Herbicidal water dispersible granule with strong resistance to hard water, its preparation method and application

Abstract

The present application discloses a kind of corn field's herbicidal water dispersible granule, active ingredient includes mesotrione, ametryn and dichlorprop. Compared with the existing single active ingredient preparation, the herbicidal water dispersible granule of the present application adopts triple action mechanism, in addition to having significant herbicidal effect, but also can expand the herbicidal spectrum;Water dispersible granule has high suspension rate, strong hard water resistance, suitable for different regions corn field a variety of malignant weed control, such as barnyard grass, crabgrass, green dogtail grass, senna, amaranthus retroflexus, chenopodium etc., stable efficacy, long persistence, less preparation residue, can significantly reduce the resistance of weed EC 50 , and no phytotoxicity to crops, good safety, in line with the safety requirements of pesticide preparation.

Description

Technical Field

[0001] This invention belongs to the field of pesticide formulations, specifically relating to a water-dispersible herbicide granule with strong resistance to hard water, its preparation method, and its application. Background Technology

[0002] Mesotrione is an organic compound with the molecular formula C14H13NO7S. It is a benzoylcyclohexanedione herbicide, an effective competitive hydroxyphenylpyruvate dioxygenase (HPPD) enzyme inhibitor, selective for maize crops, and has a rapid metabolism and high tolerance in susceptible crops.

[0003] Atmetryn, also known as amethoxam, is a triazine-based selective systemic herbicide with the molecular formula C9H17N5. It is a colorless crystalline solid at room temperature and pressure, with a water solubility of 185 mg / L (20°C). It is sensitive to strong acids and alkalis, readily hydrolyzing to form a 6-hydroxyl form. It can be adsorbed by the soil at a depth of 0-5 cm, forming a herbicide layer that allows weeds to come into contact with the herbicide as they germinate, providing the best control against newly sprouted weeds. Applicable crops include corn, cotton, and citrus, and it controls weeds such as barnyard grass, goosegrass, bermudagrass, crabgrass, paspalum notoginseng, foxtail, millet, foxtail millet, and goosegrass. It has a rapid weed-killing effect and is a typical photosynthesis inhibitor. It inhibits electron transport during photosynthesis in sensitive plants, leading to the accumulation of nitrite in the leaves, causing damage and death.

[0004] 2,4-D is a selective systemic herbicide of the phenoxyacetic acid class. It disrupts the vascular tissue of dicotyledonous plants, interfering with their growth and development, causing stem and leaf distortion, and thickening or cracking of the stem base. It is less volatile and has a slower rate of action than 2,4-D. 2,4-D is very sensitive to seedlings of grasses, with resistance gradually increasing after the 3-4 leaf stage, reaching its peak at the late tillering stage, and then increasing again during spikelet differentiation. Its effectiveness decreases significantly at temperatures below 18°C, and it is ineffective against weeds that have not yet emerged.

[0005] With the large-scale planting of corn and the long-term use of single herbicides, weed resistance has become an increasingly prominent problem. Traditional binary compound herbicide formulations (such as nicosulfuron + atrazine) have reduced efficacy due to increased weed resistance, especially against grassy weeds (such as foxtail grass) and broadleaf weeds (such as dayflower and velvetleaf).

[0006] Currently, the registered formulations for the above three single-agent mixtures are all wettable powders. Wettable powders are solid-solid dispersions, which are prone to sedimentation under hard water or drought conditions, leading to uneven spraying. Furthermore, long-term storage may result in clumping, affecting the release of active ingredients and field efficacy. Therefore, wettable powders have significant shortcomings in terms of resistance management, environmental friendliness, and crop safety. Summary of the Invention

[0007] The purpose of this invention is to systematically solve the above problems by optimizing the proportion of active ingredients, using a compound adjuvant system, and upgrading the dosage form.

[0008] Therefore, the present invention provides a water-dispersible granule for weed control, the active ingredients of which include mesotrione, atrazine, and MCPA.

[0009] Preferably, by weight percentage, the herbicidal water-dispersible granules of the present invention comprise: 7-19% nicosulfuron, 20-50% atrazine, 3-12% MCPA, 1-5% dispersant, 1-3% wetting agent, 5-10% disintegrant, 1-3% stabilizer, 1-5% anti-hard water agent, 2-5% binder, and filler to make up to 100%.

[0010] Preferably, the herbicidal water-dispersible granules of the present invention contain 10-15% nicosulfuron, 30-35% atrazine, and 5-10% MCPA.

[0011] The wetting agent is selected from one or more of the following: sodium lauroyl sarcosinate, sodium N-lauroyl glutamate, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, alkyl naphthalene sulfonate, trisiloxane polyoxyethylene ether, sodium dodecyl sulfate, sodium isooctanol succinate sulfonate, sodium oleoyl methyl taurate, higher fatty acid glycerides, sorbitan fatty acid esters, fatty alcohol polyoxyethylene ether, and alkylphenol polyoxyethylene ether phosphate.

[0012] The dispersant is selected from one or more of the following: glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, sodium alkyl sulfonate, alkyl naphthalene sulfonate formaldehyde condensate, sodium naphthalene sulfonate formaldehyde condensate, lignin sulfonate, polycarboxylate, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, dodecyl trimethylammonium salt, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty amide benzene sulfonic acid, p-methoxy fatty amide benzene sulfonic acid, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, and polyoxyethylene sorbitan fatty acid ester.

[0013] The disintegrant is selected from one or more of sodium sulfate, calcium sulfate, sodium bicarbonate, ammonium sulfate, polyvinylpyrrolidone, magnesium chloride, sodium carboxymethyl starch, urea, CCMS, PS, CCMC, L-HPC, MCC, and PVPP.

[0014] The filler is selected from one or more of the following: diatomaceous earth, kaolin, attapulgite, talc, activated clay, pumice, saponin, calcite, sand, dolomite, montmorillonite, calcium carbonate, zeolite, and acidic clay.

[0015] The adhesive is selected from one or more of starch, dextrin, sucrose, carboxymethyl cellulose, carboxyethyl cellulose, gelatin, gum arabic, xanthan gum, and hydroxypropyl methyl cellulose.

[0016] The anti-hard water agent is selected from one or more of the following: triacetic acid, sulfonated lignin, polyaspartic acid, phosphonocarboxylic acid copolymer, alcohol ether carboxylate, crystalline sodium pyrophosphate, and sodium hexametaphosphate.

[0017] Preferably, the anti-hard water agent is a mixture of sulfonated lignin and polyaspartic acid. The ratio of the two is 4-8:1-1.5.

[0018] The stabilizer is one or more of sodium chloride, sodium tripolyphosphate, silica, and bentonite.

[0019] This invention also provides a method for preparing a water-dispersible granule containing nicosulfuron, atrazine, and 2,4-D, comprising the following steps: S1. Mix the active ingredients (nicosulfuron, atrazine, MCPA) with dispersants, wetting agents, disintegrants, stabilizers, anti-hard water agents and fillers in a certain proportion; S2. Pulverize to D90≤5μm using an air jet mill; S3. Add the pulverized mixture from S2 to the binder aqueous solution, mix again, and then perform fluidized bed granulation to control the particle size to 0.1-1.5 mm. S4. Dry at 45℃-60℃. The dried granules are passed through a 20-40 mesh sieve to remove fine powder (<100 mesh) and large particles (>10 mesh) to obtain a water-dispersible granule product containing nicosulfuron, atrazine, and 2,4-D.

[0020] This invention also provides the application of a water-dispersible granule containing nicosulfuron, atrazine, and 2,4-D in the control of field weeds in crops. Preferably, the crop is corn.

[0021] By adopting the above technical solution, the present invention has the following beneficial effects: 1. The herbicidal activity of this invention is not a simple sum of the activities of each component. Compared with existing single formulations, it adopts a triple action mechanism (HPPD + photosynthetic inhibition + hormone interference), which not only has a significant herbicidal effect, but also broadens the spectrum of weed control.

[0022] 2. Low formulation residue, significantly reducing EC50 in resistant weeds. 50 It has no phytotoxicity and is safe for crops, meeting the safety requirements for pesticide formulations.

[0023] 3. The water-dispersible granules of this invention have a high suspension rate, good resistance to hard water, stable efficacy, are suitable for the control of weeds in corn fields, have good safety, and play a positive role in the protection of the ecological environment. Detailed Implementation

[0024] The present invention will be further described below with reference to embodiments, but the present invention is not limited thereto.

[0025] All reagents used in the following embodiments of the present invention can be obtained commercially or in-house. The 97% nicosulfuron technical grade used in the embodiments and comparative examples was purchased from Changqing (Hubei) Biotechnology Co., Ltd.; the 95% atrazine technical grade was purchased from Andomai Agan Co., Ltd.; and the 97% 2,4-D technical grade was purchased from Shandong Qingyuan Nongguan Crop Science Co., Ltd. Unless otherwise specified, all percentages mentioned in the following embodiments are mass percentages.

[0026] Example 1: The formulation of 45% nicosulfuron-atrazine-2,4-D water-dispersible granules is as follows: 10% nicosulfuron, 30% Atrazine 5% 2,4-D, 4% sulfonated lignin, 0.8% polyaspartic acid, 4% polycarboxylate 3% alkylnaphthalene sulfonate, 4% sodium sulfate 1% sodium chloride 2.5% Carboxyethyl cellulose Make up the difference with silica.

[0027] Example 2: The formulation of 50% nicosulfuron-methyl·atrazine·2,4-D water-dispersible granules is as follows: 8% nicosulfuron, 32% Atrazine 10% 2,4-D, 4.5% sulfonated lignin, 0.5% polyaspartic acid, 5% alkylnaphthalene sulfonate formaldehyde condensate, 2% sodium alkyl sulfonate 4% sodium sulfate 1% sodium chloride 2.5% Carboxyethyl cellulose The remaining bentonite is replenished to 100%.

[0028] Example 3: The formulation of 55% nicosulfuron-atrazine-2,4-D water-dispersible granules is as follows: 15% nicosulfuron, 30% Atrazine 10% 2,4-D, 5% sulfonated lignin, 0.6% polyaspartic acid, 4% polycarboxylate 2% sodium alkyl sulfonate 4% sodium sulfate 0.5% sodium chloride 3% starch The remaining diatomaceous earth should be replenished to 100%.

[0029] Example 4: The formulation of 60% nicosulfuron-atrazine-2,4-D water-dispersible granules is as follows: 15% nicosulfuron, 35% Atrazine 10% 2,4-D, 5.5% sulfonated lignin, 1% polyaspartic acid, 4% polycarboxylate 2% Sodium Dodecyl Sulfate 4% magnesium chloride, 1% sodium chloride 3.5% Carboxymethyl cellulose The remaining kaolin is replenished to 100%.

[0030] Comparative Example 1: 52% nicosulfuron-methyl·atrazine water-dispersible granules 12% nicosulfuron, 40% Atrazine 4.5% sulfonated lignin, 1% polyaspartic acid, 5% sodium lignosulfonate 2% Sodium Dodecyl Sulfate 4% sodium sulfate 1% sodium chloride 3% Gum Arabic The remaining bentonite is replenished to 100%.

[0031] Comparative Example 2: 57% Atrazine·2,4-D Water Dispersible Granules 45% Atrazine 12% 2,4-D, 5.5% crystalline sodium pyrophosphate, 4% polycarboxylate 2% sodium alkyl sulfonate 4% sodium sulfate 2.5% carboxyethyl cellulose, The remaining diatomaceous earth should be replenished to 100%.

[0032] Comparative Example 3: 60% nicosulfuron-methyl·2,4-D water-dispersible granules 35% nicosulfuron, 25% 2,4-D, 4% polycarboxylate 3% alkylnaphthalene sulfonate, 4% sodium sulfate 1% sodium chloride 4% starch aqueous solution, The remainder is replenished with silica to bring the total to 100%.

[0033] Comparative Example 4: 75% nicosulfuron-methyl water-dispersible granules 75% nicosulfuron, 5.0% sulfonated lignin, 0.8% polyaspartic acid, 5% sodium lignosulfonate 2% Sodium Dodecyl Sulfate 4% sodium sulfate 1% sodium tripolyphosphate 2.5% starch aqueous solution, The remaining bentonite is replenished to 100%.

[0034] Comparative Example 5: 90% Atrazine Water Dispersible Granules 90% nicosulfuron, 6% Sodium Hexametaphosphate 2% polycarboxylate 1% alkylnaphthalene sulfonate, 2% sodium sulfate 2% carboxyethyl cellulose, The remaining silica is replenished to 100%.

[0035] Comparative Example 6: 69% 2,4-D water-dispersible granules 69% nicosulfuron, 5% sodium lignosulfonate 2% Sodium Dodecyl Sulfate 4% sodium sulfate 2% Hydroxypropyl Methylcellulose The remaining bentonite is replenished to 100%.

[0036] Application Example 1 Foliar spray treatment: 1) Test conditions 1.1) Test Target barnyard grass ( ‌Echinochloa crusgalli Harvested from Harbin, Heilongjiang Province, green foxtail grass ( Setaria green Collected from Tai'an, Shandong, by the genus *Hydrocotyle* (Ma Tang). Digitaria sanguinalis (L.) Scop.It was collected from Huangdao, Shandong.

[0037] 1.2) Cultivation conditions The target weeds were cultivated using a pot method. Plastic flowerpots were filled to two-thirds full with topsoil collected from farmland, dried, and sieved. These were then placed in enamel trays, with initial soil moisture maintained at 20%. Plump, uniform weed seeds were selected, soaked in 25°C warm water for 6 hours, and then germinated in a 28°C (dark) biochemical incubator. The newly sprouted weed seeds were then evenly distributed on the soil surface and covered with 5mm of soil. After treatment, the plants were placed in a controlled-light greenhouse, with water added periodically to the enamel trays to maintain soil moisture.

[0038] The experiment was conducted in a controlled greenhouse at a temperature of 18–30°C, under natural light, and with a relative humidity of 57%–72%. The soil type was loam, with an organic matter content of 1.63%, pH = 7.1, available nitrogen of 84.3 mg / kg, available phosphorus of 38.5 mg / kg, and available potassium of 82.1 mg / kg.

[0039] 1.3) Instruments and Equipment The "3WBD-20-Jialihe" backpack electric sprayer was purchased from Henan Chutian Industrial Development Co., Ltd. The AX124ZH type 0.01% electronic balance was purchased from Juding Tianheng (Suzhou) Weighing Equipment Co., Ltd.; the ZDR2000 intelligent data recorder was purchased from Hangzhou Zeda Instrument Co., Ltd.; and the SPX-80S-II intelligent biochemical incubator was purchased from Shanghai Shengke Instrument Equipment Co., Ltd.

[0040] 2) Experimental Design 2.1) Reagents The procurement details for the required technical grade mesotrione, atrazine, and MCPA are provided in the example. Acetone is used as the solvent, and 0.1% emulsifier T is used. Dilute with an 80% aqueous solution; dilute immediately before use.

[0041] 2.2) Test Treatment 2.2.1) Dosage setting Based on preliminary experiments, this study included both single-use and mixed dosages. Water containing the same solvent and emulsifier but without the drug was used as a blank control.

[0042] 2.2.2) Experimental repetition Each treatment was repeated 4 times, with 3 pots per treatment each time. 20 weed seeds were sown in each pot, for a total of 60 seeds per treatment.

[0043] 2.3) Processing method 2.3.1) Processing time and number of times Weed control treatments were applied to barnyard grass, green foxtail grass, and crabgrass at the 1-leaf-1-heart stage. The treatment was administered once.

[0044] 2.3.2) Methods of using instruments and administering medication The cultured test material was evenly placed on a 0.5m² area. 2 On the platform, use a backpack electric sprayer to spray the soil surface at a rate of 450 kg / ha. The spraying pressure is 0.3 MPa. After all the pesticide has been sprayed, close the air valve and remove the flowerpot after 30 seconds. Then open the air valve and spray 50 mL of clean water to clean the spray nozzle.

[0045] 3) Test methods Pot cultivation was used. Weed cultivation is described in section 1.2, following the guidelines for indoor bioassays of pesticides (herbicides). Application methods are described in section 2.3.2, using the foliar application method.

[0046] 4) Data survey and statistical analysis 4.1) Survey Methods The absolute number method was used. Surviving weed seedlings were cut along the soil surface with a blade, and the fresh weight of the weeds was weighed using an analytical balance. Dead weeds were counted as having a fresh weight of zero.

[0047] 4.2) Survey time and number of times An investigation was conducted 15 days after the incident, for a total of one investigation.

[0048] 4.3) Data Statistical Analysis The Colby test was used to evaluate the combined effects of any two or three treatments on weeds. At 15 days, aboveground green tissue from each treatment was harvested, weighed using an electronic balance, and the actual survival rate was calculated. The evaluation method for the combined effects of herbicides uses the Colby method to calculate the theoretical control efficacy of a mixture of nicosulfuron, atrazine, and MCPA, and to determine the type of combined action. The specific calculation formula is as follows: E0 = 100 (X ×Y ×Z / 100 2 ) In the formula: E0 is the theoretical fresh weight inhibition rate of the mixed herbicide on the tested weeds; X is the ratio of the fresh weight of weeds to the fresh weight of control weeds when mesotrione is used alone; Y is the ratio of the fresh weight of weeds to the fresh weight of control weeds when atrazine is used alone; Z is the ratio of the fresh weight of weeds to the fresh weight of control weeds when MCPA is used alone.

[0049] E represents the measured inhibition rate of the three herbicides on the fresh weight of the tested weeds. When E When E0 > 10%, it has a synergistic effect; 10%≤E When E0 ≤ 10%, it is an additive effect; E E0< At 10%, it has an antagonistic effect.

[0050] The results of the indoor combined toxicity tests of nicosulfuron, atrazine, and MCPA against barnyardgrass, crabgrass, and green foxtail grass are shown in Tables 1-3. Among them, the difference between the measured and theoretical fresh weight control efficacy against barnyardgrass for mixtures of nicosulfuron, atrazine, and MCPA in the range of 7-19:20-50:3:12 ranged from -0.7 to 24.9, while the difference against crabgrass was... The values ​​for green foxtail millet ranged from 3.6 to 15.3, while the differences for green foxtail millet ranged from -2.1 to 14.3, indicating that the combined effect of the three herbs on barnyard grass, crabgrass, and velvetleaf was additive or synergistic. When nicosulfuron, atrazine, and MCPA were mixed in a ratio of 10-15:30-40:5-10, the combined effect on barnyard grass, crabgrass, and velvetleaf was synergistic.

[0051] Table 1. Indoor toxicity determination of each component mixture on barnyard grass

[0052] Table 2. Indoor toxicity determination of each component mixture with crabgrass

[0053] Table 3. Indoor toxicity determination of each component mixture on green foxtail grass

[0054] Application Example 2 Daejeon Demonstration Test reagents: Examples 1-4, Comparative Examples 1-6, and commercially available 70% nitrate·2-methyl·atrazine wettable powder as a control.

[0055] In 2020, a demonstration and promotion trial was conducted at the experimental base in Qingyuan County, Fushun City, Liaoning Province. The main weeds that occurred in the field included: barnyard grass, crabgrass, green foxtail, goosegrass, reverse-branch amaranth, and lambsquarters.

[0056] Experimental method: When weeds are at the 2-3 leaf stage and corn seedlings are at the 3-6 leaf stage, use a manual sprayer with a water concentration of 35 kg / 667 m². 2Foliar spraying was used. Each treatment was repeated four times in a plot of 50 square meters. Weeds in the planting area were identified and counted 20 and 45 days after application. The plant control efficacy was calculated using the following formula. While investigating the efficacy, the occurrence of phytotoxicity in maize plants was observed for each treatment. Specific experimental agents, dosages, and results are shown in Table 4.

[0057]

[0058] The results of the weed control efficacy survey (Table 4) show that 21 days after application, Examples 1-4 all showed good control effects against barnyard grass, crabgrass, green foxtail, goosegrass, amaranth, and lambsquarters in cornfields, with a total control efficacy of 96.4-98.6%, which was significantly better than the comparative example and commercially available herbicides. 42 days after application, the control effect further improved, with the total control efficacy of Examples 1-4 against weeds in cornfields increasing to 95.8-99.0%. Furthermore, no phytotoxicity was observed during the spraying process in Examples 1-4.

[0059] Table 4. Control efficacy (%) of a mixture of nicosulfuron, atrazine, and MCPA against weeds in corn fields.

[0060] The main performance indicators of the four embodiments and six comparative examples prepared by this invention were tested. The specific test methods are as follows, and the results are shown in Table 5: Disintegration: Determined according to the "Method for Determining the Disintegration of Pesticide Water Dispersible Granules"; Thermal storage stability: The test method is in accordance with the "Test Method for Thermal Storage Stability of Pesticides" (GB / T 19136-2021). The sample is sealed and stored in a constant temperature chamber at (54±2)℃ for 14 days. After being taken out and cooled to room temperature, the specified items are measured. Suspension property: Determined according to the "Determination of Suspension Rate of Water-Dispersible Granules" (CIPAC MT 168 / MT 174); 3x D water suspension rate: Prepare three times the amount of standard hard water (1026 ppm) according to GB / T5451-2001, and test the water hardness according to standard GB5750-1985. Then, disperse the water-dispersible granules prepared in the comparative example and the example in two times the amount of standard hard water, and test the suspension rate according to GB14825-2006.

[0061] As can be clearly seen from Table 5, the suspension rate, thermal storage stability and disintegration of Examples 1-4 of the present invention can still reach a good level in water hardness of 3 times D. The suspension rate of water hardness of 3 times D can reach up to 96.7%, which is significantly better than the suspension rate of the comparative example.

[0062] Table 5. Test results of water-dispersible granules prepared from a compound of nicosulfuron, atrazine, and MCPA.

[0063] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0064] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately. Furthermore, various different embodiments of the present invention can also be arbitrarily combined, as long as they do not violate the spirit of the present invention, and should also be regarded as the content disclosed by the present invention.

Claims

1. A water-dispersible granule for weed control with strong resistance to hard water, characterized in that, The active ingredients of the water-dispersible granules include nicosulfuron, atrazine, and MCPA.

2. The herbicidal water-dispersible granule with strong resistance to hard water according to claim 1, characterized in that, The water-dispersible granules contain 7-19% nicosulfuron, 20-50% atrazine, 3-12% 2,4-D, 1-5% dispersant, 1-3% wetting agent, 5-10% disintegrant, 1-3% stabilizer, 2-5% binder, 1-5% anti-hard water agent, and filler to make up to 100%.

3. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The wetting agent is selected from one or more of the following: sodium lauroyl sarcosinate, sodium N-lauroyl glutamate, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, alkyl naphthalene sulfonate, trisiloxane polyoxyethylene ether, sodium dodecyl sulfate, sodium isooctanol succinate sulfonate, sodium oleoyl methyl taurate, higher fatty acid glycerides, sorbitan fatty acid esters, fatty alcohol polyoxyethylene ether, and alkylphenol polyoxyethylene ether phosphate.

4. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The dispersant is selected from one or more of the following: glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, sodium alkyl sulfonate, alkyl naphthalene sulfonate formaldehyde condensate, sodium naphthalene sulfonate formaldehyde condensate, lignin sulfonate, polycarboxylate, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, dodecyl trimethylammonium salt, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty amide benzene sulfonic acid, p-methoxy fatty amide benzene sulfonic acid, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, and polyoxyethylene sorbitan fatty acid ester.

5. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The disintegrant is selected from one or more of sodium sulfate, calcium sulfate, sodium bicarbonate, ammonium sulfate, polyvinylpyrrolidone, magnesium chloride, sodium carboxymethyl starch, urea, CCMS, PS, CCMC, L-HPC, MCC, and PVPP.

6. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The filler is selected from one or more of the following: diatomaceous earth, kaolin, attapulgite, talc, activated clay, pumice, saponin, calcite, sand, dolomite, montmorillonite, calcium carbonate, zeolite, and acidic clay.

7. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The anti-hardness agent is a mixture of sulfonated lignin and polyaspartic acid, with a ratio of 4-8:1-1.

5.

8. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The stabilizer is one or more of sodium chloride, sodium tripolyphosphate, silica, and bentonite.

9. A water-dispersible herbicide granule with strong resistance to hard water as described in claim 2, characterized in that, The adhesive is selected from one or more of starch, dextrin, sucrose, carboxymethyl cellulose, carboxyethyl cellulose, gelatin, gum arabic, xanthan gum, and hydroxypropyl methyl cellulose.

10. A water-dispersible herbicide granule with strong resistance to hard water according to any one of claims 1-9, characterized in that, The water-dispersible granules contain 10-15% nicosulfuron, 30-35% atrazine, and 5-10% 2,4-D.

11. A method for preparing a water-dispersible herbicidal granule with strong hard water resistance according to any one of claims 1-10, characterized in that, The preparation method includes the following steps: S1. Mix the active ingredients with dispersants, wetting agents, disintegrants, stabilizers, anti-hard water agents and fillers in a certain proportion until homogeneous; S2. Pulverize to D90≤5μm using an air jet mill; S3. Add the pulverized mixture from S2 to the binder aqueous solution, mix again, and then perform fluidized bed granulation to control the particle size to 0.1-1.5 mm. S4. Dry at 45℃-60℃. The dried granules are passed through a 20-40 mesh sieve to remove fine powder (<100 mesh) and large particles (>10 mesh) to obtain a water-dispersible granule product containing nicosulfuron, atrazine, and 2,4-D.

12. Use of the herbicidal water-dispersible granules according to any one of claims 1-10 in controlling field weeds of crops.

13. The use of the water-dispersible herbicide granules according to claim 12 in controlling field weeds of crops, characterized in that, The crop in question is corn.

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