Cosmetic product

Abstract

The present application relates to a cosmetic. [Problem] To provide a cosmetic which is excellent in use feeling. [Solution] A cosmetic comprising (A) a glycine derivative having a specific structure or a salt thereof, (B) a polyglycerin fatty acid ester, and (C) water.

Description

Technical Field

[0001] This invention relates to cosmetics. Specifically, this invention relates to cosmetics comprising glycine derivatives or their salts. Background Technology

[0002] Glycine derivatives or their salts are known to have a pore-minimizing effect (e.g., Patent Document 1) and are contained in various cosmetics. To enhance the effect obtained from dipeptide-15, it is considered to increase its content; however, according to the research of the inventors, simply increasing the content of dipeptide-15 in cosmetics tends to cause a sticky feeling after application. Therefore, in cosmetics containing glycine derivatives or their salts, it is desirable to achieve a superior user experience even with increased content.

[0003] Existing technical documents

[0004] Patent documents

[0005] Patent Document 1: Japanese Patent No. 5241058 Summary of the Invention

[0006] The inventors have surprisingly discovered that in cosmetics containing a combination of a glycine derivative having a specific structure or its salt and a polyglycerol fatty acid ester, stickiness can be suppressed, and a smooth and moist feel can be achieved, even with a high content of dipeptide-15. This invention is based on these insights.

[0007] According to this disclosure, the following invention is provided.

[0008] [1] A cosmetic product comprising:

[0009] (A) A glycine derivative or a salt thereof as shown in formula (1);

[0010] (B) Polyglycerol fatty acid esters; and

[0011] (C) Water,

[0012]

[0013] In the above formula (1), R 1 and R 2 Each can be independently composed of a hydrogen atom, alkyl, alkenyl, aryl, aralkyl, aminomethyl carbonyl, amidine, alkyl carbonyl, alkenyl carbonyl, aryl carbonyl, or aralkyl carbonyl.

[0014] R 3 It can be a hydrogen atom, alkyl, alkenyl, aryl, or aralkyl group.

[0015] Among them, R 1 R2 and R 3 They are not both hydrogen atoms.

[0016] [2] According to the cosmetic described in [1], the content of ingredient (A) is more than 0.01% by mass and less than 7% by mass relative to the total amount of the cosmetic.

[0017] [3] The cosmetic according to [1] or [2], wherein ingredient (A) contains dipeptide-15.

[0018] [4] The cosmetic according to any one of [1] to [3], wherein the number of carbon atoms in the fatty acid portion of the polyglycerol fatty acid ester is 12 or more and 17 or less.

[0019] [5] The cosmetic according to any one of [1] to [4], wherein the polyglycerol portion of the polyglycerol fatty acid ester is a dimer or more and a decamer or less.

[0020] [6] The cosmetic according to any one of [1] to [5], wherein ingredient (B) comprises polyglycerol-6 lauryl ester or polyglycerol-6 myristate ester.

[0021] [7] The cosmetic according to any one of [1] to [6], wherein the content of ingredient (B) is 0.1% by mass or more and 10% by mass or less relative to the total amount of the cosmetic.

[0022] [8] The cosmetic according to any one of [1] to [7], wherein (D) the oil content is 0% by mass or more and 40% by mass or less relative to the total amount of the cosmetic.

[0023] [9] The cosmetic according to any one of [1] to [8] is a water-based cosmetic or an oil-in-water emulsion cosmetic.

[0024] According to the present invention, cosmetics with excellent user experience can be provided. In particular, cosmetics that suppress stickiness after application and provide a smooth feel during application and a moist feel after application can be provided. Detailed Implementation

[0025] This invention relates to cosmetics comprising (A) a glycine derivative having a specific structure or a salt thereof, (B) a polyglycerol fatty acid ester and (C) water.

[0026] The following describes the ingredients that may be included in the cosmetics of the present invention.

[0027] (A) Glycine derivatives or their salts

[0028] The cosmetic of the present invention comprises a glycine derivative or a salt thereof as shown in formula (1) (hereinafter sometimes referred to as ingredient (A). The same applies to other ingredients).

[0029]

[0030] In the formula, R 1 and R 2 Each can be independently a hydrogen atom, alkyl, alkenyl, aryl, aralkyl, aminomethyl carbonyl, amidoyl, alkyl carbonyl, alkenyl carbonyl, aryl carbonyl, or aralkyl carbonyl.

[0031] Preferred R 1 and R 2 One of them is a hydrogen atom, and the other is a methyl, aminomethyl carbonyl or benzyl carbonyl group.

[0032] R 3 It can be a hydrogen atom, alkyl, alkenyl, aryl or aralkyl, preferably a hydrogen atom or methyl.

[0033] Among them, R 1 R 2 and R 3 It cannot be both hydrogen atoms at the same time.

[0034] (A) The component can be a salt of the glycine derivative shown in formula (1). There are no particular restrictions on the type of salt as long as it is a pharmacologically permissible salt, such as hydrochloride, sulfate, phosphate, hydrobromide, sodium salt, potassium salt, magnesium salt, calcium salt, magnesium salt, ammonium salt, etc. As organic salts, examples include acetate, lactate, maleate, fumarate, tartrate, methanesulfonate, p-toluenesulfonate, triethanolamine salt, amino acid salt, etc.

[0035] (A) The preferred ingredient is dipeptide-15.

[0036] (A) Ingredients may be one or more. The content of ingredient (A) relative to the total amount of the cosmetic is preferably 0.01% by mass or more, 0.05% by mass or more, or 0.3% by mass or more, preferably 7% by mass or less, 5% by mass or less, or 3% by mass or less. It should be noted that when ingredient (A) is present in the cosmetic at 1% by mass or more, the user can feel the effect of shrinking pores, which is more preferable.

[0037] (B) Polyglycerol fatty acid esters

[0038] Polyglycerol fatty acid esters can be prepared by esterifying fatty acids with polyglycerol. Here, in polyglycerol fatty acid esters, the portion derived from fatty acids is called the fatty acid portion, and the portion derived from polyglycerol is called the polyglycerol portion. The fatty acid portion is lipophilic, and the polyglycerol portion is hydrophilic. Polyglycerol fatty acid esters can form vesicles in cosmetics; these vesicles are bilayer closed structures containing other ingredients. Oil content can be retained within the bilayer of the vesicle.

[0039] The number of carbon atoms in the fatty acid portion of the polyglycerol fatty acid ester is preferably 12 or more, 13 or more, or 14 or more, and more preferably 17 or less, 16 or less, or 15 or less. The fatty acid can be a saturated fatty acid or an unsaturated fatty acid, and can also be a straight-chain fatty acid or a branched-chain fatty acid. Examples of such fatty acids include lauric acid, myristic acid, and palmitic acid. Lauric acid or myristic acid is preferred as the fatty acid.

[0040] The polyglycerol portion of the polyglycerol fatty acid ester is preferably a dimer or more, a trimer or more, or a tetramer or more, and is preferably a decamer or less, a 9mer or less, an 8mer or less, a 7mer or less, or a 6mer or less.

[0041] The OH / C ratio of polyglycerol fatty acid esters is preferably 0.20 or higher, 0.25 or higher, 0.30 or higher, 0.35 or higher, 0.40 or higher, 0.45 or higher, or 0.50 or higher; and preferably 0.80 or lower, 0.75 or lower, 0.70 or lower, 0.65 or lower, or 0.60 or lower. Polyglycerol fatty acid esters with such OH / C ratios can improve the solubilizing ability of oil in vesicles when they form vesicles, and are therefore preferred.

[0042] In this invention, the "OH / C ratio" refers to the ratio of the number of hydroxyl groups in the polyglycerol portion to the number of carbon atoms in the fatty acid portion. The OH / C ratio is also a parameter relating to the balance between hydrophilicity and lipophilicity. For example, in the case of polyglycerol-6 laurate, the fatty acid portion has 12 carbon atoms. Furthermore, the polyglycerol portion is a hexamer, in which case there are 7 hydroxyl groups (=6+1). Therefore, the OH / C ratio of polyglycerol-6 laurate is 0.58 (=7 / 12). In the case of polyglycerol-6 myristate, the fatty acid portion has 14 carbon atoms. Furthermore, the polyglycerol portion is a hexamer, in which case there are 7 hydroxyl groups (=6+1). Therefore, the OH / C ratio of polyglycerol-6 laurate is 0.50 (=7 / 14).

[0043] The polyglycerol fatty acid ester is preferably a polyglycerol monofatty acid ester. Specifically, examples of polyglycerol fatty acid esters include polyglycerol-6 myristate, polyglycerol-2 laurate, polyglycerol-4 laurate, polyglycerol-5 laurate, polyglycerol-6 laurate, and polyglycerol-10 palmitate. (B) Component preferably contains polyglycerol-6 laurate or polyglycerol-6 myristate.

[0044] (B) The content of an ingredient relative to the total amount of the cosmetic can be set at 0.1% or more by mass, 0.2% or more by mass, or 0.3% or more by mass. Alternatively, it can be set at 10% or less by mass, 5.0% or less by mass, or 3.0% or less by mass.

[0045] (C) Water

[0046] The cosmetic of the present invention comprises (C) water. The water can be water used in cosmetics, pharmaceuticals, etc., such as purified water, ion-exchanged water, tap water, etc. The water content relative to the total amount of the cosmetic of the present invention is preferably 40% by mass or more or 50% by mass or more, and preferably 95% by mass or less or 90% by mass or less.

[0047] In addition to (A) to (C), the cosmetic of the present invention may also contain (D) oil. In this case, the cosmetic of the present invention is usually in the form of an oil-in-water cosmetic or an oil-in-water cosmetic, for example, it may be a double-layer cosmetic that separates into two layers when left to stand.

[0048] (D) Oil content

[0049] Examples of oil components (D) include ester oils, silicone oils, hydrocarbon oils, higher fatty acids, higher alcohols, liquid oils, solid oils, and semi-solid oils. Ester oils, silicone oils, hydrocarbon oils, and higher alcohols are preferred. One or more components (D) may be used. In the case of a water-in-oil emulsion cosmetic, the content of component (D) relative to the total amount of the cosmetic is preferably 0.5% by mass or more, or 1% by mass or more, and preferably 40% by mass or less, or 30% by mass or less. Furthermore, in the case of a water-based cosmetic, the content of component (D) is preferably 0% by mass or more and 1% by mass or less.

[0050] Examples of ester oils include octyl caprylate, nonyl nonanoate, cetyl ethylhexanoate, isopropyl myristate, octyl dodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyl ethylhexanoate, cetyl lactate, myristyl lactate, acetylated lanolin, isocetyl stearate, isocetyl isostearate, cholesterol 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl monoisostearate, neopentyl glycol didecanoate, tripropylene glycol dinepentanoate, diisostearyl malate, glyceryl di-2-heptyl undecanoate, glyceryl diisostearate, trimethylolpropane tri(2-ethylhexanoate), and trimethylolpropane triisostearate. Pentaerythritol tetra-2-ethylhexanoate, glyceryl tri(2-ethylhexanoate), glyceryl tricaprylate, glyceryl triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristicate, glyceryl tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetylglycine ester, 2-heptylundecyl palmitate, diisobutyl adipic acid, N-lauroyl-L-glutamic acid-octyldodecyl ester, di-2-heptylundecyl adipic acid, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipic acid, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, cetyl ethylhexanoate, phytosterol macadamia oleate, etc.

[0051] Examples of silicone oils include chain polysiloxanes (such as polydimethylsiloxane, diphenylsiloxyphenyl polytrimethylsiloxane, diphenyl polysiloxane, etc.), cyclic polysiloxanes (such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecylcyclohexasiloxane, etc.), organosilicon resins forming a three-dimensional network structure, organosilicon rubbers, various modified polysiloxanes (amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, fluorine-modified polysiloxanes, etc.), acrylic organosilicones, etc., with chain polysiloxanes being preferred.

[0052] Examples of hydrocarbon oils include isododecane, isohexadecane, isoalkanes, mineral oil (liquid paraffin), ceresin, squalane, squalane, paraffin wax, pure ceresin, squalene, petrolatum, microcrystalline wax, hydrogenated polydecene, etc.

[0053] Examples of high-grade fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, benzolic acid, oleic acid, undecenoic acid, tall oil, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0054] Examples of higher alcohols include straight-chain alcohols (such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, hexadecyl alcohol, etc.) and branched-chain alcohols (such as lanolin alcohol, cholesterol, phytosterol, hexyldodecyl alcohol, isostearyl alcohol, octyldodecyl alcohol, etc.).

[0055] Examples of liquid oils include avocado oil, camellia seed oil, macadamia seed oil, corn oil, olive fruit oil, rapeseed oil, sesame oil, almond oil, wheat germ oil, camellia seed oil, castor seed oil, flaxseed oil, safflower seed oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, torreya seed oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba seed oil, germ oil, and triglycerides.

[0056] Examples of solid oils include cocoa butter, coconut oil, hydrogenated coconut oil, oil palm oil, oil palm kernel oil, hydrogenated oil palm oil, scabra kernel oil, hydrogenated oil, scabra wax, and hydrogenated castor oil. Examples of semi-solid oils include shea butter, partially hydrogenated coconut oil, and partially hydrogenated jojoba oil.

[0057] In addition, the cosmetics of the present invention may also contain polyols.

[0058] Examples of polyols include glycerol, ethylene glycol, propylene glycol, 1,3-butanediol, dipropylene glycol, polyethylene glycol, polypropylene glycol, and polybutylene glycol.

[0059] The cosmetic product of the present invention preferably contains dipropylene glycol or 1,3-butanediol. The polyols may be used alone or in combination of two or more. The content of the polyol relative to the total amount of the cosmetic product is preferably 1% or more by mass, 2% or more by mass, or 5% or more by mass, preferably 30% or less by mass, 25% or less by mass, or 20% or less by mass, but is not limited thereto.

[0060] In addition, the cosmetic products of the present invention may also contain thickeners.

[0061] As thickeners, the following can be listed:

[0062] (i) Water-soluble thickeners, such as gum arabic, tragacanth gum, galactomannan, carob gum, guar gum, ark tartar gum, carrageenan gum, pectin, agar, quince seeds (quince), algal colloids (brown algae extract) and other plant-based polymers; dextran, succinyl dextran, budding stalk polysaccharide, xanthan gum and other microbial polymers; collagen, casein, albumin, gelatin and other animal-based polymers; methylcellulose, nitrocellulose, ethylcellulose, methyl hydroxypropylcellulose, hydroxyethylcellulose, etc. Cellulose-based polymers such as sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, and cellulose powder; alginate-based polymers such as sodium alginate and propylene glycol alginate; vinyl-based polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, and carboxyvinyl polymers (carbomer); polyoxyethylene-based polymers such as hydrophobically modified polyether urethane; acrylic-based polymers such as sodium polyacrylate, ethyl polyacrylate, and polyacrylamide; polyethyleneimine; and cationic polymers.

[0063] (ii) Inorganic water-soluble polymers, such as bentonite, magnesium aluminum silicate, lithium saponite, hydropyrite, anhydrous silica, etc. Thickeners can be used alone or in combination of two or more.

[0064] The content of thickener relative to the total amount of cosmetics is preferably 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, and preferably 1.5% by mass or less, 1.0% by mass or less, or 0.8% by mass or less.

[0065] Furthermore, the cosmetic products of the present invention may also contain surfactants. The type of surfactant is arbitrary, but anionic surfactants are preferred.

[0066] Examples of anionic surfactants include, for example, N-acyl amino acid salts and N-acylmethyl taurate. Specifically, examples include N-acylglutamate salts such as potassium cocoylglutamate, N-acyl-N-methyl-β-alanine salts, N-acylsarcosinate salts, sodium N-cocoyl taurate, sodium N-cocoyl-N-methyl taurate, sodium N-lauroyl-N-methyl taurate, sodium N-stearoyl-N-methyl taurate, sodium N-cocoate-N-methyl taurate, triethanolamine N-cocoate-N-methyl taurate, triethanolamine N-palmitoyl-N-ethyl taurate, magnesium N-cocoyl taurate, magnesium N-cocoyl-N-methyl taurate, magnesium N-lauroyl-N-methyl taurate, magnesium N-lauroyl-N-methyl taurate, and magnesium N-cocoate-N-methyl taurate. The cosmetic product of the present invention preferably contains sodium methylcocoyl taurate and sodium N-stearoyl-N-methyl taurate. Anionic surfactants may be used alone or in combination of two or more.

[0067] The content of anionic surfactant relative to the total amount of cosmetics is preferably 0.01% by mass or more, 0.03% by mass or more, 0.05% by mass or more, or 0.07% by mass or more, and preferably 1.0% by mass or less, 0.7% by mass or less, 0.5% by mass or less, or 0.3% by mass or less.

[0068] In addition to the above-mentioned ingredients, the cosmetics of this invention may also incorporate any ingredients commonly used in cosmetics and pharmaceuticals. These ingredients may include, for example, surfactants, moisturizers, lower alcohols, metal ion chelating agents, neutralizing agents, pH adjusters, antioxidants, preservatives, pharmaceuticals, ultraviolet absorbers, powder components, and (daily) fragrances. As long as the effects of this invention are achieved, one or more of these ingredients may be incorporated into the cosmetics.

[0069] The cosmetic of the present invention provides a smooth feel during application. Furthermore, in the cosmetic of the present invention, as the content of ingredient (A) increases, the stickiness of the cosmetic can be suppressed, and the moist feel after application is improved.

[0070] The dosage form of the cosmetics of the present invention is not particularly limited, but it is preferred to be formulated as a water-based cosmetic or an oil-in-water emulsion cosmetic. In water-based cosmetics or oil-in-water emulsion cosmetics, the aqueous phase initially comes into contact with the skin, thus giving the skin a moisturizing feel and allowing the effects of the present invention to be felt more realistically.

[0071] Examples of cosmetics according to the present invention include skincare cosmetics (such as toners, lotions, creams, serums, poultices, masks, etc.), makeup cosmetics (such as foundations, makeup bases, etc.), skin cleansers (such as facial cleansers, makeup removers, etc.), and sunscreen cosmetics. It should be noted that these are merely illustrative examples, and the cosmetics of the present invention are not limited to these methods.

[0072] Furthermore, the cosmetics of the present invention can be manufactured using conventional methods.

[0073] Example

[0074] The invention is illustrated by the following examples, but is not limited to these examples. Unless otherwise specified, the content is expressed as a percentage of mass relative to the total amount.

[0075] [Examples 1-5 and Comparative Examples 1-3]

[0076] Water-in-oil emulsion cosmetics were prepared according to the formulations shown in Table 1, namely, Reference Example 1, Reference Example 2, Examples 1-5 and Comparative Examples 1-3.

[0077] [Usability Evaluation 1: Smoothness]

[0078] Five professional reviewers applied the cosmetics prepared according to the formulas shown in Table 1 to the skin and evaluated their usability based on the following criteria regarding smoothness during application. Smoothness during application refers to the absence of a feeling of stickiness on the skin during application. The results were recorded in Table 1 or 2.

[0079] A: All 5 ratings were unchanged compared to the benchmark.

[0080] B: 1-2 people rated it as feeling stuck during application compared to the benchmark.

[0081] C: More than 3 people rated it as feeling stuck during application compared to the benchmark.

[0082] [Usability Evaluation 2: Presence or Absence of Stickiness]

[0083] Five professional reviewers applied the cosmetics prepared according to the formulas shown in Table 1 to the skin and evaluated whether or not the skin felt sticky after application. The results were recorded in Table 1 or 2.

[0084] A: All 5 ratings were unchanged compared to the benchmark.

[0085] B: 1-2 people rated it as sticky after application compared to the benchmark.

[0086] C: More than 3 people rated the product as feeling sticky after application compared to the benchmark.

[0087] [Usability Evaluation 3: Moisture Feel]

[0088] Five professional reviewers will apply the cosmetics prepared according to the formulas shown in Table 1 to the skin and evaluate the moisturizing effect after application. The results will be recorded in Table 1 or 2.

[0089] 2:3 or more reviews indicated that the product felt moisturizing after application compared to the baseline.

[0090] 1:1 to 2 people rated the product as feeling moisturized after application compared to the baseline.

[0091] 0: All 5 rankings were rated as unchanged compared to the benchmark.

[0092] In addition, in usability evaluations 1-3, Reference Example 1, which does not contain component (A) but contains component (B), was compared and evaluated with Examples 1-5, which contain component (A) and component (B) at different concentrations. Furthermore, Reference Example 2, which does not contain component (A) but contains PEG-6 distearate instead of component (B), was compared and evaluated with Comparative Examples 1-3, which contain component (A) and PEG-6 distearate at different concentrations.

[0093] [Table 1]

[0094]

[0095] [Examples 6-8 and Comparative Examples 4-6]

[0096] Aqueous cosmetics for Reference Examples 3, 4, 6-8, and 4-6 were prepared according to the formulations shown in Table 2. Usability evaluations 1-3 were conducted using the same criteria as for Examples 1-5 and Comparative Examples 1-3. The results are recorded in Table 2.

[0097] In addition, in usability evaluations 1-3, Reference Example 3, which does not contain component (A) but contains component (B), was compared and evaluated with Examples 6-8, which contain component (A) and component (B) at different concentrations. Furthermore, Reference Example 4, which does not contain component (A) but contains PPG-13-decyltetradecyl alcohol polyether-24 instead of component (B), was compared and evaluated with Comparative Examples 4-6, which contain component (A) and PPG-13-decyltetradecyl alcohol polyether-24 at different concentrations.

[0098] [Table 2]

[0099]

Claims

1. A cosmetic product comprising: (A) A glycine derivative or a salt thereof as shown in formula (1); (B) Polyglycerol fatty acid esters; and (C) Water, In the above formula (1), R 1 and R 2 Each can be independently a hydrogen atom, alkyl, alkenyl, aryl, aralkyl, aminomethyl carbonyl, amidine, alkyl carbonyl, alkenyl carbonyl, aryl carbonyl, or aralkyl carbonyl. R 3 It can be a hydrogen atom, alkyl, alkenyl, aryl, or aralkyl group. in, R 1 R 2 and R 3 They are not both hydrogen atoms.

2. The cosmetic product according to claim 1, wherein, (A) The content of the ingredient is more than 0.01% by mass and less than 7% by mass relative to the total amount of cosmetics.

3. The cosmetic product according to claim 1 or 2, wherein, (A) The ingredient contains dipeptide-15.

4. The cosmetic product according to claim 1 or 2, wherein, The fatty acid portion of the polyglycerol fatty acid ester has 12 or more but less than 17 carbon atoms.

5. The cosmetic product according to claim 1 or 2, wherein, The polyglycerol fatty acid ester contains more than 2 polymers and less than 10 polymers.

6. The cosmetic product according to claim 1 or 2, wherein, (B) The ingredients contain polyglycerol-6 lauryl ester or polyglycerol-6 myristate ester.

7. The cosmetic product according to claim 1 or 2, wherein, (B) The content of the ingredient is more than 0.1% by mass and less than 10% by mass relative to the total amount of cosmetics.

8. The cosmetic product according to claim 1 or 2, wherein, (D) The oil content relative to the total amount of cosmetics is more than 0% by mass and less than 40% by mass.

9. The cosmetic product according to claim 1 or 2, wherein it is a water-based cosmetic product or an oil-in-water emulsion cosmetic product.

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