Degradable metal barrier membrane for alveolar ridge preservation and uses thereof

Abstract

A kind of degradable metal barrier film for alveolar ridge preservation, made of degradable metal, the degradable metal is magnesium-based or zinc-based or molybdenum-based degradable metal material;The degradable metal barrier film is in film or in net shape, the metal barrier film is flat structure or in arched structure.The degradable metal barrier film for alveolar ridge preservation of the application, the degradable metal system (magnesium-based / zinc-based / molybdenum-based) is applied to oral site preservation for the first time, realizes the integration of the triple function of "mechanical support, biodegradation, biological activity".The degradable metal barrier film can be used as the preparation of medical devices for alveolar ridge preservation.

Description

Technical Field

[0001] This invention relates to the field of oral medicine technology, and in particular to a biodegradable metal barrier membrane for alveolar ridge preservation and its uses. Background Technology

[0002] After tooth extraction, the blood clot in the alveolar socket is unstable, and the gingival soft tissue often collapses into the socket. Simultaneously, the alveolar bone wall undergoes physiological resorption due to the loss of physiological stimulation, leading to a loss of alveolar ridge height and width. This insufficient bone volume can cause significant difficulties for subsequent implant restorations or fixed prosthetic restorations. Alveolar ridge preservation (also known as extraction site preservation or alveolar bone site preservation) refers to methods used during or after tooth extraction to maximize the preservation of the alveolar ridge morphology after the extraction socket heals. This involves surgical procedures such as immediately implanting bone augmentation material into the extraction socket, covering the wound surface with a collagen membrane or transplanted mucosa, aiming to reduce alveolar socket bone wall resorption and soft tissue collapse during the healing process.

[0003] To address this issue, the "extraction site preservation" technique is commonly used clinically. Its core principle is to maintain the space in the bone defect and promote bone regeneration using various barrier or bone-healing-promoting instruments. Currently, the mainstream site preservation instruments are mainly divided into three categories: the first category is non-degradable metal membranes, represented by titanium membranes; the second category is natural biomembranes, represented by collagen membranes; and the third category is synthetic biodegradable polymer membranes, represented by polylactic acid (PLA), polyglycolic acid (PGA), and their copolymer membranes. Among these, titanium membranes, with their excellent mechanical strength, can effectively resist soft tissue compression to maintain bone growth space, but require a second surgery for removal; collagen membranes are natural biodegradable materials and do not require a second surgery, but their mechanical support is extremely poor, easily collapsing under chewing pressure or soft tissue traction, and their bone-inducing activity is weak; while synthetic polymer membranes combine biodegradability with a certain degree of mechanical strength, their degradation products easily trigger local inflammatory reactions, and they lack active bone-inducing ability, resulting in limited bone growth.

[0004] Therefore, it is essential to develop a biodegradable metal barrier membrane for alveolar ridge preservation that possesses sufficient mechanical strength to maintain space, is biodegradable to avoid secondary surgery, has anti-infective activity, and can actively promote new bone formation, and its applications are necessary to overcome the shortcomings of existing technologies. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of existing technologies and provide a biodegradable metal barrier membrane for alveolar ridge preservation, which integrates the functions of "mechanical support, biodegradation, and bioactivity". This biodegradable metal barrier membrane can be used as a medical device for the preparation of alveolar ridge preservation.

[0006] The above-mentioned objectives of the present invention are achieved through the following technical measures.

[0007] A biodegradable metal barrier membrane for alveolar ridge preservation is provided, which is made of a biodegradable metal, wherein the biodegradable metal is a magnesium-based, zinc-based, or molybdenum-based biodegradable metal material; The biodegradable metal barrier membrane is in the form of a membrane or a mesh, and the metal barrier membrane has a planar structure or an arched structure.

[0008] Preferably, in the above-mentioned biodegradable metal barrier membrane for alveolar ridge preservation, the biodegradable metal is a magnesium-based biodegradable metal, and the magnesium-based biodegradable metal is high-purity magnesium or medical magnesium alloy with a purity of not less than 99.9 wt.%.

[0009] Preferably, in the above-mentioned biodegradable metal barrier membrane for alveolar ridge preservation, the magnesium-based biodegradable metal is pure magnesium or a medical magnesium alloy, and the medical magnesium alloy is a magnesium-calcium (Mg-Ca), magnesium-zinc (Mg-Zn), magnesium-strontium (Mg-Sr) alloy, etc.

[0010] In another preferred embodiment, the biodegradable metal barrier membrane for alveolar ridge preservation described above is a zinc-based biodegradable metal, which is pure zinc or a medical zinc alloy.

[0011] Preferably, in the above-mentioned biodegradable metal barrier membrane for alveolar ridge preservation, the zinc-based biodegradable metal is a medical zinc alloy, such as a zinc-magnesium (Zn-Mg) or zinc-lithium (Zn-Li) alloy.

[0012] In another preferred embodiment, the biodegradable metal barrier membrane for alveolar ridge preservation is a molybdenum-based biodegradable metal, which is pure molybdenum or a medical-grade molybdenum alloy; the medical-grade molybdenum alloy is a molybdenum-rhenium or molybdenum-zinc-copper alloy.

[0013] Furthermore, the biodegradable metal barrier membrane used for alveolar ridge preservation has a thickness of 0.05 mm to 0.5 mm.

[0014] Furthermore, the aforementioned biodegradable metal barrier membrane for alveolar ridge preservation has a degradation time that matches the initial healing and bone remodeling cycle of the extraction socket, thus preventing the occurrence and progression of alveolar bone defects after tooth extraction and delaying alveolar bone resorption. Preferably, the degradation time of the biodegradable metal barrier membrane is 3-6 months.

[0015] Furthermore, the aforementioned biodegradable metal barrier membrane for alveolar ridge preservation has a surface with a micro-nano-scale rough structure, a biodegradable polymer coating, a biodegradable inorganic coating, or a coating loaded with bioactive substances.

[0016] Furthermore, the aforementioned biodegradable metal barrier membrane for alveolar ridge preservation is provided with extension wings or with small holes for use with fixation pins.

[0017] The present invention also provides the use of the above-mentioned biodegradable metal barrier membrane for alveolar ridge preservation in the preparation of medical devices for alveolar ridge preservation.

[0018] This invention relates to a biodegradable metal barrier membrane for alveolar ridge preservation, made of a biodegradable metal, specifically a magnesium-based or zinc-based biodegradable metal material. The biodegradable metal barrier membrane is membrane-like or mesh-like, and has a planar or arched structure. This invention innovatively applies a biodegradable metal system (magnesium-based / zinc-based) to oral site preservation, achieving a triple function of "mechanical support, biodegradation, and bioactivity." This invention innovatively selects magnesium-based or zinc-based metals that can be safely degraded in vivo as the core material. Their metallic properties provide immediate and sufficient mechanical strength, effectively resisting soft tissue pressure and achieving reliable "tent-like" space maintenance, overcoming the shortcomings of easily collapsing collagen membranes. Furthermore, as a biodegradable metal, its degradation cycle can be controlled through composition and process to match the bone healing cycle, avoiding the need for secondary surgery with titanium membranes. Additionally, the degradation product Mg of the magnesium-based biodegradable metal... 2+ It is itself an effective osteogenic inducer, actively stimulating bone regeneration at the molecular biological level, thus solving the problem of bioinertness in synthetic polymer membranes and other materials; when zinc-based biodegradable metals are used, their degradation product Zn 2+ In addition to its osteogenic properties, it also possesses excellent antibacterial properties, effectively reducing the risk of infection after tooth extraction. Therefore, the magnesium-based and zinc-based biodegradable metal barrier membrane provided by this invention combines sufficient mechanical strength to maintain space, biodegradability to avoid secondary surgery, and the ability to actively promote new bone formation. This biodegradable metal barrier membrane can be used as a medical device for alveolar ridge preservation. Attached Figure Description

[0019] The invention will be further described with reference to the accompanying drawings, but the contents of the drawings do not constitute any limitation on the invention.

[0020] Figure 1 This is a schematic diagram of a biodegradable metal barrier membrane for alveolar ridge preservation according to the present invention.

[0021] Figure 2 This is another schematic diagram of a biodegradable metal barrier membrane for alveolar ridge preservation according to the present invention.

[0022] Figure 3 This is another schematic diagram of a biodegradable metal barrier membrane for alveolar ridge preservation according to the present invention.

[0023] Figure 4 This is an example of the use of a biodegradable metal barrier membrane for alveolar ridge preservation in site preservation surgery according to the present invention.

[0024] Figure 5 This is a schematic diagram of a biodegradable metal barrier membrane for alveolar ridge preservation, as described in Example 3.

[0025] Figure 6 This is a schematic diagram of the biodegradable metal barrier membrane for alveolar ridge preservation in Example 4.

[0026] Figure 7 This is an example of the use of a biodegradable metal barrier membrane for alveolar ridge preservation in site preservation surgery, according to Embodiment 6 of the present invention.

[0027] Figure 8 This is an example of the use of a biodegradable metal barrier membrane for alveolar ridge preservation in site preservation surgery, as described in Embodiment 7 of the present invention.

[0028] exist Figures 1 to 8 Including: Biodegradable metal barrier membrane 100, extended wings 200, pores 300. Detailed Implementation

[0029] The present invention will be further described in conjunction with the following embodiments.

[0030] Example 1 A biodegradable metal barrier membrane 100 for alveolar ridge preservation is made of a biodegradable metal, which may be magnesium-based, zinc-based, or molybdenum-based biodegradable metal materials. The biodegradable metal barrier membrane 100 can cover and provide tent-like support to the bone defect area after tooth extraction. The biodegradable metal barrier membrane 100 is membrane-like (e.g., Figure 1 (as shown) or in a mesh-like pattern (such as) Figure 2 As shown), the metal barrier membrane has a planar structure (e.g. Figure 1 , Figure 2 (as shown) or in an arched structure (such as) Figure 3 (As shown).

[0031] It should be noted that in this embodiment, the biodegradable metal barrier film 100 is mesh-like, and the mesh is a structure composed of multiple interconnected pores. Figure 2 The diagram shown is merely an illustration of a mesh structure; the shape and arrangement of the mesh are not limited to this. Figure 2 The mesh structure can also take other forms, all of which are within the protection scope of this invention.

[0032] The biodegradable metal barrier membrane 100 is membrane-like and can be a planar structure or an arched structure. The biodegradable metal barrier membrane 100 can also be mesh-like, and the metal barrier membrane can be a planar structure or an arched structure.

[0033] The macroscopic morphology of the barrier membrane includes, but is not limited to: membrane-like, mesh-like, porous scaffold-like, as well as micro-arched, dome-like, or 3D-shaped forms with specific curvatures that match the anatomical morphology of the alveolar socket, designed to better maintain space, with the intention of covering and tent-like supporting the bone defect area after tooth extraction to match the anatomical morphology of the alveolar socket.

[0034] The magnesium-based biodegradable metal is high-purity magnesium or medical-grade magnesium alloy with a purity of not less than 99.9 wt.%. Medical-grade magnesium alloys are preferably magnesium-calcium (Mg-Ca), magnesium-zinc (Mg-Zn), or magnesium-strontium (Mg-Sr) alloys.

[0035] Zinc-based biodegradable metals are pure zinc or medical-grade zinc alloys. Preferred medical-grade zinc alloys include zinc-magnesium (Zn-Mg) and zinc-lithium (Zn-Li) alloys.

[0036] Molybdenum-based biodegradable metals are pure molybdenum or medical-grade molybdenum alloys. Medical-grade molybdenum alloys are molybdenum-rhenium and molybdenum-zinc-copper alloys.

[0037] The biodegradable metal barrier membrane 100 for alveolar ridge preservation has a thickness of 0.05 mm to 0.5 mm to ensure sufficient support while taking into account the flexibility during implantation and the expected biodegradability.

[0038] The biodegradable metal barrier membrane 100 for alveolar ridge preservation has a degradation time that matches the initial healing and bone remodeling cycle of the extraction socket, aiming to prevent the occurrence and progression of alveolar bone defects after tooth extraction and delay alveolar bone resorption. The preferred degradation time for the biodegradable metal barrier membrane 100 is 3-6 months. The degradation rate of the barrier membrane can be controlled by selecting the material system (magnesium-based / zinc-based), alloy composition design, and surface modification. For magnesium-based barrier membranes, primarily used for early space maintenance and osteogenic induction, the target degradation time is preferably 3 to 6 months to match the initial healing and bone remodeling cycle of the extraction socket. For zinc-based barrier membranes, the degradation cycle can be adjusted according to the alloy composition design.

[0039] The specific steps for using the barrier membrane in alveolar ridge preservation surgery according to this embodiment are as follows: 1) After a routine tooth extraction, the extraction socket is cleaned. 2) Select a biodegradable metal barrier membrane with an appropriate shape and size based on the shape and size of the bone defect; 3) Optionally, bone graft material may be filled into the extraction socket; 4). Cover or implant the barrier membrane into the bone defect area, so that its edges are in contact with the bone wall or gingival soft tissue, and fix it with absorbable sutures or fixation pins; 5) During the postoperative healing period, the barrier membrane gradually degrades, releasing ions to promote bone formation, and is basically degraded within 3-6 months, without the need for a second surgery to remove it.

[0040] Figure 4 The illustration shows an example of the use of the barrier membrane in site preservation surgery, using a thin gingival alveolar bone extraction model as an example. From left to right, the images are: ① a lateral section view before extraction; ② the extraction socket after extraction, where the labial alveolar bone wall is extremely thin, making it prone to severe alveolar bone resorption; ③ the biodegradable metal barrier membrane is placed at the extraction socket location; ④ good alveolar ridge preservation can be achieved after healing.

[0041] This embodiment of the biodegradable metal barrier membrane for alveolar ridge preservation innovatively applies a biodegradable metal system (magnesium-based / zinc-based / molybdenum-based) to oral site preservation, achieving a triple function of "mechanical support, biodegradation, and bioactivity." This invention innovatively selects magnesium-based or zinc-based metals that can be safely degraded in vivo as the core material. Their metallic properties provide immediate and sufficient mechanical strength, effectively resisting soft tissue pressure and achieving reliable "tent-like" space maintenance, overcoming the shortcomings of collagen membranes, which are prone to collapse. Simultaneously, as a biodegradable metal, its degradation cycle can be controlled through composition and process to match the bone healing cycle, avoiding the need for secondary surgery on titanium membranes. Furthermore, the degradation product Mg of the magnesium-based biodegradable metal... 2+ It is itself an effective osteogenic inducer, actively stimulating bone regeneration at the molecular biological level, thus solving the problem of bioinertness in synthetic polymer membranes and other materials; when zinc-based biodegradable metals are used, their degradation product Zn 2+ In addition to its osteogenic properties, it also possesses excellent antibacterial properties, effectively reducing the risk of infection after tooth extraction. Therefore, the magnesium-based and zinc-based biodegradable metal barrier membrane provided by this invention combines sufficient mechanical strength to maintain space, biodegradability to avoid secondary surgery, anti-infection capabilities, and the ability to actively promote new bone formation. This biodegradable metal barrier membrane can be used as a medical device for alveolar ridge preservation.

[0042] This embodiment presents a biodegradable metal barrier membrane for alveolar ridge preservation, featuring a customizable morphology and function, and broad clinical applicability. The invention innovatively designs a multi-morphological structural system (membrane, mesh, scaffold, 3D stereoscopic morphology), particularly micro-arched, dome-shaped, and 3D structures with specific curvatures, adapting to extraction sites with different anatomical shapes, maximizing bone regeneration space, and solving the problem of poor adaptability of existing planar structures. Furthermore, this invention can be further modified using surface micro / nano structures, bio-coatings, and drug delivery technologies to impart additional functions such as promoting cell adhesion, regulating degradation rate, providing local anti-infection, or enhancing osteogenic formation, achieving personalized treatment and overcoming the limitations of traditional single-function instruments.

[0043] Example 2 A biodegradable metal barrier membrane for alveolar ridge preservation is identical in other structures to that in Example 1, except that the biodegradable metal barrier membrane for alveolar ridge preservation has a micro-nano-scale rough structure, a biodegradable polymer coating, or a coating loaded with bioactive substances on its surface.

[0044] The surface of the barrier membrane can be modified according to clinical needs, including: 1. Micro- or nano-scale rough structures (i.e., micro- and nano-structures) are prepared by methods such as chemical etching, anodizing, or laser processing to increase specific surface area and promote cell adhesion and growth.

[0045] 2. Prepare biodegradable polymer coatings (such as polylactic acid and chitosan) by dip coating, spin coating or vapor deposition to precisely control their initial degradation rate in the body fluid environment.

[0046] 3. Load bioactive substances, such as bone growth factor (BMP-2), antibiotics (such as minocycline), or trace elements (such as strontium ions), through physical adsorption or covalent grafting.

[0047] This invention can further endow it with additional functions such as promoting cell adhesion, regulating degradation rate, local anti-infection or enhancing osteogenicity through surface micro-nano structures, bio-coatings and drug loading, so as to achieve personalized treatment and break through the limitation of the single function of traditional instruments.

[0048] Example 3 A biodegradable metal barrier membrane for alveolar ridge preservation, with other structures the same as in Example 1 or 2, except that: the biodegradable metal barrier membrane 100 for alveolar ridge preservation is provided with extension wings 200, such as... Figure 5 As shown. When the barrier membrane is covered or implanted in the bone defect area, its edges are made to fit the bone wall or gingival soft tissue, and it is fixed with absorbable sutures using its own extension wings.

[0049] The barrier membrane features a fixation structure at its edge, ensuring stable and easy fixation. The extended wings at the edge of the barrier membrane provide a reliable and flexible fixation method, ensuring the stability of the implant during surgery, preventing postoperative displacement, simplifying the surgeon's procedure, and improving the predictability of the surgery.

[0050] Example 4 A biodegradable metal barrier membrane for alveolar ridge preservation, with other structures the same as in Example 1 or 2, except that: this biodegradable metal barrier membrane 100 for alveolar ridge preservation has small holes 300 for use with fixation pins, such as... Figure 6 As shown. The small hole 300 is used with a fixation pin, which can be used to fix the membrane through the small hole 300. When the barrier membrane is covered or implanted in the bone defect area, its edges are made to fit the bone wall or gingival soft tissue, and it is fixed by the fixation pin through its own fixation hole.

[0051] The barrier membrane has small holes 300 at its edge for fixation, providing stable fixation and ease of operation. These small holes at the edge of the barrier membrane offer a reliable and flexible fixation method, ensuring the stability of the implant during surgery, preventing postoperative displacement, simplifying the surgeon's procedure, and improving the predictability of the surgery.

[0052] Example 5 Use of the biodegradable metal barrier membrane for alveolar ridge preservation, as described in any one of Examples 1 to 4, in the preparation of a medical device for alveolar ridge preservation.

[0053] The solution in this embodiment has the following advantages: 1. This invention innovatively applies a biodegradable metal system (magnesium-based / zinc-based / molybdenum-based) to oral site preservation, achieving a triple function of "mechanical support, biodegradation, and bioactivity." This invention innovatively selects magnesium-based or zinc-based metals that can be safely degraded in vivo as the core material. Their metallic properties provide immediate and sufficient mechanical strength, effectively resisting soft tissue pressure and achieving reliable "tent-like" space maintenance, overcoming the shortcomings of collagen membranes and other materials prone to collapse. Simultaneously, as biodegradable metals, their degradation cycle can be controlled through composition and process to match the bone healing cycle, avoiding the need for secondary surgery on titanium membranes. Furthermore, the degradation product Mg of the magnesium-based biodegradable metal... 2+ It is itself an effective osteogenic inducer, actively stimulating bone regeneration at the molecular biological level, thus solving the problem of bioinertness in synthetic polymer membranes and other materials; when zinc-based biodegradable metals are used, their degradation product Zn 2+ In addition to its osteogenic properties, it also possesses excellent antibacterial properties, effectively reducing the risk of infection after tooth extraction. Therefore, the magnesium-based and zinc-based biodegradable metal barrier membranes provided by this invention offer clinicians a wider range of options for different patient conditions.

[0054] 2. Customizable morphology and function, with broad clinical adaptability. This invention innovatively designs a multi-morphological structural system (membrane, mesh, scaffold, 3D three-dimensional morphology), especially micro-arched, dome-shaped, and 3D structures with specific curvatures, to adapt to extraction sites with different anatomical shapes, maximizing bone regeneration space and solving the problem of poor adaptability of existing planar structures. Furthermore, this invention can be further modified with surface micro-nano structures, bio-coatings, and drug delivery technologies to provide additional functions such as promoting cell adhesion, regulating degradation rate, local anti-infection, or enhancing osteogenic formation, achieving personalized treatment and overcoming the limitations of traditional single-function instruments.

[0055] 3. Stable fixation and easy operation. The extended wings or fixation holes designed at the edge of the barrier membrane provide a reliable and flexible fixation method, ensuring the stability of the implant during surgery, preventing postoperative displacement, simplifying the surgeon's operation, and improving the predictability of the surgery.

[0056] Example 6 The biodegradable metal barrier membrane for alveolar ridge preservation, as described in any of Examples 1 to 4, is used in the alveolar ridge preservation surgery of this embodiment. Figure 7 As shown, examples of its use in site preservation surgery, from left to right, are: ① the extraction socket after tooth extraction; ② placing the barrier membrane at the labial bone defect site, with or without collagen membrane (collagen plug) covering the crown of the extraction socket; ③ achieving good alveolar ridge preservation after healing.

[0057] The biodegradable metal barrier membrane for alveolar ridge preservation in this embodiment has the characteristics of integrating three functions: mechanical support, biodegradation, and bioactivity.

[0058] Example 7 The biodegradable metal barrier membrane for alveolar ridge preservation, as described in any of Examples 1 to 4, is used in the alveolar ridge preservation surgery of this embodiment. Figure 8 The following are examples of the use of the barrier membrane in immediate implant surgery, from left to right: ① Extraction socket after tooth extraction; ② The barrier membrane is placed at the labial bone defect site, bone filling material can be placed in the extraction socket, and the implant can be inserted. The coronal side may or may not be covered with a collagen membrane; ③ After healing, good alveolar ridge preservation and implant-osseointegration can be achieved. The biodegradable metal barrier membrane for alveolar ridge preservation in this embodiment has the characteristics of integrating "mechanical support, biodegradation, and bioactivity".

[0059] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A degradable metal barrier membrane for alveolar ridge preservation, characterized by: Made of a biodegradable metal, wherein the biodegradable metal is a magnesium-based, zinc-based, or molybdenum-based biodegradable metal material; The biodegradable metal barrier membrane is in the form of a membrane or a mesh, and the metal barrier membrane has a planar structure or an arched structure.

2. The degradable metal barrier film for alveolar ridge preservation according to claim 1, wherein: The biodegradable metal is a magnesium-based biodegradable metal, which is high-purity magnesium or medical magnesium alloy with a purity of not less than 99.9 wt.%; the medical magnesium alloy is a magnesium-calcium, magnesium-zinc, or magnesium-strontium alloy.

3. The degradable metal barrier film for alveolar ridge preservation according to claim 1, wherein: The biodegradable metal is a zinc-based biodegradable metal, which is pure zinc or a medical zinc alloy; the medical zinc alloy is a zinc-magnesium or zinc-lithium alloy.

4. The biodegradable metal barrier membrane for alveolar ridge preservation according to claim 1, characterized in that: The biodegradable metal is a molybdenum-based biodegradable metal, which is pure molybdenum or a medical-grade molybdenum alloy; the medical-grade molybdenum alloy is a molybdenum-rhenium or molybdenum-zinc-copper alloy.

5. The biodegradable metal barrier membrane for alveolar ridge preservation according to any one of claims 1 to 4, characterized in that: The thickness of the biodegradable metal barrier film is 0.05 mm to 0.5 mm.

6. The biodegradable metal barrier membrane for alveolar ridge preservation according to claim 5, characterized in that: The degradation time of the biodegradable metal barrier membrane is matched with the initial healing and bone remodeling cycle of the extraction socket.

7. The biodegradable metal barrier membrane for alveolar ridge preservation according to claim 6, characterized in that: The degradation time of the biodegradable metal barrier membrane is 3-6 months.

8. The biodegradable metal barrier membrane for alveolar ridge preservation according to claim 6, characterized in that: The surface of the biodegradable metal barrier membrane has a micro-nano-scale rough structure, a biodegradable polymer coating, an inorganic coating, or a coating loaded with bioactive substances.

9. The biodegradable metal barrier membrane for alveolar ridge preservation according to claim 8, characterized in that: The biodegradable metal barrier film is provided with extended wings or with small holes for use with fixing nails.

10. Use of the biodegradable metal barrier membrane for alveolar ridge preservation as described in any one of claims 1 to 9 in the preparation of a medical device for alveolar ridge preservation.

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