An automatic device for determining the disintegration time limit of orally disintegrating tablets

CN122084846AActive Publication Date: 2026-05-26JINRI PHARM (CHINA) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINRI PHARM (CHINA) CO LTD
Filing Date
2026-04-24
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing oral disintegration tablet disintegration time limit testing devices cannot accurately identify the true disintegration state in the sieve adhering material and turbid medium during the research and development stage, resulting in misjudgment of disintegration endpoint, low testing efficiency and lack of process data to support formulation optimization.

Method used

The device employs a fully automated oral disintegration tablet disintegration time determination system, comprising a constant temperature water bath disintegration device, a reciprocating direct-drive immersion module, a standard sieve basket, a transparent observation water bath, and a force feedback detection mechanism. Through a suspension mechanism and an optical displacement detection system, it achieves objective and continuous monitoring of the disintegration process. The suspension adjustment ensures that the receiving mechanism is stably positioned directly below the lowest point of the sieve basket's trajectory, ensuring accurate collection of the falling disintegrated sediment. Data is fused through multi-level optical detection and the force feedback main detection system.

Benefits of technology

It enables objective and continuous monitoring of the disintegration process of orally disintegrating tablets, overcomes the subjective errors of traditional visual observation, provides accurate disintegration data, and provides objective and detailed data basis for analyzing the role of excipients and optimizing the formula during the research and development stage.

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Abstract

The present invention discloses a device for measuring the disintegration time limit of a fully automatic orally disintegrating tablet, belonging to the technical field of measuring the time limit of orally disintegrating tablets. It includes a constant temperature water bath disintegration device, on the surface of which a reciprocating direct drive immersion module is configured. The output end of the reciprocating direct drive immersion module is assembled with a standard sieve basket to drive the standard sieve basket to perform reciprocating lifting movements in the vertical direction. A transparent observation water bath cylinder for storing constant temperature water is configured at the position directly below the up and down lifting of the standard sieve basket. Through a suspension mechanism and an optical displacement detection system based on force feedback, objective and continuous monitoring of the disintegration process of the orally disintegrating tablet is realized, and the disintegration state that is difficult to judge by the naked eye in the prior art, especially in the case of turbid solution or adhesion, is converted into a continuously measurable signal, overcoming the problems of relying on subjective experience and being easily interfered by observation conditions in the prior art.
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