Collagen peptoid and preparation method and application thereof

The two-step method of polymerization and hydrogenation catalysis to prepare collagen peptides solves the industrialization problem of existing collagen synthesis processes, and realizes the preparation of high-purity collagen peptides with flexible structures, which are suitable for the medical regeneration field.

CN122167728APending Publication Date: 2026-06-09SUZHOU XIANJUE BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU XIANJUE BIOTECHNOLOGY CO LTD
Filing Date
2026-05-08
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

In existing technologies, the synthesis process of collagen has problems such as high research and development difficulty, long cycle and many impurities. In particular, the solid phase synthesis method has small batch size, long cycle and many impurities in the final product, which makes it difficult to meet the needs of industrial production.

Method used

A two-step method involving polymerization and hydrogenation catalysis was used to prepare collagen peptides. The random polycondensation and hydrogenation catalysis simplified the preparation process, making it suitable for industrial production. The monomer ratio was adjusted by GMA modification to obtain the target peptides.

Benefits of technology

This invention enables the simple preparation of collagen peptides, which are suitable for mass production. The structure can be flexibly adjusted, and the purity is high, making them adaptable to different application scenarios. It also reduces the sensitizing structure of natural collagen and expands the application value in the field of medical regeneration.

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Abstract

The present application relates to the technical field of bioengineering, in particular to a collagen peptoid and a preparation method and application thereof. The present application provides a method different from conventional solid-phase synthesis of collagen peptoids. The preparation method of the collagen peptoid provided only needs two-step reactions of polymerization (random polycondensation) and hydrogenation catalysis, and the reactions are carried out in a homogeneous solution, so that the preparation method is simple and suitable for large-scale industrialized preparation. Moreover, the structure of the collagen peptoid provided can be flexibly changed according to needs on the basis of different monomer proportions, and the target peptoid can be quickly prepared.
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Claims

1. A method for preparing collagen peptides, characterized in that, The preparation method is as follows: (1) Two or more monomers undergo random polycondensation of amino and carboxyl groups to obtain collagen polypeptide polymer products; (2) The polymerization product obtained in step (1) is subjected to hydrogenation catalysis to remove the tripeptide side protection group to obtain collagen pseudopeptide. The monomer is selected from one or more of GPD, GPE, GPK, GPR, GPO, GER, GPH, GPQ, GPN, and GPW. The collagen pseudopeptide is modified with GMA.

2. The preparation method according to claim 1, characterized in that, The GMA modification is achieved by the secondary hydroxyl, carboxyl, amino, or guanidine group in the collagen peptide undergoing a ring-opening reaction with the epoxy group in the GMA.

3. The preparation method according to claim 1, characterized in that, The GMA modification rate is 5%-40%.

4. Collagen peptides prepared by the preparation method according to any one of claims 1-3.

5. The collagen peptide according to claim 4, characterized in that, The collagen peptide is a GER-neutral collagen peptide, an electrically neutral collagen peptide, or a positively charged collagen peptide; the amino acid sequence of the GER-neutral collagen peptide is: (GPO)a-co-(GPD)b-co-(GPE)c-co-(GPR)d-co-(GPK)e-co-(GER)f, a:b:c:d:e:f=4-8:1:1:1:1:2; the amino acid sequence of the electrically neutral collagen peptide is: (GPO)a-co-(GPD)b-co-(GPE)c-co-(GPR)d-co-(GPK)e, a:b:c:d:e=4-8:1.5:1.5:1.5:1.5; the amino acid sequence of the positively charged collagen peptide is: (GPR)d-co-(GPK)e, d:e=1:

1.

6. The application of the collagen peptide according to claim 4 in the preparation of materials for medical regeneration.

7. The application according to claim 6, characterized in that, The application described is organoid culture or vascularization culture.