Amide-substituted cycloalkyl compounds, their preparation methods and their pharmaceutical applications
CN122094932APending Publication Date: 2026-05-26JIANGSU HENGRUI MEDICINE CO LTD +1
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Patent Information
- Application Number
- CN202480065504.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2024-03-19
- Filing Date
- 2024-10-11
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
The existing RXFP1 small molecule agonists have problems with short half-life and high clearance in terms of pharmacokinetic properties, resulting in limited efficacy and prone to side effects of hypotension.
Method used
An amide-substituted cycloalkyl compound is developed by the preparation method of the preparation of the compound and its pharmaceutically acceptable salts for use as a modulator of RXFP1 for the treatment and/or prevention of RXFP1-mediated or dependent diseases.
Benefits of technology
This compound has good pharmacokinetic properties, extends the half-life, reduces clearance, improves the durability of the drug effect, and reduces the risk of hypotension.
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Figure CN122094932A_ABST
Abstract
This disclosure relates to amide-substituted cycloalkyl compounds, their preparation methods, and their pharmaceutical applications. Specifically, this disclosure relates to an amide-substituted cycloalkyl compound of general formula (I), its preparation method, pharmaceutical compositions containing such compounds, and their use as therapeutic agents, particularly as RXFP1 modulators, and in the preparation of medicaments for treating and / or preventing RXFP1-mediated or dependent diseases or conditions.
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