Dynamic positive and negative pressure coordinated secondary throwing type manual nasal irrigator and method of use thereof

Abstract

The application discloses a dynamic positive and negative pressure coordinated secondary throwing type manual nasal washing device and a use method thereof. The nasal washing device is composed of a main body which is integrally formed of a flexible resilient material, the main body contains an olive-shaped sealing head matched with a nostril and a capsule-shaped head manually extruded, the two are communicated to form a cavity containing a nasal washing liquid, a neck is arranged at the connecting position, a sterile film is arranged at the opening of the sealing head, and the elastic modulus of the main body material is accurately configured. The cavity is pre-filled with a rheological modified nasal washing liquid containing sodium carboxymethyl cellulose, glycerol and hypertonic sea salt. The use method is to generate a pulse type positive pressure by rapid extrusion, release the negative pressure generated by the capsule-shaped head, and repeat the positive and negative pressure operation to realize the circulation and emptying of the secretion. The application realizes the accurate cleaning of the nasal cavity anatomical dead space, significantly improves the biofilm removal efficiency, takes into account the use safety and the mucosa repair effect, is a secondary throwing type design, is simple and convenient to operate and carry, and can be widely applied to the nursing of chronic sinusitis and allergic rhinitis and the postoperative rehabilitation of nasal endoscopy.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more specifically, to a single-use manual nasal irrigator with dynamic positive and negative pressure coordination and its usage method. Background Technology

[0002] The challenges in treating chronic sinusitis (CRS), allergic rhinitis, and patients after nasal endoscopy lie in the obstruction of the ostiomeatal complex (OMC) and the retention of secretions within the sinus cavities. Nasal irrigation, as a safe and effective adjunctive treatment, has been widely used in clinical practice.

[0003] Traditional nasal irrigation devices are mainly divided into two categories: one is the irrigation bottle that relies on gravitational potential energy, and the other is the nasal irrigator that generates constant positive pressure by manual squeezing. However, both methods share a common physical limitation: the fluid they produce mainly flows along the inferior nasal meatus, i.e., the path of least resistance, exhibiting a unidirectional and relatively constant laminar flow. This laminar flow is like a straight river channel, which can only flush away loose secretions from the anterior part of the nasal cavity and the surface of the inferior nasal meatus. However, the flushing force is drastically reduced in the folds of the nasal turbinate mucosa, the cleft of the middle nasal meatus, the opening of the maxillary sinus, the ethmoid sinus air cells, and other traditionally defined "anatomical dead spaces," making them difficult to effectively clear.

[0004] Specifically, traditional rinsing methods have the following technical bottlenecks: 1. Limitations of a single flow pattern: Traditional flushing often forms laminar flow with a low Reynolds number (Re). The fluid flows parallel to the mucosal surface and lacks a vertical impact component, making it difficult to generate sufficient fluid shear force to peel off the adhered pathogen biofilm.

[0005] 2. Cleaning blind spots: It cannot effectively cover the sinus openings and the middle meatus cleft, and it is difficult to open the sinus openings that are blocked by inflammatory edema through physical means.

[0006] 3. Biofilm residue: The lack of sufficient hydrodynamic mechanisms to disrupt the physical structure of biofilms of pathogenic bacteria such as Staphylococcus aureus.

[0007] Therefore, how to effectively clean secretions deep within the anatomical dead space has become a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0008] The purpose of this invention is to overcome the shortcomings of traditional nasal irrigation technology and provide a disposable manual nasal irrigator with dynamic positive and negative pressure coordination and its usage method. By constructing a bidirectional fluid circulation of "pulsed positive pressure oscillation - active negative pressure replacement" and combining it with rheologically modified nasal irrigation solution, it can achieve precise targeting and replacement repair of secretions deep in the anatomical dead space.

[0009] To achieve the above objectives, the present invention provides the following technical solution: In a first aspect, the present invention provides a disposable manual nasal irrigator with dynamic positive and negative pressure coordination, comprising a nasal irrigator body integrally molded from a flexible and resilient material. The nasal irrigator body has a sealing head for sealing connection with the nasal cavity and a bladder-shaped head for manually squeezing to generate power. The sealing head and the bladder-shaped head are internally connected to form a cavity for containing nasal irrigation fluid, and the sealing head has an opening. A neck is formed at the connection between the sealing head and the bladder-shaped head.

[0010] The sealing head is configured to match the opening of the human nostril, preferably in the shape of an olive, with a cross-section that has a larger diameter in the middle and smaller diameters at both ends, to accommodate nostrils of different sizes and form an effective seal. When inserted into one nostril and closed in conjunction with the soft palate, it can transform the open nasal airway into a U-shaped semi-closed pressure vessel.

[0011] Pressing the sac-like head generates a pulsed positive pressure, driving the nasal wash solution to accelerate into the nasal cavity, creating a water hammer effect to loosen secretions and turbulence and vortex to peel them away. Releasing the sac-like head allows its elastic rebound to generate negative pressure within the cavity, driving the nasal wash solution to flow back at high speed and creating a pressure gradient at the sinus opening to draw out deep secretions, thus forming a two-way fluid circulation.

[0012] As a preferred embodiment, the opening of the sealing head is provided with a membrane to keep the nasal wash solution in the cavity from external contamination when not in use.

[0013] As a preferred embodiment, the main body of the nasal irrigator is made of a polymer material with a high elastic modulus. Its elastic modulus is precisely configured such that the negative pressure peak generated when the sac-like head is released is lower than the opening threshold of the Eustachian tube, thereby effectively avoiding the risk of secretory otitis media or barotrauma while introducing a strong negative pressure mechanism.

[0014] Secondly, the nasal irrigator cavity is pre-filled with nasal irrigation solution, which contains rheology-modified solutes to maintain the continuity of the liquid column during negative pressure back suction, prevent the siphon chain from breaking due to gas-liquid separation (Cavitation), and form a "liquid piston" with high cohesion.

[0015] Specifically, the rheologically modified solute includes the following key components, forming a synergistic "physical-biochemical" dual effect: 1. Sodium carboxymethyl cellulose (CMC-Na): As a polymeric liquid dressing and a non-Newtonian fluid modifier, CMC-Na has the following dual functions: Physico-rheological regulation: By slightly increasing the viscosity of the liquid, the fluid viscosity is adjusted, and the shear force during the transition from laminar to turbulent flow is enhanced. During the negative pressure suction stage, CMC-Na increases the fluid cohesion, maintains the continuity of the liquid column, ensures the stability of negative pressure conduction, and improves the displacement efficiency.

[0016] Bioadhesion and film-forming properties: After rinsing, CMC-Na can form a semi-permeable hydrogel protective film on the surface of damaged or congested nasal mucosa, physically isolating allergens and fine particulate matter (PM2.5), providing the best moist environment for the restoration of the mucociliary clearance system (MCC) function, and accelerating epithelial cell repair.

[0017] 2. Glycerin: Provides highly hygroscopic lubrication and has the following functions: It reduces mechanical friction damage to the mucous membrane cilia by high-speed fluid, alleviating the dryness during rinsing.

[0018] In synergy with sea salt, it smooths the osmotic pressure gradient, reduces the stinging sensation that hypertonic saline may cause, and improves patient compliance.

[0019] 3. Hypertonic sea salt and purified water: Provide a high-density momentum transfer medium and utilize the osmotic pressure gradient to eliminate mucosal edema. The sea salt solution increases the physical density (ρ) of the fluid. According to the momentum theorem, a high-density fluid has greater momentum at the same flow rate, enhancing the physical flushing efficiency. At the same time, the residual hypertonic sea salt component induces dehydration and contraction of the inferior turbinate and sinus ostium mucosal cells through the osmotic pressure difference, achieving chemical expansion and further opening the ventilation and drainage channels.

[0020] Preferably, the rheologically modified solute is a combination of 0.5%-0.8% sodium carboxymethyl cellulose and 3%-5% glycerol, and further, 0.9%-3% sea salt is added, with the remainder being purified water, forming a smart responsive fluid with "shear-thixotropic recovery" characteristics: when injected at high speed under positive pressure, the polymer chains untangle, and the viscosity drops instantly, ensuring that the fluid can penetrate deep into the narrow sinus opening; when drawn back under negative pressure, the fluid viscosity recovers rapidly, forming a liquid piston with high cohesion, ensuring the continuity of negative pressure conduction.

[0021] Thirdly, the present invention provides a method for using a disposable manual nasal irrigator employing the above-mentioned dynamic positive and negative pressure coordination, comprising the following steps: S1. Closed-loop construction: Adopt a vertical body position, insert the sealing head of the nasal irrigator and tightly block one side of the anterior nasal cavity, and at the same time coordinate with mouth breathing or vocalization to reflexively raise the soft palate, close the nasopharynx, and construct a U-shaped semi-closed pressure vessel between the bilateral nasal cavities and the nasopharynx, which lays the foundation for subsequent pressure transmission. S2. Positive Pressure Pulse Release: Rapidly squeezing the sac-like head accelerates the injection of nasal irrigation solution into the nasal cavity, generating a water hammer effect—the kinetic energy of the liquid is converted into pressure potential energy upon impact with the nasal turbinates and soft tissues, generating an instantaneous hydraulic shock wave that physically loosens the dried crusts and biofilms on the sinus ostia and mucosal surface. Simultaneously, driven by the high-density momentum of the sea salt solution, the flow velocity increases dramatically, causing the Reynolds number (Re) to instantly exceed the critical value (Re>4000), breaking the laminar flow into turbulent flow and generating multi-directional disordered turbulent shear force, scouring the mucosal surface in all directions. When flowing through complex anatomical structures such as the nasal turbinates and sinus ostia, the high-speed turbulence forms shearing vortices behind them. These microscopic vortices act like "liquid drills," penetrating deep into anatomical gaps for rotational peeling. The non-Newtonian fluid properties of CMC-Na give the vortices a stronger "cohesive gripping force," effectively entraining the peeled pathological secretions. S3. Negative Pressure Aspiration and Replacement: The sac-like head is released and repositioned using its elastic potential energy, increasing the volume of the cavity and causing a sudden drop in pressure, driving high-speed fluid recirculation. The high-speed recirculating fluid forms a low-pressure zone at the sinus opening—according to Bernoulli's equation (P + 1 / 2ρv² + ρgh = constant), the surge in the main flow velocity leads to a significant decrease in local static pressure. At this time, the sinus cavity still maintains a relatively high pressure, thus forming a significant pressure gradient inside and outside the sinus opening (ΔP = P_inside_sinus - P_flow_channel>0). This pressure difference overcomes the surface tension and pathological resistance of the sinus opening obstruction, forcibly "drawing" the purulent secretions trapped deep in the anatomical dead space into the main flow channel. In a vertical position, the initial negative pressure aspiration and gravitational potential energy work together to establish a continuous fluid bridge across the sinus opening, forcibly opening the sinus opening blocked by edema, forming an active siphon, and achieving continuous drainage. S4. Circulation and emptying: Repeat steps S2 and S3 once or more until the aspirated secretions can be discharged into the nasal cavity with the nasal wash solution.

[0022] Through the above steps, this invention achieves a four-in-one treatment mode of "turbulent vortex loosening → pressure differential active replacement → siphon complete emptying → biochemical mucosal repair".

[0023] [Beneficial Effects] Compared with the prior art, the present invention has the following significant advantages: 1. From "Surface Irrigation" to "Precision Targeting of Dead Space": Traditional irrigation can only clean the surface of the inferior nasal meatus. This invention utilizes a dual mechanism of "vortex washing + differential pressure suction" to precisely target traditionally defined "anatomical dead spaces" such as the maxillary sinus opening, ethmoid sinus air cells, and the middle nasal meatus cleft. Step 1 (Drilling): Use eddy currents to penetrate deep into the dead cavity and gaps, mechanically agitating and suspending the accumulated material; Step 2 (Suction): Using the Bernoulli pressure difference, the suspended matter is forcibly replaced from the dead space to the main channel; Step 3 (Excretion): Using the siphon effect, waste is completely expelled from the body.

[0024] 2. Significantly improved biofilm removal efficiency. Experiments show that the combination of turbulent shear force and CMC-Na thickening fluid significantly disrupts the physical structure of Staphylococcus aureus biofilm, and its removal rate is significantly higher than that of ordinary physiological saline laminar flow flushing.

[0025] 3. Eustachian tube safety assurance: Although a powerful negative pressure mechanism has been introduced, the peak negative pressure generated by the system is strictly controlled within the Eustachian tube opening threshold by precisely adjusting the elastic modulus of the bottle, thus avoiding the risk of secretory otitis media or barotrauma.

[0026] 4. After the mucosal repair and barrier reconstruction flushing is completed, the residual hypertonic sea salt components continue to act, inducing mucosal cells to dehydrate and shrink through osmotic pressure difference, thus achieving chemical expansion; CMC-Na forms a semi-permeable hydrogel protective film on the damaged mucosal surface; glycerol molecules lock in moisture, providing the best moist environment for the restoration of the mucus-ciliary clearance system function and blocking the secondary invasion of aerosol particles.

[0027] 5. Easy to operate and highly compliant: The single-use design eliminates the need for cleaning and disinfection, ensuring sterility; manual operation requires no external power supply and is easy to carry; the precise rheological formula reduces the stinging sensation that may be caused by hypertonic saline, improving patient comfort and compliance. Attached Figure Description

[0028] Figure 1 This is a schematic diagram of the overall structure of the disposable manual nasal irrigator with dynamic positive and negative pressure coordination provided in an embodiment of the present invention.

[0029] Figure 2 for Figure 1 Schematic diagram of the three-dimensional structure.

[0030] Figure 3 This is a schematic diagram illustrating the fluid dynamics principle of the nasal irrigator of the present invention in use, showing the formation of a U-shaped semi-enclosed pressure vessel.

[0031] Figure 4 This is a sample image of the product prototype manufactured according to the present invention.

[0032] Figure 5 This is a product sample image from the inspection report submitted by this invention.

[0033] Table 1 shows a comparison of the cleaning effects of traditional nasal irrigators and the nasal irrigator of this invention.

[0034] The meanings of the markings in the attached diagram are as follows: 1-Nasal irrigator body; 1-1-Sealing head; 1-2-Bag-shaped head; 1-3-Neck; 2-Membrane; 3-Cavity. Detailed Implementation

[0035] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. However, it should be understood that the specific embodiments of this invention are only for explaining the invention and are not intended to limit the scope of protection of this invention.

[0036] Example 1: Implementation of the nasal irrigator structure like Figure 1 As shown, this embodiment provides a disposable manual nasal irrigator with dynamic positive and negative pressure coordination, comprising a nasal irrigator body 1 integrally molded from a medical polymer material with high elastic modulus (such as medical-grade polypropylene, polyethylene, or thermoplastic elastomer). The nasal irrigator body 1 has a sealing head 1-1 and a bladder-shaped head 1-2, which are internally connected to form a cavity 3 for containing nasal irrigation fluid. A neck 1-3 is formed at the connection between the sealing head 1-1 and the bladder-shaped head 1-2. This necking design facilitates gripping and squeezing, and also helps control the hydrodynamic characteristics.

[0037] like Figure 2 As shown, the sealing head 1-1 is olive-shaped with a cross-section that has a larger diameter in the middle and smaller diameters at both ends. This biomimetic design can adapt to nostrils of different sizes and form an effective radial seal when inserted. A tearable thin film diaphragm 2 is provided at the opening of the sealing head 1-1. This diaphragm keeps the nasal wash solution inside the cavity 3 sterile at the factory. It can be easily torn off before use, ensuring the product's single-use nature is protected from external contamination.

[0038] The sac-like heads 1-2 are ellipsoidal or cylindrical, with precisely calculated wall thickness to give them a specific elastic modulus. This elastic modulus is configured to generate sufficient water hammer effect and turbulence intensity during compression, while the negative pressure peak generated during release is strictly controlled below the Eustachian tube opening threshold (typically below 20 mmHg) to ensure safe use.

[0039] Example 2: Formulation and Implementation of Nasal Wash Solution This embodiment provides a rheology-modified nasal irrigation solution for use with a nasal irrigator, the formulation of which is as follows by weight percentage: Sodium carboxymethyl cellulose (CMC-Na): 0.6% Glycerin: 4% Sea salt: 2.1% (equivalent to hypertonic saline concentration) Purified water: Balance Preparation method: Under sterile conditions, heat purified water to 40-50℃, slowly add CMC-Na while stirring, and stir until completely dissolved to form a transparent colloidal solution; after cooling to room temperature, add glycerol and sea salt, and continue stirring until completely dissolved; filter to sterilize, fill into the nasal irrigator cavity 3, and seal with a sealing machine to form a membrane 2 at the sealing head 1-1.

[0040] The nasal wash formulated with this method exhibits typical non-Newtonian fluid properties: under high-speed shear conditions (corresponding to the positive pressure jet stage), the viscosity decreases to approximately 5-10 mPa·s, facilitating penetration into narrow crevices; under low-speed or static conditions (corresponding to the negative pressure backflow and static repair stages), the viscosity recovers to approximately 50-100 mPa·s, enhancing cohesion and mucosal adhesion.

[0041] Example 3: Implementation of the usage method Combination Figure 3 , Figure 3 Part (a) shows water flowing into the nasal cavity. Figure 3 Part (b) shows the flow of water through the nasal cavity. Figure 3 Section (c) illustrates the pressure difference formed by water flow, and the effects of transverse shear force, eddies, siphons, and water hammer on different surfaces in different directions, according to Bernoulli's principle. This embodiment details the method of use of the invention and its fluid dynamics principles.

[0042] Step 1: Constructing a Closed Loop The patient should sit or stand upright with their head slightly tilted forward. Using the nasal irrigator of this invention, after tearing open the membrane 2, insert the sealing head 1-1 into the left anterior nasal cavity and gently rotate it until it fits snugly. The patient should open their mouth and slowly utter an "ah" sound. This action induces a reflexive elevation of the soft palate (upper palate), closing the nasopharynx. At this time, the left nasal cavity, nasopharynx, and right nasal cavity together form a U-shaped semi-closed pressure vessel, establishing the anatomical basis for subsequent pressure transmission.

[0043] Step 2: Positive pressure pulse release With the patient's mouth open, quickly squeeze the sac-like head 1-2 with your thumb and forefinger for 0.2-0.5 seconds. The following physical effects will occur: Water hammer effect: When liquid is injected into the nasal cavity at high speed and impacts the nasal turbinates and soft palate, its kinetic energy is instantly converted into pressure potential energy, generating a transient hydraulic shock wave. According to the water hammer pressure formula ΔP = ρ·a·Δv (where a is the propagation speed of the pressure wave), this shock wave can effectively loosen dry crusts and bacterial biofilms attached to the mucous membrane surface.

[0044] Turbulence generation: Driven by the high-density sea salt solution, the flow velocity increases dramatically, causing the Reynolds number (Re) to instantly exceed 4000. According to the Reynolds number formula Re = ρvL / μ, the high density ρ and high flow velocity v work together to break the laminar flow into turbulent flow, generating multi-directional disordered shear forces.

[0045] Vortex stripping: When high-speed turbulent flow passes through complex anatomical structures such as the middle nasal turbinate and uncinate process, detachment vortices are formed behind these turbulent fluids. These microscopic vortices act like countless "liquid drills," penetrating traditionally unsanitary areas such as the middle nasal meatus fissure and the opening of the ethmoid sinus air cells to perform rotational stripping. The thickening properties of CMC-Na give the vortices a stronger cohesive gripping force, effectively entraining the detached pathological secretions.

[0046] Step 3: Negative pressure suction and replacement When the sac-like heads 1-2 are deformed by approximately 80%, quickly release your fingers. The sac-like heads 1-2, utilizing their high elastic modulus, instantly return to their original position (approximately 0.1-0.3 seconds), causing a sudden increase in the volume of cavity 3. This results in a sharp drop in internal pressure, creating an initial negative pressure that drives the liquid to flow back at high speed. At this point, the following core replacement process occurs: Bernoulli pressure gradient formation: Fluid refluxes rapidly within the main nasal passage, causing a sharp increase in velocity. According to Bernoulli's equation P + 1 / 2ρv² + ρgh = constant, the increase in velocity v leads to a significant decrease in local static pressure P. Fluid within the sinus cavities (such as the maxillary and ethmoid sinuses) remains relatively static, maintaining a higher static pressure. This pressure gradient ΔP = Pinner sinus - Pflow passage > 0 becomes the core driving force for secretion drainage.

[0047] Active siphon establishment: In a vertical position, the initial negative pressure draws fluid into the sinus ostium, establishing a continuous "fluid bridge" across it. Subsequently, gravitational potential energy (ρgh term) works in synergy with the sustained negative pressure to form an active siphon. Even if the sinus ostium is narrowed due to inflammatory edema, this pressure-assisted siphon can forcibly open the channel, continuously draining purulent secretions from deep within the sinus cavity to the main drainage channel.

[0048] Maintaining liquid column continuity: During this critical phase, the fluid cohesion provided by CMC-Na is crucial. It prevents gas-liquid separation (cavitation) that can occur during high-speed flow, ensuring the continuity of the liquid column, avoiding interruptions in negative pressure, and making the siphon process stable and continuous.

[0049] Step 4: Circularly drain the air Repeat steps two and three 3-5 times. Each positive pressure pulse further loosens deep residue, and each negative pressure suction removes it. The suctioned secretions flow back into cavity 3 with the nasal wash solution, and the amount and characteristics of the discharge can be observed through the transparent capsule head 1-2. After rinsing, discard the entire nasal irrigator.

[0050] Step 5: After rinsing to repair the mucosa, a small amount of nasal rinse solution remains on the surface of the nasal mucosa. At this time, the following biochemical repair process occurs: Osmotic dehydration: The residual hypertonic sea salt components continue to act, inducing dehydration and contraction of the mucosal cells of the inferior turbinate and sinus ostium through osmotic pressure difference, reducing mucosal edema, achieving chemical volume expansion, and further opening the ventilation and drainage channels.

[0051] Biofilm formation: CMC-Na forms a semi-permeable hydrogel protective film with a thickness of approximately 10-50 micrometers on the surface of damaged or congested mucous membranes. This film can physically isolate secondary invasion by allergens, PM2.5 and other aerosol particles, while providing a moist microenvironment for epithelial cell migration and repair.

[0052] Moisturizing and lubricating: Glycerin molecules strongly lock in water through their hydroxyl structure, maintaining the moisture of the mucosal surface, relieving the dryness that may occur after rinsing, and providing the best conditions for the restoration of the mucociliary clearance system.

[0053] Table 1 Comparative experiment To verify the technical effect of the present invention, the following comparative experiment was conducted: Sixty patients with chronic sinusitis were randomly divided into two groups. The experimental group used the nasal irrigator and nasal solution described in Examples 1-2 of this invention, while the control group used a commercially available traditional gravity-type nasal irrigator and saline solution. Nasal irrigation was performed twice daily for four consecutive weeks.

[0054] Evaluation indicators include: Lund-Kennedy nasal endoscopy score, SNOT-22 quality of life score, and subjective score of secretion clearance rate.

[0055] Results: The experimental group showed significantly better improvement in all indicators than the control group (P<0.05). In particular, endoscopic observation showed that the experimental group had significantly higher cleanliness in the anatomical dead space areas such as the middle nasal meatus and olfactory cleft, and more significant reduction in mucosal edema.

[0056] The present invention provides a single-use manual nasal irrigator with dynamic positive and negative pressure coordination and its usage method, which has broad industrial applicability in the medical device field. The product has a simple structure and mature manufacturing process, and can be mass-produced using conventional medical plastic processing techniques such as injection molding. The nasal irrigation solution formula is stable, and the filling process is simple. The product is designed for single use, conforming to the modern medical trend towards sterile and convenient use. It can be widely used in the daily care of patients with chronic sinusitis and allergic rhinitis, the rehabilitation treatment of patients after nasal endoscopy, and nasal health care for susceptible populations, demonstrating good market prospects and social benefits.

[0057] Figure 4 The prototype of the product produced by this invention has shown significant effectiveness after trial use.

[0058] Figure 5 The image shown in the inspection report of this invention is of the product sample. The inspection agency is Standard Biotech (Qingdao) Co., Ltd., and the report number is CY2504260NC1-1. The inspection conclusion is that all tested items of the sample meet the requirements of the technical requirements of the "Nasal Mucosal Cleansing Solution".

[0059] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art can make various improvements and modifications without departing from the spirit and principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A disposable manual nasal irrigator with dynamic positive and negative pressure coordination, characterized in that, include: A nasal irrigator body (1) is integrally formed from a flexible and resilient material. The nasal irrigator body (1) has a sealing head (1-1) for sealing connection with the nasal cavity and a bladder head (1-2) for manually squeezing to generate power. The sealing head (1-1) and the bladder head (1-2) are internally connected to form a cavity (3) for containing nasal irrigation fluid. The shape of the sealing head (1-1) is configured to match the opening of the human nostril. When it is inserted into one nostril and closed with the soft palate, it can transform the open nasal airway into a U-shaped semi-closed pressure vessel. By pressing the bladder head (1-2), a pulsed positive pressure can be generated, which drives the nasal irrigation fluid to be injected into the nasal cavity at an accelerated speed, generating a water hammer effect for loosening secretions and turbulence and eddies for peeling secretions. By releasing the bladder head (1-2), its elastic rebound can generate negative pressure in the cavity (3), driving the nasal irrigation fluid to flow back at high speed and forming a pressure gradient at the sinus opening for sucking out deep secretions, thereby forming a bidirectional fluid circulation.

2. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 1, characterized in that, The sealing head (1-1) is olive-shaped, with a cross-section that has a large diameter in the middle and small diameters at both ends, in order to fit nostrils of different sizes and form a seal.

3. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 1 or 2, characterized in that, A neck (1-3) is formed at the connection between the sealing head (1-1) and the sac-like head (1-2).

4. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 1, characterized in that, The opening of the sealing head (1-1) is provided with a membrane (2) to keep the nasal wash solution in the cavity (3) from external contamination when not in use.

5. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 1, characterized in that, The main body (1) of the nasal irrigator is made of a high elastic modulus polymer material, the elastic modulus of which is configured such that the negative pressure peak generated when the sac-like head (1-2) is lower than the opening threshold of the Eustachian tube.

6. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 1, characterized in that, The cavity (3) is pre-filled with nasal wash solution, which contains rheology-modified solutes to maintain the continuity of the liquid column during negative pressure backflow and prevent gas-liquid separation.

7. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 6, characterized in that, The rheologically modified solutes include sodium carboxymethyl cellulose (CMC-Na) and / or glycerol.

8. The disposable manual nasal irrigator with dynamic positive and negative pressure coordination according to claim 7, characterized in that, The nasal wash also includes a hypertonic sea salt solution, which is used to increase the liquid density to enhance momentum transfer and to use osmotic pressure to help eliminate mucosal edema.

9. A method of using a disposable manual nasal irrigator employing dynamic positive and negative pressure coordination as described in any one of claims 1 to 8, characterized in that, Includes the following steps: S1. Closed loop construction: Adopt a vertical body position, insert the sealing head (1-1) of the nasal irrigator and tightly block one side of the anterior nasal cavity. At the same time, cooperate with mouth breathing or vocalization to raise the soft palate and close the nasopharynx, thus constructing a U-shaped semi-closed pressure vessel between the bilateral nasal cavities and the nasopharynx. S2, Positive Pressure Pulse Release: Quickly squeeze the sac-like head (1-2) to accelerate the injection of nasal wash into the nasal cavity, generating a water hammer effect to loosen secretions and forming turbulent and eddy currents to peel off the adhering substances on the mucosal surface; S3, Negative pressure suction and replacement: Release the sac-like head (1-2), use its elastic potential energy to reset it, so that the volume of the cavity (3) increases and the pressure drops sharply, driving the liquid to flow back at high speed; the high-speed flowing liquid forms a low-pressure area at the sinus opening, and through the Bernoulli effect, the secretions deep in the sinus cavity are suctioned to the main channel and discharged with the liquid. S4. Circulation and emptying: Repeat steps S2 and S3 once or more until the secretions are discharged into the cavity (3).

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