Preparation method and application of kidney-removable optical diagnosis probe-cell conjugate

By conjugating a kidney-clearable optical diagnostic probe to cells to form a probe-cell conjugate, the problem of the lack of targeting in existing diagnostic probes is solved, achieving high sensitivity and high specificity for early disease diagnosis, and applicable to non-invasive detection of various cells and diseases.

CN122124291APending Publication Date: 2026-06-02SUN YAT SEN UNIV
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Patent Information

Application Number
CN202610259594.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-04
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing renal clearance optical diagnostic probes lack active targeting of lesion sites, resulting in insufficient diagnostic sensitivity and specificity, making it difficult to achieve non-invasive detection of early diseases.

Method used

A renal-clearable optical diagnostic probe was fused with maleimide-modified polyethylene glycol and incubated with Traut's pretreated cells to form a renal-clearable optical diagnostic probe-cell conjugate. This conjugate utilizes the active migration of cells to the disease site and releases fragments that can be cleared by the kidneys.

Benefits of technology

It achieves high sensitivity and high specificity for non-invasive diagnosis of disease sites, and can rapidly detect disease markers through urine analysis, making it suitable for early diagnosis of various cell types and disease types.

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a preparation method and application of a kidney-removable optical diagnosis probe-cell conjugate. The kidney-removable optical diagnosis probe-cell conjugate is obtained by fusing a kidney-removable optical diagnosis probe with a maleimide modified polyethylene glycol chain and then incubating the fusion product with Traut's pretreated cells. The method is simple, convenient, time-saving and efficient, and is suitable for various kidney removable optical diagnosis probes and various cell types. Meanwhile, the method has little influence on cell viability, disease targeting ability and physiological barrier crossing ability. Besides, the kidney-removable optical diagnosis probe-cell conjugate constructed by the method can release kidney-removable fragments in a disease microenvironment, further realizes early diagnosis of various diseases through urine analysis, and has high sensitivity and high specificity.
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