Active oxygen response type glycyrrhizic acid anti-inflammatory hydrogel and application thereof in preparation of medicine for treating compression neuralgia

The reactive oxygen species-responsive glycyrrhizic acid anti-inflammatory hydrogel prepared by one-pot method solves the problem of drug delivery for high reactive oxygen species and mechanical compression pain caused by diabetic lumbar disc herniation. It achieves high drug loading, reactive oxygen species-dependent controlled release and relief of neuralgia, providing a minimally invasive, intelligent and long-lasting treatment solution.

CN122163537APending Publication Date: 2026-06-09THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY (GUANGZHOU SEVERE MATERNAL TREATMENT CENTER GUANGZHOU ROUJI HOSPITAL)
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Patent Information

Application Number
CN202610655987.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-13
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies struggle to achieve precise drug delivery in cases of high reactive oxygen species and mechanical compression pain caused by lumbar disc herniation in patients with diabetes. Existing hydrogel drug delivery systems suffer from low drug loading rates, complex preparation processes, and difficulty in adapting to the pathological microenvironment. Existing treatment methods are also short-lived and invasive.

Method used

A one-pot method was used to prepare reactive oxygen species-responsive glycyrrhizic acid anti-inflammatory hydrogels. Glycyrrhizic acid served as both the gel framework and the drug, forming a three-dimensional network structure through dynamic covalent cross-linking of borate esters. This enabled reactive oxygen species-responsive drug delivery and precise regulation of macrophage polarization and inflammatory responses.

Benefits of technology

It achieves high drug loading and reactive oxygen species-dependent controlled release, adapts to the pathological microenvironment, significantly improves analgesic effect and reduces the side effects of invasive drug delivery, and provides a minimally invasive, intelligent and long-lasting local treatment solution.

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Abstract

The invention discloses active oxygen response type glycyrrhizic acid anti-inflammatory hydrogel and application thereof in preparation of a medicine for treating compression neuralgia, and belongs to the technical field of biomedical materials.The active oxygen response type glycyrrhizic acid anti-inflammatory hydrogel is prepared by taking glycyrrhizic acid and 1, 4-phenylboronic acid as raw materials, conducting water bath heating in an alkaline environment until a uniform mixed solution is formed, and conducting natural cooling to the room temperature to obtain the active oxygen response type glycyrrhizic acid anti-inflammatory hydrogel. The active oxygen response type glycyrrhizic acid anti-inflammatory hydrogel has good injectability, self-repairability, biocompatibility and biodegradability, and can specifically split boric acid ester bonds in a high-active oxygen pathological microenvironment of diabetes mellitus complicated with lumbar disc herniation and release glycyrrhizic acid as required; the PI3K-AKT signal channel is regulated in a targeted manner to promote the polarization of macrophages from a pro-inflammatory M1 phenotype to a repairable M2 phenotype, so that the inflammatory response of dorsal root ganglions and dorsal spinal horns is remarkably inhibited, the dorsal root ganglion compression neuropathic pain caused by diabetes combined with lumbar disc herniation is effectively relieved, and the PI3K-AKT compound has a good clinical transformation prospect.
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