A scalp hair loss prevention composition, and a method of making and using same

Abstract

This invention provides a scalp anti-hair loss composition, its preparation method, and its application, comprising: cyclodextrin, caffeine, anti-hair loss plant extract, oil-controlling component, and soothing component; the anti-hair loss plant extract and the caffeine form a supramolecular complex, and the cyclodextrin encapsulates the caffeine and the anti-hair loss plant extract to form a supramolecular sustained-release system; by constructing a supramolecular sustained-release system of cyclodextrin, caffeine, and multiple plant extracts, which works synergistically with the oil-controlling and soothing components, this invention successfully solves the technical problems in existing anti-hair loss compositions, such as rapid release of active ingredients, low bioavailability, easy aggregation and pilling, and lack of synergistic oil-controlling and soothing effects. It achieves slow and continuous release of active ingredients, improving the anti-hair loss effect and user experience, while also possessing oil-controlling and soothing effects, adapting to more scalp needs.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, and in particular to a scalp anti-hair loss composition, its preparation method, and its application. Background Technology

[0002] With the accelerated pace of modern life, increased environmental pressure, and the influence of unhealthy lifestyle habits, hair loss is showing a significant growth trend globally, and the age of onset is constantly decreasing. This not only affects people's appearance but also easily leads to mental health problems, thus creating an ever-expanding market demand for scalp anti-hair loss care. Scalp anti-hair loss compositions have become a research hotspot in the fields of cosmetics and personal care.

[0003] Currently, most scalp anti-hair loss compositions on the market achieve their effects by adding ingredients such as caffeine and plant extracts. Caffeine, a commonly used active ingredient for hair loss prevention, can effectively inhibit hair follicle miniaturization and promote hair follicle metabolism. Plant extracts for hair loss prevention, such as extracts from arborvitae leaves, Polygonum multiflorum, and Sophora flavescens, have mild anti-hair loss and nourishing effects and are widely used in anti-hair loss products. Meanwhile, approximately 68.3% of people with hair loss have oily hair, and most also experience scalp sensitivity. Excessive DHT (dihydrotestosterone) and excessive scalp sebum secretion create a vicious cycle of "sebum accumulation - hair follicle atrophy - worsening hair loss." Sensitive scalps are prone to redness, stinging, and other discomfort. Therefore, oil control and soothing effects have become important requirements for scalp anti-hair loss compositions.

[0004] However, existing scalp anti-hair loss compositions still suffer from numerous technical bottlenecks, making it difficult to meet actual usage needs. Specific defects include: Firstly, the release efficiency of active ingredients is unreasonable. Core anti-hair loss ingredients such as caffeine and anti-hair loss plant extracts are mostly added directly, lacking an effective delivery system. This results in rapid release of active ingredients on the scalp surface, failing to sustainably act on the hair follicle target area, leading to low bioavailability. Furthermore, some plant extracts, due to their large molecular weight, have a transdermal penetration rate of less than 5 μg·cm⁻¹. - ²·h - ¹ First, it is difficult to penetrate the scalp barrier to exert its effect, seriously affecting the anti-hair loss effect. Second, the ingredients have poor compatibility. When caffeine is mixed with anti-hair loss plant extracts, it is easy to cause agglomeration, which not only further reduces the efficacy, but also makes the product texture heavy and sticky, and it is easy to cause pilling when used, affecting the user experience. Many mainstream anti-hair loss products have this kind of skin texture defect. Third, the efficacy is singular. Most products only focus on the single function of anti-hair loss, ignoring the synergistic need for oil control and soothing. Some oil control products can only reduce sebum secretion and cannot inhibit DHT (dihydrotestosterone), while traditional anti-hair loss products are prone to sebum accumulation and clogging hair follicles. At the same time, they lack effective soothing ingredients and are difficult to relieve the redness, stinging and other discomforts of sensitive scalps, and cannot adapt to the comprehensive needs of various scalp types such as oily and sensitive scalps.

[0005] To address these issues, the industry has attempted to optimize anti-hair loss effects through ingredient blending, but these are mostly simple ingredient mixing methods lacking systematic synergistic design and failing to fundamentally solve the core problems of rapid release of active ingredients and low bioavailability. Some technologies have attempted to use delivery technologies such as microcapsules, but these have drawbacks such as complex preparation processes, high costs, and difficulty in achieving synergistic sustained release of multiple active ingredients. Summary of the Invention

[0006] To address the technical problems of existing anti-hair loss compositions, such as rapid release of active ingredients, low bioavailability, easy agglomeration and pilling, and lack of synergistic oil-control and soothing effects, the present invention aims to provide an anti-hair loss composition for the scalp, its preparation method, and its application. By constructing a supramolecular sustained-release system that works synergistically with oil-controlling and soothing components, the invention successfully solves the technical problems of existing anti-hair loss compositions, such as rapid release of active ingredients, low bioavailability, easy agglomeration and pilling, and lack of synergistic oil-control and soothing effects. This results in a slow and continuous release of active ingredients, improving the anti-hair loss effect and user experience, while also providing oil-control and soothing effects to meet a wider range of scalp needs.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: On one hand, the present invention provides a scalp anti-hair loss composition, comprising: cyclodextrin, caffeine, anti-hair loss plant extract, oil-controlling component and soothing component; wherein the anti-hair loss plant extract and the caffeine form a supramolecular complex, and the cyclodextrin encapsulates the supramolecular complex to form a supramolecular sustained-release system.

[0008] The purpose of this invention is to provide a scalp anti-hair loss composition, its preparation method, and its application. By constructing a supramolecular sustained-release system of cyclodextrin, caffeine, and various plant extracts, which works synergistically with oil-controlling and soothing components, this invention successfully solves the technical problems of existing anti-hair loss compositions, such as excessively rapid release of active ingredients, low bioavailability, easy agglomeration and pilling, and lack of synergistic oil-controlling and soothing effects. This invention achieves slow and continuous release of active ingredients, improving the anti-hair loss effect and user experience, while also possessing oil-controlling and soothing effects, thus meeting more scalp needs.

[0009] In some embodiments, the anti-hair loss plant extract includes at least one or more of the following: Rehmannia glutinosa root extract, Platycladus orientalis leaf extract, Watercress leaf extract, and Watercress stem extract.

[0010] In some embodiments, the oil-controlling component includes: water, butylene glycol, caprylyl glycol, 1,2-pentanediol, and oil-controlling plant extracts; the oil-controlling plant extracts include at least one or more of the following: Forsythia fruit extract, Pueraria lobata root extract, and Anemarrhena asphodeloides root extract.

[0011] In some embodiments, the soothing component includes water, butylene glycol, and soothing plant extracts, wherein the soothing plant extracts include at least one or more of swertia sprout extract, gentian root extract, and gentian extract.

[0012] In some embodiments, the product includes a moisturizing component, which includes one or more of trehalose, 1,2-hexanediol, and butylene glycol.

[0013] In some embodiments, the method includes an antioxidant and preservative component, the antioxidant and preservative component comprising p-hydroxyacetophenone and 1,2-hexanediol.

[0014] In some embodiments, the product comprises the following components, by weight percentage: Cyclodextrin: 2.0%–3.0%; Caffeine: 0.3%–0.7%; Anti-hair loss plant extracts: 0.3%–0.5%; Moisturizing ingredients: 4.5%–5.5%; Oil-controlling components: 0.8%–1.2%; Soothing components: 0.8%–1.2%; Antioxidant and preservative components: 0.8%–1.2%; Water: Balance.

[0015] On the other hand, the present invention provides a method for manufacturing a scalp anti-hair loss composition, comprising the following steps: S1 premixes cyclodextrin, caffeine, and anti-hair loss plant extracts, then dissolves them in an appropriate amount of water for later use, thus obtaining a supramolecular mixed system; S2 adds the remaining water to the reaction vessel, heats and keeps it at a certain temperature to disinfect the water, then cools it down to obtain cooled disinfected water; S3 adds moisturizing and antioxidant / preservative components to the cooled disinfectant water, stirs until dissolved, and obtains a mixed system. After cooling the mixture in step S4, add the supramolecular mixture from step S1, the oil-controlling component, and the soothing component in sequence. Stir to ensure that each material is dissolved evenly. Adjust the pH value of the system to a range suitable for the scalp. After cooling to room temperature, the scalp anti-hair loss composition is obtained.

[0016] In some embodiments, in step S2, the heating temperature is 85°C to 100°C, the heat preservation time is 8 to 12 minutes, and the cooling temperature is 68 to 72°C. In step S4, the cooling temperature is 38℃~42℃, and citric acid or sodium citrate is added to adjust the pH of the system to 4.5~6.5.

[0017] The present invention provides an application of the scalp anti-hair loss composition as described in any one of the preceding claims, the composition being used to prepare any one of the following anti-hair loss daily chemical products: scalp essence, shampoo, scalp lotion, and conditioner.

[0018] This invention provides a scalp anti-hair loss composition, its preparation method, and its application, which have the following beneficial effects: 1) This invention provides a scalp anti-hair loss composition, its preparation method, and its application. By constructing a supramolecular sustained-release system that works synergistically with oil-controlling and soothing components, it successfully solves the technical problems in existing anti-hair loss compositions, such as excessively rapid release of active ingredients, low bioavailability, easy agglomeration and pilling, and lack of synergistic oil-controlling and soothing effects. It achieves slow and continuous release of active ingredients, improves the anti-hair loss effect and user experience, and at the same time has oil-controlling and soothing effects, adapting to more scalp needs.

[0019] 2) The specific mechanism is as follows: The anti-hair loss plant extract and caffeine first form a basic supramolecular complex through π-π conjugation. Then, cyclodextrin, with a hydrophobic inner wall in a near-cylindrical shape and a hydrophobic nonpolar layer, encapsulates this basic supramolecular complex through van der Waals forces and hydrophobic interactions, ultimately forming a supramolecular sustained-release system of "cyclodextrin-caffeine-anti-hair loss plant extract." This system not only significantly improves the water solubility of caffeine and plant extracts but also prevents the aggregation of active ingredients through steric hindrance, while achieving slow and sustained release. In vitro release experiments verified that this synergistic system exhibits no burst release phenomenon; the cumulative release rate is only 28.6% after 1 hour, controlled at 82.1% after 12 hours, and slowly releases to 96.5% after 24 hours, effectively solving the problems of excessively rapid release and low bioavailability of active ingredients in existing anti-hair loss compositions (Comparative Example 1, without supramolecular system, has a burst release rate of 65.8% after 1 hour). Simultaneously, transdermal absorption experiments show that this synergistic system facilitates a transdermal transdermal rate of 18.6 μg·cm⁻¹. - ²·h - ¹ The hair follicle accumulation reached 27.3 μg / g, which is 32.1% and 46.5% higher than that of the control group without supramolecular system, respectively. The core mechanism is that the encapsulation effect of cyclodextrin prevents caffeine and anti-hair loss plant extracts from agglomerating, improves their solubility and stability, and synergistically promotes the transdermal penetration of active ingredients, prolongs the anti-hair loss effect time and improves the absorption efficiency of hair follicles. In addition, the encapsulation effect of cyclodextrin can also effectively prevent the agglomeration of various active ingredients. Combined with stability and pilling tests, it is confirmed that the system did not separate, change color or precipitate after being placed at 4℃, 25℃ and 45℃ for 6 months. There was no pilling phenomenon after application, which significantly improved the user experience and solved the technical defects of existing products that are prone to agglomeration and pilling from the mechanism.

[0020] The anti-hair loss components (Chinese Rehmannia glutinosa root extract, Platycladus orientalis leaf extract, Watercress leaf extract, Watercress stem extract) achieve anti-hair loss by inhibiting the production of dihydrotestosterone (DHT), repairing damaged hair follicles, and reducing hair follicle atrophy. In addition, they work synergistically with caffeine—caffeine promotes scalp blood circulation and delivers nutrients to hair follicles. The two form a synergistic anti-hair loss mechanism of "inhibiting damage + supplementing nutrition". Human clinical trials have verified that after using the composition of this invention for 28 days, the hair loss reduction rate reached 42.7%, which is more than 77% higher than that of the comparative example 1 (22.8%) without supramolecular system. The forsythia fruit extract, kudzu root extract, and anemarrhena root extract in the oil-controlling component synergistically inhibit the secretion of sebaceous glands in the scalp. The oil-controlling component contains polyols such as butylene glycol, which play a dispersing and solubilizing role, improving the solubility and efficacy of the oil-controlling plant extracts. Caprylyl glycol and 1,2-pentanediol in the oil-controlling component synergistically help stabilize the oil-controlling system, avoiding component stratification and failure, forming a complete oil-controlling synergistic mechanism of "inhibiting secretion + promoting absorption + stabilizing the system". The improvement rate of scalp sebum secretion reached 35.6%, which is significantly better than Comparative Example 1 (20.3%) and Comparative Example 3 (18.9%) of the existing conventional formula. The soothing components (Swertia spp. extract, Gentiana macrophylla extract, and Gentiana scabra extract) soothe the scalp by inhibiting inflammatory factors and repairing the scalp barrier. Simultaneously, the dispersing effect of butylene glycol in the soothing components enhances their even distribution on the scalp, resulting in a 40.2% relief rate for scalp itching, superior to other formulations. It is suitable for a wider range of scalp types, especially sensitive and oily scalps with hair loss, achieving a synergistic effect of "anti-hair loss + oil control + soothing".

[0021] The moisturizing components, antioxidant and preservative components, and supramolecular sustained-release system work synergistically to balance gentleness and system stability, with a clear synergistic mechanism: In terms of moisturizing, the moisturizing components—trehalose, 1,2-hexanediol, and butylene glycol—work together to form a moisturizing mechanism: trehalose locks in moisture on the scalp surface, butylene glycol penetrates deep into the stratum corneum to replenish moisture, and 1,2-hexanediol helps enhance the moisturizing effect. These three components work together to maintain the scalp's water-oil balance. Simultaneously, butylene glycol also helps stabilize the supramolecular system, reducing the dissociation of the cyclodextrin encapsulation structure and further enhancing the sustained-release effect. In terms of antioxidant and preservative components, the antioxidant and preservative components are p-hydroxyacetophenone and 1,2-hexanediol in a 1:1 mass ratio. These two components work synergistically to exert dual antioxidant and preservative effects, protecting the activity of active ingredients such as caffeine and plant extracts in the supramolecular system, inhibiting microbial growth, extending the product's shelf life, and being gentle and non-irritating. They also work synergistically with the supramolecular system to reduce the irritation of the active ingredients. Based on stability test data and human trial verification, this moisturizing, antioxidant and preservative synergistic system can effectively protect the activity of active ingredients, extend the product's shelf life, and is gentle and non-irritating, suitable for sensitive scalps. It solves the problems of irritation from preservative ingredients, short shelf life and water-oil imbalance in some existing anti-hair loss products from a mechanistic perspective.

[0022] This invention utilizes a synergistic and adaptable preparation process to achieve a unified balance between process, components, and efficacy, taking into account both industrial production and market application value. It ensures the complete dissolution of cyclodextrin, effectively encapsulating caffeine and anti-hair loss plant extracts to form a stable supramolecular system, while avoiding high-temperature degradation of the activity of plant extracts, caffeine, and other active ingredients, thus meeting the stability requirements of each component. Simultaneously, the process is simple and easy to implement, requiring no complex equipment, resulting in low production costs and suitability for large-scale industrial production. Furthermore, the synergistic effect of the components gives the product multiple benefits, including anti-hair loss, oil control, soothing, and moisturizing, with significantly superior performance compared to existing conventional formulas. It has a wide range of applications, suitable for preparing various anti-hair loss daily chemical products such as scalp serums, shampoos, scalp lotions, and conditioners, catering to different product forms and possessing broad market prospects. Attached Figure Description

[0023] Figure 1 This is a photograph of the scalp anti-hair loss composition provided in Example 1 of the present invention before centrifugation.

[0024] Figure 2 This is a photograph of the scalp anti-hair loss composition provided in Example 1 of the present invention after centrifugation at 4000 rpm for 30 minutes. Detailed Implementation

[0025] The technical solution of the present invention will be clearly and completely described below with reference to specific embodiments. However, those skilled in the art will understand that the embodiments described below are some embodiments of the present invention, but not all embodiments, and are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall be followed. Where the manufacturers of reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0026] On one hand, the present invention provides a scalp anti-hair loss composition, comprising: cyclodextrin, caffeine, anti-hair loss plant extract, oil-controlling component, and soothing component; wherein the anti-hair loss plant extract and the caffeine form a supramolecular complex, and the cyclodextrin encapsulates the supramolecular complex to form a supramolecular sustained-release system.

[0027] The purpose of this invention is to provide a scalp anti-hair loss composition, its preparation method, and its application. By constructing a supramolecular sustained-release system of cyclodextrin, caffeine, and various plant extracts, which works synergistically with oil-controlling and soothing components, this invention successfully solves the technical problems of existing anti-hair loss compositions, such as excessively rapid release of active ingredients, low bioavailability, easy agglomeration and pilling, and lack of synergistic oil-controlling and soothing effects. This invention achieves slow and continuous release of active ingredients, improving the anti-hair loss effect and user experience, while also possessing oil-controlling and soothing effects, thus meeting more scalp needs.

[0028] Preferably, cyclodextrin, caffeine, and anti-hair loss plant extracts are mixed in water to form a supramolecular sustained-release system.

[0029] Preferably, the cyclodextrin is β-cyclodextrin.

[0030] Preferably, the anti-hair loss plant extract includes at least one or more of the following: Rehmannia chinensis root extract, Thuja orientalis leaf extract, Nasturtium officinale leaf extract, and Nasturtium officinale stem extract.

[0031] Preferably, the oil-controlling component includes: water, butylene glycol, caprylyl glycol, 1,2-pentanediol, and oil-controlling plant extracts; the oil-controlling plant extracts include at least one or more of the following: Forsythia suspensa fruit extract, Pueraria lobata root extract, and Anemarrhena asphodeloides root extract.

[0032] Preferably, the soothing component comprises: water, butylene glycol, and soothing plant extracts, wherein the soothing plant extracts include at least one or more of Swertia bimaculata extract, Gentiana macrophylla extract, and Gentiana scabra extract.

[0033] Preferably, it further includes a moisturizing component, said moisturizing component comprising one or more of trehalose, 1,2-hexanediol, and butylene glycol.

[0034] Preferably, it further includes: an antioxidant and preservative component, wherein the antioxidant and preservative component comprises: p-hydroxyacetophenone and 1,2-hexanediol, wherein the p-hydroxyacetophenone and the 1,2-hexanediol are compounded in a mass ratio of 1:1.

[0035] Preferably, the product comprises the following components, in 100% by mass: Cyclodextrin: 2.0%–3.0%; Caffeine: 0.3%–0.7%; Anti-hair loss plant extracts: 0.3%–0.5%; Moisturizing ingredients: 4.5%–5.5%; Oil-controlling components: 0.8%–1.2%; Soothing components: 0.8%–1.2%; Antioxidant and preservative components: 0.8%–1.2%; Water: Balance.

[0036] On the other hand, the present invention provides a method for manufacturing a scalp anti-hair loss composition, comprising the following steps: S1 premixes cyclodextrin, caffeine, and anti-hair loss plant extracts, then dissolves them in an appropriate amount of water for later use, thus obtaining a supramolecular mixed system; S2 adds the remaining water to the reaction vessel, heats and keeps it at a certain temperature to disinfect the water, then cools it down to obtain cooled disinfected water; S3 adds moisturizing and antioxidant / preservative components to the cooled disinfectant water, stirs until dissolved, and obtains a mixed system. After cooling the mixture in step S4, add the supramolecular mixture from step S1, the oil-controlling component, and the soothing component in sequence. Stir to ensure that each material is dissolved evenly. Adjust the pH value of the system to a range suitable for the scalp. After cooling to room temperature, the scalp anti-hair loss composition is obtained.

[0037] Preferably, in step S2, the heating temperature is 85℃~100℃, the heat preservation time is 8~12min, and the cooling temperature is 68~72℃; In step S4, the cooling temperature is 38℃~42℃, and citric acid or sodium citrate is added to adjust the pH of the system to 4.5~6.5.

[0038] This invention provides an application of the scalp anti-hair loss composition as described in any one of the preceding claims, wherein the composition is used to prepare any one of the anti-hair loss daily chemical products, namely, scalp essence, shampoo, scalp lotion, and conditioner, wherein the amount of the scalp anti-hair loss composition added to the scalp essence or scalp lotion is 80% to 100% by mass, and the amount of the scalp anti-hair loss composition added to the shampoo is 20% to 40% by mass.

[0039] The specifications of the extracts used are as follows: Platycladus orientalis leaf extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 20:1, with solids ≥2.0% and total flavonoids ≥0.8%, resulting in a liquid extract with a pH of 4.5 to 6.5. Chinese Rehmannia glutinosa root extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 15:1, with solids ≥2.0% and catalpol ≥0.5%, resulting in a liquid extract with a pH of 4.5 to 6.5. Watercress leaf extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 20:1, with solids ≥1.5% and total flavonoids ≥0.6%, in liquid form, pH 4.5 to 6.5; Anemarrhena asphodeloides root extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 15:1, with solids ≥1.5% and anemarrhena saponin BⅡ ≥0.8%, resulting in a liquid extract with a pH of 5.0 to 7.0. Forsythia fruit extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 20:1, with solids ≥2.0% and forsythosides ≥1.0%, in liquid form, pH 4.5 to 6.5; Pueraria lobata extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 15:1, with solids ≥1.5% and total isoflavones ≥0.8%, resulting in a liquid extract with a pH of 5.0 to 7.0. Swertia japonica extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 20:1, with solids ≥1.5% and swertia glycosides ≥1.0%, in liquid form, pH 4.5 to 6.5; Gentiana macrophylla extract: extracted with ethanol-water solution at a weight ratio of 8:1 to 15:1, with solids ≥1.2% and gentiopicroside ≥0.5%, in liquid form, pH 5.0 to 7.0; Gentian extract: extracted with ethanol-water solution at a weight ratio of 10:1 to 20:1, with solids ≥1.5% and gentiopicroside ≥0.8%, in liquid form, pH 4.5 to 6.5.

[0040] Example 1 This invention provides a method for preparing a supramolecular sustained-release scalp hair loss prevention composition, comprising the following steps: S1 Weigh 2.5g β-cyclodextrin, 0.5g caffeine, 0.3g Platycladus orientalis leaf extract, 0.05g Rehmannia glutinosa root extract, and 0.05g Sophora flavescens leaf extract, premix them evenly, add 10g deionized water to dissolve, stir at 250r / min for 12min at 25℃, and set aside to obtain a supramolecular mixed system. S2 Weigh 79g of deionized water and add it to the reaction vessel. Heat it to 85℃ and keep it at that temperature for 10 minutes for disinfection. Then cool it down to 70℃ to obtain the cooled disinfected water. S3 adds 1.0g trehalose, 4.0g butanediol, 1.0g 1,2-hexanediol and 0.5g p-hydroxyacetophenone to the cooled disinfectant water, and stirs at 400r / min until completely dissolved to obtain a mixed system; S4. The mixture was cooled to 40°C, and the supramolecular mixture prepared in step S1, the oil-controlling components (0.5g butylene glycol, 0.05g forsythia fruit extract, 0.05g kudzu root extract, 0.05g anemarrhena root extract, 0.05g caprylyl glycol, 0.05g 1,2-pentanediol) and the soothing components (0.2g butylene glycol, 0.05g swertia spp. extract, 0.05g gentian root extract, 0.05g gentian root extract) were added sequentially. After each addition, the mixture was stirred at 400r / min for 6min until all materials were completely dissolved and homogeneous. Citric acid was added to adjust the pH of the system to 5.9. After cooling to room temperature, samples were taken and sent for testing to obtain the supramolecular sustained-release scalp hair loss prevention composition.

[0041] Among them, the extract of Platycladus orientalis leaves was extracted with ethanol-water solution at a material-to-liquid ratio of 15:1, with solids ≥2.0% and total flavonoids ≥0.8%, and was a liquid extract with a pH of 5.5. Chinese Rehmannia glutinosa root extract: extracted with ethanol-water solution, with a solid-liquid weight ratio of 13:1, solids ≥2.0%, catalpol ≥0.5%, liquid extract, pH 5.5; Watercress leaf extract: extracted with ethanol-water solution at a weight ratio of 15:1, with solids ≥1.5% and total flavonoids ≥0.6%, liquid, pH 5.5; Anemarrhena asphodeloides root extract: extracted with ethanol-water solution at a weight ratio of 13:1, with solids ≥1.5%, anemarrhena saponin BⅡ ≥0.8%, liquid extract, pH 6.0; Forsythia fruit extract: extracted with ethanol-water solution at a weight ratio of 15:1, with solids ≥2.0% and forsythosides ≥1.0%, liquid, pH 5.5; Pueraria lobata extract: extracted with ethanol-water solution at a weight ratio of 12:1, with solids ≥1.5% and total isoflavones ≥0.8%, resulting in a liquid extract at pH 6.0. Swertia japonica extract: extracted with ethanol-water solution at a weight ratio of 15:1, with solids ≥1.5% and swertia glycosides ≥1.0%, liquid, pH 5.5; Gentiana macrophylla extract: extracted with ethanol-water solution at a weight ratio of 12:1, with solids ≥1.2% and gentiopicroside ≥0.5%, liquid, pH 6.0; Gentian extract: extracted with ethanol-water solution at a weight ratio of 15:1, with solids ≥1.5% and gentiopicroside ≥0.8%, in liquid form at pH 5.5.

[0042] Comparative Example 1 (Acyclic dextrin, no supramolecular system) Comparative Example 1 provides a method for preparing a scalp anti-hair loss composition. The method omits the addition of cyclodextrin in step S1, and the remaining steps are consistent with Example 1. The difference from Example 1 is that step S1 specifically involves: taking 0.5g of caffeine, 0.3g of Platycladus orientalis leaf extract, 0.05g of Rehmannia glutinosa root extract, and 0.05g of Sophora flavescens leaf extract, premixing them evenly, adding 10g of deionized water to dissolve them, and stirring at 250r / min for 12min at 25°C for later use to obtain the mixed system. The amount of deionized water added in S2 is increased from 79g to 81.5g.

[0043] Comparative Example 2 (Cyclodextrin encapsulates only caffeine, a binary supramolecular system) Comparative Example 2 provides a method for preparing a scalp anti-hair loss composition. The remaining steps are the same as in Example 1, except that step S1 is as follows: take 2.5g of β-cyclodextrin and 0.5g of caffeine, premix them evenly, add 10g of deionized water to dissolve them, stir at 250r / min for 12min at 25℃, then add 0.3g of Platycladus orientalis leaf extract, 0.05g of Rehmannia glutinosa root extract, and 0.05g of Sophora flavescens leaf extract, stir evenly, and set aside.

[0044] Comparative Example 3 (Conventional anti-hair loss formula in existing technology, without supramolecular system or oil-controlling compound components) Comparative Example 3 provides a method for preparing a scalp anti-hair loss composition. The remaining steps are the same as in Example 1, except that step S1 is as follows: take 0.5g of caffeine, 0.3g of Platycladus orientalis leaf extract, 0.05g of Rehmannia glutinosa extract and 0.05g of Sophora flavescens leaf extract, premix them evenly, add 10g of deionized water to dissolve them, stir at 250r / min for 12min at 25℃, and set aside to obtain a mixed system; S2 Weigh 82.25g of deionized water and add it to the reaction vessel. Heat to 85℃ and keep warm for 10 minutes for disinfection. Cool down to 70℃ to obtain the cooled disinfected water. S3 adds 1.0g trehalose, 4.0g butanediol, 1.0g 1,2-hexanediol and 0.5g p-hydroxyacetophenone to the cooled disinfectant water, and stirs at 400r / min until completely dissolved to obtain a mixed system; S4. Cool the system to 40℃, and add the mixture prepared in step S1 and the soothing components (0.2g butylene glycol, 0.05g swertia extract, 0.05g gentian extract, and 0.05g gentian extract) in sequence. After each addition, stir at 400r / min for 6min until all materials are completely dissolved and homogeneous. Add citric acid or sodium citrate to adjust the pH of the system to 5.9. After cooling to room temperature, sample and send for testing to obtain the scalp anti-hair loss composition.

[0045] Experimental methods 1. In vitro release test The dialysis bag method was used. Each sample was placed in a dialysis bag and then placed in a buffer solution simulating scalp sweat. The solution was kept at 37℃ and 100 rpm and shaken at a constant temperature. Samples were taken at 1h, 4h, 12h, and 24h. The contents of caffeine and Platycladus orientalis leaf extract in the buffer solution were detected by high performance liquid chromatography. The cumulative release rate at each time point was calculated, and the presence of burst release was observed. Each experiment was repeated 3 times, and the average value was taken as the experimental result.

[0046] 2. Transdermal absorption test Using a Franz diffusion cell, fresh pigskin (subcutaneous fat removed, thickness 0.3 mm) was fixed between the supply and receiving cells of the diffusion cell. Each sample was evenly applied to one side of the pigskin epidermis. A pre-set receiving solution containing 20% ​​ethanol was added to the receiving cell. The mixture was stirred at a constant temperature of 37℃ and 500 r / min. Samples were taken at 2h, 4h, 8h, 12h, and 24h to detect the content of caffeine and arborvitae leaf extract in the receiving solution. The transdermal absorption rate and hair follicle accumulation were calculated, and the transdermal absorption effect of each sample was compared. Each experiment was repeated 3 times, and the average value was taken as the experimental result.

[0047] 3. Stability and pilling test Each sample was placed in a constant temperature environment of 4℃ (low temperature), 25℃ (normal temperature), and 45℃ (high temperature) for 6 months. The appearance, layering, discoloration and precipitation of the samples were observed every month to evaluate the stability of the samples. Pilling test: Take equal amounts of each sample and apply them evenly to the surface of fresh pigskin (simulating scalp). Rub repeatedly with your fingers for 1 minute with the same force. Observe whether pilling or flaking occurs on the skin surface and evaluate the user experience. Each group of experiments is repeated 5 times and the average value of the results is taken.

[0048] 4. Anti-hair loss, oil control, and soothing effects: Human clinical trials Sixty volunteers aged 20-45 (30 men and 30 women, all with seborrheic alopecia, accompanied by varying degrees of scalp oiliness and itching, hair loss grade I-II, and who had not used any anti-hair loss products in the past 3 months) were randomly divided into 4 groups of 15 participants each. Each group used the compositions prepared in Example 1 and Comparative Examples 1-3 (all prepared as scalp serums, with standardized usage and dosage), applied once daily to the scalp and massaged for 3 minutes until fully absorbed, for 28 consecutive days. The daily hair loss amount was measured before use, after 14 days, and after 28 days to assess the reduction rate. Scalp sebum secretion was recorded using a sebum analyzer, and scalp itching was recorded using the Visual Analogue Scale (VAS). The sebum secretion improvement rate and itching relief rate were calculated. All data were statistically analyzed using SPSS 26.0. P < 0.05 was considered statistically significant, and the differences between Example 1 and each comparative example reached a highly significant P < 0.01 level. The experimental data of Example 1 and Comparative Examples 1-3, tested using the above experimental methods, are shown in Tables 1-4 below: Table 1. Results of in vitro release experiments for Examples 1 and Comparative Examples 1-3

[0049] Table 2. Transdermal absorption test results of Example 1 and Comparative Examples 1-3

[0050] Table 3. Stability and rubbing test results of Example 1 and Comparative Examples 1-3

[0051] Table 4. Results of human clinical trials on the anti-hair loss, oil control, and soothing effects of Example 1 and Comparative Examples 1-3.

[0052] From Table 1, we can observe that Example 1 (the present invention) has no burst release phenomenon, the cumulative release rate is controlled at over 80% in 12 hours, and the slow release reaches over 95% in 24 hours, with a sustained release effect that is significantly better than the comparative examples; Comparative examples 1 and 3 do not have supramolecular systems and show obvious burst release, with the active ingredient released too quickly; Comparative example 2 is a binary supramolecular system, with a sustained release effect that is better than comparative examples 1 and 3, but weaker than the multi-component supramolecular system of the present invention.

[0053] From Table 2, we can observe that the transdermal absorption rate and hair follicle accumulation of Example 1 are significantly higher than those of the comparative examples, increasing by 32.1% and 46.5% respectively compared to Comparative Example 1. This indicates that the multi-component supramolecular system of the present invention can effectively improve the transdermal absorption efficiency of the active ingredient and the hair follicle accumulation, thereby enhancing the anti-hair loss effect. The transdermal effect of Comparative Example 2 is better than that of Comparative Examples 1 and 3, but weaker than that of Example 1. This indicates that the key step in constructing the supramolecular sustained-release system is to first form a complex of caffeine and anti-hair loss plant extract through π-π conjugation and then encapsulate it with cyclodextrin, which has a significant synergistic effect.

[0054] From Table 3, we can observe that Example 1 has good stability, with no abnormalities under various temperature conditions and no pilling, resulting in a good user experience. Each comparative example has varying degrees of stability problems or pilling, with comparative examples 1 and 3 showing obvious pilling, and comparative example 3 exhibiting the worst stability. This further demonstrates the advantages of the supramolecular system of this invention in terms of stability and user experience.

[0055] From Table 4, we can observe that the anti-hair loss effect, scalp oil improvement effect and itching relief effect of Example 1 are significantly better than those of the comparative examples. After 28 days of use, the hair loss reduction rate reached 42.7%, which is more than 77% higher than that of Comparative Example 1. At the same time, the oil control and soothing effects are outstanding, which fully demonstrates the technical advantages of the supramolecular system and component synergy of the present invention.

[0056] This experimental example is used to verify the system stability of the supramolecular sustained-release scalp hair loss prevention composition provided in Example 1. The test was conducted in accordance with the industry standard QB / T2660-2024 "Cosmetics Skin Care Lotions", as follows: Test samples: The supramolecular sustained-release scalp anti-hair loss composition of Example 1 was prepared into scalp anti-hair loss essence (10ml / bottle) using the following process, with 8 bottles per group, and no batch number marking: S1 filtration: The composition is filtered through a 0.22μm microporous membrane to remove insoluble particles and impurities; S2 degassing: Vacuum degassing for 15 minutes under a vacuum of 0.07 MPa to eliminate bubbles in the system; S3 Filling: The degassed liquid is quantitatively filled into 10ml light-proof bottles under cleanroom (Class 10,000) conditions; S4 Sealing: The capping machine is used for sealing. After passing the light inspection, the scalp anti-hair loss essence is obtained.

[0057] 2.1 Accelerated stability test: The test temperature is 25℃ (room temperature), 40±1℃ (high temperature), and -8±2℃ (low temperature); the test period is 6 months (August 29, 2025 - February 28, 2026); the test standard is QB / T 2660, and the test items are appearance, odor, and pH value (25℃).

[0058] 2.2 Centrifugation stability test: The centrifugation conditions were 4000 rpm and 30 min; the test item was whether the system separated into layers.

[0059] 3. Test Methods: Appearance, odor, and pH value tests all followed the QB / T2660 standard method; centrifugation tests were conducted using a laboratory high-speed centrifuge, and the system state was directly observed after completion. The test results of Example 1 using the above experimental methods are shown in Table 5 below: Table 5. Stability test results of Example 1

[0060] Table 5 shows the results of the accelerated stability test: During the 6-month test period, the sample test results met the standard requirements at all temperature conditions of 25℃, 40±1℃, and -8±2℃, with no abnormal changes. Specifically, the appearance maintained the specified color at each time point, with no foreign matter, no layering, no discoloration, and no sedimentation. The odor met the specified fragrance at each time point, with no off-odor or fragrance loss. The pH value was stable at 5.95~5.99 at 25℃, 5.85~5.92 at 40±1℃, and 5.92~5.99 at -8±2℃, all within the range of 4.0~8.5 of the QB / T2660 standard, and highly compatible with the physiological pH value of the scalp.

[0061] like Figure 1-2 As shown, the centrifugal stability test results of the scalp anti-hair loss composition provided in Example 1 are as follows: after centrifugation at 4000 rpm for 30 min, the sample system is homogeneous, with no stratification, no precipitation, and no crystallization. The scalp anti-hair loss composition of this invention has been verified through accelerated stability testing under multiple temperature conditions for more than 6 months and centrifugal stability testing at 4000 rpm / 30 min. All test indicators meet the requirements of QB / T 2660 standard. The composition system has excellent stability and can maintain stable physicochemical properties under normal temperature, high temperature and low temperature conditions. It also has strong resistance to centrifugal stratification. This proves that the formulation and preparation process of the composition of this invention are reasonable, the product has a long shelf life, and can meet the stability requirements of industrial production, warehousing and transportation and market application.

[0062] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A scalp anti-hair loss composition, characterized in that, include: The product contains cyclodextrin, caffeine, anti-hair loss plant extract, oil-controlling components, and soothing components; the anti-hair loss plant extract and the caffeine form a supramolecular complex, and the cyclodextrin encapsulates the supramolecular complex to form a supramolecular sustained-release system.

2. The scalp anti-hair loss composition according to claim 1, characterized in that, The anti-hair loss plant extract includes at least one or more of the following: Rehmannia glutinosa root extract, Platycladus orientalis leaf extract, Watercress leaf extract, and Watercress stem extract.

3. The scalp anti-hair loss composition according to claim 1, characterized in that, The oil-controlling components include: water, butylene glycol, caprylyl glycol, 1,2-pentanediol, and oil-controlling plant extracts; the oil-controlling plant extracts include at least one or more of the following: Forsythia fruit extract, Pueraria lobata root extract, and Anemarrhena asphodeloides root extract.

4. The scalp anti-hair loss composition according to claim 1, characterized in that, The soothing components include: water, butylene glycol, and soothing plant extracts, wherein the soothing plant extracts include at least one or more of the following: swertia shoot extract, gentian root extract, and gentian extract.

5. The scalp anti-hair loss composition according to claim 1, characterized in that, include: The moisturizing component includes one or more of trehalose, 1,2-hexanediol, and butylene glycol.

6. The scalp anti-hair loss composition according to claim 1, characterized in that, include: The antioxidant and preservative components include p-hydroxyacetophenone and 1,2-hexanediol.

7. The scalp anti-hair loss composition according to any one of claims 1-6, characterized in that, It comprises the following components by weight percentage: Cyclodextrin: 2.0%–3.0%; Caffeine: 0.3%–0.7%; Anti-hair loss plant extracts: 0.3%–0.5%; Moisturizing ingredients: 4.5%–5.5%; Oil-controlling components: 0.8%–1.2%; Soothing components: 0.8%–1.2%; Antioxidant and preservative components: 0.8%–1.2%; Water: Balance.

8. A method for manufacturing a scalp anti-hair loss composition, characterized in that, Manufacturing the scalp anti-hair loss composition as described in any one of claims 1-7 comprises the following steps: S1 premixes cyclodextrin, caffeine, and anti-hair loss plant extracts, then dissolves them in an appropriate amount of water for later use, thus obtaining a supramolecular mixed system; S2 adds the remaining water to the reaction vessel, heats and keeps it at a certain temperature to disinfect the water, then cools it down to obtain cooled disinfected water; S3 adds moisturizing and antioxidant / preservative components to the cooled disinfectant water, and stirs until dissolved to obtain a mixed system. After cooling the mixture in step S4, add the supramolecular mixture from step S1, the oil-controlling component, and the soothing component in sequence. Stir to ensure that each material is dissolved evenly. Adjust the pH value of the system to a range suitable for the scalp. After cooling to room temperature, the scalp anti-hair loss composition is obtained.

9. The method for manufacturing the scalp anti-hair loss composition according to claim 8, characterized in that, In step S2, the heating temperature is 85℃~100℃, the heat preservation time is 8~12min, and the cooling temperature is 68~72℃; In step S4, the cooling temperature is 38℃~42℃, and citric acid or sodium citrate is added to adjust the pH of the system to 4.5~6.

5.

10. The application of the scalp anti-hair loss composition according to any one of claims 1 to 7, characterized in that, The composition is used to prepare any one of the following anti-hair loss daily chemical products: scalp essence, shampoo, scalp lotion, and conditioner.

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