A neurology cerebrospinal fluid sampling and testing device

Abstract

The application belongs to the technical field of auxiliary diagnosis of neurological diseases, and discloses a cerebrospinal fluid sampling and detecting device for neurology, which comprises a neutralizing cylinder, an acidifying cylinder, an air storage cylinder and a fixing frame, and a sample storage assembly is arranged on the fixing frame; an air inlet pipe is arranged in the inner cavity of the neutralizing cylinder, a sealing cover is arranged on the top of the neutralizing cylinder, and a one-way valve is arranged on the sealing cover and the air inlet end of the air inlet pipe; the top of the acidifying cylinder is connected with the bottom of the neutralizing cylinder, a needle tube is arranged at the bottom of the acidifying cylinder, a one-way valve is arranged on the top of the needle tube, and the main air pipe on the side of the acidifying cylinder is connected with the air storage cylinder through a connecting seat; the air storage cylinder is connected with the connecting seat through an air cylinder interface, a certain amount of inert gas is stored in the air storage cylinder, and a piston is arranged in the air storage cylinder; by means of injection and back extraction of the air storage cylinder, the processes of air exclusion, sample suction and hydrogen sulfide gas purging can be completed, the operation is simple and convenient, and a good reaction environment is provided; the neutralizing cylinder and the acidifying cylinder are simple in structure and can be used as disposable consumables without cleaning.

Description

Technical Field

[0001] This invention relates to the field of auxiliary diagnostic technology for neurological diseases, and in particular to a cerebrospinal fluid sampling and testing device for neurology. Background Technology

[0002] Cerebrospinal fluid (CSF) is a transparent fluid located between the ventricles, spinal canals, and meninges of the brain. It plays a buffering and protective role, and abnormal changes in CSF are often associated with neurological diseases. The hydrogen sulfide content in CSF is a reference for diagnosing various diseases, such as Down syndrome and Alzheimer's disease. Hydrogen sulfide in CSF typically exists in two forms: free H₂S and acid-labile sulfides. Currently, its detection usually involves acidification with phosphoric acid to release the hydrogen sulfide. Due to its poor stability, it is then dissolved in sodium hydroxide solution for neutralization, forming stable sulfides for detection. Therefore, appropriate sampling and detection devices are used.

[0003] In the prior art, Chinese Patent CN115541861B discloses a neurological fluid sampling and detection device. This device, comprising a sampling component, a reaction component, and a measuring component, processes hydrogen sulfide in cerebrospinal fluid. However, in actual use, to minimize the influence of air, operators need to manually pull the syringe to draw the sample, then invert the sampling component and install it onto the reaction component. The syringe is then pushed to inject the sample from the sampling component into the reaction component. Additionally, the syringe is used to vent gas through multiple air nozzles. Finally, pressing the elastic sheet punctures the inner chamber, allowing sodium hydroxide to enter the third inner bag and react with the hydrogen sulfide. The current methods are cumbersome, and the empty spaces within the reaction components always contain air, which oxidizes the released hydrogen sulfide, leading to a decrease in its concentration. Another Chinese patent, CN119198208B, discloses a cerebrospinal fluid sampling and detection device for neurology. While this reduces operator workload, its structure is more complex, requiring cleaning and disinfection after use, making it unsuitable for disposable containers and posing a risk of sample contamination. Furthermore, the internal space still contains air, affecting subsequent testing. The aforementioned devices also suffer from the problem of hydrogen sulfide gas remaining in the reaction components for too long, easily adhering to the inner walls and resulting in lower detected concentrations. Therefore, there is an urgent need for a sampling and detection device with a simple structure, convenient operation, and reduced air interference to meet current usage requirements. Summary of the Invention

[0004] The present invention aims to provide a cerebrospinal fluid sampling and detection device for neurology, in order to solve the problems of complex structure, cumbersome operation and poor reaction environment of the current devices.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A neurological cerebrospinal fluid sampling and testing device includes a neutralization cylinder, an acidification cylinder, a gas storage cylinder, and a fixing frame. The neutralization cylinder, acidification cylinder, and gas storage cylinder are all mounted on the fixing frame, and a sample storage component is mounted on the fixing frame. The sample storage component is located below the acidification cylinder.

[0007] The neutralization cylinder is equipped with an air inlet pipe, which is M-shaped. Its two ends are the air outlets, located in the inner cavity of the neutralization cylinder, and its middle part is the air inlet. It passes through the bottom of the neutralization cylinder and communicates with the inner cavity of the acidification cylinder. The top of the neutralization cylinder is equipped with a sealing cover. Both the sealing cover and the air inlet end of the air inlet pipe are equipped with one-way valves. The one-way valve on the sealing cover only allows gas to be discharged outside the neutralization cylinder, while the one-way valve at the air inlet end of the air inlet pipe only allows gas to enter the neutralization cylinder.

[0008] The top of the acidification cylinder is connected to the bottom of the neutralization cylinder. A needle tube is installed at the bottom of the acidification cylinder, and the top of the needle tube is located inside the acidification cylinder. A one-way valve is installed at the top of the needle tube, which only allows gas or liquid to enter the acidification cylinder through the needle tube. A main gas pipe is installed on the side of the acidification cylinder, and the main gas pipe is connected to the gas storage cylinder through a connecting seat.

[0009] The bottom of the gas storage cylinder is equipped with a gas cylinder interface, and a valve assembly is installed inside the gas cylinder interface. The gas cylinder interface is connected to a connecting seat. The gas storage cylinder stores a certain amount of inert gas. A piston is slidably installed inside the gas storage cylinder. A connecting rod is installed on the piston to drive the piston to move. The connecting rod is connected to a drive assembly on a fixed frame and moves with the drive assembly.

[0010] Furthermore, the valve assembly includes a positioning post fixedly installed in the air cylinder interface and a valve plug slidably installed at the bottom of the positioning post. The valve plug is in the shape of an inverted frustum and seals the valve port at the bottom of the air cylinder interface. A positioning spring is sleeved on the positioning post to limit the position of the valve plug. The valve plug is located directly above the ejector pin assembly, which is installed in the connecting seat.

[0011] Furthermore, a connecting pipe is provided on the connecting seat, which is connected to the main air pipe. The ejector assembly includes a ejector rod that is movably set inside the connecting seat and a lead screw that is rotatably set. The top end of the lead screw passes through the bottom end of the ejector rod, and the two are threaded together. The top end of the ejector rod is located in the inner cavity of the connecting seat, directly below the valve plug.

[0012] Furthermore, the needle tube is equipped with a side connector, which is equipped with a one-way valve. The one-way valve is connected to one end of the auxiliary air tube, and the other end of the auxiliary air tube extends out of the acidification cylinder and is connected to the suction tube inside the fixture. The other end of the suction tube is connected to the syringe.

[0013] Furthermore, the one-way valve includes a valve body and a flexible diaphragm disposed on the valve body. The valve body has several valve holes, and the flexible diaphragm blocks the valve holes. The flexible diaphragm can deform under force.

[0014] Furthermore, the sample storage assembly includes a movable sleeve that is slidably mounted on a fixed column, a placement cylinder mounted on the movable sleeve, and a sample storage tube mounted on the placement cylinder. The fixed column is mounted on a fixed frame and has a sliding groove and several positioning holes. A positioning pin and a compression spring that pushes the positioning pin to move are slidably mounted inside the movable sleeve. In the initial state, the positioning pin is located in one of the positioning holes.

[0015] Furthermore, the fixed frame is provided with several fixing rings, and the gas storage cylinder and the connecting seat are respectively inserted into the corresponding fixing rings. The gas storage cylinder is located above the connecting seat. The fixed frame is provided with several elastic clamps, and the neutralization cylinder and the acidification cylinder are clamped and fixed in the corresponding elastic clamps.

[0016] Furthermore, the drive assembly includes an electric cylinder mounted on a fixed frame and a control end, the control end being configured to control the electric cylinder to perform telescopic movements, and a retaining plate being provided at the top of the telescopic end of the electric cylinder, the retaining plate being connected to the top of the connecting rod on the piston.

[0017] Furthermore, the neutralization cylinder is equipped with several guide plates arranged at an angle and in a staggered manner to guide the gas to move in an S-shaped path within the neutralization cylinder cavity. The neutralization cylinder is also equipped with a fixed cylinder that penetrates all the guide plates. The top opening of the fixed cylinder is higher than the topmost set of guide plates, and the bottom opening is lower than the bottommost set of guide plates.

[0018] Furthermore, both the neutralization cylinder and the acidification cylinder are made of transparent material, and both have scale lines printed on their surfaces.

[0019] The principles and beneficial effects of the technical solution are as follows:

[0020] This invention provides a cerebrospinal fluid sampling and detection device for neurology.

[0021] 1. Connect the neutralization cylinder, acidification cylinder, and gas storage cylinder in a corresponding airtight sequence. Push the gas storage cylinder to allow the inert gas inside to enter the acidification cylinder. This will cause the air in the acidification cylinder to enter the neutralization cylinder through the air inlet pipe. After the inert gas and air enter the neutralization cylinder, they will cause the air in the neutralization cylinder to be discharged together through the one-way valve on the sealing cap until the air in the neutralization cylinder and the acidification cylinder are completely discharged and filled with inert gas. Under the action of the one-way valve, air will not enter the interior of either cylinder through the syringe or the interface on the sealing cap, providing a good reaction environment.

[0022] 2. After purging the air, retract the gas storage cylinder to create a negative pressure inside the acidification cylinder. The one-way valve at the bottom of the inlet pipe changes, and the one-way valve at the top of the syringe opens. Under the action of negative pressure, the cerebrospinal fluid sample in the sample storage component is drawn into the acidification cylinder through the syringe. After the predetermined amount is drawn, the gas storage cylinder is pushed again to continuously add inert gas into the acidification cylinder. The inert gas carries the hydrogen sulfide gas released after acidification into the neutralization cylinder through the one-way valve at the bottom of the inlet pipe, preventing hydrogen sulfide from remaining for too long and adhering to the inner wall, which would affect the concentration detection.

[0023] 3. Staff only need to push and pull the gas storage tank to complete the processes of removing air, aspirating samples, and purging hydrogen sulfide gas. The operation is simple and convenient, and manual operation can be replaced by the drive component, further reducing manual operation.

[0024] 4. Before aspirating cerebrospinal fluid into the acidification chamber, air is drawn from the syringe to fill the syringe with cerebrospinal fluid. Then, inert gas is drawn to further reduce the amount of air entering the acidification chamber and optimize the reaction environment.

[0025] 5. The neutralization and acidification cylinders have a simple structure with no unnecessary moving parts. They can be cast in one piece and used as disposable consumables. No cleaning or disinfection is required, thus avoiding sample contamination. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the structure of the present invention;

[0027] Figure 2 This is a schematic diagram of the assembly structure of the present invention;

[0028] Figure 3 This is a schematic diagram of a half-section of the neutralization cylinder in this invention;

[0029] Figure 4 This is a schematic diagram of a half-section of the acidification cylinder in this invention;

[0030] Figure 5 This is a half-sectional schematic diagram of the connecting seat and the partial gas storage cylinder in this invention;

[0031] Figure 6 This is a cross-sectional view of the connection structure between the neutralization cylinder, acidification cylinder, connecting cylinder and gas storage cylinder in this invention.

[0032] Figure 7 For the present invention Figure 6 Enlarged view of point A in the middle;

[0033] Figure 8 For the present invention Figure 6 Enlarged view of point B in the middle;

[0034] Figure 9 This is a schematic diagram of the structure of the fixing frame in this invention;

[0035] Figure 10 This is a schematic diagram of the sample storage component in the present invention in its initial state;

[0036] Figure 11 This is a schematic diagram of the sample storage component in the sample loading state in this invention;

[0037] The corresponding labels in the attached diagram are named as follows: 1. Neutralization cylinder; 101. Sealing cap; 102. Air inlet pipe; 103. Guide plate; 104. Fixing cylinder; 2. Acidification cylinder; 201. Needle tube; 202. Main air pipe; 203. Side connector; 204. Auxiliary air pipe; 205. Scale line; 3. Air storage cylinder; 301. Air cylinder interface; 302. Positioning spring; 303. Positioning pin; 304. Valve plug; 305. Piston; 4. Connecting seat; 401. Connecting pipe; 402. 403. Lead rod; 5. Sample storage tube; 501. Placement tube; 502. Moving sleeve; 503. Compression spring; 504. Positioning pin; 6. Fixing frame; 601. Fixing column; 602. Slide groove; 603. Positioning hole; 604. Elastic clamp; 605. Fixing ring; 7. One-way valve; 701. Valve body; 702. Flexible diaphragm; 703. Valve hole; 8. Electric cylinder; 801. Control end; 802. Clamping plate; 9. Syringe; 901. Suction tube. Detailed Implementation

[0038] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments:

[0039] like Figures 1-11 As shown, a cerebrospinal fluid sampling and testing device for neurology includes a neutralization cylinder 1, an acidification cylinder 2, a gas storage cylinder 3, and a fixing frame 6. The neutralization cylinder 1, the acidification cylinder 2, and the gas storage cylinder 3 are all mounted on the fixing frame 6. A sample storage component is mounted on the fixing frame 6. The sample storage component is used to store cerebrospinal fluid samples. The sample storage component is located below the acidification cylinder 2. The sample loading operation can be performed by moving the sample storage component upward.

[0040] The neutralization cylinder 1 has an inlet pipe 102 inside its cavity. The inlet pipe 102 is M-shaped, with its two ends serving as outlets. It is located inside the neutralization cylinder 1 and its middle section serves as the inlet, penetrating the bottom of the neutralization cylinder 1 and communicating with the cavity of the acidification cylinder 2. The neutralization cylinder 1 contains a certain amount of sodium hydroxide solution, and its liquid level is lower than the top of the inlet pipe 102. The liquid level is approximately 2 / 3 of the height of the inlet pipe 102. The outlet of the inlet pipe 102 is close to the bottom of the neutralization cylinder 1, so that the gas enters the sodium hydroxide solution and is at the bottom of the solution, prolonging its residence time in the solution. The top of the neutralization cylinder 1 is equipped with a sealing cap 101. Both the sealing cap 101 and the inlet of the inlet pipe 102 are equipped with one-way valves 7. The one-way valve 7 on the sealing cap 101 only allows gas to be discharged outside the neutralization cylinder 1, while the one-way valve 7 at the inlet of the inlet pipe 102 only allows gas to enter the neutralization cylinder 1.

[0041] The top of the acidification cylinder 2 is airtightly connected to the bottom of the neutralization cylinder 1 to form an integral reaction chamber. A syringe 201 is installed at the bottom of the acidification cylinder 2, with the top of the syringe 201 located inside the cavity of the acidification cylinder 2. The cavity of the acidification cylinder 2 contains a certain amount of phosphoric acid solution, and its liquid level is lower than the top of the syringe 201, with the liquid level height being approximately 2 / 3 of the height of the syringe 201. A one-way valve 7 is installed at the top of the syringe 201, which only allows gas or liquid to enter the acidification cylinder 2 through the syringe 201. A main gas pipe 202 is installed on the side of the acidification cylinder 2, and the main gas pipe 202 is airtightly connected to the gas storage cylinder 3 through a connecting seat 4.

[0042] The bottom of the gas storage cylinder 3 is provided with a gas cylinder interface 301, and a valve assembly is provided inside the gas cylinder interface 301. The gas cylinder interface 301 is connected to the connecting seat 4 in an airtight manner. A certain amount of inert gas is stored in the gas storage cylinder 3, so that the inside of the gas storage cylinder 3 is in a positive pressure state. A piston 305 is slidably arranged inside the gas storage cylinder 3. A connecting rod is provided on the piston 305 for driving the piston 305 to move. The connecting rod is connected to the drive assembly on the fixed frame 6 and moves with the drive assembly.

[0043] In use, the operator simply connects the neutralization cylinder 1 containing sodium hydroxide solution and the acidification cylinder 2 containing phosphoric acid solution together to form a reaction chamber. This chamber is then secured to the mounting bracket 6. The main gas pipe 202 of the acidification cylinder 2 is connected to the connecting seat 4, thus connecting to the gas storage cylinder 3. The sample storage assembly is then moved so that the needle 201 at the bottom of the acidification cylinder 2 is inserted into the sample storage assembly, contacting the cerebrospinal fluid sample inside. The needle 201 has a closed tip with an opening on the side to prevent rubber debris from entering. The valve assembly is then opened, allowing the inert gas in the gas storage cylinder 3 to enter the acidification cylinder 2 under positive pressure through the main gas pipe 202, thus activating the reaction chamber. 2. A positive pressure is formed in the inner cavity, which pushes the one-way valve 7 at the air inlet end of the air inlet pipe 102 to open. The inert gas carries the air through it into the inner cavity of the neutralization cylinder 1. Subsequently, the inert gas continuously enters the inner cavity of the acidification cylinder 2, thereby replacing all the air inside. Similarly, after the inert gas and air enter the inner cavity of the neutralization cylinder 1, they are discharged outside the neutralization cylinder 1 through the one-way valve 7 on the sealing cover 101 until all the air inside is replaced by inert gas, providing a good reaction environment for the subsequent acidification reaction and preventing hydrogen sulfide gas from reacting with oxygen in the air. During this process, the one-way valve 7 at the top of the needle tube 201 is always closed due to the positive pressure, and air will not enter the acidification cylinder 2 through it.

[0044] After gas filling is completed, when the internal pressures of neutralization cylinder 1, acidification cylinder 2, and gas storage cylinder 3 are balanced, the driving assembly pushes the connecting rod to move piston 305 a short distance, allowing a small amount of inert gas to enter the reaction chamber formed by acidification cylinder 2 and neutralization cylinder 1. The one-way valve 7 on the sealing cap 101 automatically discharges the corresponding amount of inert gas to balance the pressure. At this time, the driving assembly pulls back the connecting rod to move piston 305 back, drawing inert gas from acidification cylinder 2 into gas storage cylinder 3, creating a negative pressure inside acidification cylinder 2. Under the action of the negative pressure, the one-way valve 7 at the inlet end of the inlet pipe 102... Keep valve 7 closed to block gas flow and prevent sodium hydroxide solution in neutralization cylinder 1 from being drawn back into acidification cylinder 2. At the same time, one-way valve 7 at the top of syringe 201 is opened by negative pressure, and under the action of negative pressure suction, cerebrospinal fluid sample in sample storage component is drawn into acidification cylinder 2 through syringe 201, so that cerebrospinal fluid sample is mixed with phosphoric acid solution. After the target amount of cerebrospinal fluid sample is drawn, drive component stops moving and no longer draws cerebrospinal fluid sample, thus completing sample loading, and waits for cerebrospinal fluid sample to undergo acidification reaction with phosphoric acid to release hydrogen sulfide gas;

[0045] During the acidification reaction, the control drive assembly slowly pushes the connecting rod again, causing the piston 305 to move downwards, continuously injecting the inert gas from the gas storage tank 3 into the acidification tank 2. This purges the released hydrogen sulfide gas, leading it into the neutralization tank 1. The process is roughly the same as the inert gas replacing air, except that after the hydrogen sulfide gas enters the neutralization tank 1 through the inlet pipe 102, it dissolves in the sodium hydroxide solution, undergoing a neutralization reaction to form a stable sulfide, which is easier to detect. Excess inert gas... The gas is discharged through the one-way valve 7 on the sealing cover 101. Through continuous purging with inert gas, the hydrogen sulfide gas released from the cerebrospinal fluid is carried into the neutralization cylinder 1 by the inert gas to carry out the neutralization reaction. This reduces the residence time of hydrogen sulfide gas in the acidification cylinder 2, prevents it from adhering to the inner wall of the device and causing a decrease in concentration, and allows it to react with sodium hydroxide solution as soon as possible. This replaces the traditional method of waiting for the hydrogen sulfide gas to be released before transferring it to the sodium hydroxide solution, which can effectively improve the working efficiency of the device and shorten the detection time.

[0046] Furthermore, the neutralization cylinder 1 and acidification cylinder 2, which come into contact with the sample and reaction solution, have a simple structure with no extra moving parts, are easy to manufacture, and can be used as disposable consumables. They are discarded after use and do not require cleaning or disinfection, thus avoiding sample contamination. At the same time, the entire operation of the device is simple for the staff. They only need to assemble the neutralization cylinder 1 and acidification cylinder 2, snap them into the fixing frame 6, and then move the sample storage component into place. No other additional operations are required. Subsequent operations such as air replacement, cerebrospinal fluid sample extraction, and hydrogen sulfide gas purging can all be completed by the drive component driving the gas storage cylinder 3 in conjunction with each set of one-way valves 7, reducing the number of operation steps for the staff and alleviating their workload.

[0047] In this embodiment, the valve assembly includes a positioning post 303 fixedly disposed in the air cylinder inlet 301 and a valve plug 304 slidably disposed at the bottom of the positioning post 303. The valve plug 304 is in the shape of an inverted frustum cone and seals the valve port at the bottom of the air cylinder inlet 301. A positioning spring 302 is sleeved on the positioning post 303 to limit the position of the valve plug 304. The valve plug 304 is located directly above the ejector pin assembly, which is disposed in the connecting seat 4. Under the action of the positioning spring 302, the valve plug 304 seals the valve port, preventing the leakage of inert gas in the gas storage cylinder 3. After the gas storage cylinder 3 is connected to the connecting seat 4 through the gas cylinder interface 301, the ejector pin assembly presses against the valve plug 304, separating it from the valve port, thereby allowing the inert gas to be discharged from the gas storage cylinder 3. At the same time, after use, the injection piston 305 is pushed to empty the gas storage cylinder 3, and then inert gas is filled into the gas storage cylinder 3 through the gas cylinder interface 301. After filling, under the action of the positioning spring 302, the valve plug 304 automatically seals the valve port for the next use, making the gas storage cylinder 3 reusable and improving its practicality.

[0048] In this embodiment, a connecting pipe 401 is provided on the connecting seat 4, which is connected to the main gas pipe 202. The ejector assembly includes an ejector rod 402 movably disposed within the connecting seat 4 and a lead screw 403 rotatably disposed. The lead screw 403 can only rotate, while the ejector rod 402 can only move vertically. The top end of the lead screw 403 passes through the bottom end of the ejector rod 402, and the two are threaded together. The top end of the ejector rod 402 is located in the inner cavity of the connecting seat 4, directly below the valve plug 304. By rotating the lead screw 403, the ejector rod 402 is driven to move upward, thereby pushing the valve plug 304 to open it, thus realizing the opening and closing control of the inert gas passage. At the same time, by adjusting the upward movement distance of the ejector rod 402, the opening degree of the valve plug 304 can be controlled, thereby controlling the flow rate of the inert gas to meet different usage requirements.

[0049] In this embodiment, a side connector 203 is provided on the needle tube 201, and a one-way valve 7 is provided on the side connector 203. The one-way valve 7 is connected to one end of the auxiliary air tube 204, and the other end of the auxiliary air tube 204 extends out of the acidification cylinder 2 and is connected to the suction tube 901 in the fixing frame 6. The other end of the suction tube 901 is connected to the syringe 9. After gas filling is completed, before retracting the inert gas in the acidification cylinder 2, negative pressure suction can be generated by retracting the syringe 9. This suction force is then used to draw air from the syringe 201 through the suction tube 901 and the auxiliary air tube 204. At this time, the one-way valve 7 at the top of the syringe 201 remains closed, while the one-way valve 7 at the side connector 203 is opened under pressure. This allows the air in the syringe 201 to be drawn into the syringe 9, filling the syringe 201 with cerebrospinal fluid sample. When the syringe 9 is stopped, the drive assembly drives the gas storage cylinder 3 to perform suction. At this time, the one-way valve 7 at the top of the syringe 201 is opened under negative pressure, while the one-way valve 7 at the side connector 203 remains closed due to the loss of negative pressure from the syringe 9. This allows the cerebrospinal fluid sample to be drawn into the acidification cylinder 2, while the small amount of air in the syringe 201 does not enter the acidification cylinder 2. This further optimizes the reaction environment inside the device and improves the accuracy of the detection.

[0050] In this embodiment, the one-way valve 7 includes a valve body 701 and a flexible diaphragm 702 disposed on the valve body 701. The valve body 701 has several valve holes 703, which are sealed by the flexible diaphragm 702. The flexible diaphragm 702 can deform under pressure. By changing the installation direction of the flexible diaphragm 702, it deforms under positive or negative pressure, thereby controlling the opening of the valve body 701. Under normal pressure and in the initial state, it is always in the closed state, requiring no manual operation. This design is not only simple and reliable but also highly responsive.

[0051] In this embodiment, the sample storage assembly includes a movable sleeve 502 slidably disposed on a fixed column 601, a placement cylinder 501 disposed on the movable sleeve 502, and a sample storage tube 5 disposed on the placement cylinder 501. The fixed column 601 is disposed on a fixed frame 6, and the fixed column 601 is provided with a sliding groove 602 and a plurality of positioning holes 603. A positioning pin 504 and a compression spring 503 for pushing the positioning pin 504 to move are slidably disposed in the movable sleeve 502. In the initial state, the positioning pin 504 is located in one of the positioning holes 603. In the initial state, after the acidification cylinder 2 and neutralization cylinder 1 are inserted into the fixing frame 6, the placement cylinder 501 is not directly below them to avoid interference and prevent the staff from placing the sample tube 5 containing the cerebrospinal fluid sample into the placement cylinder 501. After the sample tube 5 is placed into the placement cylinder 501, the positioning pin 504 is pulled to disengage it from the positioning hole 603, releasing the lock between the moving sleeve 502 and the fixing post 601. Rotating the moving sleeve 502 will cause the placement cylinder 501 to rotate the sample tube 5 to directly below the needle tube 201. At this time, the positioning pin 504... Located within the chute 602, pushing the movable sleeve 502 upwards will move the sample storage tube 5 upwards, allowing the needle 201 to be inserted into the sample storage tube 5 for easy extraction of cerebrospinal fluid samples. After the movable sleeve 502 moves upwards into position, under the action of the compression spring 503, the positioning pin 504 is inserted into the positioning hole 603 in the chute 602, locking the movable sleeve 502 and maintaining the sample loading position of the sample storage tube 5. This eliminates the need for staff to constantly support it, reducing their burden and making each sample loading more convenient and standardized.

[0052] In this embodiment, the fixing frame 6 is provided with several fixing rings 605. The gas storage cylinder 3 and the connecting seat 4 are respectively inserted into the corresponding fixing rings 605. The gas storage cylinder 3 is located above the connecting seat 4. The fixing frame 6 is provided with several elastic clips 604. The neutralization cylinder 1 and the acidification cylinder 2 are clamped and fixed in the corresponding elastic clips 604. When installing the gas storage cylinder 3, it can be directly inserted into the corresponding fixing ring 605 to align and connect with the connecting seat 4 at the bottom. After use, it can also be easily removed from the fixing frame 6 for easy filling with inert gas. After splicing the neutralization cylinder 1 and the acidification cylinder 2 together, they can be directly snapped into the elastic clips 604 to install them on the fixing frame 6. At the same time, they are airtightly connected with the connecting pipe 401 and the exhaust pipe 901. When disassembling, the acidification cylinder 2 and the neutralization cylinder 1 can be pulled towards the opening of the elastic clip 604. The operation is simple and convenient.

[0053] In this embodiment, the drive assembly includes an electric cylinder 8 mounted on the fixed frame 6 and a control terminal 801. The control terminal 801 is configured to control the extension and retraction of the electric cylinder 8. A locking plate 802 is provided at the top of the extension and retraction end of the electric cylinder 8, and the locking plate 802 is connected to the top of the connecting rod on the piston 305. After the gas storage cylinder 3 is installed on the fixed frame 6, rotating the locking plate 802 will lock it into place at the top of the connecting rod of the piston 305. The extension and retraction of the electric cylinder 8 is controlled by the control terminal 801, thereby driving the piston 305 to move through the connecting rod, pushing or drawing inert gas. This eliminates the need for manual operation, reducing the burden on workers, and makes the operation more stable and reliable, avoiding large fluctuations in airflow speed caused by human factors, which could affect the purging effect.

[0054] In this embodiment, a plurality of guide plates 103 are provided inside the neutralization cylinder 1. The guide plates 103 are arranged at an inclined and staggered manner to guide the gas to move in an S-shaped path within the inner cavity of the neutralization cylinder 1. A fixed cylinder 104 is provided inside the neutralization cylinder 1, which penetrates all the guide plates 103. The top opening of the fixed cylinder 104 is higher than the top set of guide plates 103, and the bottom opening is lower than the bottom set of guide plates 103. After hydrogen sulfide gas enters the sodium hydroxide solution along with the inert gas, it will rise naturally. The inclined guide plates 103 guide the gas path, causing it to move in an S-shaped path within the sodium hydroxide solution. This prolongs the contact time between the hydrogen sulfide gas and the sodium hydroxide solution, facilitating their reaction and preventing the hydrogen sulfide gas from escaping from the sodium hydroxide solution before it has fully reacted. When taking liquid, a pipette or other tool is inserted into the fixed cylinder 104 to draw up the reacted solution for testing, avoiding obstruction by the guide plates 103 and preventing interference with liquid collection by the operator.

[0055] In this embodiment, both the neutralization cylinder 1 and the acidification cylinder 2 are made of transparent material, and both have scale lines 205 printed on their surfaces. The transparent material allows staff to observe the internal conditions of the device, and the scale lines 205 allow staff to clearly understand the amount of cerebrospinal fluid sample added, facilitating subsequent data recording.

[0056] The above descriptions are merely embodiments of the present invention, and common knowledge regarding specific technical solutions or characteristics is not elaborated upon here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the technical solutions of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A cerebrospinal fluid sampling and detection device for neurology, characterized in that: It includes a neutralization cylinder (1), an acidification cylinder (2), a gas storage cylinder (3) and a fixing frame (6). The neutralization cylinder (1), the acidification cylinder (2) and the gas storage cylinder (3) are all mounted on the fixing frame (6). A sample storage component is mounted on the fixing frame (6) and the sample storage component is located below the acidification cylinder (2). The neutralization cylinder (1) is provided with an air inlet pipe (102) in the inner cavity. The air inlet pipe (102) is M-shaped, with its two ends being air outlets located in the inner cavity of the neutralization cylinder (1). Its middle part is the air inlet, which penetrates the bottom of the neutralization cylinder (1) and communicates with the inner cavity of the acidification cylinder (2). The top of the neutralization cylinder (1) is provided with a sealing cap (101). Both the sealing cap (101) and the air inlet end of the air inlet pipe (102) are provided with one-way valves (7). The one-way valve (7) on the sealing cap (101) only allows gas to be discharged outside the neutralization cylinder (1), while the one-way valve (7) at the air inlet end of the air inlet pipe (102) only allows gas to enter the neutralization cylinder (1). The top of the acidification cylinder (2) is connected to the bottom of the neutralization cylinder (1). A needle tube (201) is provided at the bottom of the acidification cylinder (2). The top of the needle tube (201) is located in the inner cavity of the acidification cylinder (2). A one-way valve (7) is provided at the top of the needle tube (201), which only allows gas or liquid to enter the acidification cylinder (2) through the needle tube (201). A main gas pipe (202) is provided on the side of the acidification cylinder (2). The main gas pipe (202) is connected to the gas storage cylinder (3) through a connecting seat (4). The bottom of the gas storage cylinder (3) is provided with a gas cylinder interface (301), and a valve assembly is provided inside the gas cylinder interface (301). The gas cylinder interface (301) is connected to the connecting seat (4). The gas storage cylinder (3) stores a certain amount of inert gas. A piston (305) is slidably provided inside the gas storage cylinder (3). A connecting rod for driving the piston (305) to move is provided on the piston (305). The connecting rod is connected to the drive assembly on the fixed frame (6) and moves with the drive assembly.

2. The cerebrospinal fluid sampling and detection device for neurology according to claim 1, characterized in that: The valve assembly includes a positioning post (303) fixedly disposed in the air cylinder inlet (301) and a valve plug (304) slidably disposed at the bottom of the positioning post (303). The valve plug (304) is in the shape of an inverted frustum and seals the valve port at the bottom of the air cylinder inlet (301). A positioning spring (302) is sleeved on the positioning post (303) to limit the position of the valve plug (304). The valve plug (304) is located directly above the ejector assembly. The ejector assembly is disposed in the connecting seat (4).

3. The cerebrospinal fluid sampling and detection device for neurology according to claim 2, characterized in that: The connecting seat (4) is provided with a connecting pipe (401), which is connected to the main air pipe (202). The ejector assembly includes a ejector rod (402) that is movably disposed in the connecting seat (4) and a lead screw (403) that is rotatably disposed. The top end of the lead screw (403) passes through the bottom end of the ejector rod (402), and the two are threaded together. The top end of the ejector rod (402) is located in the inner cavity of the connecting seat (4) and is directly below the valve plug (304).

4. The cerebrospinal fluid sampling and detection device for neurology according to claim 3, characterized in that: The needle tube (201) is provided with a side connector (203), and the side connector (203) is provided with a one-way valve (7). The one-way valve (7) is connected to one end of the auxiliary air tube (204), and the other end of the auxiliary air tube (204) extends out of the acidification cylinder (2) and is connected to the suction tube (901) in the fixing frame (6). The other end of the suction tube (901) is connected to the syringe (9).

5. A cerebrospinal fluid sampling and detection device for neurology according to claim 4, characterized in that: The one-way valve (7) includes a valve body (701) and a flexible membrane (702) disposed on the valve body (701). The valve body (701) has a plurality of valve holes (703). The flexible membrane (702) blocks the valve holes (703). The flexible membrane (702) can deform under force.

6. The cerebrospinal fluid sampling and detection device for neurology according to claim 1, characterized in that: The sample storage assembly includes a movable sleeve (502) slidably mounted on a fixed column (601), a placement cylinder (501) mounted on the movable sleeve (502), and a sample storage tube (5) mounted on the placement cylinder (501). The fixed column (601) is mounted on a fixed frame (6). The fixed column (601) is provided with a sliding groove (602) and a plurality of positioning holes (603). A positioning pin (504) and a compression spring (503) for pushing the positioning pin (504) to move are slidably mounted in the movable sleeve (502). In the initial state, the positioning pin (504) is located in one of the positioning holes (603).

7. A cerebrospinal fluid sampling and detection device for neurology according to claim 6, characterized in that: The fixing frame (6) is provided with several fixing rings (605), the gas storage cylinder (3) and the connecting seat (4) are respectively inserted into the corresponding fixing rings (605), the gas storage cylinder (3) is located above the connecting seat (4), the fixing frame (6) is provided with several elastic clips (604), the neutralization cylinder (1) and the acidification cylinder (2) are clamped and fixed in the corresponding elastic clips (604).

8. The cerebrospinal fluid sampling and detection device for neurology according to claim 1, characterized in that: The drive assembly includes an electric cylinder (8) mounted on the fixed frame (6) and a control end (801). The control end (801) is configured to control the electric cylinder (8) to perform extension and retraction actions. A retaining plate (802) is provided at the top of the extension and retraction end of the electric cylinder (8). The retaining plate (802) is connected to the top of the connecting rod on the piston (305).

9. A cerebrospinal fluid sampling and detection device for neurology according to claim 1, characterized in that: The neutralization cylinder (1) is provided with a plurality of guide plates (103), which are arranged in an inclined and staggered manner to guide the gas to move in an S-shaped path in the inner cavity of the neutralization cylinder (1). The neutralization cylinder (1) is provided with a fixed cylinder (104), which penetrates all the guide plates (103). Its top opening is higher than the top set of guide plates (103), and its bottom opening is lower than the bottom set of guide plates (103).

10. A cerebrospinal fluid sampling and detection device for neurology according to claim 1, characterized in that: Both the neutralization cylinder (1) and the acidification cylinder (2) are made of transparent material, and both have scale lines (205) printed on their surfaces.

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