A soothing repair composition and method of making the same

Abstract

This invention discloses a soothing and repairing composition and its preparation method, relating to the field of topical skin preparation technology. The composition comprises: 0.1-5% of a cell stress protectant selected from at least one of tetrahydromethylpyrimidine carboxylic acid, trehalose, and betaine; 0.01-2% of an instant soothing agent selected from at least one of saccharide isomers, acetyl dipeptide-1 cetyl ester, and erythritol; 0.5-10% of a biomimetic stratum corneum lipid comprising ceramide or analogues, cholesterol, and free fatty acids, wherein the molar ratio of the three is (1-5):(1-3):(0.5-2); 1-8% of a skin barrier repair agent selected from at least one of panthenol, nicotinamide, and biosaccharide gum-1; 0.05-3% of a plant anti-inflammatory complex encapsulated by a carrier system, the complex comprising a specific proportion of a first plant extract and a second active ingredient; the remainder being a carrier. This invention achieves both immediate soothing and long-lasting barrier repair through the synergistic effect of multiple components.

Description

Technical Field

[0001] This application relates to the field of topical skin preparations, and more particularly to a soothing and repairing composition and its preparation method. Background Technology

[0002] The skin is an important physical and immune barrier for the human body, and its health directly depends on the integrity of the stratum corneum structure. When the skin barrier is damaged, it leads to increased transepidermal water loss and makes it easier for external irritants and pathogens to invade, thus causing or exacerbating a series of problems such as dryness, redness, burning, stinging, and sensitivity. Repairing the skin barrier and relieving sensitivity symptoms are key areas of ongoing focus in the cosmetics and topical formulation industry.

[0003] Currently, most soothing and repairing products on the market follow several approaches: first, supplementing lipid components, such as adding ceramides or cholesterol alone, to fill the lipid gaps between cells; second, using anti-inflammatory ingredients, such as directly adding dipotassium glycyrrhizate or bisabolol, to reduce inflammatory responses; and third, providing cooling agents, such as alcohol or menthol, for temporary sensory relief. However, skin barrier repair is a systematic process, and relying on a single or few pathways is unlikely to achieve fundamental and lasting improvement. Secondly, regarding lipid supplementation, simply adding a single lipid or randomly mixing multiple lipids cannot accurately simulate the optimal molar ratio between ceramides, cholesterol, and free fatty acids in the stratum corneum of healthy skin, resulting in low repair efficiency and difficulty in rebuilding the dense and orderly lipid layered structure. Furthermore, many plant-based active ingredients with clear anti-inflammatory effects (such as baicalin and some flavonoids) suffer from poor water or lipid solubility, chemical instability, and low transdermal absorption, greatly limiting their ultimate bioavailability and actual efficacy. Summary of the Invention

[0004] This application provides a soothing and repairing composition to improve the above-mentioned problems.

[0005] To achieve the above objectives, this application adopts the following technical solution: In a first aspect, this application provides a soothing and repairing composition comprising, by weight percentage: 0.1-5% of a cell stress protectant, selected from at least one of tetrahydromethylpyrimidine carboxylic acid, trehalose, and betaine; 0.01-2% of an instant soothing agent, selected from at least one of carbohydrate isomers, acetyl dipeptide-1 cetyl ester, and erythritol; 0.5-10% biomimetic stratum corneum lipids, which contain ceramides or ceramide analogs, cholesterol, and free fatty acids in a molar ratio of (1-5):(1-3):(0.5-2). 1-8% of a skin barrier repair agent, selected from at least one of panthenol, niacinamide, and biosaccharide gum-1; 0.05-3% of a plant anti-inflammatory complex encapsulated by a carrier system, the plant anti-inflammatory complex comprising a first plant extract and a second active ingredient, wherein the first plant extract is selected from one of Citrus aurantium extract, Centella asiatica extract, and Glycyrrhiza uralensis extract, and the second active ingredient is selected from one of baicalin, dipotassium glycyrrhizate, and bisabolol, and the weight ratio of the first plant extract to the second active ingredient is 1:(0.2-3); The remainder is a pharmaceutically or cosmetically acceptable carrier.

[0006] In conjunction with the first aspect, optionally, the ceramide or ceramide analogue is selected from at least two of ceramide AP, ceramide EOP, ceramide NP, ceramide NS, and phytoceramide; the free fatty acid is selected from at least one of oleic acid, linoleic acid, and linolenic acid.

[0007] In conjunction with the first aspect, optionally, the carrier system is a liposome, nanoemulsion, or polymer micelle. When the carrier system is a liposome, its wall material contains hydrogenated lecithin and cholesterol, with an average particle size of 50-300 nm.

[0008] In conjunction with the first aspect, the composition may optionally further include a neurosensory modulator comprising 0.001-0.5% by weight of the total composition, said neurosensory modulator being selected from at least one of kava extract, menthol lactate, and acetyl tetrapeptide-15.

[0009] In conjunction with the first aspect, the composition may optionally further include an anti-inflammatory agent comprising 0.01-1% of the total weight of the composition, wherein the anti-inflammatory agent is selected from at least one of bisabolol, α-bisabolol, and asiaticoside.

[0010] In conjunction with the first aspect, optionally, the pharmaceutically or cosmetically acceptable carrier includes an aqueous phase and an oil phase, the oil phase comprising an emollient selected from at least two of squalane, squalene, caprylic / capric triglyceride, isononyl isononanoate, and bis-diglyceride polyacryl adipate-2.

[0011] In conjunction with the first aspect, optionally, the composition further comprises a skin microecological regulator selected from at least one of α-glucan oligosaccharides, inulin, and lactobacillus fermentation products, wherein the content is 0.001-0.5% of the total weight of the composition.

[0012] A second aspect of the present invention provides a topical preparation in the form of a serum, lotion, cream or gel, comprising a soothing and repairing composition as described in any of the first aspects.

[0013] Optionally, in conjunction with the second aspect, the topical preparation has a pH value of 5.0-6.5 and a viscosity of 1000-50000 mPa·s (25°C).

[0014] A third aspect of this invention provides a method for preparing a soothing and repairing composition as described in any of the first aspects, comprising: Based on the type of the selected carrier, prepare liposome, nanoemulsion, or polymer micelle dispersions containing the plant anti-inflammatory complex; A biomimetic stratum corneum lipid, a skin barrier repair agent, and an oil phase component are provided, and the biomimetic stratum corneum lipid, the skin barrier repair agent, and the oil phase component are stirred and dissolved evenly at 65-80°C. A cell stress protectant and a transient soothing agent are provided, and the cell stress protectant and the transient soothing agent are dissolved in water to obtain an aqueous phase, and stirred and dissolved evenly at 65-80°C; The oil phase and the aqueous phase are mixed and homogenized and emulsified to form a primary emulsion; The primary emulsion is cooled to 40-50°C, and the liposomes, nanoemulsions, or polymer micelle dispersions containing the plant anti-inflammatory complex are added and stirred until homogeneous. Adjust pH and viscosity.

[0015] In summary, the above composition has the following technical effects: The composition of this invention simultaneously covers multiple repair pathways, including cell protection, immediate soothing, biomimetic barrier repair, active repair promotion, and highly effective anti-inflammatory effects. The components work synergistically to comprehensively intervene in the root causes and manifestations of skin sensitivity problems, resulting in better effects than products with single or few mechanisms.

[0016] Utilizing a specific molar ratio of biomimetic stratum corneum lipids, this method repairs the skin's physical barrier more precisely and efficiently than arbitrarily adding ceramides or lipid mixtures. Encapsulating plant-based anti-inflammatory complexes via a carrier system solves the challenges of active ingredient stability and transdermal absorption, significantly enhancing its bioavailability and ultimate efficacy.

[0017] The wide range of ingredients available across functional categories provides flexibility for formulation development. Furthermore, stepwise preparation and control of specific process parameters ensure the good physical and chemical stability of compositions containing complex systems such as thermosensitive active ingredients and liposomes. Detailed Implementation

[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be purchased from the market or prepared by existing methods.

[0020] This application discloses a soothing and repairing composition comprising, by weight percentage: 0.1-5% of a cell stress protectant, selected from at least one of tetrahydromethylpyrimidine carboxylic acid, trehalose, and betaine.

[0021] Understandably, cellular stress protectants target upstream factors that cause skin barrier damage. Environmental stressors such as UV radiation, pollution, and dryness can trigger stress responses in skin cells, damaging proteins and cellular function. The selected tetrahydromethylpyrimidine carboxylic acid (ectoin), trehalose, and betaine are all potent osmotically modulating and compatible solutes or moisturizing factors that can stabilize cell membranes and enzyme proteins, thereby enhancing the skin's own resilience and health at the cellular level.

[0022] Furthermore, it also includes: 0.01-2% of an instant soothing agent, selected from at least one of saccharide isomers, acetyl dipeptide-1 cetyl ester, and erythritol. Understandably, when skin is sensitive, nerve endings are activated, producing a burning or stinging sensation. Saccharide isomers (such as Xinfuyi) and acetyl dipeptide-1 cetyl ester can act on specific sensory receptors in the skin (such as TRPV1) to quickly soothe overactive nerve signals, significantly reducing discomfort within minutes to tens of minutes, improving the user experience, and breaking the vicious cycle of sensitivity and discomfort.

[0023] Furthermore, it also includes: The biomimetic stratum corneum lipids comprise 0.5-10% of ceramides or ceramide analogs, cholesterol, and free fatty acids in a molar ratio of (1-5):(1-3):(0.5-2). Understandably, a healthy skin barrier relies on the ordered structure of the intercellular lipid bilayer, primarily composed of ceramides (approximately 50%), cholesterol (approximately 25%), and free fatty acids (approximately 15%) in a specific ratio. This application does not arbitrarily add a single ceramide or lipid mixture, but precisely simulates the optimal molar ratio range of natural lipids ((1-5):(1-3):(0.5-2)). When these three lipids coexist in this ratio, they can self-assemble to form the densest and most stable laminar liquid crystal structure, thereby most efficiently repairing the damaged lipid barrier and restoring its water-locking and protective functions.

[0024] Optionally, in some embodiments, the ceramide or ceramide analogue is selected from at least two of ceramide AP, ceramide EOP, ceramide NP, ceramide NS, and phytoceramide; the free fatty acid is selected from at least one of oleic acid, linoleic acid, and linolenic acid.

[0025] Understandably, by selecting at least two of the following ceramides—AP, EOP, NP, NS, and phytoceramides—and combining them with specific unsaturated fatty acids such as oleic acid and linoleic acid, the diversity and structure of natural skin lipids can be more accurately simulated. The complementarity of different ceramide isoforms in their polar head groups and carbon chain structures, combined with the synergy of the selected free fatty acids in terms of fluidity and stereoconfiguration, jointly promotes the self-assembly of the lipid mixture at a set molar ratio, forming a denser, more stable, and highly similar layered liquid crystal structure to healthy skin. This not only significantly enhances the efficiency and integrity of repairing the skin's physical barrier and improves long-lasting water retention, but the optimized lipid composition also helps promote the penetration and delivery of other active ingredients, thereby synergistically strengthening the overall soothing and repairing efficacy of the composition at multiple levels.

[0026] Furthermore, it also includes: 1-8% of a skin barrier repair agent, selected from at least one of panthenol, niacinamide, and biosaccharide gum-1. Understandably, panthenol (a precursor to vitamin B5) can penetrate deep into the skin and be converted into coenzyme A, promoting lipid synthesis; niacinamide can increase the synthesis of barrier lipids such as ceramides; and biosaccharide gum-1 has excellent moisturizing and cell-protective effects. These components provide nutrition to repairing skin cells and, synergistically with the supplemented biomimetic lipids, achieve a combination of exogenous supplementation and endogenous promotion.

[0027] Furthermore, it also includes: 0.05-3% of a plant anti-inflammatory complex encapsulated by a carrier system, the plant anti-inflammatory complex comprising a first plant extract and a second active ingredient, wherein the first plant extract is selected from one of Citrus aurantium extract, Centella asiatica extract, and Glycyrrhiza uralensis extract, and the second active ingredient is selected from one of baicalin, dipotassium glycyrrhizate, and bisabolol, and the weight ratio of the first plant extract to the second active ingredient is 1:(0.2-3).

[0028] Understandably, inflammation is a key factor in the persistence and exacerbation of problems after the skin barrier is damaged. Optimizing the ratio (1:0.2-3) can leverage the synergistic effect of ingredients like Citrus aurantium and baicalin. More importantly, liposomes and nanoemulsions are used for encapsulation. This avoids the technical challenges commonly encountered with plant extracts and active ingredients, such as baicalin, such as poor stability, low water or lipid solubility, and low transdermal absorption. Understandably, the carrier protects the active ingredient from degradation during storage and promotes its penetration through the stratum corneum during use, delivering it directly to the site of action, thereby significantly improving bioavailability and ultimate efficacy.

[0029] Optionally, the carrier system is a liposome, nanoemulsion, or polymer micelle; when the carrier system is a liposome, its wall material contains hydrogenated lecithin and cholesterol, with an average particle size of 50-300 nm.

[0030] Understandably, liposomes composed of hydrogenated lecithin and cholesterol are used, with their average particle size precisely controlled within the range of 50-300 nm. This carrier system effectively encapsulates the diverse water- and lipid-soluble plant active ingredients, solving the challenges of compatibility and stability. Secondly, the specific combination of hydrogenated lecithin and cholesterol forms a highly stable and biocompatible bilayer membrane, ensuring the integrity and sustained-release properties of the active ingredients during storage and use. Most importantly, the 50-300 nm particle size range provides optimal skin permeability, effectively penetrating the stratum corneum barrier and forming a reservoir in the deep epidermis for sustained action. This significantly enhances the bioavailability of the plant-based anti-inflammatory complex, ultimately strengthening the overall efficacy of the composition in anti-inflammatory, soothing, and repairing aspects.

[0031] The remainder is a pharmaceutically or cosmetically acceptable carrier. Understandably, the carrier provides a stable and safe matrix for the aforementioned active modules and ensures the product's usability and user experience by adjusting the dosage form, viscosity, and skin feel.

[0032] Optionally, in some embodiments, the composition further includes 0.001-0.5% by weight of a neurosensory modulator, wherein the neurosensory modulator is selected from at least one of kava extract, menthol lactate, and acetyl tetrapeptide-15.

[0033] Understandably, by introducing neurosensory modulators selected from kava extract, menthol lactate, or acetyl tetrapeptide-15 at 0.001-0.5% of the total weight of the composition, the soothing mechanism of the composition is expanded and deepened at the level of nerve signal transduction. These ingredients can target sensory neuron receptors in the skin, gently regulating neuronal excitability and the release of inflammatory mediators, thereby providing a deeper and more lasting layer of neurosensory soothing in addition to the rapid calming effect provided by cellular stress protection and instant soothing agents. Their trace addition can synergize with the barrier repair and anti-inflammatory modules in the composition, jointly blocking the vicious cycle of barrier damage-nerve ending sensitivity-intensified inflammation, significantly reducing the intensity and frequency of discomfort such as burning, stinging, and itching from the root of perception, achieving a complete pathway from skin physiological repair to neurosensory regulation.

[0034] Optionally, in some embodiments, the composition further includes 0.01-1% by weight of an anti-inflammatory agent selected from at least one of bisabolol, α-bisabolol, and asiaticoside.

[0035] Understandably, by introducing an additional 0.01-1% by weight of an anti-inflammatory agent selected from bisabolol, α-bisabolol, or asiaticoside, a multi-level, multi-target synergistic anti-inflammatory network is formed with the plant anti-inflammatory complex encapsulated by a carrier system in the core component. These supplementary anti-inflammatory agents have well-defined and complementary mechanisms of action; for example, bisabolol and α-bisabolol effectively inhibit the release of pro-inflammatory factors (such as IL-1α and IL-6), while asiaticoside promotes collagen synthesis and repair. Their synergistic effect with the targeted delivery of the plant anti-inflammatory complex achieves broader coverage and stronger inhibition of inflammatory pathways, thereby rapidly relieving visible redness and swelling and enhancing the skin's tolerance to external stimuli.

[0036] Optionally, in some embodiments, the pharmaceutically or cosmetically acceptable carrier comprises an aqueous phase and an oil phase, the oil phase containing an emollient selected from at least two of squalane, squalene, caprylic / capric triglyceride, isononyl isononanoate, and bis-diglyceride polyacryladiate-2.

[0037] Understandably, by limiting the oil-phase emollients to at least two selected from squalane, squalene, caprylic / capric triglyceride, isononyl isononanoate, and bis-diglyceride polyacryladiate-2, the performance of the formulation's base carrier is optimized. This selection not only provides excellent spreadability and a refreshing or moisturizing feel to meet the needs of different dosage forms, but the selected emollients also exhibit excellent skin compatibility and low irritation. They are well-compatible with and synergistically work with the core functional ingredients, especially the biomimetic stratum corneum lipids, to jointly construct a stable and homogeneous lipid environment, thereby ensuring the stable presence of the active ingredients in the formulation.

[0038] Optionally, in some embodiments, the composition further comprises a skin microecological regulator selected from at least one of α-glucan oligosaccharides, inulin, and lactobacillus fermentation products, and the content of the skin microecological regulator is 0.001-0.5% of the total weight of the composition.

[0039] Understandably, by introducing skin microecological regulators, such as α-glucan oligosaccharides, inulin, or lactobacillus fermentation products, at a weight of 0.001-0.5% of the total composition, the repair dimension is further expanded from the physical barrier and immune inflammation levels to maintaining the balance of the skin's surface microbial barrier. These ingredients, acting as prebiotics or post-biotics, selectively nourish beneficial skin flora and inhibit the excessive proliferation of potentially harmful bacteria, thereby helping to restore a healthy skin microecology. This effect has a profound synergistic effect with the core physical barrier repair and anti-inflammatory modules of the composition. A balanced microenvironment can not only directly reduce chronic low-grade inflammation caused by dysbiosis but also indirectly strengthen the function of keratinocytes, promoting the restoration of barrier homeostasis. This, in turn, consolidates and enhances the overall formula's long-lasting soothing, anti-allergic, and self-repairing capabilities at a more fundamental ecological level.

[0040] Based on the same inventive concept, this application also proposes a topical preparation in the form of an essence, lotion, cream or gel, comprising the soothing and repairing composition described above.

[0041] Optionally, the topical preparation has a pH value of 5.0-6.5 and a viscosity of 1000-50000 mPa·s (25°C).

[0042] Based on the type of the selected carrier, prepare liposome, nanoemulsion, or polymer micelle dispersions containing the plant anti-inflammatory complex; A biomimetic stratum corneum lipid, a skin barrier repair agent, and an oil phase component are provided, and the biomimetic stratum corneum lipid, the skin barrier repair agent, and the oil phase component are stirred and dissolved evenly at 65-80°C. A cell stress protectant and a transient soothing agent are provided, and the cell stress protectant and the transient soothing agent are dissolved in water to obtain an aqueous phase, and stirred and dissolved evenly at 65-80°C; The oil phase and the aqueous phase are mixed and homogenized and emulsified to form a primary emulsion; The primary emulsion is cooled to 40-50°C, and the liposomes, nanoemulsions, or polymer micelle dispersions containing the plant anti-inflammatory complex are added and stirred until homogeneous. Adjust pH and viscosity.

[0043] The present invention will be further illustrated below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Experimental methods in the following embodiments, unless otherwise specified, are generally determined according to national standards. If no corresponding national standard exists, then common international standards, conventional conditions, or conditions recommended by the manufacturer are followed. The present invention is described in detail below through multiple embodiments, but the scope of protection of the present invention is not limited thereto. Unless otherwise specified, all amounts in the embodiments are weight percentages (wt%), and all raw materials used are commercially available cosmetic or pharmaceutical grade products.

[0044] Example 1 This application provides a soothing and repairing composition comprising the following components: Tetrahydromethylpyrimidine carboxylic acid 2.0%, carbohydrate isomers 0.8%, biomimetic stratum corneum lipid mixture 4.0% (of which, the molar ratio of ceramide NP:ceramide EOP:cholesterol:linoleic acid = 2:1:1.5:1), panthenol 5.0%, liposome-encapsulated Citrus aurantium extract / baicalin complex (Citrus aurantium:baicalin = 1:1) 1.5% (based on the dry weight of the complex, the average particle size of the liposomes is approximately 150 nm, and the wall material is hydrogenated lecithin:cholesterol = 5:1), bisabolol 0.3%, peppermint extract 0.05%, α-glucan oligosaccharide 0.05%, glycerol 5.0%, bis-diglyceride polyacryladiate-23.0%, caprylic / capric triglyceride 4.0%. Hydrogenated lecithin (also used as an emulsifier) ​​1.5%, xanthan gum 0.1%, preservative (phenoxyethanol / ethylhexylglycerin) 0.8%. Add deionized water to 100%.

[0045] The preparation method is as follows: Hydrogenated lecithin and cholesterol were dissolved in ethanol and rotary evaporated to form a membrane. Citrus aurantium extract and baicalin were dissolved in PBS buffer, the lipid membrane was hydrated, and the membrane was obtained by sonication and extrusion to obtain a liposome dispersion with a particle size of approximately 150 nm.

[0046] A mixture of biomimetic stratum corneum lipids, panthenol, bisabolol, bis-diglyceride polyacryladiate-2, caprylic / capric triglyceride, and hydrogenated lecithin as an emulsifier was mixed, heated to 75°C, and stirred to dissolve.

[0047] Tetrahydromethylpyrimidine carboxylic acid, sugar isomers, glycerol, and α-glucan oligosaccharides were dissolved in deionized water, heated to 75°C, and stirred until dissolved.

[0048] Under high-speed shearing (3000 rpm), the oil phase is slowly added to the aqueous phase, and shearing is continued for 15 minutes to obtain a primary emulsion.

[0049] Cool the primary emulsion to 45°C, then slowly add the liposome dispersion from step 1, kava extract, and pre-dispersed xanthan gum slurry, stirring until homogeneous. Cool to 35°C, adjust the pH to 5.8 with citric acid solution, add water to the total volume, stir until homogeneous, and discharge. The resulting essence is a slightly milky white liquid with a pH of 5.8 and a viscosity of approximately 3500 mPa·s (25°C).

[0050] Example 2 This application provides a soothing and repairing composition comprising the following components: Trehalose 3.0%, Acetyl dipeptide-1 cetyl ester 0.15%, Biomimetic stratum corneum lipid mixture 1.8% (plant ceramide:ceramide AP:cholesterol:oleic acid:linolenic acid molar ratio = 1:0.5:1.2:0.5:0.3), Niacinamide 2.0%, Biosaccharide gum-1 1.0%, Nanoemulsion-encapsulated Centella asiatica extract / hydroxyasiaticoside complex (Centella asiatica:hydroxyasiaticoside = 1:0.3) 0.8%, α-bisabolol 0.2%, Acetyl tetrapeptide-15 0.01%, Inulin 0.1%, Squalane 3.0%, Isononyl isononanoate 7.0%, Caprylic / Capric triglyceride 3.0%, Emulsifier (Cetearyl glucoside / Cetearyl alcohol) 2.5%, Carbomer 0.15%, 1,2-Pentanediol 1.5%, Deionized water to 100%.

[0051] The preparation method is as follows: Using a high-pressure homogenization method, Centella asiatica extract, asiaticoside, medium-chain triglycerides and emulsifiers were mixed and injected into the aqueous phase under high-speed shearing. The mixture was then processed by a high-pressure homogenizer to form nanoemulsions with a particle size of approximately 80 nm.

[0052] The biomimetic stratum corneum lipid mixture, α-bisabolol, squalane, isononyl isononanoate, caprylic / capric triglyceride and emulsifier are mixed and heated to 70°C to dissolve evenly.

[0053] Dissolve trehalose, acetyl dipeptide-1 cetyl ester, nicotinamide, biosaccharide gum-1, inulin, and 1,2-pentanediol in deionized water, heat to 70°C, and uniformly disperse carbomer in the solution.

[0054] Add the oil phase to the aqueous phase and homogenize and emulsify for 5 minutes to obtain an emulsion.

[0055] Cool to 40°C, add nanoemulsion and acetyl tetrapeptide-15, and stir until homogeneous. Neutralize to pH 6.0 with triethanolamine, homogenize, and then discharge.

[0056] The resulting emulsion was white and milky, with a pH of 6.0 and a viscosity of approximately 12,000 mPa·s (25°C).

[0057] Example 3 This application provides a soothing and repairing composition comprising the following components: Betaine 1.5%, erythritol 2.0%, biomimetic stratum corneum lipid mixture 6.0% (ceramide NS:ceramide EOP:cholesterol:linoleic acid:oleic acid molar ratio = 1.5:1:2.5:0.8:0.7), panthenol 4.0%, nicotinamide 1.0%, licorice extract / bibasil complex encapsulated in polymer micelles (licorice:bibasil = 1:2) 2.2%, bisabolol 0.4%, menthol lactate 0.08%, Lactobacillus fermentation product 0.2%, squalene 2.0%, caprylic / capric triglyceride 12.0%, isononyl isononanoate 5.0%, emulsified wax 4.5%, cetearyl alcohol 1.0%, acrylate / C10-30 alkanol acrylate crosspolymer 0.2%, preservative 0.7%, deionized water to 100%.

[0058] The preparation method is as follows: Using dialysis, licorice extract, bisabolol, and polycaprolactone-polyethylene glycol block copolymer were dissolved in acetone, placed in a dialysis bag, and dialyzed in deionized water to replace the solvent, thus obtaining a micelle dispersion.

[0059] The biomimetic stratum corneum lipid mixture, bisabolol, menthol lactate, squalene, caprylic / capric triglyceride, isononyl isononanoate, emulsified wax, and cetearyl alcohol are mixed, heated to 80°C, melted, and stirred evenly.

[0060] Betaine, erythritol, panthenol, and nicotinamide are dissolved in deionized water, heated to 80°C, and then a pre-dispersed acrylic polymer is added.

[0061] Add the aqueous phase to the oil phase and emulsify at high speed using a homogenizer for 10 minutes to obtain a paste.

[0062] Stir and cool to 45°C, then add the polymer micelle dispersion and lactobacillus fermentation product sequentially, stirring until homogeneous. Continue cooling to 30°C, adjust the pH to 6.2 with sodium hydroxide solution, and discharge. The resulting cream has a smooth, creamy texture, pH 6.2, viscosity of approximately 45000 mPa·s (25°C), and a strong moisturizing effect.

[0063] Example 4 This application provides a soothing and repairing composition comprising the following components: Tetrahydromethylpyrimidine carboxylic acid 1.0%, trehalose 2.0%, saccharide isomers 0.5%, biomimetic stratum corneum lipid vesicles 1.0% (ceramide AP:ceramide NP:cholesterol:linolenic acid molar ratio = 1:1:1.2:0.6, pre-formed into nanovesicles), panthenol 3.0%, liposome-encapsulated Centella asiatica extract / dipotassium glycyrrhizate complex (Centella asiatica:dipotassium glycyrrhizate = 1:0.5) 0.6% (average particle size 200nm), asiaticoside 0.5%, carbomer 0.8%, glycerol 5.0%, pentylene glycol 2.0%, sodium hydroxide as needed (for neutralization), deionized water to 100%.

[0064] The preparation method is as follows: Liposome-encapsulated complexes (using the same method as in Example 1) and biomimetic stratum corneum lipid nanovesicles (using the thin film hydration-extrusion method) were prepared separately.

[0065] Carbomer was uniformly dispersed in a portion of deionized water and allowed to swell overnight to obtain a gel matrix.

[0066] Tetrahydromethylpyrimidine carboxylic acid, trehalose, sugar isomers, panthenol, asiaticoside, glycerol, and pentylene glycol were dissolved in the remaining water to obtain an aqueous solution of the active ingredient.

[0067] The aqueous solution of the active ingredient was slowly added to the carbomer gel matrix under low-speed stirring.

[0068] Neutralize to pH 5.5 with sodium hydroxide solution to form a transparent gel.

[0069] Finally, under gentle stirring, the liposome-encapsulated complex and biomimetic stratum corneum lipid nanovesicles were added and stirred until homogeneous. The resulting product was a transparent or translucent gel, refreshing and non-sticky, with a pH of 5.5 and a viscosity of approximately 18,000 mPa·s (25°C).

[0070] Example 5 This application provides a soothing and repairing composition comprising the following components: Tetrahydromethylpyrimidine carboxylic acid 0.5%, erythritol 1.0%, biomimetic stratum corneum lipid mixture 2.5% (ceramide NP:cholesterol:oleic acid molar ratio = 3:2:1), panthenol 2.0%, nanoemulsion-encapsulated Citrus aurantium extract / baicalin complex (Citrus aurantium:baicalin = 1:0.8) 0.8%, squalane 2.0%, caprylic / capric triglyceride 8.0%, emulsifier 1.8%, preservative 0.6%, deionized water to 100%.

[0071] The preparation method is as follows: Referring to the nanoemulsion and emulsification process of Example 2, the post-processing steps are simplified, and no neurosensory modulators, additional anti-inflammatory agents, or microecological regulators are added. This example demonstrates a simplified formulation without optional components that still provides basic barrier repair and soothing effects.

[0072] Comparative Example 1 However, the plant anti-inflammatory complex (Citrus aurantium extract and baicalin) was added directly to the aqueous phase without being encapsulated in liposomes.

[0073] Comparative Example 2 The formulation is basically the same as in Example 1, except that the biomimetic stratum corneum lipids are replaced with equal amounts of the same type of ceramides, cholesterol and free fatty acids mixed in a random ratio (molar ratio of approximately 1:1:1).

[0074] Table 1: Weight percentage (wt%) of each raw material in the examples

[0075] Table 2: Weight percentage (wt%) of each raw material in the comparative example

[0076] Table 1 presents formulation examples (serums, lotions, creams, gels, and basic versions) with different focuses within the scope of this invention, demonstrating the flexibility in component selection and dosage range. Table 2 focuses on the core comparison with Example 1, presenting the key differences between Comparative Example 1 (lacking carrier encapsulation) and Comparative Example 2 (lacking a specific lipid ratio), providing a clear formulation basis for understanding the aforementioned comparative experimental data.

[0077] Table 3: Performance Test Data of Examples and Comparative Samples

[0078] It can be seen that Comparative Example 1 (unencapsulated) is significantly inferior to Example 1 in terms of active ingredient stability (content retention rate of only 65%) and in vitro transdermal efficacy (low transdermal amount, IL-6 inhibition rate of only 30%), which proves the necessity of carrier encapsulation for ensuring the final biological efficacy of plant anti-inflammatory complex.

[0079] Comparative Example 2 (random lipid ratio) showed significantly lower performance than the examples using a specific molar ratio of lipids in both the core in vitro barrier repair (TEWL recovery rate of only 62%) and human barrier improvement (TEWL decline rate of only 14.5%), indicating that this specific ratio is a non-obvious technical feature for achieving efficient barrier repair.

[0080] This invention discloses a soothing and repairing composition and its preparation method. The composition, by weight percentage, comprises: 0.1-5% of a cell stress protectant selected from at least one of tetrahydromethylpyrimidine carboxylic acid, trehalose, and betaine; 0.01-2% of an instant soothing agent selected from at least one of saccharide isomers, acetyl dipeptide-1 cetyl ester, and erythritol; 0.5-10% of biomimetic stratum corneum lipids, comprising ceramides or analogues, cholesterol, and free fatty acids, with a molar ratio of (1-5):(1-3):(0.5-2); 1-8% of a skin barrier repair agent selected from at least one of panthenol, niacinamide, and biosaccharide gum-1; 0.05-3% of a plant anti-inflammatory complex encapsulated by a carrier system, the complex comprising a specific proportion of a first plant extract and a second active ingredient; the remainder being a carrier. This invention achieves integrated repair across the entire pathway, from immediate relief to long-lasting barrier repair, and from cell protection to highly effective anti-inflammatory effects, through the synergistic effect of multiple components and multiple targets, especially by utilizing biomimetic lipid ratios and carrier encapsulation technology. The product is stable and highly effective.

[0081] Various embodiments of the present invention may exist in the form of a range; it should be understood that the description in the form of a range is merely for convenience and brevity and should not be construed as a hard limitation on the scope of the invention; therefore, it should be considered that the range description has specifically disclosed all possible subranges and single numerical values ​​within that range. For example, it should be considered that the range description from 1 to 6 has specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and single numbers within the range, such as 1, 2, 3, 4, 5, and 6, regardless of the range. Furthermore, whenever a numerical range is referred to herein, it means including any referenced number (fraction or integer) within the range referred to.

[0082] The above description is merely a specific embodiment of the present invention, enabling those skilled in the art to understand or implement the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A soothing and repairing composition, characterized in that, By weight percentage, it includes the following components: 0.1-5% of a cell stress protectant, selected from at least one of tetrahydromethylpyrimidine carboxylic acid, trehalose, and betaine; 0.01-2% of an instant soothing agent, selected from at least one of carbohydrate isomers, acetyl dipeptide-1 cetyl ester, and erythritol; 0.5-10% biomimetic stratum corneum lipids, which contain ceramides or ceramide analogs, cholesterol, and free fatty acids in a molar ratio of (1-5):(1-3):(0.5-2). 1-8% of a skin barrier repair agent, selected from at least one of panthenol, niacinamide, and biosaccharide gum-1; 0.05-3% of a plant anti-inflammatory complex encapsulated by a carrier system, the plant anti-inflammatory complex comprising a first plant extract and a second active ingredient, wherein the first plant extract is selected from one of Citrus aurantium extract, Centella asiatica extract, and Glycyrrhiza uralensis extract, and the second active ingredient is selected from one of baicalin, dipotassium glycyrrhizate, and bisabolol, and the weight ratio of the first plant extract to the second active ingredient is 1:(0.2-3); The remainder is a pharmaceutically or cosmetically acceptable carrier.

2. The soothing and repairing composition according to claim 1, characterized in that, The ceramide or ceramide analogue is selected from at least two of ceramide AP, ceramide EOP, ceramide NP, ceramide NS, and phytoceramide; the free fatty acid is selected from at least one of oleic acid, linoleic acid, and linolenic acid.

3. The soothing and repairing composition according to claim 1, characterized in that, The carrier system is a liposome, nanoemulsion, or polymer micelle; when the carrier system is a liposome, its wall material contains hydrogenated lecithin and cholesterol, with an average particle size of 50-300 nm.

4. The soothing and repairing composition according to claim 1, characterized in that, The composition further includes 0.001-0.5% by weight of a neurosensory modulator, wherein the neurosensory modulator is selected from at least one of kava pepper extract, menthol lactate, and acetyl tetrapeptide-15.

5. The soothing and repairing composition according to claim 1, characterized in that, The composition further includes an anti-inflammatory agent comprising 0.01-1% of the total weight of the composition, wherein the anti-inflammatory agent is selected from at least one of bisabolol, α-bisabolol, and asiaticoside.

6. The soothing and repairing composition according to claim 1, characterized in that, The pharmaceutically or cosmetically acceptable carrier comprises an aqueous phase and an oil phase, wherein the oil phase contains an emollient selected from at least two of squalane, squalene, caprylic / capric triglyceride, isononyl isononanoate, and bis-diglyceride polyacryl adipate-2.

7. The soothing and repairing composition according to claim 1, characterized in that, The composition further comprises a skin microecological regulator, which is selected from at least one of α-glucan oligosaccharides, inulin, and lactobacillus fermentation products, and its content accounts for 0.001-0.5% of the total weight of the composition.

8. A topical preparation, in the form of a serum, lotion, cream, or gel, characterized in that, It comprises the soothing and repairing composition as described in any one of claims 1-7.

9. A topical preparation according to claim 8, characterized in that, The topical preparation has a pH value of 5.0-6.5 and a viscosity of 1000-50000 mPa·s (25℃).

10. A method for preparing the soothing and repairing composition according to any one of claims 1-7, characterized in that, include: Based on the type of the selected carrier, prepare liposome, nanoemulsion, or polymer micelle dispersions containing the plant anti-inflammatory complex; A biomimetic stratum corneum lipid, a skin barrier repair agent, and an oil phase component are provided, and the biomimetic stratum corneum lipid, the skin barrier repair agent, and the oil phase component are stirred and dissolved evenly at 65-80°C. A cell stress protectant and a transient soothing agent are provided, and the cell stress protectant and the transient soothing agent are dissolved in water to obtain an aqueous phase, and stirred and dissolved evenly at 65-80°C; The oil phase and the aqueous phase are mixed and homogenized and emulsified to form a primary emulsion; The primary emulsion is cooled to 40-50°C, and the liposomes, nanoemulsions, or polymer micelle dispersions containing the plant anti-inflammatory complex are added and stirred until homogeneous. Adjust pH and viscosity.

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