Nocardia-like strain n25 for complete degradation of don and its use in degradation of fusarium toxins
By isolating and identifying Nocardia-like bacteria N25, the complete degradation of DON into carbon dioxide and water was achieved, solving the problem of DON toxin residue in grains and demonstrating efficient and stable detoxification capabilities.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUAZHONG AGRI UNIV
- Filing Date
- 2025-12-04
- Publication Date
- 2026-06-05
AI Technical Summary
Existing technologies cannot completely eliminate the toxicity of deoxynivalenol (DON) toxin in grains and their products. Conventional methods are difficult to completely degrade it, and intermediate metabolites formed by existing microbial degradation methods still have high toxicity.
A strain of Nocardioides sp. N25 was isolated and identified. This strain can completely degrade DON into carbon dioxide and water. Through a unique metabolic pathway, it forms a variety of intermediate metabolites such as 3-epi-DON, α-/β-8-OH-DON and 8-OH-3-epi-DON, ultimately eliminating the toxicity completely.
It achieves complete degradation of DON, forming non-toxic carbon dioxide and water. Furthermore, strain N25 maintains high degradation activity under a wide range of temperature and pH conditions, making it suitable for detoxification of grains and their products, thus solving the problem of toxin residues in existing technologies.
Smart Images
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