Metabolic homeostasis-regulating full-nutrition weight loss meal replacement powder and preparation method thereof

Abstract

The present application provides a kind of metabolism steady state regulation type full nutrition weight loss meal replacement powder, by 82~90 weight parts of endocrine regulation component, 4~8 weight parts of metabolic activation component, 3~5 weight parts of nutrient component and 2~6 weight parts of flavor component, also provides the preparation method of metabolism steady state regulation type full nutrition weight loss meal replacement powder.The present application will realize synchronous intervention to three major core problems of energy metabolism, endocrine coordination, tissue function, reconstructs the metabolic homeostasis of organism, realizes the effective management of body weight.

Description

Technical Field

[0001] This invention belongs to the field of meal replacement powder technology, specifically relating to a metabolic homeostasis-regulating, all-nutritional weight loss meal replacement powder and its preparation method. Background Technology

[0002] With the global overweight and obesity rate soaring, the drawbacks of traditional starvation weight loss models are becoming increasingly apparent. Decreased basal metabolic rate, muscle loss, and severe rebound have become the core pain points for people trying to lose weight. Against this backdrop, the market demand for weight loss products has shifted from rapid weight loss to healthy fat loss and metabolic stability.

[0003] Currently available weight-loss meal replacement powders often focus solely on low-calorie design. However, long-term consumption of these powders suffers from the following key drawbacks: 1) Nutritional imbalance, leading to muscle loss and a decreased basal metabolic rate, resulting in a "weight loss-rebound" cycle; 2) Formulas are mostly based on simple calorie replacement, lacking targeted nutritional interventions for core pathological aspects of obesity such as insulin resistance and lipid metabolism disorders, thus failing to improve metabolic health; 3) Processing techniques can easily damage the activity of heat-sensitive functional ingredients, making the claimed effects difficult to achieve. Therefore, there is an urgent need for a comprehensive nutritional solution that can systematically regulate metabolic homeostasis and combine efficient weight loss with overall health benefits. Summary of the Invention

[0004] To address the problems in the existing technology, this invention provides a metabolic homeostasis-regulating, all-nutritional weight-loss meal replacement powder and its preparation method, which simultaneously intervenes in three core issues: energy metabolism, endocrine coordination, and tissue function, thereby rebuilding the body's metabolic homeostasis and achieving effective weight management.

[0005] The technical problem solved by this invention is achieved by the following technical solution: The first objective of this invention is to provide a metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder, comprising 82-90 parts by weight of endocrine-regulating components, 4-8 parts by weight of metabolic-activating components, 3-5 parts by weight of nutrient components, and 2-6 parts by weight of flavor components. The endocrine regulatory component includes a dual-source protein, complex dietary fiber, and functional fat in a mass ratio of 25~35:20~30:25~35, wherein the dual-source protein is composed of concentrated whey protein and soy protein isolate. The metabolic activating components include green tea extract, coffee powder, white kidney bean extract, and L-carnitine; The nutrient components include multivitamins and multiminerals; The flavor components are sweeteners, flavoring agents, and / or anticaking agents; The endocrine regulatory components and metabolic activation components synergistically activate the lipid oxidation pathway and maintain the basal metabolic rate.

[0006] In this invention, coffee powder provides chlorogenic acid and caffeine, synergistically enhancing energy expenditure and insulin sensitivity with EGCG; white kidney bean extract provides an α-amylase inhibitor, assisting in postprandial blood glucose management; and L-carnitine serves as an essential cofactor for fatty acid β-oxidation in mitochondria. The proportions of dual-source protein, complex dietary fiber, and functional fats control the energy density of the meal replacement powder at 150-180 kcal / 100g. Simultaneously, in synergy with the natural metabolism activation module, it facilitates the activation of the UCP1 lipolysis pathway and the AMPK energy metabolism pathway, achieving a dual improvement in fat oxidation efficiency and basal metabolic rate, resulting in good weight loss and reduced rebound.

[0007] Furthermore, the mass ratio of the concentrated whey protein to the soy protein isolate is 3.5~4.5:1.

[0008] Preferably, the mass ratio of the concentrated whey protein to the soy protein isolate is 4:1.

[0009] This invention utilizes a dual-source protein system of whey protein concentrate and soy protein isolate. It leverages the rapid stimulation of anabolic metabolism and satiety hormones by whey protein, while combining the sustained-release properties and cost-effectiveness of soy protein to provide a continuous supply of amino acids during weight loss, thus providing a material basis for maintaining core lean body mass. If the ratio of the two is greater than 4.5:1, although a feeling of fullness is achieved quickly, reducing food intake, the lack of sustained-release properties of soy protein isolate leads to a faster decline in satiety, resulting in urgency to eat more, increased calorie intake, and hindering weight loss. If the ratio is less than 3.5:1, the sustained-release effect of soy protein isolate prolongs the duration of satiety signals, reducing food intake, but resulting in less energy supply. This can easily lead to problems such as fatigue and poor concentration during weight loss and affect metabolic efficiency. While whey protein concentrate can help improve insulin sensitivity, a too-low ratio weakens its synergistic effect with functional fats and metabolic activating components, reducing fat oxidation efficiency.

[0010] Furthermore, the complex dietary fiber includes glucomannan, oat beta-glucan, inulin, pectin, and guar gum.

[0011] Furthermore, the green tea extract contains more than 50% EGCG. EGCG in the green tea extract helps activate the AMPK pathway, promotes lipid oxidation, and inhibits the synthesis of new lipids.

[0012] Furthermore, the functional fats include triglyceride powder, flaxseed, and low-GI maltodextrin.

[0013] Furthermore, the multivitamin includes at least two of vitamins A, D, E, K, B vitamins, and C.

[0014] Furthermore, the complex minerals include citrates or glycine salts of calcium, magnesium, zinc, chromium, iron, phosphorus, sodium, selenium, and potassium.

[0015] Furthermore, the sweetener is selected from at least one of erythritol, steviol glycosides, and mogrosides.

[0016] Furthermore, the flavoring agent is selected from at least one of natural vanillin, anthocyanin, and limonene.

[0017] Furthermore, the anti-caking agent is selected from silicon dioxide, tricalcium phosphate, microcrystalline cellulose, or magnesium stearate.

[0018] Furthermore, a metabolic homeostasis-regulating complete nutritional weight-loss meal replacement powder comprises the following components by weight percentage: 20-28 parts of whey protein concentrate 5-7 parts soy protein isolate 6-9 parts of glucomannan 5-8 parts of oat beta-glucan 4-6 parts inulin 4-6 parts pectin 2-3 parts guar gum 3-5 parts of triglyceride powder 2-3 parts flaxseed 20-26 parts of low-GI maltodextrin Green tea extract 1.5-3 parts 1-2 parts coffee powder 1-1.5 parts of white kidney bean extract L-carnitine 0.5~1.5 parts Multivitamins 1.5 to 3 servings 1-3 parts of compound minerals 2-5 parts sweetener Flavoring agent 0.5~1 part Anti-caking agent 0.5~1 part.

[0019] Furthermore, a metabolic homeostasis-regulating complete nutritional weight-loss meal replacement powder comprises the following components by weight percentage: 22-26 servings of whey protein concentrate 5.5-6.5 parts soy protein isolate 6.5-8 parts glucomannan 5-7 parts of oat beta-glucan Inulin 4.5~5.5 parts 4-5 parts pectin 2.5-3 parts guar gum 3-5 parts of medium-chain triglycerides 2.5 to 3 parts flaxseed 21-24 parts of low-GI maltodextrin Green tea extract 1.5~2.5 parts 1-2 parts coffee powder 1-1.5 parts of white kidney bean extract L-L-carnitine tartrate 1~1.5 parts Multivitamins 1.5 to 3 servings 1-3 parts of compound minerals 2-4 parts erythritol Steviosides 0.1~0.5 parts 0.5-1 part of natural vanillin 0.5 to 1 part of silicon dioxide.

[0020] The second objective of this invention is to provide a method for preparing a metabolic homeostasis-regulating, complete nutritional weight-loss meal replacement powder, comprising the following steps: 1) Raw material pretreatment: L-carnitine, some compound vitamins, and some compound minerals were microencapsulated to form microencapsulated powder; green tea liposome powder was prepared from green tea; other raw materials were dried, pulverized, and sieved; the microencapsulated compound vitamin portion consisted of the water-soluble vitamins in the compound vitamins; 2) Dry mixing: First, concentrate whey protein, soy protein isolate, white kidney bean extract, and inactive ingredients from compound dietary fiber and functional fats are mixed for 12-20 minutes at 15-20 rpm to obtain a uniform carrier base. Then, microcapsule powder, green tea liposome powder, coffee powder, triglyceride powder, and active ingredients from compound dietary fiber and functional fats are added and mixed for 18-25 minutes at 10-15 rpm to ensure that the active ingredients are evenly dispersed in the carrier base. Finally, the remaining nutrient components and flavor components are added and mixed for 25-30 minutes at 8-12 rpm. 3) Packaging: The mixed powder is sieved and then packaged to obtain meal replacement powder.

[0021] This invention microencapsulates L-carnitine, some complex vitamins, and some complex minerals before mixing, preparing green tea into liposomes. L-carnitine and some water-soluble vitamins, such as vitamin C and vitamin B, are easily oxidized during storage. Microencapsulation prevents oxidation and extends the product's shelf life. Furthermore, microencapsulation of some vitamins and minerals allows for slow release in the stomach after consumption, improving absorption. Active ingredients in green tea extract, such as EGCG, are easily destroyed in the gastrointestinal tract, resulting in low absorption. By preparing green tea extract into liposomes, the active ingredients are slowly released, directly delivering them into cells and targeting fat cells, resulting in high bioavailability and effective weight loss.

[0022] This invention first mixes concentrated whey protein, soy protein isolate, white kidney bean extract, and inactive components, then adds active ingredients, microcapsule powder, green tea liposome powder, etc., to avoid the potential for localized overheating or static electricity buildup caused by directly mixing active components. Finally, nutrients and flavoring ingredients are added to prevent them from floating and agglomerating.

[0023] Furthermore, the microencapsulation process involves dissolving L-carnitine, some compound vitamins, some compound minerals, and wall materials in pure water at a ratio of 1:3-5, homogenizing under high pressure, and then spray drying to obtain microencapsulated powder.

[0024] Furthermore, the particle size of the microcapsule powder is controlled at 100-200 mesh, and the activity retention rate is ≥85%.

[0025] Furthermore, the wall material is selected from one of hydroxypropyl methylcellulose, maltodextrin, and chitosan.

[0026] Furthermore, the preparation method of green tea liposome powder is as follows: green tea extract, soybean lecithin, and cholesterol are dissolved in anhydrous ethanol, and the mixture is evaporated under reduced pressure to form a lipid film. Then, phosphate buffer is added for hydration, and the mixture is ultrasonically treated to obtain a liposome suspension. Subsequently, the suspension is freeze-dried at low temperature to obtain green tea liposome powder.

[0027] Furthermore, the pH value of the phosphate buffer solution is 6-7.

[0028] Furthermore, the ultrasonic treatment is performed at 1000-3000 rpm for 10-15 minutes.

[0029] Furthermore, the mass ratio of soybean phospholipids to cholesterol is 5-10:1.

[0030] Furthermore, other raw materials, except for the microcapsule powder and green tea liposome powder, are vacuum dried at 60~65℃ with a vacuum degree of -0.08~-0.06MPa for 2-3 hours.

[0031] Furthermore, the compound dietary fiber and flaxseed powder are pulverized by an ultra-fine pulverizer and then passed through a 120-mesh sieve; the concentrated whey protein, soy protein isolate, low-GI maltodextrin, triglyceride powder, and white kidney bean extract are passed through an 80-mesh sieve; and the coffee powder and remaining flavor components are passed through a 100-mesh sieve to remove impurities and coarse particles.

[0032] Furthermore, a method for preparing a metabolic homeostasis-regulating complete nutritional weight-loss meal replacement powder includes the following steps: 1) Raw material pretreatment: L-carnitine microencapsulation: L-carnitine, a portion of compound vitamins, a portion of compound minerals, and wall material are dissolved in pure water at a ratio of 1:3-5. After high-pressure homogenization, the mixture is spray-dried to obtain microencapsulated powder. The microencapsulated compound vitamin portion consists of the water-soluble vitamins in the compound vitamins. Preparation of green tea liposome powder: Green tea extract, soybean lecithin, and cholesterol were dissolved in anhydrous ethanol, and the mixture was evaporated under reduced pressure to form a lipid film. Then, phosphate buffer was added for hydration, and the mixture was ultrasonically treated to obtain a liposome suspension. Subsequently, the suspension was freeze-dried at low temperature to obtain green tea liposome powder. 2) Dry mixing: First, concentrate whey protein, soy protein isolate, white kidney bean extract, oat beta-glucan, pectin, guar gum, and flaxseed powder are mixed for 12-20 minutes at a speed of 15-20 rpm to obtain a uniform carrier base. Then, microcapsule powder, green tea liposome powder, coffee powder, triglyceride powder, low-GI maltodextrin, inulin, and glucomannan are added and mixed for 18-25 minutes at a speed of 10-15 rpm to ensure that the active ingredients are evenly dispersed in the carrier base. During this process, the machine is stopped for 30 seconds every 10 minutes to release static electricity. Finally, the remaining compound vitamins, compound minerals, erythritol, steviol glycosides, natural vanillin, and silicon dioxide are added and mixed for 25-30 minutes at a speed of 8-12 rpm. 3) Packaging: The mixed powder is sieved using a vibrating screen and then packaged using a nitrogen-filled packaging machine to obtain meal replacement powder.

[0033] Compared with the prior art, the beneficial technical effects of the present invention are as follows: This invention achieves simultaneous intervention in three core areas: energy metabolism, endocrine regulation, and tissue function. It breaks through the limitations of traditional meal replacement powders that only focus on low calorie intake, and realizes nutritional intervention, which combines efficient weight loss with comprehensive health benefits.

[0034] Through a synergistic system of protein, dietary fiber, and prebiotics, it provides a lasting feeling of fullness while regulating appetite-related hormones at different levels to achieve a negative energy balance with low hunger. Complex fiber and white kidney bean extract slow down carbohydrate absorption, stabilizing blood sugar and insulin levels; L-carnitine and epigallocatechin gallate (EGCG) from green tea extract synergistically promote the transport and oxidation of fatty acids to mitochondria, increasing the proportion of energy supplied by lipid oxidation; and sufficient high-quality protein and essential micronutrients ensure muscle tissue synthesis and repair, maintaining a high level of metabolically active tissue.

[0035] This invention reduces chronic low-grade inflammation and oxidative stress associated with obesity by providing a comprehensive range of antioxidant complex vitamins, complex minerals, and green tea polyphenols, thereby improving the sensitivity of the insulin signaling pathway and protecting the metabolic function of tissues such as the liver and blood vessels.

[0036] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, and in order to make the above and other objects, features and advantages of the present invention more apparent and understandable, specific embodiments of the present invention are described below. Attached Figure Description

[0037] Figure 1 The change rate of human body composition indicators in Experiment 1 and Experiment 2 in the experimental examples of this invention.

[0038] Figure 2 The percentage change in metabolic indicators is the percentage change in experimental group 1 and experimental group 2 in the experimental examples of this invention. Detailed Implementation

[0039] The technical solution of the present invention will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanatory of the present invention and should not be construed as limiting the scope of protection of the present invention. All technologies implemented based on the above content of the present invention are covered within the scope of protection intended by the present invention.

[0040] In addition, unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be obtained by purchasing them from the market or prepared by existing methods. Example 1

[0041] A metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder comprises: 24 parts concentrated whey protein, 6 parts soy protein isolate, 7 parts glucomannan, 6 parts oat β-glucan, 5 parts inulin, 4 parts pectin, 3 parts guar gum, 4 parts medium-chain triglycerides, 3 parts flaxseed, 23 parts low-GI maltodextrin, 2 parts green tea extract, 1.5 parts coffee powder, 1.2 parts white kidney bean extract, 1.3 parts L-carnitine tartrate, 2 parts multivitamins, 2 parts multiminerals, 2-4 parts erythritol, 0.1-0.5 parts steviol glycosides, 0.5-1 part natural vanillin, and 0.5-1 part silicon dioxide. The multivitamins include vitamins A, D, E, B vitamins, and C; the multiminerals include calcium citrate, zinc citrate, and magnesium citrate.

[0042] A method for preparing a metabolic homeostasis-regulating, complete nutritional weight-loss meal replacement powder includes the following steps: 1) Raw material pretreatment: Weigh out each raw material according to the specified proportions and set aside.

[0043] L-carnitine microencapsulation: L-carnitine, a portion of compound vitamins, a portion of compound minerals, and hydroxypropyl methylcellulose are dissolved in purified water at a ratio of 1:4. After high-pressure homogenization, the mixture is spray-dried to obtain microencapsulated powder. The microencapsulated compound vitamin portion consists of water-soluble vitamins from the compound vitamins.

[0044] Preparation of green tea liposome powder: Green tea extract, soybean lecithin, and cholesterol were dissolved in anhydrous ethanol, and the mixture was evaporated under reduced pressure to form a lipid film. Then, phosphate buffer solution at pH 6 was added for hydration, and the mixture was sonicated for 15 min to obtain a liposome suspension. Subsequently, the suspension was freeze-dried at low temperature to obtain green tea liposome powder. 2) Dry mixing: First, concentrate whey protein, soy protein isolate, white kidney bean extract, oat beta-glucan, pectin, guar gum, and flaxseed powder were mixed for 15 minutes at 18 rpm to obtain a uniform carrier base. Then, microcapsule powder, green tea liposome powder, coffee powder, triglyceride powder, low-GI maltodextrin, inulin, and glucomannan were added and mixed for 20 minutes at 15 rpm to ensure that the active ingredients were evenly dispersed in the carrier base. During this process, the machine was stopped for 30 seconds every 10 minutes to release static electricity. Finally, the remaining compound vitamins, compound minerals, erythritol, steviol glycosides, natural vanillin, and silicon dioxide were added and mixed for 30 minutes at 12 rpm. 3) Packaging: The mixed powder is sieved using a vibrating screen and then packaged using a nitrogen-filled packaging machine to obtain meal replacement powder. Example 2

[0045] A metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder comprises: 22 parts concentrated whey protein, 6.5 parts soy protein isolate, 6.5 parts glucomannan, 7 parts oat β-glucan, 4.5 parts inulin, 5 parts pectin, 2.5 parts guar gum, 5 parts medium-chain triglycerides, 2.5 parts flaxseed, 24 parts low-GI maltodextrin, 1.5 parts green tea extract, 2 parts coffee powder, 1 part white kidney bean extract, 1.5 parts L-carnitine tartrate, 1.5 parts multivitamins, 3 parts multiminerals, 2 parts erythritol, 0.5 parts steviol glycosides, 0.5 parts natural vanillin, and 1 part silicon dioxide.

[0046] Multivitamins include vitamins A, D, E, B vitamins, C, and K, while multiminerals include calcium glycinate, zinc glycinate, magnesium glycinate, potassium glycinate, and selenium glycinate.

[0047] The preparation method is the same as in Example 1. Example 3

[0048] A metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder comprises: 26 parts concentrated whey protein, 5.5 parts soy protein isolate, 8 parts glucomannan, 5 parts oat β-glucan, 5.5 parts inulin, 4 parts pectin, 3 parts guar gum, 3 parts medium-chain triglycerides, 3 parts flaxseed, 21 parts low-GI maltodextrin, 2.5 parts green tea extract, 1 part coffee powder, 1.5 parts white kidney bean extract, 1 part L-carnitine tartrate, 3 parts multivitamins, 1 part multimineral, 4 parts erythritol, 0.1 parts steviol glycosides, 1 part natural vanillin, and 0.5 parts silicon dioxide.

[0049] Multivitamins include vitamins A, D, E, B vitamins, C, and K, while multiminerals include calcium glycinate, magnesium glycinate, ferric citrate, chromium citrate, and potassium citrate.

[0050] Comparative Example 1 Unlike Embodiment 1 of the present invention, no endocrine regulatory components are added.

[0051] Comparative Example 2 Unlike Example 1 of this invention, no L-carnitine is added.

[0052] Experimental Example 1 160 obese adults (BMI ≥ 28 kg / m²) 2Patients must have at least one abnormal metabolic marker (fasting blood glucose ≥6.1 mmol / L, or TG ≥1.7 mmol / L, or blood pressure ≥140 / 90 mmHg). Exclusion criteria: malignant tumors; severe mental illness; severe or end-stage renal impairment (stage IV or creatinine clearance <30 mL / min); patients who are unable to cooperate or refuse to participate in the study due to special circumstances.

[0053] Patients were randomly divided into four groups of 40 each for intervention. The male-to-female ratio was equal in each group. The intervention lasted for 12 weeks, during which patients received standardized lifestyle guidance.

[0054] Experimental Group 1: A placebo was given for lunch each day, and the meal replacement powder of Example 1 of this invention was used to replace dinner each day; Experimental Group 2: The meal replacement powder of this invention was used to replace two meals a day, namely lunch and dinner.

[0055] Comparison group: Use the Comparison Group 1 meal replacement powder to replace two meals a day, replacing lunch and dinner respectively.

[0056] Comparison Group 2: The Comparison Group 2 meal replacement powder replaced two meals a day, replacing lunch and dinner respectively.

[0057] Indicators were measured one day before the intervention and one day after the intervention cycle ended, and the changes were averaged. See Table 1 for the average changes of each indicator in the two groups of patients before and after 12 weeks of intervention; Appendix Figure 1 The rate of change of body composition indicators, attached Figure 2 This represents the rate of change in metabolic indicators.

[0058] Table 1 Comparison of Weight Loss Effects of Meal Replacement Powders index Experiment 1 Experimental Group 2 Comparison of a group Comparison of Group 2 Weight(kg) -3.10± 1.8* -6.6 ± 2.4* -3.2± 1.5* -5.1±1.7* Body fat percentage (%) -4.3 ± 2.0* -4.9± 1.1* -2.1± 0.8* -3.5± 1.0* Waist circumference (cm) -3.8 ± 1.7* -6.7± 1.0* -2.8± 0.9* -4.3± 1.1* HOMA-IR -0.8 ± 0.8* -1.9 ± 0.8* -0.7± 0.5* -1.2± 0.6* Triglycerides (TG, mmol / L) -0.268 ± 0.225* -0.50 ± 0.16* -0.18± 0.12* -0.32± 0.14* Serum uric acid (UA, μmol / L) -17 ± 12 -45 ± 10* -15± 8* -28± 9* Note: HOMA-IR: Insulin Resistance Index; * indicates comparison with baseline. As can be seen from the table, the second experimental group showed a more significant decrease in weight, body fat percentage, and waist circumference, with higher compliance and a stronger feeling of satiety. This demonstrates that the meal replacement powder of this invention is effective in weight control and achieves a low-stress negative energy balance. The second experimental group also showed a significant decrease in fat mass index, and the fat-free mass reflects the stable bone and muscle content, indicating effective weight control.

[0059] In Experiment 2, the HOMA-IR (Insulin Resistance Index), cholesterol, triglycerides, serum uric acid, and blood pressure all showed significant improvement. The HOMA-IR in Experiment 2 was significantly better than in Experiment 1, indicating increased insulin sensitivity and optimized substrate metabolic axis, thus demonstrating a significant effect on weight loss. The significant decrease in triglyceride levels in Experiment 2 validated improved efficiency in hepatic and peripheral fat metabolism. The significant reduction in serum uric acid in Experiment 2 not only improved metabolic indicators for weight loss but also suggested improved purine metabolism and renal excretion. Combined with the comprehensive improvement in serum uric acid, blood lipids, and blood glucose, this indicates synergistic repair of the body's metabolic network and a return to homeostasis in the overall internal environment.

[0060] Compared to Group 2, which lacked dual-source protein, complex dietary fiber, and functional fats, Group 1 showed the weakest weight loss and metabolic improvement effects. Its body fat percentage and waist circumference reductions were only 42.9% and 41.8% of those in Group 2, respectively, confirming the core supporting role of endocrine regulatory components. Group 2, lacking L-carnitine, could not efficiently transport fatty acids, resulting in lower weight loss and metabolic indicator improvements compared to Group 2. Its weight loss was 22.7% lower and its body fat percentage reduction was 28.6% lower, further highlighting the synergistic effect of L-carnitine and green tea extract. Without L-carnitine, the treatment primarily inhibits adipocyte differentiation and promotes lipase activity through EGCG, while slightly enhancing the body's antioxidant capacity, focusing only on the single stage of fat breakdown. The fatty acids produced after fat breakdown are difficult for the body to metabolize and consume quickly, easily accumulating again in the body. Furthermore, the treatment cannot improve fatty acid transport efficiency, leading to a plateau in weight loss and severe rebound. When L-carnitine and green tea extract work together, the green tea extract EGCG is responsible for activating the fat breakdown pathway and promoting the release of fatty acids from fat cells. As a "carrier" of fatty acids, L-carnitine can quickly transport the broken-down fatty acids to the mitochondria of cells for oxidation and energy supply, avoiding the accumulation of fatty acids. At the same time, it works with MCT powder to improve energy metabolism efficiency and enhance the sustainability of weight loss.

[0061] The synergistic effect of L-carnitine and green tea extract relies on the graded premixing process in this preparation method. The three-stage premixing process evenly disperses the metabolic activating components, ensuring that L-carnitine and green tea extract are evenly distributed in the product and avoiding local concentration imbalances that could affect synergistic efficiency. At the same time, the pretreatment and premixing process of macro-components ensures the functional performance of core components such as dual-source protein and complex dietary fiber. This is also the core manifestation of the deep adaptation of this preparation method and formula design to achieve the goal of "metabolic homeostasis weight loss".

[0062] Experiment Example 2 Case 1, female, 38 years old, initial weight 83.7 kg, obese for 2 years.

[0063] Diagnosis: 1. Obesity 2. Severe fatty liver 3. Grade 2 primary hypertension, high risk.

[0064] After using the meal replacement powder of this invention to replace two meals, and after 4 months of intervention, weight decreased by 24.1% and body fat percentage decreased by 20.2%; low-density cholesterol (LDL-C) decreased from 3.69 mmol / L to 2.51 mmol / L, alanine aminotransferase decreased from 112 U / L to 43 U / L, aspartate aminotransferase decreased from 57 U / L to 30 U / L, and uric acid level decreased from 452 μmol / L to 394 μmol / L.

[0065] Case 2, male, 28 years old, initial weight 96.8 kg, obese for 8 years.

[0066] Diagnosis: 1. Obesity 2. Fatty liver 3. Dyslipidemia 4. Hyperuricemia 5. Sleep apnea-hypopnea syndrome.

[0067] After using the meal replacement powder of this invention to replace two meals, and after two months of intervention, the weight decreased by 7.9%, the body fat percentage decreased by 9.2%, the waist circumference decreased by 10cm, and the hip circumference decreased by 8.5cm; the snoring symptoms at night were significantly reduced.

[0068] Case 3, male, 10 years old, initial weight 52.7 kg, obese for 3 years.

[0069] Diagnosis: 1. Obesity 2. Impaired glucose tolerance.

[0070] After using the meal replacement powder of this invention to replace two meals, and after 3 months of intervention, the child's weight decreased by 15.5%, body fat percentage decreased by 15.5%, height increased by 5.6cm, and skeletal muscle increased by 0.8kg. Not only did it not affect the child's growth and development, but it also effectively reduced weight and body fat percentage, and the child's health condition was improved.

[0071] The complete nutritional weight-loss meal replacement powder provided by this invention, through its unique formula design and preparation process, achieves multi-target intervention. In clinical applications, it not only demonstrates excellent weight-loss effects but also comprehensively improves three core metabolic indicators: blood uric acid, blood glucose, and blood lipids, strongly supporting its core function of systemically regulating metabolic homeostasis. This invention enhances satiety and regulates appetite-related hormones through the synergistic combination of high protein, high fiber, and prebiotics, intervening in energy-endocrine metabolism to achieve sustained weight loss with low hunger. Through the synergistic effects of white kidney bean extract, L-carnitine, epigallocatechin gallate, and medium-chain triglycerides, it achieves carbohydrate blocking, fat blocking, and fat oxidation activation, reducing carbohydrate and fat absorption, promoting fat oxidation, and regulating the substrate metabolic axis. Through the antioxidant, anti-inflammatory, and hepatoprotective effects of green tea extract, complex vitamins, and complex minerals, it improves the sensitivity of the insulin signaling pathway and maintains long-term metabolic homeostasis.

[0072] The sequence numbers of the above embodiments of the present invention are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments.

[0073] The embodiments of the present invention have been described above, but the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims, and these forms are all within the protection scope of the present invention.

Claims

1. A metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder, characterized in that: It consists of 82-90 parts by weight of endocrine regulatory components, 4-8 parts by weight of metabolic activating components, 3-5 parts by weight of nutrient components, and 2-6 parts by weight of flavor components. The endocrine regulatory component includes a dual-source protein, complex dietary fiber, and functional fat in a mass ratio of 25~35:20~30:25~35, wherein the dual-source protein is composed of concentrated whey protein and soy protein isolate. The metabolic activating components include green tea extract, coffee powder, white kidney bean extract, and L-carnitine; The nutrient components include multivitamins and multiminerals; The flavor components are sweeteners, flavoring agents, and / or anticaking agents; The endocrine regulatory components and metabolic activation components synergistically activate the lipid oxidation pathway and maintain the basal metabolic rate.

2. The metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder as described in claim 1, characterized in that: The mass ratio of concentrated whey protein to soy protein isolate is 3.5~4.5:

1.

3. The metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder as described in claim 1, characterized in that: The green tea extract contains more than 50% EGCG.

4. The metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder as described in claim 1, characterized in that: The functional fats include triglyceride powder, flaxseed, and low-GI maltodextrin.

5. The metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder as described in claim 1, characterized in that, Includes the following components by weight percentage: 20-28 parts of whey protein concentrate 5-7 parts soy protein isolate 6-9 parts of glucomannan 5-8 parts of oat beta-glucan 4-6 parts inulin 4-6 parts pectin 2-3 parts guar gum 3-5 parts of triglyceride powder 2-3 parts flaxseed 20-26 parts of low-GI maltodextrin Green tea extract 1.5-3 parts 1-2 parts coffee powder 1-1.5 parts of white kidney bean extract L-carnitine 0.5~1.5 parts Multivitamins 1.5 to 3 servings 1-3 parts of compound minerals 2-5 parts sweetener Flavoring agent 0.5~1 part Anti-caking agent 0.5~1 part.

6. A method for preparing a metabolic homeostasis-regulating, fully nutritious weight-loss meal replacement powder according to any one of claims 1-5, characterized in that, Includes the following steps: 1) Raw material pretreatment: L-carnitine, some compound vitamins, and some compound minerals were microencapsulated to form microencapsulated powder; green tea liposome powder was prepared from green tea; other raw materials were dried, pulverized, and sieved; the microencapsulated compound vitamin portion consisted of the water-soluble vitamins in the compound vitamins; 2) Dry mixing: First, concentrate whey protein, soy protein isolate, white kidney bean extract, and inactive ingredients from compound dietary fiber and functional fats are mixed for 12-20 minutes at 15-20 rpm to obtain a uniform carrier base. Then, microcapsule powder, green tea liposome powder, coffee powder, triglyceride powder, and active ingredients from compound dietary fiber and functional fats are added and mixed for 18-25 minutes at 10-15 rpm to ensure that the active ingredients are evenly dispersed in the carrier base. Finally, the remaining nutrient components and flavor components are added and mixed for 25-30 minutes at 8-12 rpm. 3) Packaging: The mixed powder is sieved and then packaged to obtain meal replacement powder.

7. The preparation method of a metabolic homeostasis-regulated complete nutritional weight-loss meal replacement powder as described in claim 6, characterized in that, The microencapsulation process is as follows: L-carnitine, some compound vitamins, some compound minerals and wall material are dissolved in pure water at a ratio of 1:3-5, homogenized under high pressure and then spray-dried to obtain microencapsulated powder.

8. The preparation method of a metabolic homeostasis-regulating complete nutritional weight loss meal replacement powder as described in claim 6, characterized in that, The preparation method of green tea liposome powder is as follows: green tea extract, soybean lecithin, and cholesterol are dissolved in anhydrous ethanol, and the mixture is evaporated under reduced pressure to form a lipid film. Then, phosphate buffer is added for hydration, and the mixture is ultrasonically treated to obtain a liposome suspension. Subsequently, the suspension is freeze-dried at low temperature to obtain green tea liposome powder.

9. The preparation method of a metabolic homeostasis-regulated complete nutritional weight loss meal replacement powder as described in claim 6, characterized in that: The pH value of the phosphate buffer solution is 6-7.

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