Method for promoting cartilage regeneration based on auditory central regulation and application

By targeting and modulating the auditory cortex, and using chemogenetic methods or sound stimulation to inhibit auditory cortex nerve activity, the treatment bottleneck of cartilage damage and osteoarthritis in existing technologies has been overcome, achieving effective treatment of cartilage regeneration and osteoarthritis.

CN122163803APending Publication Date: 2026-06-09SHANGHAI YANGZHI REHABILITATION HOSPITAL
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Patent Information

Application Number
CN202610454613.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-08
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Current technologies lack effective interventions to promote hyaline cartilage regeneration and delay or reverse osteoarthritis, and existing treatments cannot fundamentally solve the problems of cartilage damage and osteoarthritis.

Method used

By targeting and modulating the auditory cortex—the auditory center—using chemogenetic methods or sound stimulation to inhibit the activity of auditory cortex nerves, the expression of cartilage anabolic and degenerative markers is regulated, thereby promoting cartilage regeneration and repair.

Benefits of technology

It significantly promotes cartilage regeneration, repairs cartilage damage, delays or treats osteoarthritis, upregulates the expression of Col2, Acan, and PRG4 at the molecular level, downregulates the expression of Col1 and Mmp13, and significantly relieves pain behaviorally, providing a novel, safe and effective treatment strategy.

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Abstract

This invention relates to the fields of regenerative medicine and neuromodulation technology, specifically disclosing the application of mediators that inhibit the activity of the auditory cortex in the preparation of drugs or intervention devices for promoting cartilage regeneration, repairing cartilage damage, and delaying or treating osteoarthritis. This invention promotes cartilage damage repair and osteoarthritis treatment by modulating the auditory cortex of the auditory center, providing two technical means: a chemogenetic method involving targeted injection of a viral vector carrying an artificial inhibitory receptor into the auditory cortex followed by administration of a DREADD agonist; and a sound stimulation method involving outputting sound stimulation to the individual at a level 5 dB higher than the ambient background noise. Animal experiments have confirmed that both methods can upregulate the expression of cartilage synthesis markers Col2, Acan, and PRG4, downregulate the expression of degradation markers Col1 and Mmp13, improve histological scores, and alleviate pain. This invention also provides an intervention device, including a sound insulation unit, a sound acquisition unit, a control unit, and a sound output unit. This device has the advantages of being non-invasive, easy to operate, and highly safe, providing an innovative strategy for cartilage regeneration and osteoarthritis treatment.
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