Chinese herbal medicine freckle-removing cream and preparation method thereof

Abstract

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a traditional Chinese medicine freckle-removing cream and its preparation method. Background Technology

[0002] Age spots are a skin problem caused by abnormal pigmentation, and their formation is related to a variety of factors such as endocrine disorders, microcirculation disorders, ultraviolet radiation, and mental stress. Currently, age spot removal products on the market are mainly divided into two categories: chemical age spot removal products and traditional Chinese medicine age spot removal preparations.

[0003] Chemical-based spot-removing products often contain chemical ingredients such as hydroquinone and retinoic acid. While these can lighten spots to some extent, they are highly irritating and can easily damage the skin barrier, making them unsuitable for sensitive skin. Furthermore, they only block pigment production on the surface and cannot address the underlying physiological issues causing pigmentation, leading to a tendency for rebound pigmentation after treatment. Traditional Chinese medicine spot-removing preparations use natural herbs as raw materials and are relatively safe, but they often suffer from less effective spot-removing results.

[0004] Therefore, developing a safe, gentle, and effective spot-removing product that has a good skin feel and can regulate pigmentation from the root has become a pressing technical problem in the cosmetics industry. Summary of the Invention

[0005] Therefore, this invention provides a traditional Chinese medicine freckle-removing cream and its preparation method to solve the technical problems of existing chemical freckle-removing products being highly irritating and prone to rebound, as well as traditional Chinese medicine freckle-removing preparations having poor skin feel, unstable active ingredients, and low transdermal absorption efficiency.

[0006] To achieve the above objectives, the embodiments of the present invention provide the following technical solutions:

[0007] According to a first aspect of the present invention, the present invention provides a traditional Chinese medicine freckle-removing cream, which is made from a decoction of traditional Chinese medicine and a natural oil-in-water emulsion system. The decoction of traditional Chinese medicine comprises the following medicinal materials in parts by weight: 22-28 parts Rehmannia glutinosa, 12-18 parts Polygonatum odoratum, 12-18 parts Benincasa hispida seeds, 6-10 parts Bombyx mori, 6-10 parts Tribulus terrestris, 8-12 parts Crataegus pinnatifida, 10-15 parts Agrimonia pilosa, 5-8 parts Allium macrostemon, 10-15 parts Polygonum multiflorum vine, 8-12 parts Albizia julibrissin bark, 8-12 parts Platycladus orientalis seed, 16-20 parts Imperata cylindrica root, 4-8 parts Perilla frutescens leaf, 2-4 parts Zanthoxylum bungeanum, and 3-6 parts Magnolia officinalis bark. The natural oil-in-water emulsion system comprises the following raw materials in parts by weight: 15-20 parts olive oil emulsifying wax, 35-40 parts shea butter, 15-20 parts jojoba oil, 22-28 parts grapeseed oil, and vitamin E. 1.5-2 portions.

[0008] Furthermore, the decoction of the Chinese herbal medicines includes the following ingredients in parts by weight: 25 parts Rehmannia glutinosa, 15 parts Polygonatum odoratum, 15 parts winter melon seeds, 8 parts Bombyx mori, 8 parts Tribulus terrestris, 10 parts hawthorn, 12 parts Agrimonia pilosa, 6 parts Allium macrostemon, 12 parts Polygonum multiflorum vine, 10 parts Albizia julibrissin bark, 10 parts Platycladus orientalis seed, 18 parts Imperata cylindrica root, 6 parts Perilla frutescens leaf, 3 parts Sichuan pepper, and 5 parts Magnolia officinalis bark.

[0009] Furthermore, the natural oil-in-water emulsion system comprises the following raw materials in parts by weight: 18 parts olive oil emulsifying wax, 36 parts shea butter, 18 parts jojoba oil, 25 parts grapeseed oil, and 1.8 parts vitamin E.

[0010] Furthermore, the preparation method of the herbal decoction includes: pulverizing each herb to 40 mesh, adding 10 times the amount of deionized water; first soaking at 60℃ for 30 minutes, then heating to 92℃ and refluxing for 60 minutes at a gentle boil, and finally cooling to 80℃ and continuing extraction for 30 minutes; after filtration, adding 6 times the amount of water to the residue and extracting again, combining the two filtrates, and concentrating under reduced pressure at 65℃ until the relative density is 1.10-1.15 at 50℃ to obtain the herbal decoction.

[0011] Studies have found that the above methods can maximize the extraction and retention of water-soluble active ingredients such as polysaccharides, saponins, and flavonoids, effectively reduce the damage to heat-sensitive ingredients, and significantly improve the dissolution rate of active ingredients.

[0012] According to a second aspect of the present invention, the present invention provides a method for preparing the herbal freckle-removing cream as described above, the method comprising:

[0013] The decoction of the Chinese herbal medicines is heated to 75-80℃ and kept at that temperature to obtain the aqueous phase.

[0014] Mix olive oil emulsified wax with shea butter, heat in a water bath to 75-80℃ to melt, then add jojoba oil and grapeseed oil, stir until the system is completely homogeneous and transparent, keep warm to obtain the oil phase;

[0015] Under the stirring of a high-speed homogenizer at 2500 rpm, the oil phase is slowly and uniformly added to the aqueous phase. After the addition is complete, the temperature is maintained at 75-80℃ and homogenization is continued for 5 minutes. When the emulsion temperature drops below 45℃, vitamin E is added and stirred slowly until uniform. Finally, the emulsion is degassed under vacuum, cooled to room temperature, and then packaged to obtain the herbal freckle-removing cream.

[0016] The active ingredients of this herbal freckle-removing cream are: Rehmannia glutinosa, Polygonatum odoratum, and winter melon seeds as principal ingredients, which nourish blood and yin, remove freckles and whiten skin; Bombyx batryticatus, Tribulus terrestris, hawthorn, Agrimonia pilosa, and Allium macrostemon as assistant ingredients, which invigorate blood, dissipate nodules, and clear the meridians to eliminate freckles; Polygonum multiflorum vine, Albizia julibrissin bark, and Platycladus orientalis seed as adjuvant ingredients, which calm the mind, relieve depression, and regulate qi; and Imperata cylindrica root, Perilla frutescens leaf, Zanthoxylum bungeanum, and Magnolia officinalis bark as guiding ingredients, which clear heat, promote surface penetration, and guide the medicine to the skin. This formula is based on the traditional Chinese medicine theory of "nourishing internally and soothing externally to calm the mind and eliminate blemishes": Rehmannia glutinosa and Polygonatum odoratum nourish yin, blood, and body fluids, regulating skin metabolism disorders and pigmentation caused by deficiency heat or fluid depletion from within, laying the material foundation for blemish removal; Bombyx mori, Tribulus terrestris, and Magnolia officinalis bark act directly on the skin, traditionally used to dispel wind and eliminate blemishes, and modern pharmacology has proven that they can effectively inhibit tyrosinase activity and scavenge free radicals, directly blocking and lightening blemishes from the outside; Hawthorn, Agrimonia pilosa, and Allium macrostemon invigorate blood circulation and disperse stagnation, improving facial microcirculation and promoting the metabolism and elimination of deposited pigments; Polygonum multiflorum vine and Albizia julibrissin bark calm the mind, regulating pigmentation induced by mental and neurological factors such as emotions, stress, and sleep. The combined effects of these herbs, through nourishing yin and blood, inhibiting production, promoting metabolism, and regulating internal factors, work synergistically to achieve a comprehensive blemish-removing effect.

[0017] The embodiments of the present invention have the following advantages:

[0018] The composition of this invention, through the multi-target synergistic effect of "nourishing yin and blood, promoting blood circulation and unblocking collaterals, calming the mind and relieving depression, and directly inhibiting melanin", not only focuses on decomposing existing pigmentation spots, but also pays attention to regulating the internal body environment that leads to pigmentation (such as yin deficiency and blood dryness, poor circulation, and emotional distress), thereby reducing the recurrence rate and achieving a more stable spot removal effect.

[0019] All core active ingredients are derived from traditional Chinese medicine, avoiding the potential irritation of chemical skin-lightening ingredients. At the same time, it uses highly skin-friendly natural oils such as shea butter and jojoba oil, along with olive oil emulsifying wax, to construct an emulsification system. The product has a delicate, moisturizing, and non-greasy texture, effectively repairing the skin barrier and making it suitable for a wider range of people, including those with sensitive skin.

[0020] The optimized decoction process ensures the efficient extraction and stable preservation of active ingredients from traditional Chinese medicine. The micron-sized emulsion particles formed by the natural emulsification system can better promote the transdermal penetration of water-soluble and fat-soluble active ingredients, thereby improving the overall bioavailability of the formula.

[0021] The formula combines the moisturizing and nourishing ingredients of Polygonatum odoratum and Rehmannia glutinosa, the repairing ingredients of Agrimonia pilosa, with the antioxidant ingredients of Vitamin E and various natural oils, giving this product a comprehensive skin care effect of moisturizing, nourishing, and improving skin radiance while removing blemishes. Detailed Implementation

[0022] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] Example 1

[0024] This embodiment provides a traditional Chinese medicine freckle-removing cream, the raw materials of which are: 25 parts Rehmannia glutinosa, 15 parts Polygonatum odoratum, 15 parts winter melon seeds, 8 parts Bombyx mori, 8 parts Tribulus terrestris, 10 parts hawthorn, 12 parts Agrimonia pilosa, 6 parts Allium macrostemon, 12 parts Polygonum multiflorum vine, 10 parts Albizia julibrissin bark, 10 parts Platycladus orientalis seed, 18 parts Imperata cylindrica root, 6 parts Perilla frutescens leaf, 3 parts Sichuan pepper, 5 parts Magnolia officinalis bark; 18 parts olive oil emulsifying wax, 36 parts shea butter, 18 parts jojoba oil, 25 parts grapeseed oil, and 1.8 parts vitamin E.

[0025] The preparation method of the above-mentioned herbal freckle-removing cream includes the following steps:

[0026] (1) Pulverize each medicinal material to 40 mesh, add 10 times the amount of deionized water; first soak at 60℃ for 30 minutes, then heat to 92℃ and reflux for 60 minutes, and finally cool down to 80℃ and continue to extract for 30 minutes; after filtration, add 6 times the amount of water to the residue and extract once more, combine the two filtrates, and concentrate under reduced pressure at 65℃ to a relative density of 1.10-1.15 (measured at 50℃) to obtain the decoction of Chinese herbal medicine;

[0027] (2) Heat the decoction of Chinese herbal medicines to 75-80℃ and keep it warm to obtain the aqueous phase;

[0028] (3) Mix olive oil emulsified wax with shea butter, heat in a water bath to 75-80℃ to melt, then add jojoba oil and grapeseed oil, stir until the system is completely uniform and transparent, keep warm, and obtain the oil phase;

[0029] (4) Under the stirring of a high-speed homogenizer at 2500 rpm, the oil phase of step (3) is slowly and uniformly added to the aqueous phase of step (2). After the addition is completed, the temperature is maintained at 75-80℃ and homogenization is continued for 5 minutes. When the emulsion temperature drops below 45℃, vitamin E is added and stirred slowly until uniform. Finally, the emulsion is degassed under vacuum, cooled to room temperature and filled into a container to obtain the herbal freckle cream.

[0030] Example 2

[0031] This embodiment provides a traditional Chinese medicine freckle-removing cream, which differs from Embodiment 1 only in the amount of raw materials. Specifically, the raw materials in this embodiment are: 22 parts Rehmannia glutinosa, 16 parts Polygonatum odoratum, 14 parts winter melon seeds, 10 parts Bombyx mori, 10 parts Tribulus terrestris, 8 parts hawthorn, 14 parts Agrimonia pilosa, 5 parts Allium macrostemon, 15 parts Polygonum multiflorum vine, 10 parts Albizia julibrissin bark, 8 parts Platycladus orientalis seed, 18 parts Imperata cylindrica root, 5 parts Perilla frutescens leaf, 3 parts Zanthoxylum bungeanum, 6 parts Magnolia officinalis bark; 16 parts olive oil emulsifying wax, 38 parts shea butter, 15 parts jojoba oil, 28 parts grapeseed oil, and 1.5 parts vitamin E.

[0032] Example 3

[0033] This embodiment provides a traditional Chinese medicine freckle-removing cream, which differs from Embodiment 1 only in the amount of raw materials. Specifically, the raw materials in this embodiment are: 28 parts Rehmannia glutinosa, 16 parts Polygonatum odoratum, 12 parts winter melon seeds, 7 parts Bombyx mori, 8 parts Tribulus terrestris, 12 parts hawthorn, 10 parts Agrimonia pilosa, 8 parts Allium macrostemon, 10 parts Polygonum multiflorum vine, 8 parts Albizia julibrissin bark, 10 parts Platycladus orientalis seed, 20 parts Imperata cylindrica root, 8 parts Perilla frutescens leaf, 3 parts Sichuan pepper, 5 parts Magnolia officinalis bark; 20 parts olive oil emulsifying wax, 35 parts shea butter, 20 parts jojoba oil, 23 parts grapeseed oil, and 2 parts vitamin E.

[0034] Comparative Example 1

[0035] The herbal freckle-removing cream provided in this comparative example was prepared according to the method provided in CN 103356412A.

[0036] Experimental Example 1

[0037] A total of 120 volunteers with pigmentation issues such as melasma and sunspots (involving dry, oily, combination, and sensitive skin) were selected, including 45 males and 75 females, aged 20-55 years. The volunteers were randomly divided into treatment groups 1-3 and a control group, with 30 volunteers in each group. There were no statistically significant differences in age, gender, pigmentation type, or other general characteristics among the groups (P>0.05), making them comparable.

[0038] Treatment methods:

[0039] Treatment groups 1-3: Apply the herbal freckle-removing creams from Examples 1-3 twice a week for 4 weeks as one course of treatment, and continue for 3 courses of treatment.

[0040] Control group: The herbal freckle-removing cream applied to the control group (comparison ratio 1) was used in the same way as treatment groups 1-3, with the same usage and course of treatment.

[0041] Criteria for evaluating therapeutic efficacy:

[0042] Significant effect: The color of the pigmentation spot is significantly lighter, and the area of ​​the pigmentation spot disappears by more than 60% as seen by the naked eye; Improvement: The color of the pigmentation spot is lighter, and the area of ​​the pigmentation spot disappears by more than 30% and less than or equal to 60% as seen by the naked eye; Ineffective: The color of the pigmentation spot does not change significantly, and the area of ​​the pigmentation spot disappears by less than or equal to 30% as seen by the naked eye.

[0043] The results of each group of experiments are shown in Table 1 below.

[0044] Table 1

[0045]

[0046] Simultaneously, a questionnaire survey was conducted among volunteers in treatment groups 1-3 regarding their experience with the product and any rebound effects. The results showed that the product left the skin feeling smooth, moisturized, and non-greasy after application. There were no skin irritation reactions such as stinging, redness, or itching during use, and no significant rebound was observed after discontinuing use for 3 months.

[0047] The results show that the herbal freckle-removing cream of this invention can effectively lighten age spots, sun spots and other pigmentation, significantly improve skin radiance and smoothness, and has no obvious rebound after discontinuation. It is suitable for dry, oily, combination and sensitive skin, and has good safety and tolerability.

[0048] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A traditional Chinese medicine freckle-removing cream, characterized in that, Made from a decoction of traditional Chinese medicine and a natural oil-in-water emulsion system, the decoction of traditional Chinese medicine comprises the following medicinal materials in parts by weight: Rehmannia glutinosa 22-28 parts, Polygonatum odoratum 12-18 parts, winter melon seeds 12-18 parts, Bombyx mori 6-10 parts, Tribulus terrestris 6-10 parts, Crataegus pinnatifida 8-12 parts, Agrimonia pilosa 10-15 parts, Allium macrostemon 5-8 parts, Polygonum multiflorum vine 10-15 parts, Albizia julibrissin bark 8-12 parts, Platycladus orientalis seed 8-12 parts, Imperata cylindrica root 16-20 parts, Perilla frutescens leaf 4-8 parts, Zanthoxylum bungeanum 2-4 parts, Magnolia officinalis bark 3-6 parts; the natural oil-in-water emulsion system comprises the following raw materials in parts by weight: olive oil emulsifying wax 15-20 parts, shea butter 35-40 parts, jojoba oil 15-20 parts, grapeseed oil 22-28 parts, and vitamin E 1.5-2 parts.

2. The herbal freckle-removing cream according to claim 1, characterized in that, The decoction of the Chinese herbal medicines includes the following ingredients in parts by weight: 25 parts Rehmannia glutinosa, 15 parts Polygonatum odoratum, 15 parts winter melon seeds, 8 parts Bombyx mori, 8 parts Tribulus terrestris, 10 parts hawthorn, 12 parts Agrimonia pilosa, 6 parts Allium macrostemon, 12 parts Polygonum multiflorum vine, 10 parts Albizia julibrissin bark, 10 parts Platycladus orientalis seed, 18 parts Imperata cylindrica root, 6 parts Perilla frutescens leaf, 3 parts Sichuan pepper, and 5 parts Magnolia officinalis bark.

3. The herbal freckle-removing cream according to claim 1, characterized in that, The natural oil-in-water emulsion system comprises the following raw materials in parts by weight: 18 parts olive oil emulsifying wax, 36 parts shea butter, 18 parts jojoba oil, 25 parts grapeseed oil, and 1.8 parts vitamin E.

4. The herbal freckle-removing cream according to claim 1, characterized in that, The method for preparing the decoction of the traditional Chinese medicine includes: The medicinal materials were pulverized to 40 mesh and 10 times the amount of deionized water was added. The mixture was first soaked at 60°C for 30 minutes, then heated to 92°C and refluxed for 60 minutes at a gentle boil. Finally, the mixture was cooled to 80°C and extracted for another 30 minutes. After filtration, the residue was extracted again with 6 times the amount of water. The two filtrates were combined and concentrated under reduced pressure at 65°C until the relative density was 1.10-1.15 at 50°C, thus obtaining the decoction of the Chinese herbal medicine.

5. The preparation method of the herbal freckle-removing cream according to claim 1, characterized in that, The preparation method of the herbal freckle-removing cream includes: The decoction of the Chinese herbal medicines is heated to 75-80℃ and kept at that temperature to obtain the aqueous phase. Mix olive oil emulsified wax with shea butter, heat in a water bath to 75-80℃ to melt, then add jojoba oil and grapeseed oil, stir until the system is completely homogeneous and transparent, keep warm to obtain the oil phase; Under the stirring of a high-speed homogenizer at 2500 rpm, the oil phase is slowly and uniformly added to the aqueous phase. After the addition is complete, the temperature is maintained at 75-80℃ and homogenization is continued for 5 minutes. When the emulsion temperature drops below 45℃, vitamin E is added and stirred slowly until uniform. Finally, the emulsion is degassed under vacuum, cooled to room temperature, and then packaged to obtain the herbal freckle-removing cream.

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