Application of poly-L-lactic acid and copolymer thereof in preparation of product for bidirectionally regulating blood sugar and improving insulin resistance

By using L-polylactic acid copolymer microspheres, safe and effective bidirectional regulation of blood glucose and improvement of insulin resistance are achieved, overcoming the shortcomings of existing treatment options and making it suitable for the treatment of a variety of metabolic diseases, including diabetes and neurodegenerative diseases.

CN122124091APending Publication Date: 2026-06-02CHANGCHUN SINOBIOMATERIALS CO LTD
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Patent Information

Application Number
CN202610562652.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-24
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing treatment options are ineffective in improving insulin resistance and have side effects and treatment dependence. They also lack specificity, especially in steroid-induced diabetes, where blood glucose management and hormone therapy are difficult to balance.

Method used

Polymer microspheres made of polylactic acid (PLA) or copolymers containing repeating L-lactic acid units can achieve bidirectional regulation of blood glucose, improve insulin resistance, protect mitochondrial function, inhibit liver inflammation, and reduce hepatocyte damage via injection or oral administration.

Benefits of technology

It achieves safe and effective improvement of insulin resistance, reduces treatment frequency, and improves patient compliance. It is applicable to the treatment of a variety of metabolic diseases, including diabetes, neurodegenerative diseases, and metabolic-related fatty liver disease.

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Abstract

The invention belongs to the technical field of medicines, and relates to an application of poly-L-lactic acid and a copolymer thereof in preparation of a product for bidirectionally regulating blood sugar and improving insulin resistance. In particular, the present invention relates to the use of a polymer in the preparation of a medicament, the polymer comprising poly-L-lactic acid or a copolymer comprising a poly-L-lactic acid repeating unit, the poly-L-lactic acid repeating unit; the medicine is used for one or more of the following purposes: bidirectionally regulating blood sugar, improving insulin resistance, protecting a mitochondrial function, repairing nervous system injury, inhibiting liver inflammatory response and relieving liver cell injury.
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