A traditional Chinese medicine composition for relieving esophageal reflux cough

Abstract

The present application relates to the field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition for relieving esophageal reflux cough, which comprises a first extraction component and a second extraction component, wherein the first extraction component is obtained by group extraction of perilla leaf and perilla stem, and the second extraction component is obtained by group extraction of rhizoma coptidis, prepared pinellia, evodia and licorice root.The two groups of raw medicinal materials are respectively decocted, filtered and concentrated to obtain the corresponding extraction components, which are then mixed to form the traditional Chinese medicine composition, which can be further prepared into oral liquid, granules, capsules, pills or powders.The present application is composed of six kinds of raw medicinal materials and prepared by group extraction and recombination, so that the composition is clear in composition and preparation process, and is suitable for preparing a medicine for relieving gastroesophageal reflux cough.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparations, specifically to a pungent and bitter traditional Chinese medicine composition for relieving esophageal reflux cough. Background Technology

[0002] Gastroesophageal reflux cough is a common type of chronic cough. It is caused by the reflux of stomach contents into the upper esophagus or even the throat, which continuously irritates the upper airway and causes coughing. Patients often experience symptoms such as acid reflux, belching, itchy throat, and a foreign body sensation in the throat. The course of the disease is often long and prone to recurrence.

[0003] Currently, clinical interventions for this type of condition mainly include Western medicine approaches such as acid suppression and gastrointestinal motility promotion, as well as traditional Chinese medicine (TCM) formulas such as cough suppressants, expectorants, stomach harmonizers, and heat-clearing and dampness-resolving formulas. While existing TCM formulas can alleviate some symptoms to a certain extent, many formulas focus on single cough suppressants, single stomach harmonizers, or generalized treatments, with broad ingredient combinations. Furthermore, the preparation often involves decocting the entire formula together, lacking specificity for the coexisting pathogenesis of stomach qi rebellion and lung qi deficiency.

[0004] However, during an attack of gastroesophageal reflux cough, there is often a mutually influential relationship between gastric dysfunction leading to reflux and lung dysfunction causing prolonged cough. If existing treatments cannot simultaneously address both lung function and stomach harmony, and only intervene unidirectionally on either cough or reflux symptoms, the reflux stimulation can continue to act on the throat, making it difficult to stably relieve the cough, resulting in insufficient therapeutic stability and frequent symptom recurrence. Therefore, it is still necessary to provide a traditional Chinese medicine composition with a clear formulation, a well-defined preparation method, and the ability to intervene based on the principles of lung function and stomach harmony. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition with pungent and bitter properties for relieving cough caused by esophageal reflux, thereby solving the technical problems existing in the prior art.

[0006] The above-mentioned technical objective of the present invention is achieved through the following technical solution: A traditional Chinese medicine composition for relieving cough caused by esophageal reflux includes: Composed of a first extraction component and a second extraction component; The first extract component was obtained by extracting perilla leaves and perilla stems in separate groups; The second extract component was obtained by extracting Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis in separate groups; Based on the raw materials used to prepare the traditional Chinese medicine composition, the following proportions are used: Perilla leaf 5-8 parts by weight, Perilla stem 6-12 parts by weight, Coptis chinensis 6-8 parts by weight, processed Pinellia ternata 8-12 parts by weight, Evodia rutaecarpa 1-2 parts by weight, and Glycyrrhiza uralensis 3-5 parts by weight. The first extract component and the second extract component are mixed to obtain the traditional Chinese medicine composition.

[0007] Preferably, the first extract component consists only of extracts of perilla leaves and perilla stems, and the second extract component consists only of extracts of Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa, and Glycyrrhiza uralensis.

[0008] Preferably, the preparation method of the first extracted component includes the following steps: Weigh out the perilla leaves and perilla stems according to the stated weight proportions, add water to 1-3 cm above the surface of the herbs, decoct for 20-30 minutes for the first time, and filter to obtain the first extract of the first group. Add the same volume of water as the first decoction, and decoct for a second time for 20-30 minutes. Filter to obtain the first group of second extracts. The first extract of the first group and the second extract of the first group are combined and concentrated to obtain the first extract component.

[0009] Preferably, the preparation method of the second extract component includes the following steps: weighing Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis according to the weight parts, adding water to 1-3 cm above the surface of the herbs, decocting for the first time for 20-30 minutes, and filtering to obtain the second group of first extract; Add the same volume of water as the first decoction, and decoct for 20-30 minutes. Filter to obtain the second extract. The first extract of the second group and the second extract of the second group are combined and concentrated to obtain the second extract component.

[0010] Preferably, the extraction processes of perilla leaves and perilla stems are independent of the extraction processes of Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis. Before obtaining the first and second extract components, perilla leaves and perilla stems are not decocted together with Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis.

[0011] Preferably, the traditional Chinese medicine composition is a paste-like extract obtained by mixing and concentrating the first extract component and the second extract component.

[0012] Preferably, the traditional Chinese medicine composition is an oral liquid, granules, capsules, pills, or powder.

[0013] Preferably, when the traditional Chinese medicine composition is granules, capsules, or powder, it is prepared by drying the paste-like extract obtained by mixing and concentrating the first extraction component and the second extraction component.

[0014] Preferably, when the traditional Chinese medicine composition is a pill, it is directly made from a paste-like extract obtained by mixing and concentrating the first extract and the second extract, or it is made from the paste-like extract after drying.

[0015] In summary, the present invention has the following main beneficial effects: This application's traditional Chinese medicine composition uses perilla leaves and perilla stems as the first extraction component, and coptis, prepared pinellia, evodia, and licorice as the second extraction component. It employs a preparation path of first extracting in groups and then mixing and compounding. By extracting raw materials that are more focused on dispersing and regulating qi separately from those that are more focused on harmonizing the stomach and suppressing nausea, the aim is to balance the dispersing and descending of lung qi and the descending of stomach qi within the same composition. Compared to the method of directly decocting all raw materials together, this application's technical solution forms the first and second extraction components separately before compounding, making the extraction process and source composition of each group of raw materials clearer, and the compositional boundaries of the composition more defined. This facilitates the development of a stable, clear, and easily implemented product plan for the target group of gastroesophageal reflux cough.

[0016] This application defines the traditional Chinese medicine composition as an extractive component formed from six raw materials: Perilla Leaf, Perilla Stem, Coptis chinensis, Prepared Pinellia ternata, Evodia rutaecarpa, and Licorice. It also specifies the weight range of each raw material. By fixing the minimum formulation framework and eliminating loose descriptions involving arbitrary substitutions and additions, the technical features of the traditional Chinese medicine composition are made more focused, and the protection boundary more stable. With this approach, the limitations regarding the composition of raw materials, grouping and extraction relationships, mixing and compounding relationships, and the absence of other traditional Chinese medicine extracts in the claims can all be found in the specific embodiments of the specification. This helps avoid problems of insufficient disclosure and unclear protection scope caused by overly broad formulation scope, unclear terminology boundaries, or unclear implementation paths.

[0017] The traditional Chinese medicine composition formed in this application can be further formulated into oral liquids, granules, capsules, pills, or powders. By changing the dosage form while keeping the sources of the first and second extraction components unchanged, the aim is to balance the preparation route of the original paste extract with the diversification of clinical administration methods. On the one hand, all the above dosage forms are based on the same traditional Chinese medicine composition, and the technical route is consistent, making it easy for those skilled in the art to implement. On the other hand, different dosage forms are all based on the same formulation framework, which is conducive to extending the preparation, packaging, and application methods without changing the core technical solution, thereby improving the practical applicability of the technical solution of this application and the completeness of the overall description in the instruction manual. Attached Figure Description

[0018] Figure 1 This is a flowchart of the method of the present invention. Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] Example 1 refer to Figure 1 A traditional Chinese medicine composition for relieving cough due to esophageal reflux includes: Composed of a first extraction component and a second extraction component; The first extract component was obtained by extracting perilla leaves and perilla stems in separate groups; The second extract component was obtained by extracting Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis in separate groups; Based on the raw materials used to prepare the traditional Chinese medicine composition, the following proportions are used: Perilla leaf 5-8 parts by weight, Perilla stem 6-12 parts by weight, Coptis chinensis 6-8 parts by weight, processed Pinellia ternata 8-12 parts by weight, Evodia rutaecarpa 1-2 parts by weight, and Glycyrrhiza uralensis 3-5 parts by weight. The first extract component and the second extract component are mixed to obtain the traditional Chinese medicine composition.

[0021] In this application, the first extractive component refers to the extractive component obtained by adding water, boiling, filtering, combining the extracts and concentrating the raw materials of perilla leaves and perilla stems.

[0022] In this application, the second extract component refers to the extract component obtained by adding water, decocting, filtering, combining the extracts and concentrating the raw materials of Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis.

[0023] In this application, group extraction means that perilla leaves and perilla stems are extracted separately as the first raw material group, and coptis, prepared pinellia, evodia and licorice are extracted separately as the second raw material group. Before obtaining the first and second extract components, the two groups of raw materials are not placed in the same extraction container for decoction.

[0024] In this application, adding water to be 1-3 cm above the drug surface means that before heating, when the raw materials are in a natural stacked state, the liquid level in the extraction container is 1-3 cm higher than the surface of all the raw materials, and the standard is that all the raw materials are submerged in the liquid.

[0025] In this application, the 20-30 min decocting time refers to the 20-30 min time starting after the extract reaches a simmering state, excluding the time for the temperature to rise from room temperature to boiling.

[0026] In this application, the same volume of water as in the first decoction means that the volume of water added in the second decoction is the same as the volume of water added to the extraction container in the first decoction.

[0027] In this application, paste extract refers to an extract that, after concentration, is in a non-free-flowing state when left to stand at 25°C.

[0028] In this application, "excluding other Chinese herbal extracts" means that, apart from extracts made from perilla leaves, perilla stems, coptis, prepared pinellia, evodia, and licorice, it does not contain extracts made from other Chinese medicinal materials; water, dextrin, refined honey, capsule shells, and other pharmaceutical excipients added to prepare oral liquids, granules, capsules, pills, or powders are not considered other Chinese herbal extracts.

[0029] The perilla leaves, perilla stems, coptis, prepared pinellia, evodia and licorice used in this application are all dried Chinese medicinal herbs that can be used medicinally. Among them, prepared pinellia is the processed pinellia slice.

[0030] Preparation of paste-like extracts from traditional Chinese medicine compositions: Weigh out 6 parts by weight of perilla leaves, 9 parts by weight of perilla stems, 7 parts by weight of coptis, 10 parts by weight of prepared pinellia, 1.5 parts by weight of evodia, and 4 parts by weight of licorice.

[0031] Perilla leaves and stems were placed in a first extraction container as the first raw material group. Water was added to the first extraction container until the liquid level was 2 cm above the surface of the first raw material group. The mixture was heated to a gentle boil and maintained at a gentle boil for 25 minutes. After filtration, the first extract of the first group was obtained. The same volume of water as the first addition was added to the filtered residue of the first raw material group. The mixture was heated again to a gentle boil and maintained at a gentle boil for 25 minutes. After filtration, the second extract of the first group was obtained. The first extract and the second extract of the first group were combined and concentrated to obtain the first extract fraction.

[0032] Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa, and Glycyrrhiza uralensis were placed in a second extraction container as the second raw material group. Water was added to the second extraction container until the liquid level was 2 cm above the surface of the raw materials. The mixture was heated to a gentle boil and maintained at a gentle boil for 25 minutes. After filtration, the first extract of the second group was obtained. The same volume of water as the first addition was added to the filtered residue of the second raw material group. The mixture was heated again to a gentle boil and maintained at a gentle boil for 25 minutes. After filtration, the second extract of the second group was obtained. The first and second extracts of the second group were combined and concentrated to obtain the second extract fraction.

[0033] The first and second extracts were placed in the same mixing container, stirred and mixed, and then concentrated. When the mixture was allowed to stand at 25°C, it reached a non-free-flowing state, thus obtaining a paste-like extract of the traditional Chinese medicine composition.

[0034] In this embodiment, the leaves and stems of Perilla frutescens are extracted in the first extraction container, while the herbs Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa, and Glycyrrhiza uralensis are extracted in the second extraction container. Before the formation of the first and second extraction components, the two groups of raw materials are not decocted together.

[0035] Example 2 Implementation method within the range of parts by weight of active pharmaceutical ingredient: To demonstrate that the weight range of each active pharmaceutical ingredient in the claims has a clear basis for implementation, the following embodiments are provided.

[0036] Implementation Method 1: Weigh 5 parts by weight of Perilla leaf, 6 parts by weight of Perilla stem, 6 parts by weight of Coptis chinensis, 8 parts by weight of processed Pinellia ternata, 1 part by weight of Evodia rutaecarpa, and 3 parts by weight of Glycyrrhiza uralensis, and prepare a paste-like extract of the traditional Chinese medicine composition according to the method of Example 1.

[0037] Implementation Method 2: Weigh 8 parts by weight of Perilla leaf, 12 parts by weight of Perilla stem, 8 parts by weight of Coptis chinensis, 12 parts by weight of processed Pinellia ternata, 2 parts by weight of Evodia rutaecarpa, and 5 parts by weight of Glycyrrhiza uralensis, and prepare a paste-like extract of the traditional Chinese medicine composition according to the method of Example 1.

[0038] Implementation Method 3: Weigh 7 parts by weight of Perilla leaf, 10 parts by weight of Perilla stem, 7 parts by weight of Coptis chinensis, 9 parts by weight of processed Pinellia ternata, 1 part by weight of Evodia rutaecarpa, and 4 parts by weight of Glycyrrhiza uralensis, and prepare a paste-like extract of the traditional Chinese medicine composition according to the method of Example 1.

[0039] The above embodiments show that the range of 5-8 parts by weight of perilla leaves, 6-12 parts by weight of perilla stems, 6-8 parts by weight of coptis, 8-12 parts by weight of processed pinellia, 1-2 parts by weight of evodia, and 3-5 parts by weight of licorice are all supported by specific embodiments, and each embodiment adopts the same grouping extraction path.

[0040] Example 3 Preparation of oral liquid: First, a paste-like extract of the traditional Chinese medicine composition was prepared according to the method in Example 1.

[0041] The paste-like extract was added to a preparation container, water was added and stirred to evenly disperse the extract, resulting in a liquid formulation. The resulting liquid formulation was filtered to remove undispersed particles and then dispensed to obtain an oral liquid.

[0042] In this embodiment, the Chinese herbal extracts in the oral liquid are derived only from the first and second extraction components, and the added water is a pharmaceutical excipient and does not belong to other Chinese herbal extracts.

[0043] Example 4 Preparation of granules: First, a paste-like extract of the traditional Chinese medicine composition was prepared according to the method in Example 1.

[0044] The paste-like extract is dried to obtain a dried extract. The dried extract is pulverized, dextrin is added, and the mixture is stirred to form a moistened soft mass. The moistened soft mass is granulated, dried, and then granulated to obtain granules.

[0045] In this embodiment, the Chinese herbal extracts in the granules are derived only from the first and second extraction components; dextrin is a pharmaceutical excipient and does not belong to other Chinese herbal extracts.

[0046] Example 5 Preparation of capsules: First, a paste-like extract of the traditional Chinese medicine composition was prepared according to the method in Example 1.

[0047] The paste-like extract is dried to obtain a dried extract. The dried extract is pulverized and sieved to obtain a dry powder. The obtained dry powder is then filled into empty capsule shells to obtain capsules.

[0048] In this embodiment, the Chinese herbal extracts in the capsule contents are derived only from the first and second extraction components; the capsule shell is the formulation carrier and does not belong to other Chinese herbal extracts.

[0049] Example 6 Preparation of powder: First, a paste-like extract of the traditional Chinese medicine composition was prepared according to the method in Example 1.

[0050] The paste-like extract is dried to obtain a dried extract. The dried extract is then pulverized and sieved to obtain a powder, which is then packaged into a powder form.

[0051] In this embodiment, the Chinese herbal extracts in the powder are derived from only the first and second extraction components.

[0052] Example 7 Preparation of pills: First, a paste-like extract of the traditional Chinese medicine composition was prepared according to the method in Example 1.

[0053] Implementation Method 1: The paste extract is further concentrated until it reaches a plastic state, then formed into strips, segmented and rolled into balls to obtain pills.

[0054] Implementation Method 2: The paste-like extract is dried to obtain a dried extract; the dried extract is pulverized and mixed with refined honey to form a plastic material, which is then segmented and rolled into balls to obtain pills.

[0055] In this embodiment, the Chinese herbal extracts in the pills are derived only from the first and second extraction components; refined honey is a molding excipient and does not belong to other Chinese herbal extracts.

[0056] Example 8 Implementation boundaries excluding other Chinese herbal extracts: When preparing traditional Chinese medicine compositions or corresponding dosage forms according to the methods described in Examples 1 to 7, the traditional Chinese medicine extracts used are derived only from perilla leaves, perilla stems, coptis, processed pinellia, evodia and licorice.

[0057] In this embodiment, extracts made from tangerine peel, phellodendron bark, fritillaria thunbergii, immature bitter orange peel, atractylodes macrocephala, or other traditional Chinese medicinal materials are not added. It should be noted that the water, dextrin, refined honey, capsule shells, and other substances added to prepare the corresponding dosage form do not change the source and composition of the herbal extracts in this application.

[0058] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for relieving cough due to esophageal reflux, characterized in that, include: Composed of a first extraction component and a second extraction component; The first extract component was obtained by extracting perilla leaves and perilla stems in separate groups; The second extract component was obtained by extracting Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis in separate groups; Based on the raw materials used to prepare the traditional Chinese medicine composition, the following proportions are used: Perilla leaf 5-8 parts by weight, Perilla stem 6-12 parts by weight, Coptis chinensis 6-8 parts by weight, processed Pinellia ternata 8-12 parts by weight, Evodia rutaecarpa 1-2 parts by weight, and Glycyrrhiza uralensis 3-5 parts by weight. The first extract component and the second extract component are mixed to obtain the traditional Chinese medicine composition.

2. The traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 1, characterized in that, The first extract component consists only of extracts of perilla leaves and perilla stems, and the second extract component consists only of extracts of Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa, and Glycyrrhiza uralensis.

3. The traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 2, characterized in that, The preparation method of the first extracted component includes the following steps: Weigh out the perilla leaves and perilla stems according to the stated weight proportions, add water to 1-3 cm above the surface of the herbs, decoct for 20-30 minutes for the first time, and filter to obtain the first extract of the first group. Add the same volume of water as the first decoction, and decoct for a second time for 20-30 minutes. Filter to obtain the first group of second extracts. The first extract of the first group and the second extract of the first group are combined and concentrated to obtain the first extract component.

4. The traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 3, characterized in that, The preparation method of the second extract component includes the following steps: weigh Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis according to the weight parts, add water to 1-3 cm above the surface of the herbs, decoct for the first time for 20-30 minutes, and filter to obtain the first extract of the second group; Add the same volume of water as the first decoction, and decoct for 20-30 minutes. Filter to obtain the second extract. The first extract of the second group and the second extract of the second group are combined and concentrated to obtain the second extract component.

5. A traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 4, characterized in that, The extraction processes of perilla leaves and perilla stems are independent of the extraction processes of Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis. Before obtaining the first and second extract components, perilla leaves and perilla stems are not decocted together with Coptis chinensis, processed Pinellia ternata, Evodia rutaecarpa and Glycyrrhiza uralensis.

6. A traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 5, characterized in that, The traditional Chinese medicine composition is a paste-like extract obtained by mixing and concentrating the first extract component and the second extract component.

7. A traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 6, characterized in that, The aforementioned Chinese medicine composition is in the form of oral liquid, granules, capsules, pills, or powder.

8. A traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 7, characterized in that, When the traditional Chinese medicine composition is in the form of granules, capsules, or powders, it is prepared by drying the paste-like extract obtained by mixing and concentrating the first extraction component and the second extraction component.

9. A traditional Chinese medicine composition for relieving esophageal reflux cough according to claim 8, characterized in that, When the traditional Chinese medicine composition is in the form of pills, it is directly prepared from a paste-like extract obtained by mixing and concentrating the first and second extract components, or prepared from the paste-like extract after drying.

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