Pharmaceutical composition for targeting neuroinflammation and application thereof

By scientifically combining multiple components of a targeted neuroinflammatory drug composition and modifying it to target the brain, multiple pathological aspects of vascular cognitive impairment are addressed, achieving highly effective neuroprotection and anti-inflammatory effects, making it suitable for industrial production.

CN122097368APending Publication Date: 2026-05-29海南省肿瘤医院(海南省肿瘤防治中心)
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Patent Information

Application Number
CN202610500570.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-16
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Current treatment options are unable to effectively block the pathological progression of vascular cognitive impairment. Single-target drugs have weak effects, natural active ingredients have low penetration rates, and existing nanodelivery carriers have poor biocompatibility, making it difficult to achieve effective treatment.

Method used

The drug composition targeting neuroinflammation consists of multiple active ingredients and plant-derived extracellular vesicles. It forms a two-level delivery system through brain-targeted modification to achieve full-chain intervention and improve the enrichment efficiency of active ingredients in central lesions.

Benefits of technology

It significantly improves cognitive function, reverses neuroinflammation and blood-brain barrier damage, has disease-modifying effects, is highly safe, and is suitable for industrial production.

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Abstract

The invention provides a pharmaceutical composition for targeting neuroinflammation and application thereof, the composition is composed of an active component and a natural nano delivery carrier for encapsulating and loading the active component, the active component comprises fisetin, pyrroloquinoline quinone, resveratrol, oroxylin A, apigenin, crocin, quercetin and picosin; the natural nano delivery carrier is a plant source extracellular vesicle of which the surface is modified with brain targeting molecules. The composition realizes intervention on vascular cognitive impairment through scientific compatibility of multiple components, overcomes the pain points of low blood-brain barrier penetration rate and poor bioavailability of natural active components by combining with a two-stage brain-targeted delivery design, has the effects of strongly resisting inflammation and remarkably improving the cognitive function, is excellent in safety, and is suitable for clinical application. The polypeptide can be used for preparing drugs for prevention or adjuvant therapy of neuroinflammation-related vascular cognitive impairment, and has extremely high clinical transformation value.
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