Organ state evaluation method based on laser speckles and organ perfusion system

By correcting laser speckle images using a vibration-speckle distortion model and optical flow method, quasi-static speckle images are generated, solving the motion artifact problem caused by vibration during organ transport and enabling real-time, accurate monitoring and assessment of organ status.

CN122171493APending Publication Date: 2026-06-09HENAN ACADEMY OF MEDICAL SCIENCES
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Patent Information

Application Number
CN202610189809.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-10
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing laser speckle technology is susceptible to vibration during organ transport, leading to the failure of motion artifact correction and making it impossible to achieve real-time and accurate monitoring of organ status, especially when organs undergo large-scale movement, making continuous monitoring difficult.

Method used

A method based on vibration-speckle distortion model and optical flow method is adopted. The original speckle image is rigidly displaced by acquiring real-time vibration data of organs, and pixel-level inverse compensation is performed by combining optical flow method to generate quasi-static speckle image. Microcirculation perfusion distribution map is calculated and evaluation area is divided. Perfusion heterogeneity index is used for real-time monitoring.

Benefits of technology

It enables real-time and accurate monitoring of organ status during organ transport, can identify local blood flow abnormalities, improves the safety and effectiveness of organ perfusion, and is applicable to organ transport, quality assessment, and post-transplantation evaluation scenarios.

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Abstract

The invention relates to the technical field of bio-optical imaging, in particular to an organ state evaluation method based on laser speckles and an organ perfusion system.The method is based on a high-frame-rate laser speckle imaging technology and combined with a physiological signal gating algorithm, an original speckle image is extracted only in a diastolic period window with the minimum organ movement, and the original speckle image is obtained; a vibration-speckle distortion model is used for carrying out preliminary correction on an original speckle image, then a light flow method is used for carrying out sub-pixel-level registration on the speckle image subjected to preliminary correction, a high-signal-to-noise-ratio microcirculation perfusion distribution diagram with motion artifacts removed is generated, perfusion heterogeneity indexes of all target evaluation areas are calculated according to the microcirculation perfusion distribution diagram, and the perfusion heterogeneity indexes of all the target evaluation areas are calculated according to the perfusion heterogeneity indexes. Therefore, whether local blood flow abnormity exists in the transferred organ or not is judged, and state evaluation and real-time monitoring of the transferred organ are achieved. The evaluation method is not only suitable for an organ transfer link, but also suitable for organ quality evaluation and immediate evaluation scenes after transplantation.
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