Oral care composition

Abstract

The present invention relates to oral care compositions which provide specific foam properties that are maintained during brushing. Good foam in turn surprisingly provides the benefits of good mouth feel, flavor impact and overall refreshment.

Description

Technical Field

[0001] This invention relates to oral care compositions. In particular, it relates to oral care compositions having improved foam stability and foam properties. Background Technology

[0002] In oral care compositions, foaming plays a crucial role in consumer acceptance. Improved foaming is generally perceived by consumers as directly related to improved taste, cleanliness, and freshness. Desired foaming also includes specific structure, density, and foam stability.

[0003] Beyond foaming, flavor impact and the taste of the composition are often even more important to consumers. It is highly desirable for oral care compositions to convey a feeling of freshness and cleanliness, as this sends a signal of sustained freshness and cleanliness to the consumer. In addition to the feeling of cleanliness, consumers also want to experience the benefits of oral care active ingredients (such as antimicrobial agents), for example, through their oral care regimen. Since many effective oral care ingredients have undesirable tastes, colors, odors, or transparency, efforts to improve these properties are common in the field.

[0004] However, the ability to formulate consumer-acceptable oral care compositions presents a challenge because many of the components used to impart flavor, deliver benefits, or serve as part of the base for oral care compositions, along with the intended benefits they are added, can increase undesirable tastes and / or sensations. Therefore, formulating oral care compositions can be a balancing act between acceptable sensory (e.g., foaming, flavor) benefits and acceptable oral care benefits.

[0005] Therefore, one object of the present invention is to provide desired foam quality and improved foam stability while maintaining a good mouthfeel and flavor impact in oral care compositions. Summary of the Invention

[0006] The inventors of this invention have discovered oral care compositions that provide specific foam properties that are maintained during brushing, unexpectedly providing the benefits of good taste and flavor impact as well as overall freshness.

[0007] According to a first aspect of the present invention, an oral care composition is provided, comprising: i. 1.5-3 wt% anionic sulfated surfactant; ii. A thickening system comprising less than 10 wt% xanthan gum; The oral care composition exhibits a change rate of 25% or less in bubble count when measured using a dynamic foam analyzer from approximately 20 seconds to approximately 7 minutes. The thickening system described herein comprises a combination of xanthan gum, carboxymethyl cellulose, and thickening silica. Detailed Implementation

[0008] Oral care composition The term "oral care composition" refers to a composition delivered to the surface of the oral cavity. This composition may be a product that, during normal use, is not intended for systemic administration or intentional swallowing, but rather for oral activity purposes, and remains in the oral cavity for a sufficient period of time to contact substantially all tooth surfaces and / or oral tissues.

[0009] Examples of the oral composition include toothpaste or dental cleaning agent, mouthwash or mouthrinse, powder (e.g., tooth powder), tablets, mints, creams, strips, or gels (e.g., chewing gum), films, topical oral gels, and denture cleaners.

[0010] The compositions of the present invention are preferably used for cleaning the surfaces of the oral cavity. Therefore, the preferred product forms of the compositions of the present invention are those suitable for brushing and / or rinsing the surfaces of the oral cavity.

[0011] The compositions of the present invention are most preferably in the form of a dental flosser. The term "dental flosser" refers to an oral composition for cleaning the surfaces of the oral cavity. This composition is not intended to be swallowed for systemic administration of a therapeutic agent, but is applied to the oral cavity for treatment and then spat out. Typically, this composition is used in conjunction with a cleaning tool such as a toothbrush, usually by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity.

[0012] Preferably, the oral care composition is an aqueous oral care composition. The term "aqueous" means that the composition according to the invention contains water. This water includes any water that may accompany other ingredients, such as humectants, particularly sorbitol.

[0013] The oral care composition is preferably alcohol-free. The term "alcohol-free" means that the composition contains no more than 1 wt%, more preferably no more than 0.5 wt% alcohol.

[0014] Preferably, the oral care composition is a gel-type composition. More preferably, the oral care composition is a gel-type dental floss composition, and more preferably a gel-type toothpaste composition. The term "gel" refers to the physical appearance of the compositions of the present invention. The gel compositions of the present invention are transparent to light, i.e., they allow visible light to pass through. Transparent gel toothpastes are popular with consumers. Undoubtedly, this is at least in part due to their appearance. On the other hand, there are some other types of dental floss compositions that are not gels but opaque. This is because such compositions typically contain opaque ingredients, such as chalk or other calcium-based abrasives. Therefore, it is preferred that the compositions according to the present invention contain no more than 5 wt%, preferably no more than 2 wt%, and more preferably no more than 1 wt% of a calcium-based abrasive.

[0015] Bubble form and structure: According to a first aspect of the invention, the oral care composition has a rate of change of 20% or less in bubble count when measured using a dynamic foam analyzer as described herein.

[0016] Preferably, the oral care composition provides a concentration greater than 170 / mm. 2 180 / mm is still preferred. 2 More preferably greater than 190 / mm 2 The initial bubble count is still preferably 170 / mm. 2 Up to 200 / mm 2 per mm of the range 2 The initial bubble count. Preferably, the oral care composition provides a bubble count of not less than 120 / mm. 2 It is still preferred to be no less than 130 / mm 2 More preferably greater than 150 / mm 2 The final bubble count. Preferably, the oral care composition has a bubble count of 120 / mm when measured using a dynamic foam analyzer as described herein. 2 Up to 170 / mm 2 140 / mm is still preferred. 2 Up to 160 / mm 2 The final bubble count within the range.

[0017] Preferably, the oral care composition provides no more than 6000 μm 2 Preferably, it should not exceed 5200 μm. 2 The initial average bubble area. Preferably, the oral care composition provides 4900 μm. 2 Up to 6000 μm 2 The preferred value is still 5000μm. 2Up to 6000 μm 2 5100 μm is still more preferred. 2 Up to 5800 μm 2 The initial average bubble area is within the range of [specific parameters]. Preferably, the oral care composition provides an initial average bubble area of ​​no more than 6500 μm. 2 It is still preferred to be less than 6400 μm 2 The final average bubble area. Preferably, the oral care composition provides 6000 μm. 2 Up to 6500 μm 2 The final average bubble area within the range.

[0018] Preferably, the oral care composition provides an initial average bubble radius of less than 40 μm, still preferably less than 39 μm. Preferably, the oral care composition provides a final average bubble radius of less than 45 μm, still preferably less than 44 μm.

[0019] Bubble measurement: The bubble count, average bubble area, and average bubble radius were measured on a dynamic foam analyzer (DFA100) from Kruss.

[0020] Three measurement modes were used to collect the maximum amount of information about foam stability: foam and liquid level height (measured by light scattering), structure (measured by image analysis of time-lapse images of the foam), and liquid content (measured by conductivity measured along an electrode string placed at different heights throughout the sample). A dynamic foam analyzer was used to acquire bubble structure using advanced software for data analysis. The following instrument settings were used: an air flow rate of 0.2 L / min, and 12% illumination for height measurement and 20% illumination for structure measurement. Height illumination was performed using 850 nm infrared light. A 50 mL solution (prepared by mixing 5 g of gel toothpaste with 50 mL of water with a hardness of 28.9 FH at 25 °C) was used, and twice that volume (90 mL) of air was mechanically purged through the liquid. The air was passed through 16–40 μm sintered glass frit in a DFA100. Foam was generated using a stirrer at 4000 rpm with an oscillation cycle of 0 seconds. The stability of the foam was evaluated over a period of 7 minutes and 25 seconds, starting immediately after the stirrer was started and passing over the sample, and stopping after 25 seconds. The measurement was then stopped after 7 minutes. The data were exported.

[0021] The data sampling intervals provided in the table below are used to obtain images for analyzing bubble structures.

[0022] This refers to frames per hour, and # FPS means frames per second.

[0023] The camera was positioned 55 mm above the bottom of the measuring container.

[0024] The oral care composition according to the invention preferably has 180 / mm 2 Up to 200 / mm 2 More preferably 185 / mm 2 Up to 195 / mm 2 The initial bubble count is within the range specified. At the end of the 7-minute and 25-second time period, the decrease in bubble count is less than 25%. More preferably, the decrease in bubble count ranges from 15% to 25%, or 15% to 20%. The oral care composition according to the invention has a bubble count change rate of 20% or less, more preferably 19% or less. The bubble count change rate is calculated using the following formula: Rate of change in bubble count (%) = X 100 in, BC 初始 (count / mm) 2 = Count of bubbles immediately after foam formation (counts / mm) 2 ) BC 最终 (count / mm) 2 = Bubble count at the end of 7 minutes and 25 seconds The oral care composition according to the invention preferably has 5000 µm 2 Up to 6000 µm 2 More preferably 5100 µm 2 Up to 5500 µm 2 The initial average bubble area is within the range of 7 minutes and 25 seconds. At the end of the time period, the increase in average bubble area is preferably no more than 30%, still preferably no more than 25%, preferably in the range of 20% to 30%, still preferably in the range of 20% to 28%, and more preferably 20% to 25%.

[0025] The rate of change of the average bubble area is calculated using the following formula: Rate of change of average bubble area (%) = X 100 MBA 初始 (µm 2 = Area of ​​the bubble immediately after foam formation MBA 最终 (µm2 = Bubble area at the end of 7 minutes and 25 seconds The oral care composition according to the invention preferably has a change rate of average bubble area of ​​no more than 30%, which has been found to provide more uniform and smaller bubbles when generated, and to provide good foam structure and stability. The oral care composition according to the invention preferably has a change rate of average bubble area in the range of 20% to 30%, still preferably in the range of 20% to 28%, and more preferably in the range of 20% to 25%.

[0026] The oral care composition according to the invention preferably has an initial average bubble radius in the range of 35 µm to 45 µm, more preferably 35 µm to 40 µm. At the end of the 7 minutes and 25 seconds time period, the increase in the average bubble radius preferably does not exceed 15%, still preferably does not exceed 14%, and preferably is in the range of 11% to 13.5%.

[0027] The rate of change of the average bubble radius is calculated using the following formula: The rate of change of average bubble radius (%) = X 100 R 初始 (µm) = Average bubble radius immediately after foam formation R 最终 (µm) = Average bubble area at the end of 7 minutes and 25 seconds The oral care composition according to the invention has a variation rate of average bubble radius ranging from 11% to 13.5%.

[0028] Thickening system The oral care composition according to a first aspect of the invention comprises less than 10 wt% of a thickening system comprising xanthan gum. The thickening system preferably comprises an additional thickener selected from thickening silica, cellulose thickeners, and mixtures thereof. More preferably, the thickening system comprises a combination of thickening silica, xanthan gum, and cellulose thickeners.

[0029] Preferably, the oral care composition comprises a thickening system, wherein the total amount of all thickeners is less than 10 wt%. More preferably, it is less than 9.5 wt%.

[0030] Preferably, the weight ratio of xanthan gum to cellulose thickener in the oral care composition is in the range of 1:2.3 to 1:3, more preferably 1:2.3 to 1:2.6.

[0031] Xanthan gum: According to a first aspect of the invention, the disclosed oral care composition comprises xanthan gum. Preferably, the xanthan gum has a weight-average molecular weight (Mb) in the range of 5 to 15 million Daltons, more preferably in the range of 5.5 million Daltons to 10 million Daltons, and more preferably in the range of 6 million Daltons to 8 million Daltons. w ).

[0032] Preferably, the xanthan gum has a viscosity in the range of 850 mPa·s to 1,700 mPa·s (measured at 25°C using a 1% solution of the gum in 1% KCl, on a Buchner LV viscometer with rotor No. 3 at 60 rpm).

[0033] The xanthan gum suitable for use in this application is available from several commercial suppliers, with Keltrol® T plus, Keltrol® SF and Keltrol T being particularly preferred.

[0034] Preferably, the xanthan gum derivative can be prepared by etherification, esterification, acetylation, amidation, or oxidation of non-derivative xanthan gum. A preferred xanthan gum derivative is prepared by reacting a non-derivative gum with a quaternary ammonium compound in an amount equal to or greater than the stoichiometric amount required for complete derivatization. The quaternary ammonium compound preferably has a single alkyl or alkenyl substituent containing 13 to 24 carbon atoms; and / or two alkyl or alkenyl substituents having 12 to 24 carbon atoms per substituent. Most preferably, the quaternary ammonium compound is an alkyl dimethyl benzyl ammonium chloride having an alkyl group containing 13 to 24 carbon atoms.

[0035] Xanthan gum has a primary structure composed of regularly repeating units, each containing five sugars: two glucose units, two mannose units, and one glucuronic acid unit. The main chain consists of β-D-glucose units linked at positions 1 and 4, i.e., the same chemical structure as cellulose. Trisaccharide side chains are linked at position 3 of every other glucose residue in the main chain. Approximately half of the terminal D-mannose residues contain pyruvate residues linked at positions 4 and 6. Preferably, the xanthan gum has a degree of substitution of less than 0.4 carboxylate groups per sugar residue.

[0036] Preferably, the oral care composition comprises 0.1 wt% to 5 wt% xanthan gum, more preferably 0.1 to 1 wt%, still preferably 0.1 to 0.75 wt%, and even more preferably 0.1 wt% to 0.5 wt% xanthan gum. Preferably, based on the weight of the oral care composition, the oral care composition comprises at least 0.15 wt%, still preferably at least 0.2 wt%, still preferably at least 0.25 wt%, still preferably at least 0.28 wt%, and most preferably at least 0.3 wt% xanthan gum, but generally not exceeding 4 wt%, still preferably not exceeding 3 wt%, still more preferably not exceeding 2.5 wt%, still more preferably not exceeding 1 wt%, most preferably not exceeding 0.75 wt%, and still more preferably not exceeding 0.5 wt% xanthan gum.

[0037] Preferred oral care compositions contain 0.1 wt% to 1 wt% xanthan gum. Preferably, the oral care composition contains at least 0.15 wt%, preferably at least 0.16 wt%, still preferably at least 0.17 wt%, most preferably at least 0.18 wt%, but generally not more than 1 wt%, still preferably not more than 0.8 wt%, still more preferably not more than 0.6 wt%, and most preferably not more than 0.3 wt% xanthan gum by weight.

[0038] Thickened silica: The oral care composition according to a first aspect of the invention preferably comprises a thickening system comprising thickening silica.

[0039] The thickened silica preferably has a weight-average particle size in the range of 45 micrometers to 250 micrometers.

[0040] Preferably, the specific surface area (BET) of the thickened silica is in the range of 125 g / m². 2 Up to 190 g / m 2 The preferred value is still 140 g / m 2 Up to 185 g / m 2 .

[0041] Preferably, the amount of thickening silica is in the range of 5 wt% to 9 wt% by weight of the oral care composition, more preferably 6 wt% to 9 wt%, and even more preferably 7.5 wt% to 9 wt% by weight of the oral care composition.

[0042] Cellulose thickener: Preferably, the oral care composition comprises a cellulose thickener. Preferably, the cellulose thickener is substituted carboxymethyl cellulose. Still preferably, the carboxymethyl cellulose has an average degree of substitution (DS) greater than 0.7 per dehydrated glucose unit, and still preferably an average degree of substitution (DS) in the range of 0.8 to 1 per dehydrated glucose unit. As used herein, the term "degree of substitution (DS)" generally refers to the average number of carboxymethyl groups substituted per dehydrated glucose unit of the carboxymethyl cellulose.

[0043] Preferably, the carboxymethyl cellulose may comprise a main chain of 8 to 12 cellulose units, more preferably in the range of 9 cellulose units. CMC is a biodegradable, highly compatible anionic polymer obtained from cellulose by replacing at least a portion of the hydroxyl groups in the cellulose molecule with carboxymethyl ether groups.

[0044] Preferably, the oral care composition comprises 0.1 wt% to 0.8 wt% of carboxymethyl cellulose, more preferably 0.1 wt% to 0.75 wt%, still preferably 0.5 wt% to 0.7 wt%, and even more preferably 0.55 wt% to 0.7 wt% of carboxymethyl cellulose. Preferably, based on the weight of the oral care composition, the oral care composition comprises at least 0.2 wt%, still preferably at least 0.3 wt%, still preferably at least 0.4 wt%, most preferably at least 0.5 wt% of carboxymethyl cellulose, but generally not exceeding 0.75 wt%, still preferably not exceeding 0.73 wt%, and still even more preferably not exceeding 0.7 wt% of carboxymethyl cellulose.

[0045] surfactants The oral care composition according to a first aspect of the invention comprises anionic sulfated surfactant. Preferably, the anionic surfactant is C8 to C9. 20 A water-soluble salt of an alkyl sulfate. More preferably, the sulfated surfactant is a primary alcohol sulfate surfactant. Preferably, the surfactant is sodium lauryl sulfate surfactant.

[0046] Preferably, the surfactant is present in an amount ranging from 0.5 wt% to 3 wt%, more preferably from 1.5 wt% to 3 wt%, and even more preferably from 2 wt% to 2.7 wt%.

[0047] Preferably, the composition contains less than 1 wt% of a surfactant selected from nonionic surfactants, amphoteric surfactants, and mixtures thereof.

[0048] water According to the first aspect, the present invention preferably contains less than 21 wt% added water.

[0049] The oral care composition according to the invention contains less than 21 wt% added water. Preferably, the composition contains less than 20 wt% added water. Still preferably, the composition contains 10 wt% to 20 wt% added water.

[0050] Preferably, the oral care composition comprises 5 wt% to 20 wt% added water, more preferably 5 wt% to 18 wt%, still preferably 10 to 18 wt%, and even more preferably 12 wt% to 18 wt% added water. Preferably, based on the weight of the oral care composition, the oral care composition comprises at least 8 wt%, still preferably at least 9 wt%, still preferably at least 10 wt%, most preferably at least 12 wt% added water, but generally not exceeding 20 wt%, still preferably not exceeding 19.5 wt%, still more preferably not exceeding 19 wt%, still more preferably not exceeding 18.5 wt%, most preferably not exceeding 18 wt%, and still more preferably not exceeding 17.5 wt% added water.

[0051] Preferably, the oral care composition may contain some water, which is present in the form of being included in other ingredients added to the composition. Preferably, the "total water content" in the composition includes added water added to the composition, as well as water contained in any ingredient added to the composition. As an example, water present with the ingredients includes those that can be added in the form of an aqueous solution. One example includes sorbitol, which can be added to the composition in the form of a 70% sorbitol solution. Therefore, in a 70% sorbitol solution, approximately 30% contains water. The water content present in this sorbitol solution contributes to the total water content.

[0052] By way of example only, the composition may contain 20 wt% added water and 56% of a 70% sorbitol solution (i.e., about 16.8 wt% water). Assuming that no other components in the formulation contain water, such a formulation would contain about 36.8% total water content (20 wt% free water + 16.8 wt% water contained in all components).

[0053] Preferably, the water used to prepare the oral care composition is deionized and free of organic impurities.

[0054] Preferably, the total water content in the composition ranges from 17 wt% to 37 wt%, more preferably from 20 wt% to 37 wt%, and even more preferably from 20 wt% to 35 wt%.

[0055] silica-based friction agents According to a first aspect of the invention, the oral care composition preferably comprises a silica-based abrasive. Preferably, the oral care composition comprises a silica-based abrasive, or a mixture of two different types of silica-based abrasives as defined below, in amounts that provide effective cleaning and whitening while minimizing abrasive damage.

[0056] Preferably, the oral care composition has a high pellicle cleaning ratio (PCR) but low tooth abrasion, which is measured as radioactive dental abrasion (RDA). Preferably, the oral care composition has a PCR value of at least 90, more preferably in the range of 90 to 102. Preferably, the oral care composition has an RDA value of less than 200, more preferably less than 150, more preferably less than 130, more preferably less than 125, and even more preferably less than 120. Preferably, the silica-based abrasive has an average particle size in the range of 0.1 micrometers to 30 micrometers, more preferably 1 micrometer to 20 micrometers, and even more preferably 5 micrometers to 15 micrometers.

[0057] Preferably, the silica-based abrasive comprises a combination of a first silica abrasive and a second silica abrasive. Preferably, the first silica abrasive comprises hydrated silica having an RDA (radioactive dentin abrasion) in the range of 130 to 180, more preferably in the range of 130 to 160. Preferably, the PCR (film cleanliness ratio) ranges from 85% to 100%, still more preferably from 85% to 95%. Preferably, the weight-average particle size D of the abrasive silica is... 90 The content is no more than 30 micrometers. Preferably, the first silica-based abrasive is present in the oral care composition in an amount ranging from 8 wt% to 10 wt%. Preferably, the silica abrasive has a refractive index ranging from 1.441 to 1.445.

[0058] Preferably, the second silica abrasive comprises hydrated silica having an RDA in the range of 160 to 330, more preferably 160 to 220. Preferably, the PCR value (film cleanliness ratio) ranges from 110% to 115%. Preferably, the weight-average particle size D of the abrasive silica is... 90 The particle size shall not exceed 12.2 micrometers. Preferably, the silica-based abrasive is present in the oral care composition in an amount ranging from 0.5 wt% to 3 wt%, more preferably from 1 wt% to 2.5 wt%. Preferably, the second silica abrasive has a weight-average particle size (Di) ranging from 7 micrometers to 11 micrometers. 50 Preferably, the silica abrasive has a refractive index in the range of 1.435 to 1.445.

[0059] Preferably, the oral care composition according to the first aspect of the invention comprises 9 wt% to 12.5 wt% of a silica-based abrasive, still preferably 9 wt% to 11 wt% of a silica-based abrasive.

[0060] Preferably, the abrasive silica has a low refractive index, having an apparent refractive index in the range of 1.41 to 1.47, preferably in the range of 1.435 to 1.445. Examples of suitable low refractive index abrasive silicas with an RI of 1.435 to 1.445 include Tixosil 63 and 73 from Rhone Poulenc; Sident 10 from Degussa; Zeodent 113 from Zeofinn; and Sorbosil AC 77 from Ineos, which has an RI of about 1.440.

[0061] wetting agent Preferably, the transparent oral care composition comprises a humectant. Preferably, the humectant is selected from sugar alcohols, and more preferably, sugar alcohols dissolved in 100 mL of aqueous solution at 20°C in an amount of 150 to 250 g. Preferably, the oral care composition comprises 35 wt% to 70 wt% of a humectant.

[0062] Non-limiting examples of wetting agents include glycerin, propylene glycol, polyethylene glycol, sorbitol, xylitol, and mixtures thereof. More preferably, the wetting agent is sorbitol, and even more preferably, the sorbitol is in the form of an aqueous solution.

[0063] More preferably, the wetting agent comprises sorbitol. Preferably, the sorbitol is a 70% aqueous solution of sorbitol. More preferably, the composition comprises 45 wt% to 70 wt% of a sorbitol solution, still preferably 45 wt% to 65 wt% of a sorbitol solution, still more preferably 45 wt% to 60 wt% of a sorbitol solution.

[0064] Preferably, the compositions disclosed herein are substantially glycerin-free. As used herein, the term "substantially glycerin-free" means that the composition does not contain added glycerin, and more preferably it means that the oral care composition contains 0 wt% glycerin by weight.

[0065] Preferably, the oral care composition comprises 50 wt% to 65 wt% sorbitol, more preferably 52 wt% to 65 wt%, still preferably 55 wt% to 60 wt%, and even more preferably 58 wt% to 60 wt% sorbitol, wherein the sorbitol is in the form of a 70% solution. Preferably, based on the weight of the oral care composition, the oral care composition comprises at least 52 wt%, still preferably at least 55 wt%, still preferably at least 56 wt%, most preferably at least 58 wt% sorbitol, but generally not exceeding 65 wt%, still preferably not exceeding 63 wt%, still more preferably not exceeding 62 wt%, still more preferably not exceeding 61 wt%, most preferably not exceeding 60.5 wt%, and still more preferably not exceeding 60 wt% sorbitol, wherein the sorbitol is in the form of a 70% solution.

[0066] Zinc compounds Preferably, the oral care composition according to the first aspect of the invention comprises a zinc compound.

[0067] Preferably, the oral care composition may comprise a zinc compound, which is a zinc ion source. Preferably, the zinc compound is a zinc salt. Zinc ions have been found to help reduce gingivitis, plaque, sensitivity, and improve bad breath. However, many zinc compounds are only slightly soluble and therefore must be used in relatively large quantities to provide an effective amount of zinc ions. Unfortunately, many zinc compounds also have an unpleasant consumer astringency, especially when used at relatively high concentrations. The compositions disclosed herein allow for the effective incorporation of zinc ions into oral care compositions. Examples of suitable zinc compounds that can be used as a zinc ion source include, for example, zinc oxide, zinc citrate, zinc sulfate, zinc chloride, zinc lactate, zinc gluconate, zinc malate, zinc tartrate, zinc carbonate, zinc phosphate, and other zinc salts. Preferably, the zinc ion source is zinc citrate. Preferably, the zinc salt is selected from zinc lactate, zinc oxide, zinc chloride, zinc phosphate, and zinc citrate. Preferably, the zinc ion source is zinc sulfate, and still preferably zinc sulfate heptahydrate. In another embodiment, the zinc ion source is zinc citrate, preferably zinc citrate trihydrate.

[0068] Zinc ions, derived from zinc compounds, i.e., zinc ion sources, are present in the oral care composition in an effective amount. The effective amount of zinc ions is defined as at least 1000 ppm, preferably 2000 ppm to 15000 ppm. More preferably, zinc ions are present in an amount of 3000 ppm to 13000 ppm, and even more preferably in an amount of 4000 ppm to 10000 ppm. This is the total amount of zinc ions present in the composition for delivery to the tooth surface.

[0069] The amount of zinc compound (zinc ion source) used in the oral composition of the present invention can vary from 0.01 wt% to 8 wt% based on the total weight of the composition, typically from 0.1 wt% to 5 wt%, or 1 wt% to 4 wt%, or 1.5 wt% based on the total weight of the composition. Preferably, the zinc ion source / zinc salt is present in an amount ranging from 0.01 wt% to 5 wt% by weight of the oral care composition, more preferably from 0.1 wt% to 4 wt%, still preferably from 0.1 wt% to 3 wt%, further preferably from 0.1 wt% to 1 wt%, and most preferably from 0.1 wt% to 0.5 wt%.

[0070] Preferably, the oral care composition may contain a water-soluble zinc compound, preferably those having a water solubility of at least 10 g in 100 mL of water at 20°C. Preferably, the oral care composition contains a zinc compound selected from zinc sulfate, zinc chloride, zinc nitrate, and mixtures thereof. Preferably, the zinc compound is selected from zinc sulfate. More preferably, it is zinc sulfate heptahydrate. According to Lide, DR CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, pp. 4-96, zinc sulfate has a water solubility of 57.7 g / 100 g water at 25°C.

[0071] Preferably, the zinc compound is slightly soluble in water. Preferably, the slightly soluble zinc salt has a solubility of 1 to 8 grams in 100 mL of water. Preferably, the zinc compound is selected from at least one of zinc citrate, zinc oxide, zinc lactate, zinc gluconate, zinc glycinate, zinc oleate, zinc hydroxide, and zinc peroxide. More preferably, the salt is zinc citrate. Combinations of two or more such compounds may also be used.

[0072] In one embodiment of the invention, preferably, the oral care composition contains less than 0.1 wt% of a water-soluble zinc compound having a solubility of greater than 10 g / 100 g water at 20°C.

[0073] Fluoride ion source Preferably, the oral care composition comprises a fluoride ion source. The fluoride ion source can be an inorganic or organic compound. Specific examples include, but are not limited to, sodium fluoride, potassium fluoride, tin fluoride, sodium silicon fluoride, ammonium fluoride, aluminum fluoride, silver fluoride, hexamine hydrofluoride, decanolamine hydrofluoride, octadeceneamine hydrofluoride, and mixtures thereof. Sodium fluoride and ammonium fluoride are preferred, and sodium fluoride is more preferred from the viewpoint of maximizing the uptake of fluoride ions into tooth enamel, etc. One, or a combination of two or more of these fluoride ion sources can be included in the dental cleaning composition of the present invention. Furthermore, the dental cleaning composition of the present invention may contain other fluorides, such as sodium monofluorophosphate, as a fluoride compound other than the aforementioned fluoride ion source, which does not directly provide fluoride ions. Preferably, the composition contains 0.002 wt% to 5 wt%, more preferably 0.01 wt% to 1 wt%, even more preferably 0.05 wt% to 1 wt%, and still more preferably 0.05 wt% to 0.5 wt% of a fluoride ion source.

[0074] Optional components Teeth whitening agent: Preferably, the oral care composition according to the invention may contain a teeth whitening agent. The whitening agent preferably contains green and / or blue pigments. In the context of the invention, pigments are generally understood to be hues / materials that are insoluble in the relevant medium at a relevant temperature. This contrasts with soluble dyes. In the context of the invention, "relevant medium" is human saliva, i.e., a liquid medium in which the composition is used during brushing at an oral temperature (i.e., up to 37°C). As a reasonable approximation, the relevant medium can be considered to be water, and the relevant temperature is 25°C.

[0075] Preferably, the blue pigment is Pigment Blue 15, more preferably Pigment Blue 15:1, 15:2, 15:3, 15:4, 15:5, or 15:6, and most preferably 15:1. The preferred pigment is a blue pigment, specifically phthalocyanine blue pigment, CI number 74160, covarine blue. The preferred green pigment is phthalocyanine green, preferably phthalocyanine green CI-74260.

[0076] Preferably, the total pigment content in the composition is from 0.01 wt% to 3 wt%, more preferably from 0.02 wt% to 2 wt%.

[0077] Enzymes: Preferably, the oral care composition according to the invention may comprise an oral care enzyme system, such as an enzyme system that generates hydrogen peroxide (e.g., the oxidoreductase glucose oxidase), amylase, glucanase and / or mutanase, (optionally in the presence of a compound that provides zinc ions and / or an 8-hydroxyquinoline derivative), lactoperoxidase, lactoferrin, lysozyme and mixtures thereof.

[0078] Flavoring agent: Preferably, the oral care composition according to the invention may contain at least one flavoring agent, for example, used to enhance the flavor of the composition. Any oral-acceptable natural or synthetic flavoring agent may be used. The flavoring agent may be added in oil form, or it may be added in an adsorbed and microencapsulated flavoring form. The flavoring agent described herein also encompasses components that provide aroma and / or other sensory effects in the mouth, including cooling or warming effects.

[0079] Any oral-acceptable natural or synthetic flavoring agents may be used, including but not limited to essential oils and various flavoring aldehydes, esters, alcohols and similar materials, tea flavoring agents, vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, wintergreen oil, peppermint oil, clove oil, laurel oil, fennel oil, eucalyptus oil, citrus oil, fruit oil, sassafras, and flavorings, including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, etc.; flavorings derived from legumes and nuts, such as coffee, cocoa, kola nut, peanut, almond, etc.; and flavoring agents that have been adsorbed and microencapsulated. The flavoring agents described herein also encompass components that provide aroma and / or other sensory effects in the mouth, including cooling or warming effects. Examples of such ingredients include menthol, carvone, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cassia seed, oxanone, α-ionone, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthane-3-carboxamide, N,2,3-trimethyl-2-isopropylbutyramide, 3-(1-menthoxy)-propane-1,2-diol, cinnamaldehyde glycerol acetal (CGA), menthone glycerol acetal (MGA), etc. One or more flavorants are optionally present in a total amount of about 0.01 wt% to about 5 wt% based on the total weight of the composition, for example, about 0.03 wt% to about 2.5 wt%, optionally about 0.05 wt% to about 1.5 wt%, further optionally about 0.1 wt% to about 0.3 wt%, and in some embodiments, and in various embodiments, about 0.01 wt% to about 1 wt%, about 0.05 to about 2%, about 0.1% to about 2.5%, and about 0.1% to about 0.5%.

[0080] Preferably, the oral care composition according to the invention may contain at least one sweetener, for example, used to enhance the flavor of the composition. Sweeteners available herein include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup, partially hydrolyzed starch, hydrogenated starch hydrolysate, ethanol, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and its salts (e.g., sodium saccharin), sucralose, dipeptide-based high-intensity sweeteners, cyclohexanesulfonates, and dihydrochalcones. One or more sweeteners are optionally present in a total amount that depends largely on the selected one or more specific sweeteners, but is typically 0.005 wt% to 5 wt% of the total weight of the composition, optionally 0.005 wt% to 0.25 wt%, and further optionally 0.05 wt% to 0.23 wt%.

[0081] Adhesive: Preferably, the adhesive comprises a synthetic polymer, such as a polyacrylate and a carboxyvinyl polymer, such as Carbopol®.

[0082] Acceptable carriers for cosmetics: Preferably, the oral care composition may contain a cosmetically acceptable carrier. Preferably, the carrier comprises starch, sucrose, or a mixture thereof.

[0083] Vitamins: Preferably, the oral care composition may contain optional ingredients, including vitamins such as vitamin C, and plant extracts.

[0084] Desensitizing agents: Preferably, the oral care composition may contain a desensitizing agent, such as potassium bicarbonate, potassium oxalate, potassium nitrate, and strontium salt.

[0085] Anti-tartar agent: Preferably, the oral care composition may contain an anti-tartar agent. The anti-tartar agent may be selected from alkali metal pyrophosphates, hypophosphite-containing polymers, organophosphonates, and citrate phosphates.

[0086] Bleach: Preferably, the composition may contain at least one teeth whitening or teeth bleaching agent. Suitable bleaching agents include at least one of peroxides, metal chlorites, and persulfates. Peroxides may include at least one of hydroperoxides, hydrogen peroxide, alkali metal and alkaline earth metal peroxides, organic peroxy compounds, and peroxy acids. Alkali metal and alkaline earth metal peroxides include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof. Other peroxides include perborates, urea peroxide, and mixtures thereof. Suitable metal chlorites may include calcium chlorite, barium chlorite, magnesium chlorite, sodium chlorite, lithium chlorite, and potassium chlorite. Preferably, the teeth whitening and teeth bleaching agents may be present in the oral care composition in an amount ranging from 1 wt% to 20 wt% by weight of the composition.

[0087] Other optional components that can be included are effervescent systems, such as the sodium bicarbonate / citric acid system, and color-changing systems.

[0088] pH adjuster: Preferably, the oral care composition comprises at least one pH adjuster. The pH adjuster may include an acidifier for lowering the pH, an alkalizer for raising the pH, and a buffer for controlling the pH within a desired range. Any oral-acceptable pH adjuster may be used, including but not limited to carboxylic acids, phosphoric acids, and sulfonic acids; acid salts (e.g., monosodium citrate, disodium citrate, and monosodium malate); alkali metal hydroxides such as sodium hydroxide; carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, and pyrophosphate); imidazoles, etc. The at least one pH adjuster may optionally be present in an amount sufficient to effectively maintain the composition within an oral-acceptable pH range.

[0089] Preferably, the oral care composition according to the invention comprises a hydroxide ion source. Preferably, the hydroxide ion source is an alkali metal hydroxide. More preferably, it is selected from sodium hydroxide, potassium hydroxide, or mixtures thereof. More preferably, the hydroxide ion source is sodium hydroxide. Preferably, the oral care composition comprises 0.05 wt% to 0.5 wt% of a hydroxide ion source. The amount of the hydroxide ion source is such that the composition contains 0.6 to 1.5 moles of hydroxide ions per mole of zinc ions relative to the slightly water-soluble compound.

[0090] Preferably, the composition contains 0.1 wt% to 5 wt% of a pH adjuster, more preferably 0.1 wt% to 0.5 wt% of an alkali metal hydroxide, and still more preferably sodium hydroxide.

[0091] Preferably, when measured in distilled water at 25°C using a 1% solution, the oral care composition has a pH in the range of 6 to 9, more preferably 6 to 7.5.

[0092] Sweeteners: Preferably, the oral care composition may contain a sweetener. The sweetener preferably provides an enhancement to the flavor of the composition. Any oral-acceptable natural or artificial sweetener may be used, including but not limited to dextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high-fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, isomaltitol, acesulfame potassium, glycyrrhizin, perillartine, thaumatin, aspartame, neotame, saccharin and its salts, dipeptide-based high-intensity sweeteners, cyclohexanesulfonate, etc. The amount of sweetener present in the composition depends on the sweetener selected, but typically ranges from 0.005 wt% to 5 wt% by weight of the composition. Preferably, the sweetener is saccharin.

[0093] Antibacterial agent: Preferably, the oral care composition may contain an antibacterial agent other than a zinc compound. Non-limiting examples of antibacterial agents include halogenated diphenyl ether compounds, cetylpyridinium chloride, polyphenols, phenolic compounds, stannous ions, and mixtures thereof. A non-limiting example of a halogenated diphenyl ether compound is triclosan.

[0094] Colorant: Preferably, the oral care compositions disclosed herein comprise a colorant. The colorant may include pigments, dyes, lakes, streaks, and agents that impart a particular gloss or reflectivity, such as pearlescent agents. The colorant can serve a variety of functions, including, for example, providing a white or light-colored coating on the tooth surface, acting as an indicator of the location on the tooth surface where the oral care composition has been effectively applied, and / or modifying the appearance of the composition, particularly its color and / or opacity, to enhance its appeal to consumers. Any oral-acceptable colorant may be used, including but not limited to talc, mica, magnesium carbonate, calcium carbonate, magnesium silicate, magnesium aluminum silicate, silica, titanium dioxide, zinc oxide, red, yellow, brown, and black iron oxides, ferric ammonium ferrocyanide, manganese violet, ultramarine, titanated mica, bismuth oxychloride, and mixtures thereof. Preferably, the colorant may be present in the oral care composition in an amount ranging from 0.001 wt% to 20 wt%, for example, 0.01 wt% to 10 wt%, or 0.1 wt% to 5 wt% by weight of the composition.

[0095] The oral care composition according to the invention may also contain colored particles suspended therein, such as colored silica agglomerates or other colored particles, to give the oral care composition a "spotted" appearance, preferably a dental cleaning composition.

[0096] The dental cleaning composition may also contain colored paste strips to provide a visually clear gel-type dental cleaning with colored strips or individual colored hues.

[0097] Beneficial agents: Preferably, the oral care composition may also be formulated with additional optional ingredients, such as anti-caries agents, antibacterial agents, anti-tartar agents, tartar control agents, anti-plaque agents, breath fresheners, anti-inflammatory agents, enzymes, vitamins, and anti-adhesion agents.

[0098] Other preferred optional ingredients include, but are not limited to, antimicrobial agents, fluoride ion sources, anti-tartar agents, buffers, flavoring agents, peroxide sources (e.g., hydroxide peroxide), alkali metal bicarbonates, thickeners, antimicrobial agents, titanium dioxide, cooling agents, colorants, visual cues, and mixtures thereof.

[0099] Preferably, the oral care composition may comprise an orally acceptable antiplaque agent, including a plaque disruptor, present in an effective total amount against plaque. Suitable antiplaque agents include, but are not limited to, stannous salts, copper salts, magnesium salts, and strontium salts; dimethicone copolyols such as cetyldimethicone copolyol; papain; glucosyl amylase; glucose oxidase; urea; calcium lactate; calcium glycerophosphate; strontium polyacrylate; and chelating agents such as citric acid and tartaric acid and their alkali metal salts.

[0100] preservative: Preferably, the oral care composition may contain a preservative. Non-limiting examples of preservatives may include, for example, parabens, such as methylparaben and propylparaben. Still preferably, the oral care composition according to the invention is paraben-free.

[0101] Preparation of oral care compositions The oral care composition according to the present invention can be prepared using known conventional methods.

[0102] Preferably, the dental cleaning composition is prepared using a method comprising mixing the ingredients under moderate shear and atmospheric pressure.

[0103] Refractive index The oral care composition according to a first aspect of the invention provides particles having a refractive index in the range of 1.4 to 1.46. Preferably, the refractive index is achieved by carefully managing the amount of water, the refractive particles in the composition, and the levels of humectants and thickening systems.

[0104] Package: Typically, the oral care composition is packaged.

[0105] Preferably, the oral care composition is in gel form, but more preferably when the oral care composition is a gel-type transparent toothpaste composition, the composition may be packaged in a conventional plastic laminate, metal tube or single-compartment dispenser.

[0106] Preferably, the dispenser for the dental cleaning composition can be a tube, a pump, or any other container suitable for dispensing toothpaste.

[0107] How to use: The oral care composition can be applied to the tooth surface by any physical means (e.g., a toothbrush, fingertip) or directly to sensitive areas using an applicator. The composition can be effective even when used in an individual's daily oral hygiene routine. For example, the composition can be brushed onto the teeth. The composition can be in contact with the teeth for a period of time ranging from one second to 20 hours. More preferably, 1 second to 10 hours, still more preferably 10 seconds to 1 hour, and most preferably 30 seconds to 5 minutes. The composition can be used daily, for example, by an individual once, twice, or three times a day. When the oral care composition is a biphasic composition, the two phases of the composition are mixed during application. The mixed phase is typically left on the teeth for 3 minutes to 10 hours, more preferably 3 minutes to 8 hours. Applications can be made one to five times per month.

[0108] The following embodiments are provided to facilitate understanding of the invention. These embodiments are not intended to limit the scope of the claims.

[0109] Example Example 1 - The transparent oral care composition according to the invention was prepared by following methods well known in the art. Details of the composition are provided in Table 1 below. The bubble structure of the compositions provided in Table 1 was analyzed using a dynamic foam analyzer (DFA100) from Kruss. The setup and measurement protocols were followed as provided in the invention.

[0110] Table 1

[0111] As can be seen from the data provided in Table 1, the oral care composition according to the invention has a bubble count variation rate of less than 25%, and the composition contains a thickening system containing xanthan gum and a sulfated surfactant, providing improved foam properties (good foam density, small bubble size and good stability), which enhances the mouthfeel and flavor impact of the composition.

[0112] Example 2 - Comparative Evaluation of Foam Formation and Stability The claimed formulation was compared with a comparative formulation, and various bubble parameters were analyzed as in Example 1. All bubble parameters (bubble count, average bubble area, average bubble radius) were measured continuously for up to 7 minutes. Initial bubble parameters were recorded at 20 seconds, and final bubble parameters were recorded at 444 seconds (approximately 7 minutes). The results are shown in Table 3 below.

[0113] Table 2

[0114] Table 3

[0115] As can be seen from the data above, compared with the comparative formulation A, the composition according to the present invention has better foam stability (lower bubble count reduction and lower rate of change of bubble radius).

Claims

1. An oral care composition comprising: i. 1.5-3 wt% anionic sulfated surfactant; ii. A thickening system comprising less than 10 wt% xanthan gum; in, The oral care composition exhibits a rate of change of 25% or less in bubble count when measured using a dynamic foam analyzer from approximately 20 seconds to approximately 7 minutes. The thickening system described herein comprises a combination of xanthan gum, carboxymethyl cellulose, and thickening silica.

2. The composition according to claim 1, wherein the rate of change of the bubble count is 20% or less.

3. The composition according to claim 1 or 2, wherein the sulfated surfactant is C 12 To C 20 The water-soluble salt of alkyl sulfate surfactants, preferably sodium lauryl sulfate.

4. The composition according to any one of the preceding claims, wherein the sulfated surfactant is present in an amount ranging from 2 to 3 wt% by weight of the composition.

5. The composition according to any one of the preceding claims, wherein, When measured using a dynamic foam analyzer from approximately 20 seconds to approximately 7 minutes, the rate of change of the average bubble radius ranged from 11% to 13.5%.

6. The composition according to any one of the preceding claims, wherein the xanthan gum has a weight-average molecular weight (Mi) in the range of 5 to 15 million Daltons. w ).

7. The composition according to any one of the preceding claims, wherein the composition comprises a fluoride ion source.

8. The composition according to any one of the preceding claims, wherein the composition comprises a zinc salt.

9. The composition according to any one of the preceding claims, wherein the weight ratio of the xanthan gum to the cellulose thickener ranges from 1:2.3 to 1:2.

6.

10. The composition according to any one of the preceding claims, wherein the composition comprises a wetting agent, preferably sorbitol.

11. The composition according to any one of the preceding claims, wherein the composition contains less than 21 wt% added water.

12. The composition according to any one of the preceding claims, wherein the xanthan gum is present in an amount ranging from 0.1 wt% to 5 wt%, preferably, the xanthan gum is present in an amount ranging from 0.1 wt% to 0.8 wt%.

13. The composition according to any one of the preceding claims, wherein the cellulose thickener is present in an amount ranging from 0.1 wt% to 0.8 wt%.

14. The composition according to any one of the preceding claims, wherein the composition comprises a silica abrasive, preferably a silica abrasive having a weight-average particle size in the range of 0.1 micrometer to 30 micrometers, more preferably 5 micrometers to 15 micrometers.

15. The composition according to any one of the preceding claims, wherein the thickened silica has a weight-average particle size in the range of 45 micrometers to 250 micrometers.

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