Cosmetic homologous combination extract for inhibiting sebum secretion and application thereof

Abstract

The present application relates to the field of cosmetic technology, and discloses a makeup food homologous combination extract for inhibiting sebum secretion and application thereof, which comprises the following components: water 2%-55.6%, propylene glycol 10%-30%, Rosa roxburghii fruit extract 5%-12%, Pueraria lobata extract 0.4%-2%, Anemarrhena asphodeloides root extract 0.2%-4%, and malt dextrin 5%-12%, and 1,2-hexanediol 0.01%-1%. The Rosa roxburghii fruit raw material is pretreated, and then extracted by water at 50-60 DEG C, followed by filtration, concentration and drying to obtain the Rosa roxburghii fruit extract. The Pueraria lobata raw material is crushed, and then extracted by heating reflux using 70%-80% ethanol solution, followed by filtration, solvent recovery, concentration and drying to obtain the Pueraria lobata extract. The Anemarrhena asphodeloides root extract, the Pueraria lobata extract and the Rosa roxburghii fruit extract are scientifically compounded to achieve multi-pathway synergistic inhibition of sebum secretion, and the traditional oil control product is broken through to rely on a single idea of inhibiting 5-alpha reductase, so that a more comprehensive and more fundamental oil control effect is achieved.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a cosmetic-food homologous extract that inhibits sebum secretion and its application. Background Technology

[0002] Sebum, secreted by sebaceous glands, is an important substance for maintaining the skin barrier and moisture. However, with the fast pace of modern life, irregular work and rest, unbalanced diet, and environmental stress often lead to endocrine disorders, which in turn cause epidermal microecological dysbiosis. This results in overactive sebaceous glands that secrete excessive sebum. Excessive sebum not only makes the skin appear oily and dull, but also clogs pores, causing a series of skin problems such as enlarged pores, blackheads, pimples, and even acne, seriously affecting consumers' quality of life and social confidence.

[0003] To address the problem of excessive sebum secretion, the mainstream oil-control cosmetics currently available typically focus on inhibiting the activity of 5-α reductase. 5-α reductase is a key enzyme in the human body that converts testosterone into the more potent dihydrotestosterone, which is one of the main hormones that stimulate sebaceous gland secretion. By inhibiting the activity of this enzyme, sebum production can be reduced to some extent.

[0004] However, in-depth research has revealed that the causes of excessive sebum secretion are complex and multi-dimensional, and are not limited to the androgen regulatory pathway. Skin inflammation and oxidative stress caused by external environment (such as ultraviolet radiation) are also key factors inducing sebaceous gland hyperfunction and lipid synthesis. Therefore, relying solely on a single target of inhibiting 5-α reductase, although it can play a certain role in oil control, cannot fundamentally and comprehensively address the problem of oily skin caused by multiple factors such as inflammation and oxidative stress. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a cosmetic-food homologous extract that inhibits sebum secretion and its application, solving the problem that existing oil-control products have a single mechanism and cannot comprehensively address the problem of excessive sebum secretion caused by the synergistic effects of multiple factors such as androgens, inflammation, and oxidative stress.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a cosmetic-food homologous extract for inhibiting sebum secretion, comprising, by weight percentage: Water: 2%-55.6%; Propylene glycol: 10%-30%; Prickly pear fruit extract: 5%-12%; Kudzu root extract: 0.4%-2%; Anemarrhena asphodeloides root extract: 0.2%-4%; Maltodextrin: 5%-12%; 1,2-Hexanediol: 0.01%-1%.

[0007] Preferably, a method for preparing a cosmetic-food homologous extract that inhibits sebum secretion includes the following steps: S1. First, pre-treat the prickly pear fruit raw material by extracting it with water at 50-60℃, followed by filtration, concentration and drying to obtain prickly pear fruit extract. S2. Then, the kudzu root raw material is crushed, and the kudzu root raw material is mixed with process water for extraction. Subsequently, solid-liquid separation, refining, blending and precision filtration are performed to obtain kudzu root extract. S3. Subsequently, the Anemarrhena asphodeloides root raw material is pulverized, and the Anemarrhena asphodeloides root raw material is mixed with process water for extraction. Then, solid-liquid separation, refining, blending and precision filtration are performed to obtain Anemarrhena asphodeloides root extract. S4. Finally, the prickly pear fruit extract, the kudzu root extract, and the anemarrhena root extract are mixed with water, propylene glycol, maltodextrin, and 1,2-hexanediol to obtain the final combined extract.

[0008] Preferably, the pretreatment step of the prickly pear fruit raw material in step S1 includes: taking fresh or freeze-dried prickly pear fruit, washing it, removing the core, and pulping it (if it is dried fruit, crush it directly).

[0009] Preferably, the specific steps for pulverizing the kudzu root raw material in step S2 include: first, taking dried kudzu root medicinal material, washing it, slicing it, drying it, pulverizing it, and passing it through a 40-60 mesh sieve to obtain coarse kudzu root powder.

[0010] Preferably, the specific steps for pulverizing the Anemarrhena asphodeloides root material in step S3 include: first taking dried Anemarrhena asphodeloides root, then washing, slicing, pulverizing, and finally passing it through a 40-60 mesh sieve.

[0011] Preferably, the combined extract is used in cosmetics to inhibit sebum secretion, and the combined extract assists the cosmetics in inhibiting sebum secretion by inhibiting 5-α reductase activity.

[0012] Preferably, the combined extract assists the cosmetic in inhibiting sebum secretion by suppressing the production of inflammatory factors TNF-α and IL-6.

[0013] Preferably, the combined extracts slow down oxidative stress through antioxidant effects, thereby inhibiting lipid cell differentiation and lipid synthesis, and thus assisting the cosmetic in inhibiting sebum secretion.

[0014] Preferably, the amount of the combined extract added is 5% of the total weight of the cosmetic, and the cosmetic, while inhibiting sebum secretion, also has the effects of increasing skin moisture content and reducing transepidermal water loss.

[0015] Preferably, the application of a cosmetic-food homologous extract that inhibits sebum secretion is described. This composition can be applied to various cosmetic formulations, including but not limited to: toners, serums, lotions, creams, masks, foundations, BB creams, sunscreens, color correctors, concealers, or CC creams. In addition to this composition, the product may also contain other active ingredients (such as moisturizing, whitening, repairing, and sun protection) and conventional excipients (such as solvents, skin feel modifiers, preservatives, thickeners, and fragrances).

[0016] This invention provides a cosmetic-food homologous extract that inhibits sebum secretion and its application. It has the following beneficial effects: 1. This invention scientifically combines three "cosmetic and food homologous" ingredients—Anemarrhena asphodeloides root extract, Pueraria lobata root extract, and Rosa rugosa fruit extract—to achieve multi-pathway synergistic inhibition of sebum secretion. This breaks through the traditional oil-control products' single approach of relying solely on inhibiting 5-α reductase. By having Anemarrhena asphodeloides root extract inhibit the androgen pathway (inhibiting 5-α reductase), Pueraria lobata root extract inhibit the inflammatory factor pathway (inhibiting TNF-α and IL-6), and Rosa rugosa fruit extract combat the oxidative stress pathway, these three approaches work together to target the sebaceous glands, achieving a more comprehensive and fundamental oil-control effect.

[0017] 2. This invention selects three recognized "cosmetic and food homologous" raw materials—Anemarrhena asphodeloides root, Pueraria lobata root, and Rosa rugosa fruit—as core active ingredients, ensuring the high safety and gentleness of the combined extract. This meets the current consumer demand for natural, green, and non-irritating cosmetics. Compared with some synthetic chemical oil-controlling agents, the composition of this invention is less irritating and more suitable for long-term use or for people with sensitive skin, and has good market prospects.

[0018] 3. This invention, through the compounding of specific components, achieves efficient oil control while solving the skin dryness and tightness problems often caused by traditional oil-control products. It can effectively replenish and maintain skin moisture while reducing oil, achieving the excellent effect of "oil control without drying".

[0019] 4. Through the synergistic conditioning of its composition, the present invention has a positive effect on improving the skin barrier function. Efficacy test data show that after 14 days of use, the transepidermal water loss (TEWL) of the subjects decreased significantly (change rate from -2.65% to -11.49%), which proves that the combined extract of the present invention helps to improve the health of the skin barrier and enhance the skin's own water-locking ability.

[0020] 5. This invention provides a stable, easy-to-produce and apply combined extract raw material by mixing three core extracts with excipients such as water, propylene glycol, maltodextrin and 1,2-hexanediol in a specific ratio. This raw material has good compatibility and can be easily added to a variety of cosmetic dosage forms, with strong industrial application convenience and wide applicability. Attached Figure Description

[0021] Figure 1 This is one of the schematic diagrams of the preparation process of the present invention; Figure 2 This is a second schematic diagram of the preparation process of the present invention; Figure 3 This is the third schematic diagram of the preparation process of the present invention; Figure 4 This is the fourth schematic diagram of the preparation process of the present invention; Figure 5 This is the fifth schematic diagram of the preparation process of the present invention. Detailed Implementation

[0022] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] Please see the appendix Figure 1 -Appendix Figure 5 This invention provides a cosmetic-food homologous extract that inhibits sebum secretion. By weight percentage, the extract comprises: Water: 2%-55.6%; Propylene glycol: 10%-30%; Prickly pear fruit extract: 5%-12%; Kudzu root extract: 0.4%-2%; Anemarrhena asphodeloides root extract: 0.2%-4%; Maltodextrin: 5%-12%; 1,2-Hexanediol: 0.01%-1%; The combined extract is used in cosmetics to inhibit sebum secretion. The combined extract assists cosmetics in inhibiting sebum secretion by inhibiting 5-α reductase activity, inhibiting the production of TNF-α and IL-6 inflammatory factors, and slowing down oxidative stress through antioxidant effects, thereby inhibiting lipid cell differentiation and lipid synthesis. The preferred amount of the combined extract is 5% of the total weight of the cosmetic. While inhibiting sebum secretion, the cosmetic also has the effects of increasing skin moisture content and reducing transepidermal water loss. Specifically, the extract of Anemarrhena asphodeloides contains saponins and other components that can effectively inhibit the activity of 5-α reductase, thereby reducing the production of DHT and reducing stimulation of sebaceous glands from the upstream of the androgen pathway, thus achieving an oil-controlling effect. The puerarin in the extract of Pueraria lobata has significant anti-inflammatory activity. It can significantly inhibit the production of inflammatory factors such as TNF-α and IL-6 by inhibiting inflammatory signaling pathways such as JNK and IKKβ / NF-κB, thereby cutting off the positive feedback loop of inflammation-oil and reducing sebum secretion caused by inflammation. The extract of Rosa roxburghii fruit (rich in highly active VC and SOD) is a powerful antioxidant that can effectively remove reactive oxygen free radicals in the skin. By reducing the level of oxidative stress, it can effectively slow down the lipid cell differentiation and oil synthesis process caused by this. The composition of this invention uses the above three "cosmetic and food homologous" components to work together from three different dimensions: inhibiting androgen conversion (Anemarrhena asphodeloides root), inhibiting inflammatory pathways (Pueraria lobata root), and resisting oxidative stress (Rosa roxburghii fruit), to synergistically inhibit sebum secretion, with better effects than a single pathway.

[0024] A method for preparing a cosmetic-food homologous extract that inhibits sebum secretion includes the following steps: S1. First, pre-treat the prickly pear fruit raw material by soaking it in water at 50-60℃, followed by filtration, concentration and drying to obtain prickly pear fruit extract. The pre-treatment steps for the prickly pear fruit raw material include: taking fresh or freeze-dried prickly pear fruit, washing it in sequence, removing the pit, and pulping it (if it is dried fruit, crush it directly). Specifically, fresh or freeze-dried prickly pear fruit is first taken and washed to remove surface impurities. Then, the seeds are removed, and the processed pulp (or dried fruit, directly crushed) is pulped to increase the mass transfer area during subsequent extraction. The pre-treated prickly pear pulp is placed in an extraction tank, and 6-10 times its weight of deionized water is added. The mixture is stirred and extracted at 50-60℃ for 1-2 hours. The extract is then filtered to remove fruit residue. The resulting filtrate is then centrifuged at high speed or filtered with diatomaceous earth to obtain a clear supernatant. Finally, the clear filtrate is concentrated at 50-60℃ to obtain a concentrated extract. To facilitate storage and subsequent compounding, the extract is spray-dried or freeze-dried to obtain a powdered prickly pear fruit extract. In this step, a carrier such as maltodextrin can be added to improve flowability and stability.

[0025] S2. Then, the kudzu root raw material is crushed. The kudzu root raw material is mixed with process water for extraction. Then, solid-liquid separation, refining, blending and precision filtration are performed to obtain kudzu root extract. The specific steps for crushing the kudzu root raw material include: first, take the dried kudzu root medicinal material, wash it in sequence, slice it, dry it and crush it, and pass it through a 40-60 mesh sieve to obtain kudzu root coarse powder. S3. Subsequently, the Anemarrhena asphodeloides root raw material is pulverized. The Anemarrhena asphodeloides root raw material is mixed with process water for extraction. Then, solid-liquid separation, refining, blending and precision filtration are performed to obtain Anemarrhena asphodeloides root extract. The specific steps for pulverizing the Anemarrhena asphodeloides root raw material include: first, take dried Anemarrhena asphodeloides root, then wash, slice, pulverize, and finally pass through a 40-60 mesh sieve. Specifically, the extraction steps for kudzu root extract and anemarrhena root extract are the same, as follows: First, take dried kudzu root and anemarrhena root, wash, slice, and dry them. Then, pulverize the dried kudzu root slices and anemarrhena root slices and sieve them to obtain uniform kudzu root powder and anemarrhena root powder to ensure extraction efficiency. Industrial water requires a two-stage reverse osmosis deionization water preparation system for primary treatment of the raw water, followed by double-stage reverse osmosis membrane filtration to remove ions, organic matter, and microorganisms. Then, add the treated anemarrhena root and kudzu root raw materials and a fixed amount of process water to the extraction equipment according to the predetermined process ratio. Extraction is carried out under controlled temperature, time, and stirring conditions to achieve the desired extraction efficiency. The active ingredients are fully dissolved. After extraction, solid-liquid separation is performed by filtration, centrifugation, etc., to remove insoluble impurities and obtain a crude extract containing active ingredients. The crude extract is then refined, including clarification, impurity removal, concentration or decolorization, to further improve the purity and stability of the active ingredients, thereby obtaining a refined liquid that meets the requirements. Subsequently, under environmental conditions that meet the cleanliness requirements, the refined liquid is prepared by adjusting the concentration, pH value and related physicochemical indicators to meet the product design requirements. After passing the relevant testing, it is finally filtered through a precision filtration process to remove tiny particles and potential impurities, thus obtaining a stable, safe and reliable extract of Anemarrhena asphodeloides root and Pueraria lobata root.

[0026] S4. Finally, the prickly pear fruit extract, kudzu root extract, and anemarrhena root extract are mixed with water, propylene glycol, maltodextrin, and 1,2-hexanediol to obtain the final combined extract. Specifically, the prepared prickly pear fruit extract, kudzu root extract, and anemarrhena root extract are mixed with the prescribed amounts of water, propylene glycol, maltodextrin, and 1,2-hexanediol. The roles of each component in this mixture are as follows: Water: as the primary solvent; Propylene glycol: As a solvent, moisturizer, and penetration enhancer, it helps dissolve active ingredients and facilitates skin absorption; Maltodextrin: As a carrier and stabilizer, it can protect active ingredients and improve the physical form of the final product; 1,2-Hexanediol: It acts as a moisturizer and skin feel modifier, and has a mild preservative synergistic effect; By thoroughly stirring and homogenizing, the components are dissolved or dispersed evenly, resulting in a final combined extract.

[0027] Application of a cosmetic-food homologous extract that inhibits sebum secretion. This composition can be applied to various cosmetic formulations, including but not limited to: toners, serums, lotions, creams, masks, foundations, BB creams, sunscreens, color correctors, concealers, or CC creams. In addition to this composition, the product may also contain other active ingredients (such as moisturizing, whitening, repairing, and sun protection) and conventional excipients (such as solvents, skin feel modifiers, preservatives, thickeners, and fragrances).

[0028] To verify the advantages of this invention in targeting multiple key pathways such as reducing facial oil and maintaining skin hydration, a comparative example is prepared to be compared with this embodiment. The comparative example and embodiment are as follows: Example 1: Mix the components in the above scheme and stir until completely dissolved or evenly dispersed to obtain a clear, transparent or slightly turbid homogeneous liquid, which is the preferred combination extract of the present invention; Comparative Example 1: A toner containing 5% of the extract from Example 1 was prepared, with the following formulation (by weight percentage): Combined extract of Example 1: 5% Glycerin: 3% Sodium hyaluronate (1% aqueous solution): 2% Panthenol: 0.5% Phenoxyethanol / Ethylhexylglycerin: 0.8% PEG-40 hydrogenated castor oil: 0.3% Fragrance: 0.05% Deionized water: Replenish to 100% Preparation method: Add each component to deionized water in sequence and stir until dissolved.

[0029] Comparative Example 2: A moisturizing lotion containing 5% of the extract from Example 1 was prepared, with the following formulation (by weight percentage): Combined extract of Example 1: 5% Carbomer: 0.3% Xanthan gum: 0.1% Glycerin: 4% Butylene glycol: 3% Cyclopentadimethylsiloxane: 2% Caprylic / capric triglycerides: 1.5% Triethanolamine: 0.3% Preservative: appropriate amount Deionized water: Replenish to 100% Preparation method: The aqueous phase components (water, glycerol, butylene glycol, etc.) are mixed and heated to disperse the colloids (carbomer, xanthan gum) evenly. The oil phase components (silicone oil, triglycerides) are mixed. Under homogenization conditions, the oil phase is added to the aqueous phase. After cooling to room temperature, the combined extract of Example 1, triethanolamine, and preservative are added, and the mixture is stirred evenly.

[0030] To verify the actual efficacy of the combined extract of the present invention, five subjects who were assessed by dermatologists as having excessive sebum secretion were selected and used the product of Example 2 or Example 3.

[0031] Test method: Subjects used the above product every morning and evening for 14 consecutive days. On day 0 (before use) and day 14 (after use), a professional skin test instrument was used to test the same area of ​​the subject's cheek.

[0032] Test metrics: 1. Skin oil content (oil control effect); 2. Skin stratum corneum moisture content (moisturizing effect) 3. Transdermal water loss (TEWL) (skin barrier function).

[0033] The test results are shown in the table below:

[0034] Table of changes in oil content

[0035] Skin moisture content change table

[0036] Skin Moisture Loss Change Table Test results: Oil content: Compared with day 0, the skin oil content of all 5 subjects decreased significantly on day 14, with a change rate between -20.43% and -60.32%, indicating that the composition of the present invention has excellent oil control effect; Skin hydration: Compared with day 0, the skin hydration of all 5 subjects was significantly increased on day 14, with a change rate between +55.30% and +80.26%, indicating that the composition does not cause dry skin while controlling oil, but has a good moisturizing effect. Skin moisture loss: Compared with day 0, the TEWL values ​​of all 5 subjects decreased significantly on day 14, with a change rate between -2.65% and -11.49%, indicating that the composition helps improve skin barrier function and enhance water retention capacity.

[0037] In summary, this invention provides a cosmetic-food homologous extract for inhibiting sebum secretion and its application. By scientifically combining three "cosmetic-food homologous" ingredients—Anemarrhena asphodeloides root extract, Pueraria lobata root extract, and Rosa rugosa fruit extract—it achieves multi-pathway synergistic inhibition of sebum secretion. This breaks through the traditional oil-control products' single approach of relying solely on inhibiting 5-α reductase, achieving a more comprehensive and fundamental oil-control effect. While inhibiting sebum secretion, it can also increase skin hydration and reduce transepidermal water loss, synergistically improving skin health.

[0038] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A cosmetic-food homologous extract that inhibits sebum secretion, characterized in that, By weight percentage, its combined extracts include: Water: 2%-55.6%; Propylene glycol: 10%-30%; Prickly pear fruit extract: 5%-12%; Kudzu root extract: 0.4%-2%; Anemarrhena asphodeloides root extract: 0.2%-4%; Maltodextrin: 5%-12%; 1,2-Hexanediol: 0.01%-1%.

2. A method for preparing a cosmetic-food homologous extract that inhibits sebum secretion, characterized in that, A cosmetic-food homologous extract for inhibiting sebum secretion according to claim 1 comprises the following steps: S1. First, pre-treat the prickly pear fruit raw material by extracting it with water at 50-60℃, followed by filtration, concentration and drying to obtain prickly pear fruit extract. S2. Then, the kudzu root raw material is crushed, and the kudzu root raw material is mixed with process water for extraction. Subsequently, solid-liquid separation, refining, blending and precision filtration are performed to obtain kudzu root extract. S3. Subsequently, the Anemarrhena asphodeloides root raw material is pulverized, and the Anemarrhena asphodeloides root raw material is mixed with process water for extraction. Then, solid-liquid separation, refining, blending and precision filtration are performed to obtain Anemarrhena asphodeloides root extract. S4. Finally, the prickly pear fruit extract, the kudzu root extract, and the anemarrhena root extract are mixed with water, propylene glycol, maltodextrin, and 1,2-hexanediol to obtain the final combined extract.

3. The method for preparing a cosmetic-food homologous extract for inhibiting sebum secretion according to claim 2, characterized in that, The pretreatment steps for the prickly pear fruit raw materials described in step S1 include: taking fresh or freeze-dried prickly pear fruit, washing it, removing the core, and pulping it (if it is dried fruit, crush it directly).

4. The method for preparing a cosmetic-food homologous extract for inhibiting sebum secretion according to claim 2, characterized in that, The specific steps for pulverizing kudzu root raw materials in step S2 include: first, taking dried kudzu root medicinal materials, washing them, slicing them, drying them, pulverizing them, and passing them through a 40-60 mesh sieve to obtain coarse kudzu root powder.

5. The method for preparing a cosmetic-food homologous extract for inhibiting sebum secretion according to claim 2, characterized in that, The specific steps for pulverizing Anemarrhena asphodeloides root material in step S3 include: first, taking dried Anemarrhena asphodeloides root, then washing, slicing, pulverizing, and finally passing it through a 40-60 mesh sieve.

6. The cosmetic-food homologous extract for inhibiting sebum secretion according to claim 1, characterized in that, The combined extract is used in cosmetics to inhibit sebum secretion in the skin. The combined extract assists the cosmetics in inhibiting sebum secretion by inhibiting 5-α reductase activity.

7. The cosmetic-food homologous extract for inhibiting sebum secretion according to claim 6, characterized in that, The combined extract assists the cosmetic in inhibiting sebum secretion by suppressing the production of TNF-α and IL-6 inflammatory factors.

8. The cosmetic-food homologous extract for inhibiting sebum secretion according to claim 6, characterized in that, The combined extracts slow down oxidative stress through antioxidant effects, thereby inhibiting lipid cell differentiation and lipid synthesis, and thus assisting the cosmetic in inhibiting sebum secretion.

9. The cosmetic-food homologous extract for inhibiting sebum secretion according to claim 1, characterized in that, The preferred amount of the combined extract is 5% of the total weight of the cosmetic. The cosmetic, while inhibiting sebum secretion, also has the effects of increasing skin hydration and reducing transepidermal water loss.

10. The application of a cosmetic-food homologous extract that inhibits sebum secretion, characterized in that, According to claim 1, a cosmetic-food homologous extract that inhibits sebum secretion can be applied to various cosmetic formulations, including but not limited to: toners, serums, lotions, creams, masks, foundations, BB creams, sunscreens, color correctors, concealers, or CC creams. In addition to the composition, the product may also contain other active ingredients (such as moisturizing, whitening, repairing, and sun protection) and conventional excipients (such as solvents, skin feel modifiers, preservatives, thickeners, and fragrances).

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