Oral use of the product
By using fibrous biomass as a porous matrix to adsorb active substances and flavoring agents, the contradiction between rapid release of active substances and oral comfort in existing oral products has been resolved. This has achieved uniform release of active substances and improved comfort, while reducing production costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HG INNOVATION LTD
- Filing Date
- 2026-03-19
- Publication Date
- 2026-06-09
Smart Images
Figure SMS_1 
Figure SMS_2
Abstract
Description
Technical Field
[0001] This application belongs to the field of food or pharmaceutical technology, and specifically relates to an oral product. Background Technology
[0002] In related technologies, oral products can achieve a stable supply of active substances through absorption through the oral mucosa. At the same time, these products do not require combustion and do not produce smoke, which can meet the needs of users in smoke-free environments. Therefore, the market size of oral products has been expanding in recent years.
[0003] Existing oral products typically use microcrystalline cellulose, trehalose, mannitol, isomaltitol, gelatin, croscarmellose sodium, and hydroxypropyl cellulose as base materials. However, these raw materials are expensive and have limited sources. Moreover, due to the limited water absorption and disintegration properties of the base materials, it is difficult to simultaneously achieve rapid release of active substances and oral comfort. Summary of the Invention
[0004] This application aims to provide a mouthwash that addresses the problem that mouthwashes cannot simultaneously achieve rapid nicotine release and oral comfort.
[0005] To address the aforementioned technical problems, this application provides a mouth-held product comprising the following components: fibrous biomass and characteristic substances; wherein the characteristic substances include active substances and / or flavoring agents; the fibrous biomass is a porous matrix, and the fibrous biomass is used to adsorb at least a portion of the characteristic substances.
[0006] In one embodiment, the raw materials for the fibrous biomass include at least one of the following: grapefruit peel, corn stalk core, loofah sponge, and reed stalk core.
[0007] In one embodiment, the fibrous biomass is obtained by drying the raw material or by drying, post-processing, and processing the raw material.
[0008] In one embodiment, the oral product includes one of the following: a lozenge or a lozenge pouch.
[0009] In one embodiment, the lozenge includes a first support layer, a functional layer, and a second support layer stacked sequentially; wherein at least one of the first support layer and the second support layer is a liquid-permeable layer, and the functional layer includes the sheet-like fibrous biomass and the characteristic substance.
[0010] In one embodiment, the oral bag includes a liquid-permeable bag and contents; wherein the contents are encapsulated within the liquid-permeable bag; the contents include the fibrous biomass and the characteristic substance, and the fibrous biomass is in the form of flakes or granules.
[0011] In one embodiment, the lozenge has a sheet-like single-layer structure, the main body of the lozenge is the fibrous biomass, and the characteristic substance is adsorbed in the fibrous biomass.
[0012] In one embodiment, the fibrous biomass accounts for 40% to 98% of the mass of the oral product; and / or, the active substance accounts for 1% to 10% of the mass of the oral product; and / or, the flavoring agent accounts for 1% to 50% of the mass of the oral product.
[0013] In one embodiment, the active substance includes at least one of nicotine and nicotine derivatives; and / or, the active substance includes at least one of caffeine, theophylline, tea polyphenols, vitamins, and capsaicin; and / or, the fibrous biomass includes cellulose, hemicellulose, and pectin; and / or, the flavoring agent includes at least one of flavoring, sweetener, cooling agent, salting agent, and acidifying agent.
[0014] In one embodiment, the fibrous biomass includes grapefruit peel, and the flavoring agent includes a sweetener and a cooling agent; by weight, the oral product comprises the following components: 40-98 parts grapefruit peel, 1-10 parts of the active substance, 1-49 parts of the sweetener, and 0.1-1 parts of the cooling agent.
[0015] This application provides a lozenge comprising the following components: fibrous biomass and characteristic substances; wherein the characteristic substances include active substances and / or flavoring agents; the fibrous biomass is a porous matrix and is used to adsorb at least a portion of the characteristic substances. Because the fibrous biomass contains pectin, when the lozenge enters the oral cavity, the pectin molecules rapidly absorb water and swell to form a gel layer. This gel layer can, on the one hand, slow down the disintegration rate of the lozenge, and on the other hand, encapsulate the active substances, reducing their diffusion rate, prolonging the retention time of the active substances on the oral mucosa, and improving absorption efficiency.
[0016] In addition, fibrous biomass has the characteristics of high porosity and low density, which allows active substances to be evenly dispersed in its pores, avoiding the problem of uneven drug loading caused by the high density of traditional substrates. At the same time, the loose structure can reduce the compaction density of oral products, making them lighter and thinner, reducing the foreign body sensation when they fit the oral mucosa, and improving wearing comfort.
[0017] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Detailed Implementation
[0018] The embodiments of this application will be described in detail below. These embodiments are exemplary and are only used to explain this application, and should not be construed as limiting this application. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of this application.
[0019] The terms "first" and "second" in the specification and claims of this application may explicitly or implicitly include one or more of the features. In the description of this application, unless otherwise stated, "multiple" means two or more. Furthermore, "and / or" in the specification and claims indicates at least one of the connected objects, and the character " / " generally indicates that the preceding and following objects are in an "or" relationship.
[0020] This application provides a mouth-sucking article comprising the following components: fibrous biomass and characteristic substances; wherein the characteristic substances include active substances and / or flavoring agents; the fibrous biomass is a porous matrix, and the fibrous biomass is used to adsorb at least a portion of the characteristic substances.
[0021] Fiberous biomass is a well-known concept in materials science, biomass energy, and agricultural engineering, and it mainly contains cellulose, hemicellulose, and pectin components. In this application, fibrous biomass specifically refers to a substrate obtained by directly drying natural plant biomass materials, or by drying followed by other post-processing, which has at least a porous structure and pectin components.
[0022] In some embodiments, fibrous biomass includes cellulose, hemicellulose, and pectin. Cellulose is a linear high-molecular-weight polysaccharide with dense crystalline regions formed between molecules by hydrogen bonds, exhibiting good mechanical strength and formability. Therefore, cellulose can form the skeleton of oral tablets. Hemicellulose is a branched-chain polysaccharide that can fill the gaps in the cellulose skeleton, enhancing its cohesiveness and toughness. The synergistic effect of these two components allows them to replace traditional synthetic excipients such as microcrystalline cellulose, forming a stable tablet structure during tableting. This ensures that the oral tablet is not easily broken during storage and transportation, and allows for slow disintegration in the oral cavity, avoiding either excessively rapid dissolution leading to instantaneous release of active ingredients (causing oral irritation) or excessively slow dissolution (affecting drug absorption).
[0023] In addition, pectin is a water-soluble anionic polysaccharide. When a mouthwash enters the oral cavity, pectin molecules quickly absorb water and swell to form a gel layer. This gel layer can slow down the disintegration rate of the mouthwash and encapsulate the active ingredients, reducing their diffusion rate, prolonging their residence time on the oral mucosa, and improving absorption efficiency.
[0024] In addition, fibrous biomass has the characteristics of high porosity and low density, allowing active substances to be evenly dispersed in the pores of fibrous biomass, avoiding the problem of uneven drug loading caused by the high density of traditional substrates. At the same time, the loose structure can reduce the compaction density of oral products, making them lighter and thinner, with less foreign body sensation when fitting the oral mucosa, thus improving wearing comfort.
[0025] In one embodiment, the raw materials for fibrous biomass include one of the following: grapefruit peel, corn stalk core, loofah sponge, and reed stalk core. These materials are all byproducts of agriculture, forestry, or fruits and vegetables, widely available and inexpensive. They can be processed into fibrous biomass through simple washing, drying, or secondary processing (such as crushing), which significantly reduces production costs compared to synthetic excipients (such as microcrystalline cellulose). Furthermore, their renewability aligns with the development trend of green pharmaceuticals, which is beneficial for enhancing the product's market competitiveness.
[0026] It should be noted that pomelo peel is mainly divided into three parts: exocarp, mesocarp (white pith), and endocarp. In this application, pomelo peel mainly refers to the mesocarp and endocarp.
[0027] It should also be noted that when the active ingredient is nicotine, its strong pungent and bitter taste is a key factor limiting the palatability of lozenges. Grapefruit peel contains small amounts of natural terpenes and flavonoids such as limonene and naringin, which have a fresh and delicate citrus flavor. This flavor can neutralize the bitterness of nicotine through a taste masking effect, improving patient adherence. Furthermore, its natural flavor eliminates the need for added artificial flavorings, aligning with the product's positioning as natural and healthy.
[0028] In one embodiment, the oral product includes one of the following: a lozenge or a lozenge pouch.
[0029] In some embodiments, the lozenge includes a first support layer, a functional layer, and a second support layer stacked sequentially; wherein at least one of the first support layer and the second support layer is a liquid-permeable layer, and the functional layer includes sheet-like fibrous biomass and a characteristic substance. Since the characteristic substance is adsorbed in the fibrous biomass, the thickness of the fibrous biomass is the same as the thickness of the functional layer, and the thickness of the fibrous biomass is 3mm to 4mm.
[0030] Specifically, the thickness of the fibrous biomass is 3 mm, 3.5 mm, 4 mm, or any value within the above range.
[0031] In some embodiments, the oral bag includes a liquid-permeable bag and contents; wherein the contents are encapsulated within the liquid-permeable bag; the contents include fibrous biomass and a specific substance, the fibrous biomass being in a sheet-like or granular structure. That is, in some embodiments, the liquid-permeable bag encapsulates one, two, or more sheets of fibrous biomass adsorbed with the specific substance. In some embodiments, the liquid-permeable bag encapsulates granular fibrous biomass adsorbed with the specific substance.
[0032] In some embodiments, the lozenge has a single-layer structure in the form of a sheet; the main body of the lozenge is fibrous biomass, and the characteristic substances are adsorbed in the fibrous biomass.
[0033] In some embodiments, the fibrous biomass accounts for 40% to 98% of the mass of the oral product. This range of fibrous biomass usage ensures that the oral product has a suitable shape, structure, and formability, while also ensuring that it can carry active substances and flavorings for slow release.
[0034] In some embodiments, the active substance accounts for 1% to 10% of the mass of the oral product. This range of active substance dosage ensures the functional effect of the oral product while also matching the fibrous biomass to achieve controlled release, improve utilization efficiency, and enhance safety.
[0035] In some embodiments, the flavoring agent accounts for 1% to 50% of the mass of the oral product. The range of flavoring agent dosage ensures compatibility with fibrous biomass and active substances, does not damage the structure of the oral product, and can also mask off-flavors and improve taste.
[0036] In one embodiment, the oral product comprises, by weight parts: 40-98 parts of fibrous biomass, 1-10 parts of active substance, and 1-50 parts of flavoring agent. This composition not only ensures the structural stability of the oral product but also meets flavor requirements.
[0037] Specifically, by weight, oral products include the following components: 50-90 parts of fibrous biomass, 2-8 parts of active substance, and 5-40 parts of flavoring agent.
[0038] Specifically, by weight, oral products include the following components: 60-80 parts of fibrous biomass, 3-6 parts of active substance, and 15-30 parts of flavoring agent.
[0039] Specifically, by weight, oral products include the following components: 65-75 parts of fibrous biomass, 4-5 parts of active substance, and 20-25 parts of flavoring agent.
[0040] In one embodiment, the active substance includes at least one of nicotine and nicotine derivatives. For example, nicotine includes natural nicotine and / or synthetic nicotine, and nicotine derivatives include one or more of nicotine salts, nicotine in a matrix such as a glycobase or an organometallic complex, nicotine-resin combinations, nicotine inclusion complexes, and non-covalently bound nicotine.
[0041] Non-covalently bonded nicotine includes nicotine lactate, nicotine malate, nicotine salicylate, nicotine cyclodextrin encapsulated complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, and nicotine benzoate. Nicotine derivatives also include nicotine with substituents, such as 6-methylnicotine, 6-methylnicotine lactate, 6-methylnicotine malate, 6-methylnicotine salicylate, 6-methylnicotine cyclodextrin encapsulated complex, 6-methylnicotine hydrochloride, 6-methylnicotine dihydrochloride, 6-methylnicotine tartrate, 6-methylnicotine tartrate dihydrate, 6-methylnicotine sulfate, 6-methylnicotine zinc chloride, and one or more mixtures of 6-methylnicotine benzoate.
[0042] It should be noted that nicotine is a basic nitrogen-containing heterocyclic compound (pKa≈8.0) and exists in a cationic state in the oral microenvironment (pH≈6.5~7.0). Pectin molecules contain a large number of carboxyl groups (-COOH), which can form ionic complexes with nicotine cations, further slowing down the release rate of nicotine, avoiding sudden rises and falls in blood drug concentration, and reducing the risk of addiction.
[0043] In one embodiment, the active substance may further include at least one of caffeine, theophylline, tea polyphenols, vitamins, and capsaicin.
[0044] In one embodiment, the flavoring agent includes at least one of flavoring, sweetener, cooling agent, salting agent, and acidifying agent. These can mask residual off-flavors, thereby improving the taste.
[0045] In one embodiment, the flavoring includes at least one of the following: bergamot flavoring, eucalyptus flavoring, citrus flavoring, lemon flavoring, peppermint flavoring, peppermint flavoring, menthol, licorice flavoring, wintergreen flavoring, tobacco flavoring, coffee flavoring, vanilla flavoring, lime flavoring, apple flavoring, peach flavoring, mango flavoring, cherry flavoring, blueberry flavoring, strawberry flavoring, cola flavoring, cinnamon flavoring, pandan flavoring, and watermelon flavoring.
[0046] In one embodiment, the sweetener includes at least one of the following: rock sugar, xylitol, sorbitol, mannitol, iodine, lactitol, maltitol, isomaltitol, hydrogenated starch hydrolysate, erythritol, maltodextrin, aspartame, acesulfame potassium, sodium saccharin, sucralose, neotame, cyclamate, alitane, steviol glycosides, arabinitol, and monk fruit sweetener.
[0047] In one embodiment, the cooling agent includes at least one of the following: menthol, menthol derivatives, WS-3, and WS-23.
[0048] In one embodiment, the saltiness agent includes at least one of the following: sodium chloride, monosodium glutamate, and amino acid salt.
[0049] In one embodiment, the acidulant includes at least one of the following: citric acid, malic acid, fumaric acid, and phosphoric acid.
[0050] In one embodiment, the fibrous biomass is grapefruit peel, and the flavoring agents include sweeteners and cooling agents; the oral product comprises the following components by weight: 40-98 parts grapefruit peel, 1-10 parts active substance, 1-49 parts sweetener, and 0.1-1 part cooling agent.
[0051] Specifically, by weight, the oral product comprises the following components: 45-85 parts grapefruit peel, 1-10 parts nicotine, 5-40 parts sweetener, and 0.1-0.5 parts cooling agent. The nicotine includes at least one of nicotine and nicotine derivatives.
[0052] Specifically, by weight, the oral product comprises the following components: 55-75 parts grapefruit peel, 4-5 parts nicotine, 20-30 parts sweetener, and 0.2-0.4 parts cooling agent. The nicotine includes at least one of nicotine and nicotine derivatives.
[0053] This application also provides a method for preparing an oral article, the method comprising: Step 1: Cut the fibrous biomass to obtain sheet-like fibrous biomass.
[0054] The dimensional parameters of the sheet-like fibrous biomass include: thickness 3mm~4mm, length 24mm~36mm, and width 1mm~1.4mm.
[0055] Specifically, the thickness of the sheet-like fibrous biomass is 3 mm, 3.5 mm, 4 mm or any value within the above range; the length is 24 mm, 30 mm, 36 mm or any value within the above range; and the width is 1 mm, 1.2 mm, 1.4 mm or any value within the above range.
[0056] Step 2: After adding the active substance and / or flavoring agent to the flake fibrous biomass, a oral product is obtained.
[0057] Step 2 specifically includes: 2.1 Add water to the flavoring agent and obtain the flavor liquid by heating.
[0058] The heating parameters include: heating temperature of 50℃~80℃ and heating time of 10min~60min.
[0059] Specifically, the heating temperature is 50℃, 65℃, 80℃ or any value within the above range; the heating time is 10min, 30min, 60min or any value within the above range.
[0060] 2.2 After adding the flaky fibrous biomass to the flavor liquid, stir-fry until sugar frosting appears to obtain the flaky fibrous biomass containing flavoring agent.
[0061] It should be noted that before adding the flaky fibrous biomass to the flavor liquid, the flaky fibrous biomass needs to be soaked in water, which can remove impurities and reduce bitterness.
[0062] The soaking time is 25 to 40 minutes.
[0063] Specifically, the soaking time is 25 min, 30 min, 40 min, or any value within the above range.
[0064] 2.3 After adding the active substance to the fibrous biomass containing the flavoring agent, the product is obtained after being left to stand for 2 to 4 days.
[0065] To better understand this solution, examples and comparative models are also provided below.
[0066] Example 1 The preparation of lozenges includes: 1. Cut the fibrous biomass to obtain sheet-like fibrous biomass.
[0067] The dimensions of the sheet-like fibrous biomass are: 3mm thick, 30mm long, and 1.2mm wide.
[0068] 2. Soak the flaky fibrous biomass in clean water for 30 minutes to remove some of the bitterness and impurities, then squeeze out the water. 3. Put rock sugar in a pot, add water and heat until melted, then pour in the flakes of fiber biomass and stir-fry until sugar frosting forms; 4. Add the nicotine to the sheet-like fibrous biomass in a measured amount, and let it sit for 2 days to allow the sheet-like fibrous biomass to absorb it, ensuring that the nicotine is evenly distributed.
[0069] The fibrous biomass is grapefruit peel.
[0070] The mass fractions of grapefruit peel, rock sugar, and nicotine were 88, 10, and 2, respectively.
[0071] Example 2 The difference from Example 1 is that the fibrous biomass is corn stalk core.
[0072] Example 3 The difference from Example 1 is that the fibrous biomass is loofah sponge.
[0073] Example 4 The difference from Example 1 is that the mass fractions of grapefruit peel, rock sugar, and nicotine are 90 parts, 1 part, and 9 parts, respectively.
[0074] Example 5 The difference from Example 1 is that the mass fractions of grapefruit peel, rock sugar, and nicotine are 40 parts, 50 parts, and 10 parts, respectively.
[0075] Comparative Example 1 The difference from Example 1 is that, by mass parts, the components of the oral product include: 58 parts microcrystalline cellulose, 20 parts trehalose, 2 parts nicotine, and 20 parts rock sugar.
[0076] The following tests were performed on the oral products in the above embodiments and comparative examples.
[0077] I. Sustained-release and disintegration tests, data are shown in Figure 1.
[0078] The test method includes: 1. Placing the oral contents from the above examples and comparative examples into six tubes of a disintegration basket (stainless steel mesh diameter of 2.0 mm). 2. Maintaining the water bath temperature of the disintegrator at 37±0.5℃. 3. Raising and lowering the disintegration basket approximately 30 times per minute, with a stroke of approximately 55±2 mm. 4. Observing the disintegration of the oral contents on the sieve.
[0079] II. Flavor assessment, data are shown in Table 2.
[0080] Ten testers first smelled the aroma, then placed the oral product in their mouths to assess aroma intensity, irritation, saliva retention, and comfort, and scored each item. The average score for each indicator was then used as the final result for that indicator. A higher score indicates that the oral product effectively addresses that indicator.
[0081] Table 1. Sustained-release and disintegration test data of oral products of the examples and comparative examples.
[0082] Table 2. Flavor evaluation data of oral products from the examples and comparative examples.
[0083] As shown in Table 1, the disintegration rate of the oral product in the Examples is much lower than that in the Comparative Example, avoiding oral irritation caused by the instantaneous release of nicotine due to excessively rapid dissolution. Furthermore, the diffusion rate of nicotine in the oral product in the Examples is lower than that in the Comparative Example, prolonging the retention time of nicotine on the oral mucosa and improving nicotine absorption efficiency.
[0084] As can be seen from Table 2, compared with the comparative example, the oral product of the embodiment has higher aroma intensity, saliva retention intensity, and comfort score, and lower irritation score, indicating that the oral product of the embodiment has better flavor and comfort.
[0085] The endpoints and any values of the ranges disclosed in this application are not limited to the precise ranges or values, and these ranges or thresholds should be understood to include values close to these ranges or values. For numerical ranges, the endpoint values of the various ranges, the endpoint values of the various ranges and individual point values, and individual point values can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed herein.
[0086] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0087] Although embodiments of this application have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the claims and their equivalents.
Claims
1. A mouth-held product, characterized in that, The oral product comprises the following components: fibrous biomass and characteristic substances; The characteristic substances include active substances and / or flavoring agents; the fibrous biomass is a porous matrix, and the fibrous biomass is used to adsorb at least a portion of the characteristic substances.
2. The oral article according to claim 1, characterized in that, The raw materials for the fibrous biomass include at least one of the following: grapefruit peel, corn stalk core, loofah sponge, and reed stalk core.
3. The oral article according to claim 2, characterized in that, The fibrous biomass is obtained by drying the raw material or by drying, post-processing and processing the raw material.
4. The oral article according to claim 1, characterized in that, The oral products include one of the following: oral tablets and oral bags.
5. The oral article according to claim 4, characterized in that, The lozenge includes a first support layer, a functional layer, and a second support layer stacked in sequence. Wherein, at least one of the first support layer and the second support layer is a liquid-permeable layer, and the functional layer includes the sheet-like fibrous biomass and the characteristic substance.
6. The oral article according to claim 4, characterized in that, The oral bag includes a liquid-permeable bag and contents; The contents are encapsulated within the liquid-permeable bag; the contents include the fibrous biomass and the characteristic substance, wherein the fibrous biomass is in the form of flakes or granules.
7. The oral article according to claim 4, characterized in that, The lozenge has a single-layer structure in the form of a sheet, and the main body of the lozenge is the fibrous biomass, in which the characteristic substance is adsorbed.
8. The oral article according to any one of claims 1 to 7, characterized in that, The fibrous biomass constitutes 40% to 98% of the mass of the oral product; and / or, The active substance comprises 1% to 10% by mass in the oral product; and / or, The flavoring agent accounts for 1% to 50% of the mass of the oral product.
9. The oral article according to any one of claims 1 to 7, characterized in that, The active substance includes at least one of nicotine and nicotine derivatives; and / or, The active substance includes at least one of caffeine, theophylline, tea polyphenols, vitamins, and capsaicin; and / or, The fibrous biomass includes cellulose, hemicellulose, and pectin; and / or, The flavoring agent includes at least one of flavoring, sweetener, cooling agent, salting agent, and acidifying agent.
10. The oral article according to claim 1, characterized in that, The fibrous biomass includes grapefruit peel, and the flavoring agent includes a sweetener and a cooling agent; by weight, the oral product comprises the following components: 40-98 parts grapefruit peel, 1-10 parts of the active substance, 1-49 parts of the sweetener, and 0.1-1 parts of the cooling agent.