendly cotton layer 5. The adhesive 6 is a medical pressure-sensitive adhesive that is gentle on the skin and has low allergenicity.

[0039] Please see Figure 1 The outer side of the substrate 1 is integrally provided with a protruding piece 13, and the surface of the protruding piece 13 is provided with an anti-slip strip.

[0040] It should be noted that in this embodiment, an outwardly extending protrusion 13 is integrally formed on the outer edge of the dressing substrate 1. The edge of the protrusion 13 is provided with anti-slip strips. The patient can pinch the protrusion 13 to help align it with the skin lesion and apply it. After the treatment is completed, the entire dressing can be easily peeled off.

[0041] Please see Figure 1 The surface of the drug release layer 11 is connected to the release paper 12, and the outer side of the release paper 12 is integrally provided with a corner convex film 15 that is convenient for personnel to hold and peel off the release paper 12.

[0042] It should be noted that in this embodiment, when the drug release layer 11 is shipped, the surface is covered with a peelable release paper 12. For ease of use, the edge of the release paper 12 is integrally formed with a corner convex film 15, which the patient can easily peel off by holding the corner convex film 15.

[0043] Please see Figure 5 The thermostat 3 has a built-in microcontroller unit and uses a proportional-integral-derivative control algorithm to perform closed-loop control of the heating layer 9.

[0044] It should be noted that, in this embodiment, before using this dressing device, medical staff or patients, according to the condition of the skin lesions, insert the drug release layer 11 containing the corresponding drug into the mounting slot 2, peel off the release paper 12, hold the dressing through the protruding piece 13, and use the adhesive 6 to attach the skin-friendly cotton layer 5 to the healthy skin around the atopic dermatitis lesion area, ensuring that the drug release layer 11 accurately covers the affected area.

[0045] After powering on, the system enters the working state. Its specific workflow is as follows: The thermostat 3 reads the preset treatment temperature (e.g., set to 43℃) and treatment duration. The thermostat 3 supplies power to the heating layer 9, causing it to heat up. Simultaneously, the temperature sensor 7 collects the temperature of the skin contact surface at high frequency in real time and feeds it back to the thermostat 3. The microcontroller unit inside the thermostat 3 runs a PID control algorithm, comparing the measured temperature with the set value of 43℃. If the measured temperature is lower than the set value, the power supply to the heating layer 9 is increased; if it is close to or slightly higher than the set value, the power is reduced proportionally; if it exceeds the set value, the power supply is temporarily cut off. Through this high-speed adjustment, the skin temperature is ensured to be precisely maintained within the range of 43℃ ± 0.5℃. Under continuous constant temperature heat, capillaries in the affected area dilate, and the permeability of the stratum corneum increases. The active ingredients in the drug release layer 11, in the humid environment created by the heat and the hydrogel layer 10, accelerate penetration through the skin barrier and exert their therapeutic effects.

[0046] Please see Figure 5 The heating layer 9 is a positive temperature coefficient thermistor element or a flexible printed heating circuit.

[0047] It should be noted that in this embodiment, the heating layer 9 is composed of one or more PTC ceramic heating elements or a thin film printed with PTC thermistor conductive ink. Utilizing the unique resistance-temperature characteristics of PTC material (the resistance increases dramatically when the temperature rises to near the Curie point), this heating layer 9 not only serves as a heat source but also constitutes a physical safety barrier. When the temperature rises abnormally due to a control circuit failure, the resistance of the PTC element will increase sharply, thereby automatically limiting the current, reducing the heating power, preventing thermal runaway, and forming a dual redundancy protection with the safety alarm module 4.

[0048] Please see Figure 5 It also includes a skin hydration monitoring module 16, which is connected to a constant temperature controller 3 to monitor the hydration status of the skin's stratum corneum and trigger or adjust the thermotherapy program within the treatment temperature range based on the monitoring results.

[0049] It should be noted that in this embodiment, the system is also connected to a skin hydration monitoring module 16, which monitors the hydration status of the stratum corneum through technologies such as bioimpedance measurement. If the skin hydration is detected to be too low, it indicates that the barrier is severely damaged. The system can adjust the heating strategy through the thermostat 3, for example, by executing a program that includes a low-heat preparation phase to avoid sudden high temperatures from irritating the fragile skin.

[0050] Please see Figure 5 The safety alarm module 4 is set to a safety threshold of 49°C. When the temperature of the skin contact surface reaches or exceeds 49°C, the safety alarm module 4 will issue an audible and visual alarm and automatically cut off or reduce the power supply of the heating layer 9.

[0051] It should be noted that in this embodiment, the safety alarm module 4 continuously monitors the temperature throughout the treatment process, and the internally fixed safety threshold is 49°C. When any abnormal situation occurs causing the temperature sensor 7 to detect a skin contact surface temperature of 49°C or higher, the safety alarm module 4 is immediately triggered to emit a continuous, rapid "beep" sound from its buzzer. Simultaneously, the safety alarm module 4 sends a high-priority interrupt signal to the power supply circuit of the heating layer 9 via hardware circuitry, forcibly cutting off the main power supply or reducing the power to near zero through PWM control. This action is independent of the main control chip's software logic and serves as the last line of defense in the hardware, ensuring that the heating layer 9 stops heating, thereby completely eliminating the risk of burns. When the electronic timer 14 reaches zero, the system will sound an alarm and automatically stop heating, ending the treatment. The patient can remove the electronic timer 14, then remove the dressing using the protruding piece 13 and discard it.

[0052] Furthermore, the terms “first,” “second,” “third,” and “fourth” are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as “first,” “second,” “third,” or “fourth” may explicitly or implicitly include at least one of those features.

[0053] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "setting," "connection," "fixing," "screw connection," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0054] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A constant-temperature thermotherapy patch for skin barrier repair in atopic dermatitis, characterized in that: The device includes a substrate (1), an installation groove (2) on one side of the substrate (1), an installation cavity (8) inside the installation groove (2), a thermostat (3) inside the installation cavity (8), a heating layer (9), a hydrogel layer (10) and a drug release layer (11) arranged sequentially from the inside to the outside of the installation groove (2), the thermostat (3) controls the connection of the heating layer (9), an adhesive (6) and a temperature sensor (7) are arranged on the outside of the installation groove (2), a safety alarm module (4) is arranged on the side wall of the substrate (1) away from the installation groove (2), and an electronic timer (14) is connected to the safety alarm module (4).

2. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The dressing substrate (1) is made of a biocompatible flexible material. A skin-friendly cotton layer (5) is provided on the outer wall of the dressing substrate (1) outside the mounting groove (2). The temperature sensor (7) is located on the skin-friendly cotton layer (5). The temperature sensor (7) is a high-precision negative temperature coefficient thermistor.

3. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The adhesive (6) is located at the edge of the substrate (1) and is arranged in a circle around the edge of the substrate (1).

4. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The outer side of the dressing substrate (1) is fixedly connected to a protruding piece (13), and the surface of the protruding piece (13) is provided with an anti-slip strip.

5. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The surface of the drug release layer (11) is covered with a release paper (12), and a corner convex film (15) is connected to one corner of the release paper (12).

6. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The thermostat (3) has a built-in microcontroller unit, which performs closed-loop control of the heating layer (9) through a proportional-integral-derivative control algorithm.

7. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: It also includes a skin hydration monitoring module (16), which controls the thermostat (3).

8. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The heating layer (9) is a positive temperature coefficient thermistor element or a flexible printed heating circuit.

9. The constant temperature thermotherapy patch for skin barrier repair in atopic dermatitis as described in claim 1, characterized in that: The safety alarm module (4) is set to a safety threshold of 49°C. When the temperature of the skin contact surface reaches or exceeds 49°C, the safety alarm module (4) issues an audible and visual alarm and automatically cuts off or reduces the power supply of the heating layer (9).

10. A constant-temperature thermotherapy method for repairing the skin barrier in atopic dermatitis, applied to the dressing device according to any one of claims 1-9, characterized in that, Includes the following steps: Step 1: Remove the release paper (12) from the surface of the drug release layer (11), and fix the applicator to the atopic dermatitis area by the adhesive (6) on the edge of the applicator substrate (1), so that the drug release layer (11) and the hydrogel layer (10) are in contact with the skin of the affected area, and the skin-friendly cotton layer (5) is in contact with the skin periphery. Step 2: Start the thermostat (3), and control the heating layer (9) to start heating through its built-in microcontroller unit and proportional-integral-derivative control algorithm. At the same time, turn on the temperature sensor (7), electronic timer (14) and skin hydration monitoring module (16). Step 3: The thermostat (3) performs closed-loop thermostat control on the heating layer (9) based on the real-time temperature of the skin contact surface collected by the temperature sensor (7) to maintain the temperature of the heating layer (9) stable. At the same time, it dynamically adjusts the heating power by combining the skin hydration data fed back by the skin hydration monitoring module (16). Step 4: Set the heat therapy time using the electronic timer (14). During the heat therapy, if the temperature sensor (7) detects that the temperature of the skin contact surface reaches or exceeds 49°C, the safety alarm module (4) will immediately issue an audible and visual alarm and automatically cut off or reduce the power supply of the heating layer (9). Step 5: After the heat therapy time is over, the constant temperature controller (3) automatically shuts off the heating layer (9), and the patch is removed by the protrusion (13) on the patch substrate (1), thus completing a constant temperature heat therapy operation for the repair of the skin barrier in atopic dermatitis.

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