Bifidobacterium pseudocatenulatum, preparation method and application thereof in preventing and treating meth addiction

By isolating Bifidobacterium pseudosporidis from the feces of METH addicts, preparing Bifidobacterium pseudosporidis preparations, and constructing a METH addiction model, a safe and simple prevention and treatment of METH addiction was achieved, overcoming the shortcomings of existing treatment methods and providing a biological intervention pathway without the risk of secondary addiction.

CN122128145APending Publication Date: 2026-06-02KUNMING MEDICAL UNIVERSITY
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KUNMING MEDICAL UNIVERSITY
Filing Date
2026-02-04
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing treatments for METH addiction have risks of adverse reactions, limited applicability to certain populations, long treatment cycles, and are difficult to promote. Furthermore, novel peptide drugs and neural circuit modulation therapies are not yet mature and are difficult to apply in clinical practice.

Method used

Bifidobacterium pseudosporidis was isolated and screened from the feces of individuals with low levels of METH addiction. Addiction-related physiological regulatory strains were prepared, and a METH addiction model was constructed by gavage colonization. Bifidobacterium pseudosporidis preparations were then prepared for the prevention and treatment of METH addiction.

Benefits of technology

This method provides a safe, simple, and highly targeted biological intervention that significantly improves METH addictive behavior without requiring complex treatment equipment, offering highly effective treatment with no risk of secondary addiction.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122128145A_ABST
    Figure CN122128145A_ABST
Patent Text Reader

Abstract

This invention discloses a strain of *Bifidobacterium pseudosporidis*, its preparation method, and its application in the prevention and treatment of METH addiction. *Bifidobacterium pseudosporidis* was isolated from fecal samples of individuals with low levels of METH addiction, and its strain identity was confirmed after isolation, purification, and identification. A METH addiction model was constructed by gavage colonization of C57 mice with this strain, and addiction-related indicators were detected in the model mice. The results showed that compared with the addiction model mice without colonization of this strain, the conditioned place preference score of the colonized group was significantly reduced (P<0.05). This *Bifidobacterium pseudosporidis* has a significant effect on improving METH addictive behavior and can be used to prepare biological agents with preventive and / or therapeutic functions for METH addiction. This invention reveals that *Bifidobacterium pseudosporidis* has the advantages of high safety and strong targeting, and can achieve the prevention and intervention of METH addiction without complex treatment equipment, providing a novel biological treatment option for the clinical treatment of METH addiction.
Need to check novelty before this filing date? Find Prior Art