A laboratory virus stock clarification centrifuge

Abstract

This invention discloses a laboratory viral stock clarification centrifuge, relating to the field of centrifuge technology, including a centrifuge frame, control cabinet, centrifuge main unit, drive unit, and anti-overflow locking device. This invention utilizes the flow guiding and interception coordination between the first upstream section, second upstream section, first midstream section, second midstream section, expansion sealing chamber, and overflow chamber to block viral stock or cleaning fluid overflowing between the lower casing and upper cover, preventing direct leakage and pollution. Through the cooperation of a floating head, elastic membrane, contact, extrusion head, and piezoelectric element, the continuous increase in viral stock leakage inside and outside the overflow chamber is converted into an electrical signal of corresponding strength. The control system can automatically activate the compensation device based on this electrical signal to perform secondary sealing compensation of the sealing chamber. Simultaneously, the control system can also judge the compensation effect based on signal changes; when leakage weakens, centrifugation operation is maintained; when leakage continues to worsen, the sealing strength of the expansion sealing element is further enhanced.

Description

Technical Field

[0001] This invention relates to the field of centrifuge technology, specifically a laboratory virus stock solution clarification centrifuge. Background Technology

[0002] Laboratory virus stock solution clarification centrifuges are key equipment used in biopharmaceutical and virology research to efficiently separate and clarify virus culture media containing cell debris, protein impurities, and particulate impurities. This equipment utilizes the strong centrifugal field created by high-speed rotation to cause components of different densities and particle sizes to migrate and separate into layers in a very short time, achieving rapid separation of effective viral components from impurity components. This results in a highly clarified virus stock solution suitable for subsequent purification or detection processes.

[0003] Existing centrifuge units rely solely on connecting flanges for locking. In cases of internal sealing failure, sudden shutdowns for repairs, or maintenance, the internal viral stock or residual cleaning fluid can easily leak directly from between the lower casing and the upper cover, causing pollution and safety hazards to the equipment, the environment, and operators. Summary of the Invention

[0004] The purpose of this invention is to provide a laboratory virus stock solution clarification centrifuge to solve the problem of insufficient protection against liquid spillage inside the centrifuge unit in the prior art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a laboratory virus stock solution clarification centrifuge, comprising a centrifuge rack and an anti-overflow locking device, a control cabinet mounted on the centrifuge rack, a drive device mounted on the centrifuge rack, and a centrifuge host mounted on the drive device; The anti-overflow locking device includes a compensation plate, a locking element, and a guide plate. The compensation plate is installed on the upper cover of the centrifuge unit, and the guide plate is installed on the lower casing of the centrifuge unit. An expansion element is installed inside the compensation plate, a detection opening and closing device is installed inside the guide plate, and an opening assembly is installed inside the guide plate. The opening assembly is connected to the compensation plate, and the locking element is connected to both the compensation plate and the guide plate. An expansion sealing element is installed inside the compensation plate, and a compensation device is connected to the outside of the compensation plate via a pipeline. A liquid replenishment device is connected to the outside of the guide plate, and a collection element is connected to the outside of the guide plate via a pipeline.

[0006] The control cabinet houses the control system for operating the entire centrifuge. The drive unit propels the centrifuge unit to clarify the viral stock solution. The centrifuge rack also features a piping system connected to the centrifuge unit, used for inputting or outputting the materials required for centrifugation.

[0007] Furthermore, the guide plate includes a second midstream section, which is designed at an angle. The top of the second midstream section is the second upstream section, and the bottom of the second midstream section is the second downstream section. The second midstream section is provided with an expansion sealing cavity, and the bottom of the expansion sealing cavity is provided with an overflow cavity. The bottom of the overflow cavity is provided with several drainage cavities. There is an opening and closing port between the drainage cavity and the overflow cavity. The drainage cavity is connected to the collection device through a pipe. The detection opening and closing device includes a trigger and a floating element. The trigger is installed in the overflow cavity, and the floating element is movably installed at the opening and closing port.

[0008] When the primary sealing and locking structure of the upstream section between the compensation plate and the guide plate fails, the viral stock may overflow directly from between the lower casing and the upper cover. Alternatively, when the centrifuge shuts down due to a sudden internal malfunction and the upper cover needs to be opened for maintenance, the residual viral stock inside the centrifuge may also overflow from between the lower casing and the upper cover the moment the upper cover is opened. In addition, during centrifuge maintenance, residual cleaning fluid that has not been completely drained may also leak out from between the lower casing and the upper cover. After overflowing from between the lower casing and the upper cover, the aforementioned overflowing liquid will pass through the gap between the first and second upstream sections and flow along the slopes of the first and second midstream sections into the expansion sealing cavity, and then further fall into the overflow cavity, thereby achieving interception and collection of the overflowing liquid and preventing the overflowing liquid from leaking directly downwards and causing contamination and harm to the centrifuge body, other laboratory equipment, and operators.

[0009] Furthermore, the floating component includes a floating head that fits into the opening and closing port. The floating head has a cavity inside, an elastic membrane is installed at the top of the floating head, and a connecting rod is installed at the bottom of the floating head. The connecting rod passes through the opening and closing port and is fitted with a limit ring. The limit ring is movably connected to the drainage chamber and has a passage opening.

[0010] Under normal conditions, the floating head remains engaged with the opening / closing port, blocking the overflow chamber and drainage chamber. When the floating head is subjected to buoyancy, it moves upward and disengages from the opening / closing port, automatically opening the port. The limiting ring can move up and down along the drainage chamber. When the floating head rises, the limiting ring limits its movement via a connecting rod, keeping the floating head floating up and down and preventing it from drifting away from its original position due to the overflow liquid.

[0011] The collection device is a collection box used to collect the viral stock solution that falls into the drainage chamber.

[0012] Furthermore, the triggering element includes a trigger housing, which is installed inside the overflow cavity. The trigger housing has symmetrically installed pads on the top and bottom, and a piezoelectric element is installed between the pads. An elastic plate is installed at the bottom of the trigger housing, and a contact is installed on the elastic plate. A pressing head is installed at the top of the contact.

[0013] During operation, if the primary sealing and locking structure fails and the viral fluid continues to leak out, the viral fluid is intercepted by the overflow chamber. The viral fluid accumulated in the overflow chamber generates buoyancy on the floating head. The floating head rises under the action of buoyancy and detaches from the closure. The overflow chamber and the drainage chamber are then connected. The viral fluid in the overflow chamber falls into the drainage chamber and is collected through the pipe into the collection device, thus completing the centralized collection of the intercepted liquid.

[0014] If the overflowing viral fluid continues to increase after the opening and closing port is opened for drainage, the floating head will rise to a certain height, at which point the elastic membrane on its top will contact the contact and compress it. The pressure on the contact will cause the compression head to push upwards against the piezoelectric element between the pads. The more overflowing fluid, the stronger the buoyancy force on the floating head, and the greater the pressure exerted by the floating head on the contact. The piezoelectric element, under pressure, generates an electrical signal of corresponding strength. When the control system receives this signal, it activates the compensation device, which drives the expansion seal to seal the cavity. If the electrical signal gradually weakens or disappears, it indicates that the secondary sealing compensation is complete, effectively preventing continuous leakage of the viral fluid during operation and allowing centrifugation to continue. If the electrical signal continues to strengthen, the control system further drives the expansion seal to expand, strengthening the secondary sealing compensation until the electrical signal weakens. If the electrical signal still cannot weaken after continuous compensation, the control system shuts down the centrifuge and issues an alarm signal, thus achieving dynamic monitoring and control of the continuous leakage of the viral fluid.

[0015] Furthermore, the compensation plate includes a first midstream section, which is designed at an angle. The top of the first midstream section is the first upstream section, and the bottom of the first midstream section is the first downstream section. An expansion cavity is provided inside the first midstream section, and an expansion seal is installed on the expansion cavity. The expansion cavity is connected to the compensation device through a pipeline.

[0016] Both the first and second midstream sections are designed at an angle, so that when viral stock spills out, it can be guided into the overflow cavity along the slope of the midstream section.

[0017] The expansion element is made of a flexible elastic material, such as a rubber elastic film. The compensation device is used to input or output expansion medium into the expansion chamber through a pipeline. After the expansion medium enters the expansion chamber, it drives the expansion seal to expand. The expanded expansion seal can then seal the expansion chamber, achieving a secondary seal. The expansion medium can be gas or liquid, and is only used to fill the expansion chamber and drive the expansion seal to expand.

[0018] Furthermore, the second downstream section is also provided with several sliding cavities, each equipped with an opening assembly. The bottom of the sliding cavity is provided with an annular cavity, and the bottom of the annular cavity is provided with several liquid inlets. The liquid inlets are connected to the liquid replenishment device through pipes.

[0019] Furthermore, the unsealing assembly includes a piston rod and a retaining bolt. The piston rod is slidably installed in the sliding cavity, and a support plate is installed at the top of the piston rod. The retaining bolt passes through the first downstream section and is connected to the support plate.

[0020] The fluid replenishment device is used to input or output hydraulic oil into or out of the annular cavity through the inlet. The sealing assembly is located downstream to prevent contamination by leaked fluid.

[0021] In case of malfunction or maintenance, the operator first removes the nut from the locking mechanism, then activates the fluid replenishment device. The device slowly injects hydraulic oil into the annular cavity. The hydraulic oil compresses the piston rod in the sliding cavity, causing it to slide upwards. The piston rod, via a support plate, slowly lifts the upper cover with the compensation disc. If liquid overflows, it is intercepted by the overflow cavity. The liquid in the overflow cavity drives the floating head to rise and drain. As the upper cover opens, if the overflow continues to increase, the floating head in the overflow cavity will rise and trigger an electrical signal. The control system continuously monitors the strength of this signal. If the signal continuously increases, indicating a continuous increase in leaked liquid, the control system stops hydraulic oil output and removes some hydraulic oil, reducing the opening of the upper cover to prevent excessive leakage and untimely drainage, which could cause contamination. If the signal fluctuates within a threshold range, drainage is normal, and the control system maintains the upper cover opening unchanged. If the signal strength gradually decreases, the control system further increases the opening of the upper cover. This achieves monitoring and regulation of drainage when the upper cover is open.

[0022] Furthermore, the first upstream section is provided with several upper locking holes, and the second upstream section is provided with several lower locking holes, with the locking element passing through the upper and lower locking holes.

[0023] The locking mechanism includes bolts and nuts. The bolts pass through the upper and lower locking holes and connect to the nuts, thereby achieving primary locking of the upstream sections of the compensation plate and guide plate, respectively. A sealing element is provided between the first and second upstream sections to provide primary sealing of the upstream portions of the compensation plate and guide plate. The primary seal and the primary locking together form the primary sealing and locking structure for the centrifuge unit. The bolts pass through the lower locking hole from bottom to top, are installed and fixed in the lower locking hole, and seal the lower locking hole to prevent liquid from falling down along the lower locking hole in case of leakage.

[0024] Compared with the prior art, the beneficial effects of the present invention are: 1. By utilizing the flow guiding and interception coordination between the first upstream section, the second upstream section, the first midstream section, the second midstream section, the expansion sealing cavity, and the overflow cavity, the virus stock solution or cleaning solution overflowing from between the lower casing and the upper cover is blocked, preventing the overflowing liquid from directly leaking down and causing pollution and harm.

[0025] 2. By setting up an overflow chamber, a floating head, an opening / closing port, a liquid discharge chamber, and a collecting member, the virus stock solution that leaks out after the primary seal locking structure fails can be intercepted by the overflow chamber first. When the liquid level rises, the floating head is automatically lifted by the buoyancy of the liquid to open the liquid discharge channel, thereby achieving self-triggered discharge and centralized collection of the leaked virus stock solution.

[0026] 3. Through the cooperation of the floating head, elastic membrane, contact, extrusion head, and piezoelectric body, the continuous increase of the virus stock solution leaking out inside and outside the overflow chamber can be converted into an electric signal of corresponding intensity. The control system can automatically start the compensation device according to this electric signal to perform secondary seal compensation on the sealing cavity. At the same time, the control system can also judge the compensation effect according to the signal change. When the leakage weakens, the centrifugation operation is maintained. When the leakage continues to worsen, the sealing strength of the expansion seal is further enhanced. If the compensation is ineffective, the machine is stopped and an alarm is given in time, thereby achieving dynamic monitoring and control of the continuous leakage state of the virus stock solution.

[0027] 4. Utilize the floating head to float with the increase of the overflow liquid to trigger the contact to act, and cooperate with the signal feedback of the piezoelectric body and the drive of the compensation device to expand the expansion seal for dynamic detection and secondary seal compensation of the continuous leakage state of the virus stock solution, thereby suppressing the leakage in time. When the compensation is insufficient, the sealing effect can be continuously enhanced, and when the compensation is ineffective, the machine is stopped and an alarm is given in time, improving the response ability of the centrifuge main body to abnormal leakage conditions.

[0028] 5. Through the cooperation of the liquid supplement device, annular chamber, piston rod, and support plate, the upper end cover can be slowly lifted by hydraulic pressure in the event of a failure or maintenance, avoiding the concentrated overflow of the internal residual liquid caused by the instantaneous opening of the upper end cover. At the same time, the overflow chamber is used to intercept and collect the overflow liquid generated during the opening process, and the floating head floats with the change of the liquid level to trigger an electric signal, enabling the control system to judge the increasing and decreasing trend of the leaked liquid according to the change of the liquid level in the overflow chamber, and then automatically stop, weaken or increase the input of hydraulic oil, realizing the linkage adjustment of the opening amplitude of the upper end cover and the liquid discharge state. Reduce the risks of equipment pollution, environmental pollution, and personnel infection caused by untimely discharge of leaked liquid and excessive overflow. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is an overall three-dimensional view of the centrifuge of the present invention; Figure 2 is a three-dimensional view of the centrifuge main body and the anti-overflow lock-sealing device of the present invention; Figure 3 is a sectional view of the anti-overflow lock-sealing device of the present invention; Figure 4 is of the present invention Figure 3 partial enlarged view of area A in; Figure 5 is a sectional view of the compensation disc and the guiding disc of the present invention; Figure 6This is a perspective view of the guide plate of the present invention; Figure 7 This is a perspective view of the compensation disc of the present invention; Figure 8 This is a perspective view of the opening and closing mechanism of the present invention; Figure 9 This is a perspective view of the trigger element of the present invention; Figure 10 This is a perspective view of the floating component of the present invention.

[0030] In the diagram: 1. Centrifuge frame; 2. Control cabinet; 3. Centrifuge main unit; 4. Drive unit; 5. Anti-overflow locking device; 51. Compensation plate; 52. Guide plate; 53. Expansion seal; 54. Detection and opening device; 55. Opening assembly; 56. Locking component; 511. Upper locking hole; 512. First upstream section; 513. First midstream section; 514. First downstream section; 515. Expansion chamber; 521. Lower locking hole; 522. Second upstream section; 523. Annular cavity; 524. Liquid inlet; 525. Sliding cavity; 526. Opening and closing port; 527. 528. Overflow chamber; 529. Expansion sealing chamber; 5210. Drainage chamber; 5211. Second midstream section; 5212. Second downstream section; 541. Trigger element; 542. Floating element; 5411. Trigger shell; 5412. Piezoelectric element; 5413. Pad; 5414. Contact; 5415. Elastic plate; 5416. Extrusion head; 5421. Floating head; 5422. Connecting rod; 5423. Limiting ring; 5424. Through port; 5425. Cavity; 5426. Elastic membrane; 551. Piston rod; 552. Support plate; 553. Fixing bolt. Detailed Implementation

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] Example: Figures 1-10 As shown, the present invention provides a technical solution: a laboratory virus stock solution clarification centrifuge, including a centrifuge frame 1 and an anti-overflow locking device 5. A control cabinet 2 is installed on the centrifuge frame 1, a drive device 4 is installed on the centrifuge frame 1, and a centrifuge host 3 is installed on the drive device 4. The anti-overflow locking device 5 includes a compensation plate 51, a locking element 56, and a guide plate 52. The compensation plate 51 is installed on the upper cover of the centrifuge host 3, and the guide plate 52 is installed on the lower casing of the centrifuge host 3. An expansion element is installed inside the compensation plate 51, and a detection opening and closing device 54 is installed inside the guide plate 52. An opening component 55 is installed inside the guide plate 52 and is connected to the compensation plate 51. The locking element 56 is connected to both the compensation plate 51 and the guide plate 52. An expansion sealing element 53 is installed inside the compensation plate 51. A compensation device is connected to the outside of the compensation plate 51 through a pipe, and a liquid replenishment device is connected to the outside of the guide plate 52. A collection element is connected to the outside of the guide plate 52 through a pipe.

[0033] The control cabinet 2 houses the control system for operating the entire centrifuge. The drive unit 4 is used to drive the centrifuge host 3 to clarify and centrifuge the virus stock solution. The centrifuge rack 1 is also equipped with a piping system that is connected to the centrifuge host 3 and is used to input or output the raw materials required for centrifugation into the centrifuge host 3.

[0034] The guide plate 52 includes a second midstream section 5210, which is designed at an angle. The top of the second midstream section 5210 is the second upstream section 522, and the bottom of the second midstream section 5210 is the second downstream section 5211. The second midstream section 5210 is provided with an expansion sealing cavity 528. The bottom of the expansion sealing cavity 528 is provided with an overflow cavity 527. The bottom of the overflow cavity 527 is provided with several drainage cavities 529. An opening and closing port 526 is provided between the drainage cavity 529 and the overflow cavity 527. The drainage cavity 529 is connected to the collecting component through a pipe. The detection opening / closing device 54 includes a trigger 541 and a floating element 542. The trigger 541 is installed in the overflow cavity 527, and the floating element 542 is movably installed in the opening / closing port 526.

[0035] The first upstream section 512 is provided with a number of upper locking holes 511, and the second upstream section 522 is provided with a number of lower locking holes 521. The locking member 56 passes through the upper locking holes 511 and the lower locking holes 521.

[0036] The locking element 56 includes a bolt and a nut. The bolt passes through the upper locking hole 511 and the lower locking hole 521 and is connected to the nut, thereby achieving primary locking of the upstream sections of the compensation plate 51 and the guide plate 52. A sealing element is provided between the first upstream section 512 and the second upstream section 522 for primary sealing of the upstream portions of the compensation plate 51 and the guide plate 52. The primary seal and the primary locking together form the primary sealing and locking structure of the centrifuge host 3. The bolt passes through the lower locking hole 521 from bottom to top, is installed and fixed in the lower locking hole 521, and seals the lower locking hole 521 to prevent it from falling down along the lower locking hole 521 in case of liquid leakage.

[0037] The compensation plate 51 includes a first midstream section 513, which is designed at an angle. The top of the first midstream section 513 is the first upstream section 512, and the bottom of the first midstream section 513 is the first downstream section 514. An expansion cavity 515 is provided inside the first midstream section 513, and an expansion seal 53 is installed on the expansion cavity 515. The expansion cavity 515 is connected to the compensation device through a pipeline.

[0038] Both the first midstream section 513 and the second midstream section 5210 are designed at an angle. When the original viral fluid overflows, it can be guided into the overflow cavity 527 along the slope of the midstream section.

[0039] The expansion element is made of a flexible elastic material, such as a rubber elastic film. The compensation device is used to input or output expansion medium into the expansion chamber 515 through a pipeline. After the expansion medium enters the expansion chamber 515, it drives the expansion seal 53 to expand. The expanded expansion seal 53 can seal the expansion chamber 528, achieving a secondary seal. The expansion medium can be gas or liquid, and is only used to fill the expansion chamber 528 and drive the expansion seal 53 to expand.

[0040] The floating component 542 includes a floating head 5421, which is fitted into the opening and closing port 526. The floating head 5421 has a cavity 5425 inside. An elastic membrane 5426 is installed at the top of the floating head 5421, and a connecting rod 5422 is installed at the bottom of the floating head 5421. The connecting rod 5422 passes through the opening and closing port 526 and is fitted with a limit ring 5423. The limit ring 5423 is movably connected to the drainage chamber 529, and a passage 5424 is provided on the limit ring 5423.

[0041] Under normal conditions, the floating head 5421 remains engaged with the opening / closing port 526, blocking the overflow chamber 527 and the drainage chamber 529. When the floating head 5421 is subjected to buoyancy, it will move upward and disengage from the opening / closing port 526, thus automatically opening the opening / closing port 526. The limiting ring 5423 can move up and down along the drainage chamber 529. When the floating head 5421 floats upward, the limiting ring 5423 limits the floating head 5421 through the connecting rod 5422, keeping the floating head 5421 floating up and down and preventing it from drifting away from its original position due to random fluctuations with the overflow liquid.

[0042] The collection device is a collection box used to collect the viral stock solution that falls into the drainage chamber 529.

[0043] The trigger element 541 includes a trigger housing 5411, which is installed in the overflow cavity 527. The trigger housing 5411 has symmetrically installed pads 5413 on the upper and lower sides. A piezoelectric element 5412 is installed between the pads 5413. An elastic plate 5415 is installed at the bottom of the trigger housing 5411. A contact 5414 is installed on the elastic plate 5415. A pressing head 5416 is installed at the top of the contact 5414.

[0044] The second downstream section 5211 is also provided with several sliding cavities 525. An opening component 55 is installed in the sliding cavity 525. An annular cavity 523 is provided at the bottom of the sliding cavity 525. Several liquid inlets 524 are provided at the bottom of the annular cavity 523. The liquid inlets 524 are connected to the liquid replenishment device through pipes.

[0045] The unsealing assembly 55 includes a piston rod 551 and a retaining bolt 553. The piston rod 551 is slidably installed in the sliding cavity 525. A support plate 552 is installed at the top of the piston rod 551. The retaining bolt 553 passes through the first downstream section 514 and is connected to the support plate 552.

[0046] The fluid replenishment device is used to input or output hydraulic oil into the annular cavity 523 through the fluid inlet 524. The sealing assembly 55 is located in the downstream section to prevent it from being contaminated by leaked fluid.

[0047] The working principle of this invention is as follows: When the upstream primary sealing and locking structure between the compensation plate 51 and the guide plate 52 fails, the viral stock may overflow directly from between the lower casing and the upper cover; or when the centrifuge host 3 stops due to a sudden internal malfunction and needs to open the upper cover for maintenance, the residual viral stock inside the host will also overflow from between the lower casing and the upper cover at the moment the upper cover is opened; in addition, during the maintenance of the centrifuge host 3, residual cleaning fluid that has not been completely drained may also leak out from between the lower casing and the upper cover. After overflowing from between the lower casing and the upper cover, the overflowing liquid will pass through the gap between the first upstream section 512 and the second upstream section 522, and be introduced into the expansion sealing cavity 528 along the inclined surfaces of the first midstream section 513 and the second midstream section 5210, and then further fall into the overflow cavity 527, thereby achieving interception and collection of the overflow liquid, avoiding the overflow liquid from leaking directly downwards and causing pollution and harm to the centrifuge body, other laboratory equipment, and operators.

[0048] When the virus stock solution continues to leak out due to the failure of the primary sealing and locking structure during operation, as the virus stock solution is intercepted by the overflow chamber 527, the virus stock solution accumulated in the overflow chamber 527 generates buoyancy on the floating head 5421. The floating head 5421 floats up under the action of buoyancy and separates from the closing port 526. The overflow chamber 527 and the drainage chamber 529 are opened up, and the virus stock solution in the overflow chamber 527 falls into the drainage chamber 529 and is collected by entering the collection device through the pipe, thereby completing the centralized collection of the intercepted liquid.

[0049] If the overflowing viral stock continues to increase after the opening 526 is opened for drainage, the floating head 5421 will rise to a certain height, and its top elastic membrane 5426 will come into contact with the contact 5414, squeezing the contact 5414. The pressure on the contact 5414 will cause the squeezing head 5416 to push upwards against the piezoelectric element 5412 between the pads 5413. The more overflowing liquid, the stronger the buoyancy force on the floating head 5421, and the greater the pressure exerted by the floating head 5421 on the contact 5414. The piezoelectric element 5412, under pressure, generates an electrical signal of corresponding strength. When the control system receives this signal, it activates the compensation device, which drives the expansion seal 53 to seal the sealing cavity. If the electrical signal gradually weakens or disappears, it indicates that the secondary sealing compensation is complete, effectively preventing continuous leakage of the viral stock during operation and allowing the centrifugation operation to continue. If the electrical signal continues to strengthen, the control system controls the compensation device to further drive the expansion seal 53 to expand, strengthening the secondary sealing compensation until the electrical signal weakens; if the electrical signal still cannot be weakened after continuous compensation, the control system shuts down the centrifuge host 3 and issues an alarm signal, thereby realizing dynamic monitoring and control of the continuous leakage of virus stock solution.

[0050] In case of malfunction or maintenance, the operator first removes the nut in the locking part 56, then turns on the fluid replenishment device. The fluid replenishment device slowly inputs hydraulic oil into the annular cavity 523. The hydraulic oil squeezes the piston rod 551 in the sliding cavity 525, causing it to slide upward. The piston rod 551 slowly lifts the upper end cover with the compensation plate 51 installed through the support plate 552. At this time, if liquid overflows, the overflowing liquid will be intercepted by the overflow cavity 527. The liquid in the overflow cavity 527 drives the floating head 5421 to float and drain. As the upper end cover opens, if the overflowing liquid continues to increase, the floating head 5421 in the overflow cavity 527 will float upward and trigger the trigger to generate an electrical signal. The control system continuously monitors the change in the strength of the electrical signal. If the electrical signal continues to increase, it indicates that the leaking liquid continues to increase. The control system stops the hydraulic oil output and extracts part of the hydraulic oil to reduce the opening range of the upper end cover, so as to avoid excessive leakage of liquid and untimely drainage, which could cause leakage and pollution. If the electrical signal fluctuates within the threshold range, it indicates normal drainage, and the control system maintains a constant opening width of the top cover. If the electrical signal strength gradually decreases, the control system further increases the opening width of the top cover. This achieves monitoring and regulation of drainage when the top cover is open.

[0051] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A laboratory virus stock solution clarification centrifuge, characterized in that: The centrifuge includes a centrifuge frame (1) and an anti-overflow locking device (5). A control cabinet (2) is installed on the centrifuge frame (1), a drive device (4) is installed on the centrifuge frame (1), and a centrifuge host (3) is installed on the drive device (4). The anti-overflow locking device (5) includes a compensation plate (51), a locking element (56), and a guide plate (52). The compensation plate (51) is installed on the upper cover of the centrifuge host (3), and the guide plate (52) is installed on the lower casing of the centrifuge host (3). An expansion element is installed inside the compensation plate (51), and a detection opening and closing device (54) is installed inside the guide plate (52). An opening assembly (55) is installed inside the guide plate (52), and the opening assembly (55) is connected to the compensation plate (51). The locking element (56) is connected to the compensation plate (51) and the guide plate (52) respectively. An expansion sealing element (53) is installed inside the compensation plate (51). A compensation device is connected to the outside of the compensation plate (51) through a pipe. A liquid replenishment device is connected to the outside of the guide plate (52), and a collection element is connected to the outside of the guide plate (52) through a pipe.

2. The laboratory virus stock solution clarification centrifuge according to claim 1, characterized in that: The guide plate (52) includes a second midstream section (5210), which is designed at an angle. The top of the second midstream section (5210) is the second upstream section (522), and the bottom of the second midstream section (5210) is the second downstream section (5211). The second midstream section (5210) is provided with an expansion sealing cavity (528), and the bottom of the expansion sealing cavity (528) is provided with an overflow cavity (527). The bottom of the overflow cavity (527) is provided with a plurality of drainage cavities (529). An opening and closing port (526) is provided between the drainage cavity (529) and the overflow cavity (527). The drainage cavity (529) is connected to the collection component through a pipe. The detection opening and closing device (54) includes a trigger (541) and a floating element (542). The trigger (541) is installed in the overflow cavity (527), and the floating element (542) is movably installed in the opening and closing port (526).

3. A laboratory virus stock solution clarification centrifuge according to claim 2, characterized in that: The floating component (542) includes a floating head (5421), which is fitted into the opening and closing port (526). The floating head (5421) has a cavity (5425) inside. An elastic membrane (5426) is installed at the top of the floating head (5421). A connecting rod (5422) is installed at the bottom of the floating head (5421). The connecting rod (5422) passes through the opening and closing port (526) and is fitted with a limiting ring (5423). The limiting ring (5423) is movably connected to the drainage chamber (529). The limiting ring (5423) has a passage (5424).

4. A laboratory virus stock solution clarification centrifuge according to claim 3, characterized in that: The trigger (541) includes a trigger housing (5411), which is installed in the overflow cavity (527). The trigger housing (5411) is symmetrically installed with pads (5413) on the upper and lower sides. A piezoelectric element (5412) is installed between the pads (5413). An elastic plate (5415) is installed at the bottom of the trigger housing (5411). A contact (5414) is installed on the elastic plate (5415). A pressing head (5416) is installed at the top of the contact (5414).

5. A laboratory virus stock solution clarification centrifuge according to claim 3, characterized in that: The compensation plate (51) includes a first midstream section (513), which is designed at an angle. The top of the first midstream section (513) is the first upstream section (512), and the bottom of the first midstream section (513) is the first downstream section (514). An expansion cavity (515) is provided in the first midstream section (513). The expansion seal (53) is installed on the expansion cavity (515), and the expansion cavity (515) is connected to the compensation device through a pipeline.

6. A laboratory virus stock solution clarification centrifuge according to claim 5, characterized in that: The second downstream section (5211) is also provided with several sliding cavities (525), and an opening assembly (55) is installed in the sliding cavity (525). The bottom end of the sliding cavity (525) is provided with an annular cavity (523), and the bottom end of the annular cavity (523) is provided with several liquid inlets (524). The liquid inlets (524) are connected to the liquid replenishment device through pipes.

7. A laboratory virus stock solution clarification centrifuge according to claim 6, characterized in that: The unsealing assembly (55) includes a piston rod (551) and a fixing bolt (553). The piston rod (551) is slidably installed in the sliding cavity (525). A support plate (552) is installed at the top of the piston rod (551). The fixing bolt (553) passes through the first downstream section (514) and is connected to the support plate (552).

8. A laboratory virus stock solution clarification centrifuge according to claim 5, characterized in that: The first upstream section (512) is provided with a plurality of upper locking holes (511), and the second upstream section (522) is provided with a plurality of lower locking holes (521). The locking member (56) passes through the upper locking holes (511) and the lower locking holes (521).

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