A probe for early screening of oral cancer based on saliva, a non-invasive visualization kit and its use and method of use

By regulating the amount of VEGF165 protein in saliva using the VEGF165-G4probe probe and utilizing the catalytic activity of G4zyme, a non-invasive, simple, and highly sensitive screening method for oral squamous cell carcinoma can be achieved. This method solves the problems of high invasiveness, high false positive rate, complex operation, and high cost in existing technologies, and provides a screening method with high specificity and high sensitivity.

CN122104713APending Publication Date: 2026-05-29SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Filing Date
2026-01-28
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing technologies are insufficient for non-invasive, simple, and highly sensitive screening and auxiliary diagnosis of oral squamous cell carcinoma, especially due to the problems of traditional methods being highly invasive, having a high false positive rate, being complex to operate, or being costly.

Method used

The VEGF165-G4probe probe was used to form G4zyme by binding the VEGF165 aptamer to Hemin. The catalytic activity of G4zyme was regulated by the change in the amount of VEGF165 protein in saliva, so as to achieve visual detection. A VEGF165-G4probe kit was constructed for oral cancer screening.

Benefits of technology

It achieves highly specific and sensitive screening for oral squamous cell carcinoma, simplifies the operation process, reduces the false positive rate, and lowers costs.

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Abstract

The application discloses a probe for early screening of oral cancer based on saliva, a non-invasive visualization kit and purposes and use methods thereof, a basic principle of combining a key sequence of a VEGF165 aptamer with a G4zyme structure is used to design a VEGF165-G4 probe for early screening of oral cancer based on saliva, and then a non-invasive visualization VEGF165-G4 probe kit is prepared by using the probe, and the probe or the kit can be used for screening early oral cancer. The VEGF165-G4 probe kit is used for extensive screening of oral squamous cell carcinoma, and has the advantages of non-invasiveness, high specificity and strong sensitivity.
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