Use of liu mo decoction lyophilized powder in the preparation of products for regulating intestinal flora imbalance

By using Liu Mo Tang freeze-dried powder to regulate intestinal flora, the shortcomings of probiotic preparations and traditional Chinese medicine decoctions have been addressed, achieving improvement in intestinal flora imbalance caused by irritable bowel syndrome, restoring the structure and function of intestinal flora, and enhancing intestinal health.

CN122163709APending Publication Date: 2026-06-09SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
Filing Date
2026-05-09
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

In existing technologies, probiotic preparations have low colonization rates, poor tolerance to gastric acid, and single targets. Antibiotics easily disrupt the homeostasis of normal intestinal flora. Conventional Chinese medicine decoctions have large dosages, poor taste, and are inconvenient to store and transport, making it difficult to meet the needs of long-term standardized use and industrial promotion. Furthermore, Liu Mo Tang does not involve the application of improving the specific intestinal flora disorder of constipation type of irritable bowel syndrome.

Method used

The product offers Liu Mo Tang freeze-dried powder, which regulates the alpha and beta diversity of gut microbiota. Specific measures include increasing the abundance of Trichophyton, Oscillatoria, and Clostridium families, decreasing the abundance of Rhizobaceae and Bacteroidetes families, inhibiting the rise of abnormal microbiota, and restoring the balance between butyrate-producing bacteria and pro-inflammatory bacteria.

Benefits of technology

It effectively improves intestinal flora imbalance caused by irritable bowel syndrome, restores intestinal flora structure, enhances intestinal butyrate production, improves intestinal barrier function and motility, and reduces inflammatory response.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention provides the application of Liu Mo Tang freeze-dried powder in the preparation of products regulating intestinal flora imbalance, belonging to the field of biomedical technology. The Liu Mo Tang freeze-dried powder provided by this invention effectively improves intestinal flora imbalance, particularly in constipation-predominant irritable bowel syndrome (IBS). Constipation-predominant IBS leads to a decrease in butyrate-producing bacteria, reduced butyrate production capacity, impaired intestinal barrier function, increased permeability, and weakened intestinal motility, accompanied by pathogenic bacterial proliferation. After administration of Liu Mo Tang, the abundance of butyrate-producing bacteria is upregulated, and the increase of abnormal bacteria is inhibited, which helps restore intestinal butyrate supply, improves intestinal barrier function, and promotes the recovery of intestinal motility. By reshaping the balance between butyrate-producing bacteria and pro-inflammatory bacteria, it effectively improves intestinal flora imbalance in IBS.
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Claims

1. Application of Liumotang freeze-dried powder in the preparation of products for regulating intestinal flora imbalance.

2. The application as described in claim 1, characterized in that, The gut microbiota imbalance is constipation-predominant irritable bowel syndrome-related gut microbiota imbalance.

3. The application as described in claim 1, characterized in that, The gut microbiota imbalance includes deviations in the gut microbiota structure.

4. The application as described in claim 1, characterized in that, The Liumotang freeze-dried powder alleviates the deviation of the intestinal flora structure, and the alleviation is achieved by regulating the alpha and beta diversity of the intestinal flora.

5. The application as described in claim 1, characterized in that, The regulation of gut microbiota alpha diversity includes increasing the species richness estimation index and the number of observed species; the regulation of gut microbiota beta diversity includes increasing the abundance of Trichophyceae, Oscillatoriaceae, Clostridiumceae, and Rikenaceae at the family level of gut microbiota composition, and decreasing the abundance of Rhizobaceae and Bacteroidetes families at the genus level of gut microbiota composition, and increasing the abundance of Alpha-Bacillus, Rhizobium, Schedlerella, Anaerobic Truncate Bacteria, and Eubacterium at the genus level of gut microbiota composition, and decreasing the abundance of Rhizobium, Bacteroidetes, and Lepagogella.

6. The application as described in claim 1, characterized in that, The freeze-dried powder of Liumotang upregulates the abundance of butyric acid-producing bacteria in the families Trichophyton, Oscillatoria, and Clostridium, while inhibiting the increase of abnormal bacteria in the families Bacteroidetes, Sartella, Prevotella, and Faecalibacteriales, thus restoring the balance between butyric acid-producing and pro-inflammatory bacteria.

7. The application as described in claim 1, characterized in that, The freeze-dried powder of Liu Mo Tang includes the following raw materials in parts by weight: 1-10 parts of areca nut, 1-10 parts of agarwood, 1-10 parts of costus root, 1-10 parts of Lindera root, 1-10 parts of rhubarb, and 1-10 parts of immature bitter orange peel.

8. The application as described in claim 7, characterized in that, The preparation of the Liu Mo Tang freeze-dried powder includes the following steps: pulverize areca nut, agarwood, costus root, lindera root, rhubarb and bitter orange peel, mix with water, soak and decoct, filter and collect the filtrate, concentrate and dry to obtain Liu Mo Tang freeze-dried powder.

9. The application as described in claim 8, characterized in that, The amount of water added is 8-12 times the total weight of areca nut, agarwood, costus root, lindera root, rhubarb, and bitter orange peel.

10. The application as described in claim 8, characterized in that, The soaking time is 25-35 minutes; the decocting method includes: boiling over high heat and then simmering over low heat for 25-35 minutes; the number of decocting times is 2-4 times; the concentration conditions include a rotation speed of 35-45 r / min and a temperature of 65-75℃.