Process for the one-step synthesis of vanillin and o-vanillin

By employing a one-step synthesis method for vanillin and ortho-vanillin, and utilizing a composite catalyst and a specific solvent system, the problems of poor selectivity and separation difficulties in the synthesis of ortho-vanillin have been solved, achieving efficient and environmentally friendly production of high-purity products.

CN122167272APending Publication Date: 2026-06-09JIUWEI BIOCHEMISTRY (CHONGQING) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIUWEI BIOCHEMISTRY (CHONGQING) CO LTD
Filing Date
2026-05-09
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

The existing synthesis of ortho-vanillin suffers from poor selectivity, numerous byproducts, environmentally unfriendly processes, and difficult separation, resulting in high production costs, unstable supply, and difficulty in meeting the purity requirements of high-end pharmaceuticals.

Method used

A one-step synthesis method was adopted, using o-methoxyphenol as the starting material, which reacts with formaldehyde under the action of a composite catalyst. By optimizing the reaction parameters and post-processing, vanillin and o-vanillin were separated by utilizing the difference in solubility of a specific mixed solvent system.

Benefits of technology

It significantly improves the selectivity and yield of ortho-vanillin, simplifies the process, reduces costs, conforms to green chemical principles, and meets the purity requirements of high-end pharmaceuticals.

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Abstract

The present application relates to the chemical technology field, specifically to a method for synthesizing vanillin and ortho-vanillin by one-step method, which uses o-methoxyphenol as starting material, and carries out one-step reaction with formaldehyde under the action of composite catalyst, and then separates vanillin and ortho-vanillin by post-treatment of the reaction solution. By using the composite catalyst with specific composition, the present application realizes high-selectivity formylation of formaldehyde at the ortho position of the hydroxyl group of o-methoxyphenol, increases the generation proportion of ortho-vanillin from the source, avoids the use of toxic reagent, and has mild reaction conditions. By using the difference in solubility of specific mixed solvent system and adjusting the temperature, the present application can efficiently separate vanillin and ortho-vanillin, and solves the separation problem caused by the similar properties of isomers in the prior art. The overall process is simple and efficient, and the yield and product purity are significantly improved, which has excellent industrial application prospect.
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