Sample analysis apparatus and method of controlling the same

Abstract

This invention relates to the field of medical devices and discloses a sample analysis device and a control method for the sample analysis device. The sample analysis device includes a reagent container transfer device, a reagent container loading device, a first capping device, a reagent container storage device, a second capping device, a sample dispensing device, a reagent dispensing device, a detection device, and a controller. The controller is configured to: control the reagent container transfer device to transfer a first reagent container from the reagent container loading device to the first capping device; control the first capping device to perform a first capping action on the first reagent container; control the second capping device to perform a second capping action on the first reagent container after the first capping action; and control the reagent dispensing device to draw a first reagent from the first reagent container after the second capping action and dispense it into a reaction vessel. The first capping device automatically performs a pre-capping action on the first reagent container entering the sample analysis device, which can reduce the user's workload.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more particularly to a sample analysis device and a control method for the sample analysis device. Background Technology

[0002] A sample analysis device provided by related technology requires a reagent dispensing device to draw a first reagent from a first reagent container and dispense it into a reaction vessel during sample analysis. To prevent evaporation, deterioration, and leakage of the first reagent during storage, transportation, and use, the first reagent container is tightly sealed with its cap before leaving the factory. To ensure the reagent dispensing device can draw the first reagent from the first reagent container, a cap-opening device is incorporated into the sample analysis device. This device opens and closes the first reagent container after it enters the device. Because the cap is tightly sealed to the first reagent container before leaving the factory, the sealing force between the cap and the container body is significant, requiring considerable opening force to open the cap. If the cap-opening device were to open the cap in one go, the load on the device would need to be designed to be excessively high, and there is a risk of the device failing to open the cap or damaging the first reagent container due to excessive force.

[0003] To avoid damage to the first reagent container when opening due to excessive sealing force of the container cap, the relevant technology proposes that before or during the placement of the first reagent container into the sample analysis device, the user manually performs a pre-opening action on the container cap of the first reagent container using tools or devices on the sample analysis device to relieve part of the sealing force of the container cap. Then, the user manually loads the first reagent container, after relieving part of the sealing force of the container cap, into the reagent container storage device.

[0004] However, the above-mentioned method of manually pre-opening the first reagent container before and during the machine has the following shortcomings in practical application: (1) Manual pre-opening cannot guarantee the consistency of the container lid opening degree, which is prone to the adverse phenomenon that the airtightness of the first reagent container will deteriorate due to the container lid being pre-opened too much, which will easily lead to the deterioration of the first reagent. (2) Pre-opening the lid before and during the machine will result in a relatively long interval between the completion of the pre-opening and the use of the first reagent in the first reagent container, which will also easily lead to the deterioration of the first reagent. (3) Manual pre-opening requires users to spend more time and effort. (4) The first reagent container is loaded into the reagent container storage device by manual loading. This may result in the first reagent container containing a first reagent with quality problems being directly loaded into the reagent container storage device. For example, the first reagent container containing a first reagent with magnetic beads that have agglomeration is directly loaded into the reagent container storage device. This may cause the first reagent to precipitate or settle rapidly after the machine mixing operation, resulting in an abnormal effective concentration of magnetic beads, which in turn causes abnormal sample test results, causing patients to receive incorrect test results and easily leading to serious consequences. Summary of the Invention

[0005] The first objective of this invention is to provide a sample analysis device that aims to solve the technical problem in related technologies where manually opening the first reagent container requires users to spend a lot of time and effort.

[0006] To achieve the above objectives, the present invention provides a sample analysis device, comprising a reagent container transfer device, a reagent container loading device, a first opening device, a reagent container storage device, a second opening device, a sample dispensing device, a reagent dispensing device, a detection device, and a controller. The controller is configured to: The reagent container transfer device controls the transfer of a first reagent container, which is from the reagent container loading device and contains a first reagent and has a container cap closed, to the first cap opening device. The first cap-opening device is controlled to perform a first cap-opening action on the first reagent container from the reagent container loading device and which is covered by the container cap, so that the container cap is in a first open state. The reagent container transfer device is controlled to place the first reagent container, after the first opening action is completed, into the reagent container storage device; The second opening device is controlled to perform a second opening action on the first reagent container located inside the reagent container storage device after the first opening action has been completed, so that the container lid is in a second open state, wherein the degree of opening of the container lid in the first open state is less than the degree of opening of the container lid in the second open state; The sample dispensing device is controlled to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container; The reagent dispensing device is controlled to draw at least a portion of the first reagent from the first reagent container located inside the reagent container storage device and with the container lid in the second open state, and to dispense all or part of the drawn first reagent into the reaction vessel; The detection device is controlled to detect a test solution prepared based at least on the sample dispensed into the reaction vessel and the first reagent, in order to obtain a detection result for the sample.

[0007] A second objective of this invention is to provide a control method for a sample analysis device, the control method comprising: The reagent container transfer device controls the transfer of a first reagent container, which is from the reagent container loading device and contains a first reagent and has its lid closed, to a first lid opening device. The first capping device is controlled to perform a first capping action on the first reagent container from the reagent container loading device and which is covered by the container cap, so that the container cap is in a first open state. The reagent container transfer device controls the placement of the first reagent container, after the first opening action is completed, into the reagent container storage device; The second capping device is controlled to perform a second capping action on the first reagent container located inside the reagent container storage device after the first capping action has been completed, so that the container cap is in a second open state, wherein the degree of opening of the container cap in the first open state is less than the degree of opening of the container cap in the second open state; The sample dispensing device is controlled to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container; The control reagent dispensing device draws at least a portion of the first reagent from the first reagent container located within the reagent container storage device with the container lid in the second open state, and dispenses all or part of the drawn first reagent into the reaction vessel; The control detection device detects at least a test solution prepared based on the sample dispensed into the reaction vessel and the first reagent to obtain a test result for the sample.

[0008] The sample analysis device and its control method provided by this invention, by setting a first capping device and a second capping device in the sample analysis device, and by controlling a reagent container transfer device to transfer a first reagent container from a reagent container loading device to the first capping device; then controlling the first capping device to perform a first capping action, i.e., a pre-capping action, on the first reagent container to relieve part of the sealing force of the container cap; then controlling the reagent container transfer device to place the first reagent container after the first capping action is completed into a reagent container storage device; and then controlling the second capping device to perform a second capping action on the first reagent container to fully open the container cap, so that the reagent dispensing device can draw the first reagent from the first reagent container and dispense it into the reaction container, thereby realizing the automatic completion of the actions of first reagent container scheduling, pre-capping, loading into the reagent container storage device, full capping, and first reagent dispensing after the first reagent container enters the sample analysis device. After the first reagent container enters the sample analysis equipment, the controller automatically transfers it from the reagent container loading device to the first opening device. The controller then automatically performs a pre-opening action on the first reagent container, eliminating the need for manual intervention by the user. This saves the user time and effort, effectively reducing workload and stress. Furthermore, since the pre-opening action performed by the first opening device and the full opening action performed by the second opening device are controlled by the controller, it ensures consistency in the degree of container opening after pre-opening and shortens the interval between full opening and reagent aspiration, thus guaranteeing the stability and effectiveness of the first reagent within its shelf life. Attached Figure Description

[0009] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0010] Figure 1 This is a schematic diagram of the structure of a sample analysis device provided in an embodiment of the present invention; Figure 2 This is a schematic diagram of the sample analysis device provided in an embodiment of the present invention, in the case where the first opening position is located on the side of the transfer position away from the loading position; Figure 3 This is a schematic diagram of the sample analysis device provided in an embodiment of the present invention when the first opening position is located in the loading position; Figure 4This is a schematic diagram of the sample analysis device provided in an embodiment of the present invention, where the first opening position is located between the loading position and the transfer position; Figure 5 This is a schematic diagram of the sample analysis device provided in an embodiment of the present invention, where the second opening position is located inside the reagent container storage device; Figure 6 This is a schematic diagram of the structure of the first opening device provided in this embodiment of the invention, which uses a rotatable abutment component; Figure 7 yes Figure 6 A magnified view of a portion of the image; Figure 8 This is a schematic diagram showing at least two abutting components distributed along an inclined trajectory, as provided in an embodiment of the present invention. Figure 9 This is a schematic diagram of the first reagent container provided in an embodiment of the present invention with the container lid in a closed state; Figure 10 This is a schematic diagram of the first reagent container provided in an embodiment of the present invention with the container lid in a first open state; Figure 11 This is a schematic diagram of the first reagent container provided in an embodiment of the present invention with the container lid in a second open state; Figure 12 This is a schematic diagram of the structure of the first opening device using a hook provided in an embodiment of the present invention; Figure 13 This is a schematic diagram of the structure of the first cover-opening device using a pressing component provided in an embodiment of the present invention; Figure 14 This is a schematic diagram of the structure of the first opening device provided in an embodiment of the present invention, which adopts a rotating gripper. Figure 15 This is a schematic diagram of the distribution of the mixing device provided in an embodiment of the present invention; Figure 16 This is a schematic diagram of the distribution of the magnetic bead aggregation detection device provided in an embodiment of the present invention; Figure 17 This is a schematic diagram of the opening process of the first reagent container provided in an embodiment of the present invention; Figure 18 This is a flowchart illustrating the process of the first reagent container performing the mixing action, the first opening action, the mixing action, the magnetic bead cluster detection action, the second opening action, and the reagent dispensing action provided in the embodiments of the present invention. Figure 19 This is a schematic diagram of the sample analysis device provided in another embodiment of the present invention.

[0011] Reference numerals: 10. Sample analysis device; 100. First opening device; 110. Pushing component; 120. First driving component; 130. Support; 140. Connecting seat; 150. Elastic component; 160. Limiting structure; 170. Hook; 180. Second driving component; 190. Pressing component; 1001. Third driving component; 1002. Grasping component; 1003. Fourth driving component; 200. Reagent container storage device; 210. Reagent container interface; 300. Reagent container transfer device; 400. Reagent container loading device; 500. Scheduling device; 600. Controller; 700. Support component; 800. Sample dispensing device; 900. Reagent dispensing device; 1 01. Detection device; 102. Reaction vessel supply device; 103. Magnetic separation device; 104. Reaction device; 105. Reaction vessel transfer device; 106. Container seat; 107. Mixing device; 108. Magnetic bead aggregation detection device; 109. Opening component; 1010. Correction device; 1011. Mixing device; 11. First opening position; 12. Loading position; 13. Transfer position; 14. Second opening position; 15. Buffer position; 20. First reagent container; 21. Container lid; 2101. Protrusion; 2102. Suspended part; 22. Container body; 2201. Limiting boss; A1. First opening angle; A2. Second opening angle; A3. Inclined angle; X. First horizontal direction. Detailed Implementation

[0012] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0013] The embodiments of the present invention are applicable to sample analysis devices in which the reagent container has a container lid and the reagent container needs to be pre-opened before aspirating the reagent into the container. They are particularly applicable to sample analysis devices in which reagents are aspirated from pre-opened or fully opened reagent containers and reacted with samples collected from human or animal samples for detection.

[0014] Reference Figures 1 to 19As shown, a first aspect of the present invention provides a sample analysis device 10, which includes a sample dispensing device 800, a reagent dispensing device 900, a detection device 101, and a controller 600. The sample dispensing device 800 is used to dispense samples. The samples are collected from human or animal bodies. The reagent dispensing device 900 is used to dispense reagents. The detection device 101 is used to detect a test solution prepared based at least on the sample and reagents to obtain sample detection information. The controller 600 is used to process the sample detection information to obtain the sample detection result.

[0015] Reference Figure 1 , Figure 2 , Figure 10 and Figure 19As shown, in one embodiment, the sample analysis device 10 further includes a first capping device 100 and a second capping device. The first capping device 100 is used to perform a first capping action on a first reagent container 20 containing a first reagent and having a container cap 21, so that the container cap 21 is in a first open state. The second capping device is used to perform a second capping action on the first reagent container 20 after the first capping action is completed, so that the container cap 21 is in a second open state. The degree of opening of the container cap 21 in the first open state is less than the degree of opening of the container cap 21 in the second open state. The sample dispensing device 800 is used to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container. The reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 after the second capping action is completed and the container cap 21 is in the second open state, and dispense all or part of the drawn first reagent into the reaction container. The detection device 101 is used to detect the test solution prepared from at least the sample dispensed into the reaction container and the first reagent to obtain sample detection information. Specifically, the first reagent container 20 includes a container body 22 and a container cap 21. The top of the container body 22 has an upward-opening container opening, and the container cap 21 is used to close and open the container opening. Before the container cap 21 closes the container opening, the first reagent can be loaded into the container body 22 from the container opening. To prevent the first reagent from evaporating, deteriorating, or leaking during storage, transportation, and use, the sealing force between the container cap 21 and the container body 22 is relatively large. The first opening action performed by the first capping device 100 on the first reagent container 20 is a pre-opening action, which can relieve part of the sealing force of the container cap 21. Since the first opening action performed by the first capping device 100 on the first reagent container 20 only relieves part of the sealing force of the container cap 21, so that the container cap 21 can be easily opened by the subsequent second capping device, that is, the container cap 21 is not fully opened after the first opening action is completed. Therefore, at this time, due to the obstruction of the container cap 21, the reagent dispensing device 900 cannot directly enter the first reagent container 20 to draw the first reagent. When the second capping device performs a second capping action on the first reagent container 20 after the first capping action has been completed, the container cap 21 is in a fully open state. At this time, the reagent dispensing device 900 can enter the first reagent container 20 through the container opening without obstruction to draw the first reagent. In this embodiment, by setting the first capping device 100 in the sample analysis device 10 to automatically pre-open the cap of the first reagent container 20 entering the sample analysis device 10, the user does not need to manually pre-open the cap before the reagent is loaded, which saves the user time and effort in pre-opening the cap, thereby effectively reducing the user's workload and reducing the user's workload.In addition, the container lid 21 can be opened in two stages. The second opening can be performed according to the needs of the test, which helps to shorten the interval between when the container lid 21 is fully opened and when the first reagent is drawn, thereby reducing the risk of the first reagent volatilizing and deteriorating.

[0016] Reference Figures 1 to 5 and Figure 19 As shown, in one embodiment, the sample analysis device 10 further includes a reagent container storage device 200, which is used to store at least a first reagent container 20; a reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 and in a second open state, and to dispense all or part of the drawn first reagent into the reaction vessel. The reagent container storage device 200 can be used to store multiple reagent containers (including but not limited to the aforementioned first reagent container 20) to meet the storage requirements of reagents used for multiple detection items of the sample analysis device 10, thereby facilitating continuous detection of batch samples. The first opening device 100 is located outside the reagent container storage device 200, so that the setting of the first opening device 100 does not affect the internal structure of the reagent container storage device 200, thereby reducing the difficulty of improving the sample analysis device 10. Of course, in specific applications, the setting of the first opening device 100 is not limited to this. For example, as an alternative embodiment, the first opening device 100 can also be located inside the reagent container storage device 200.

[0017] Reference Figures 1 to 5 and Figure 19 As shown, in one embodiment, the sample analysis device 10 further includes a reagent container transfer device 300, which is used at least to transfer the first reagent container 20 after the first opening action is completed to the reagent container storage device 200. In this embodiment, the first reagent container 20 after the first opening action is completed is transferred to the reagent container storage device 200 by the reagent container transfer device 300, without the need for manual placement in the reagent container storage device 200, which helps to improve the automation level of the sample analysis device 10.

[0018] Reference Figures 1 to 4 and Figure 19As shown, in one embodiment, the sample analysis device 10 further includes a reagent container loading device 400; the reagent container loading device 400 is at least used to place a first reagent container 20 containing a first reagent and having a container lid 21 to realize the feeding of the first reagent; the reagent container storage device 200 is used to store the first reagent container 20 from the reagent container loading device 400; the reagent container transfer device 300 is at least used to transfer the first reagent container 20 from the reagent container loading device 400 to the first lid opening device 100 and the reagent container storage device 200. In this embodiment, the first reagent container 20 enters the sample analysis device 10 through the reagent container loading device 400, and is transferred to the first opening device 100 and the reagent container storage device 200 through the reagent container transfer device 300. This realizes the automatic pre-opening and automatic loading of the first reagent container 20. That is, after the first reagent container 20 is loaded into the sample analysis device 10, the sample analysis device 10 can automatically complete the actions of pre-opening the first reagent container 20, loading it into the reagent container storage device 200, fully opening the lid, and dispensing the first reagent. No manual operation is required from the user, saving the user the time and effort of pre-opening and loading the first reagent container 20, thereby effectively reducing the user's workload and reducing the user's work intensity.

[0019] In one implementation, the first capping device 100 and the second capping device are two different capping devices; that is, the first capping device 100 and the second capping device are not the same capping device, and they are independently set up and can operate independently. For example, when the first capping device 100 performs a first capping action on a first reagent container 20, the second capping device can perform a second capping action on another first reagent container 20. In this way, on the one hand, the overall operating efficiency of the sample analysis device 10 can be improved by the parallel operation of the first capping device 100 and the second capping device, and on the other hand, it is beneficial to flexibly set up the first capping device 100 and the second capping device separately. Of course, in specific applications, as an alternative implementation, the first capping device 100 and the second capping device can also be the same capping device.

[0020] In one implementation, the first opening device 100 is located outside the reagent container storage device 200, and the second opening device is located inside the reagent container storage device 200. The first opening device 100 is used to perform a first opening action on the first reagent container 20 from outside the reagent container storage device 200, and the second opening device is used to perform a second opening action on the first reagent container 20 from inside the reagent container storage device 200. In this way, on the one hand, the setting of the first opening device 100 does not affect the internal structure of the reagent container storage device 200, and on the other hand, the second opening action can be performed according to the needs of the test item, thereby shortening the interval between the container cap 21 being fully opened and the first reagent being drawn in, and thus reducing the risk of the first reagent evaporation and deterioration. Of course, in specific applications, the arrangement of the first opening device 100 and the second opening device is not limited to this. For example, as an alternative implementation, the first opening device 100 and the second opening device may both be located inside the reagent container storage device 200; or, as another alternative implementation, the first opening device 100 and the second opening device may both be located outside the reagent container storage device 200.

[0021] In one implementation, the controller 600 is configured to: control the reagent container transfer device 300 to transfer a first reagent container 20 from the reagent container loading device 400, containing a first reagent and with a container cap 21 closed, to a first cap opening device 100; control the first cap opening device 100 to perform a first cap opening action on the first reagent container 20 from the reagent container loading device 400 with the container cap 21 closed, so that the container cap 21 is in a first open state; control the reagent container transfer device 300 to place the first reagent container 20 after the first cap opening action is completed into the reagent container storage device 200; and control the second cap opening device to perform a first cap opening action on the first reagent container 20 located in the reagent container storage device 200 after the first cap opening action is completed. The second opening action causes the container lid 21 to be in a second open state, wherein the degree of opening of the container lid 21 in the first open state is less than the degree of opening of the container lid 21 in the second open state; the sample dispensing device 800 is controlled to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container; the reagent dispensing device 900 is controlled to draw at least a portion of the first reagent from the first reagent container 20 located in the reagent container storage device 200 with the container lid 21 in the second open state and dispense all or part of the drawn first reagent into the reaction container; the detection device 101 is controlled to detect the test solution prepared based at least on the sample dispensed into the reaction container and the first reagent to obtain the test result of the sample. In specific applications, when a user or operating robot loads a first reagent container 20 containing a first reagent and with a container cap 21 closed onto a reagent container loading device 400, the controller 600 can automatically control the reagent container transfer device 300 to transfer the first reagent container 20 to a first cap opening device 100, automatically control the first cap opening device 100 to perform a first cap opening action on the first reagent container 20, and automatically control the reagent container transfer device 300 to transfer the first reagent container 20 after the first cap opening action is completed into a reagent container storage device 200; automatically control the second cap opening device to perform a second cap opening action on the first reagent container 20; and automatically control the reagent dispensing device 900 to draw at least a portion of the first reagent from the first reagent container 20 and dispense it into a reaction container. This achieves the following: after the first reagent container 20 is loaded onto the sample analysis device 10, the sample analysis device 10 automatically completes the actions of pre-opening the first reagent container 20, loading it into the reagent container storage device 200, fully opening the cap, and dispensing the first reagent. The entire process does not require manual execution by the user, thus effectively reducing the user's workload and workload. Furthermore, since the pre-opening action performed by the first opening device 100 is controlled by the controller 600, it helps to ensure the consistency of the opening degree of the container lid 21 after the pre-opening is completed.Since the second opening action performed by the second opening device is performed within the reagent container storage device 200 and controlled by the controller 600, it helps to shorten the interval between the completion of full opening and the aspiration of the first reagent, thereby ensuring the stability and effectiveness of the first reagent within its shelf life.

[0022] In one implementation, the sample dispensing device 800 dispenses the sample to the reaction container, the reagent dispensing device 900 dispenses the first reagent to the reaction container, and the detection device 101 can use the same reaction container or at least two different reaction containers when detecting the test solution.

[0023] In one implementation, the sample dispensing action can be performed first, followed by the first reagent dispensing action; alternatively, the first reagent dispensing action can be performed first, followed by the sample dispensing action. That is, the sample dispensing device 800 can be controlled to first draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container, and then the reagent dispensing device 900 can be controlled to draw at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 with the container lid 21 in a second open state and dispense all or part of the drawn first reagent into the reaction container; alternatively, the reagent dispensing device 900 can be controlled to first draw at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 with the container lid 21 in a second open state and dispense all or part of the drawn first reagent into the reaction container, and then the sample dispensing device 800 can be controlled to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container.

[0024] In one implementation, the sample analysis device 10 is configured with a first reagent loading mode and a second reagent loading mode. In the first reagent loading mode, the controller 600 is configured to: first control the reagent container transfer device 300 to transfer the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the reagent container loading device 400 to the first cap opening device 100; then control the first cap opening device 100 to perform a first cap opening action on the first reagent container 20, which is covered with a container cap 21, from the reagent container loading device 400; and finally control the reagent container transfer device 300 to place the first reagent container 20, after completing the first cap opening action, into the reagent container storage device 200. In the second reagent loading mode, the controller 600 is configured to: control the reagent container transfer device 300 to place the first reagent container 20 from the reagent container loading device 400, which has not yet undergone the first opening action by the first opening device 100, into the reagent container storage device 200; when preset conditions are met, control the reagent container transfer device 300 to remove the first reagent container 20 from the reagent container storage device 200, which has not yet undergone the first opening action by the first opening device 100, and transfer it to the first opening device 100; control the first opening device 100 to perform the first opening action on the first reagent container 20; and control the reagent container transfer device 300 to place the first reagent container 20, after completing the first opening action, into the reagent container storage device 200. In the first reagent loading mode, the first reagent container 20 first undergoes the first opening action by the first opening device 100 before entering the reagent container storage device 200, which can meet the need for rapid participation of the first reagent in the testing project. In the second reagent loading mode, the first reagent container 20 is first placed into the reagent container storage device 200 without the first opening device 100 performing the first opening action. When preset conditions are met, the first reagent container 20, without the first opening action, is then removed from the reagent container storage device 200, the first opening action is performed, and then it is placed back into the reagent container storage device 200. This facilitates the rapid loading of batches of first reagents, especially suitable for situations where the number of first reagent containers 20 to be loaded exceeds the number of first reagent containers 20 that the reagent container loading device 400 can hold at one time, thus reducing the time occupied by the user. In this embodiment, by simultaneously configuring both the first reagent loading mode and the second reagent loading mode in the sample analysis device 10, the needs of the first reagent container 20 in different scenarios can be met.

[0025] In one implementation, the sample analysis device 10 also includes a human-computer interaction device; the controller 600 is further configured to: determine, according to preset rules and / or information input by the user through the human-computer interaction device, that the first reagent needs to be loaded in a second reagent loading mode, and switch the first reagent loading mode to the second reagent loading mode; wherein, the preset rules include: obtaining information that the number of first reagent containers 20 to be loaded is greater than the number of first reagent containers 20 that the reagent container loading device 400 can load at one time. In this implementation, the sample analysis device 10 operates in the first reagent loading mode by default, and the controller 600 can control the switching of the first reagent loading mode to the second reagent loading mode according to the preset rules and / or information input by the user through the human-computer interaction device, that is, the loading mode switching can be manually triggered by the user, or it can be automatically triggered by the controller 600 according to the preset rules.

[0026] As one implementation method, the human-computer interaction device includes at least one of the following: display screen, mouse, keyboard, button, knob, slider, lever, and voice interaction device.

[0027] As one implementation method, the human-computer interaction device includes a display screen, which allows the user to trigger the switching from the first reagent loading mode to the second reagent loading mode based on the information displayed on the screen. This makes the operation more intuitive and easier for the user to operate.

[0028] As one implementation, satisfying the preset conditions includes satisfying at least one of the following preset conditions: obtaining information that there is no test item requiring the reagent dispensing device 900 to perform a reagent dispensing action; obtaining information that the reagent dispensing device 900 starts performing a reagent needle cleaning action; obtaining information that there is no test item requiring the sample analysis device 10 to perform a test; obtaining information that there is a test item requiring the use of a first reagent in the first reagent container 20 located in the reagent container storage device 200 and which has not yet undergone the first opening action by the first opening device 100. If the reagent dispensing device 900 is found to have no test items requiring reagent dispensing, or if the reagent dispensing device 900 is found to have started reagent needle cleaning, or if the sample analysis device 10 is found to have no test items requiring testing, it indicates that the reagent dispensing device 900 does not need to interact with the first reagent container 20 in the reagent container storage device 200. In this case, the reagent container transfer device 300 will remove the first reagent container 20, which is located in the reagent container storage device 200 and has not yet been opened by the first opening device 100, and transfer it to the first opening device 100 to perform the first opening action. This will not cause interference and will not affect the sample detection efficiency of the sample analysis device 10. If information is obtained that a test item requires the use of the first reagent in the first reagent container 20 located in the reagent container storage device 200 and which has not yet undergone the first opening action by the first opening device 100, it indicates that a test item requires the use of the first reagent in the first reagent container 20 that has not yet undergone the first opening action by the first opening device 100. In order to ensure the smooth execution of the test item, the reagent container transfer device 300 needs to first remove the first reagent container 20 located in the reagent container storage device 200 and which has not yet undergone the first opening action by the first opening device 100 and transfer it to the first opening device 100 to perform the first opening action.

[0029] Reference Figures 1 to 5 and Figure 19As shown, in one embodiment, the sample analysis device 10 also includes a scheduling device 500. The sample analysis device 10 also has a loading position 12 and a transfer position 13, both located outside the reagent container storage device 200. The loading position 12 is used for a user to place a first reagent container 20 containing the first reagent and covered with a container cap 21 onto the reagent container loading device 400, thereby loading the first reagent into the sample analysis device 10. The scheduling device 500 is used to drive the reagent container loading device 400 to move, thereby moving the first reagent container 20 loaded on the reagent container loading device 400 and containing the first reagent and covered with a container cap 21, thus scheduling the first reagent container 20 containing the first reagent and covered with a container cap 21 from the loading position 12 to the transfer position 13. Before the aforementioned control reagent container transfer device 300 transfers the first reagent container 20, containing the first reagent and with the container cap 21 closed, from the reagent container loading device 400 to the first cap opening device 100, the controller 600 is further configured to: control the scheduling device 500 to drive the reagent container loading device 400 to move the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and has the container cap 21 closed, so as to schedule the first reagent container 20, containing the first reagent and having the container cap 21 closed, from the loading position 12 to the transfer position 13. The aforementioned control reagent container transfer device 300 to transfer the first reagent container 20, containing the first reagent and having the container cap 21 closed, from the reagent container loading device 400 to the first cap opening device 100 includes: controlling the reagent container transfer device 300 to remove the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and has the container cap 21 closed, from the transfer position 13 and transfer it to the first cap opening device 100. Loading position 12 is the initial position for loading the first reagent container 20, and transfer position 13 is an intermediate position before the first reagent container 20 is loaded into the reagent container storage device 200. Scheduling device 500 is used to schedule the first reagent container 20 between loading position 12 and transfer position 13. Reagent container transfer device 300 is used to transfer the first reagent container 20 between transfer position 13, first capping device 100, and reagent container storage device 200. In this embodiment, the first reagent container 20 is first scheduled from loading position 12 to transfer position 13 by scheduling device 500, then transferred from transfer position 13 to first capping device 100 by reagent container transfer device 300, and finally transferred from first capping device 100 to reagent container storage device 200 after pre-capping by reagent container transfer device 300.In this way, on the one hand, the operation of the reagent container transfer device 300 will not affect the user's loading work at the loading position 12, thus facilitating the safe loading of the first reagent container 20 without stopping the system. On the other hand, it allows the scheduling device 500 and the first capping device 100 to work in parallel, improving efficiency. Furthermore, it eliminates the need for the travel distance of the reagent container transfer device 300 to extend to the loading position 12, shortening its working stroke. Of course, in specific applications, as an alternative implementation, the scheduling device 500 can be omitted, and the reagent container transfer device 300 can directly transfer the first reagent container 20 from the loading position 12 to the first capping device 100 and the reagent container storage device 200.

[0030] In the above scheme, the scheduling device 500 is used to drive the reagent container loading device 400 to move, so that the reagent container loading device 400 moves the first reagent container 20 from the loading position 12 to the transfer position 13. Of course, in specific applications, the arrangement of the scheduling device 500 is not limited to this. For example, as an alternative implementation, the scheduling device 500 is used to schedule the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13. In this alternative implementation, the scheduling device 500 is used to directly drive the reagent container to move from the loading position 12 to the transfer position 13. Alternatively, as another alternative implementation, the scheduling device 500 is used to schedule a reagent container carrier loaded on the reagent container loading device 400 and carrying the first reagent container 20 from the reagent container loading device 400 to the transfer position 13. In this alternative implementation, the first reagent container 20 is loaded onto the reagent container loading device 400 via the reagent container carrier, and the scheduling device 500 is used to drive the reagent container carrier to move, so that the reagent container carrier moves the first reagent container 20 from the loading position 12 to the transfer position 13. The reagent container carrier can be a reagent rack or a reagent holder. The reagent rack has multiple placement positions for carrying reagent containers (including but not limited to the first reagent container 20), and the reagent holder has one or more placement positions for carrying reagent containers. That is, the scheduling device 500 can schedule the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13 by directly scheduling the first reagent container 20, or indirectly scheduling the first reagent container 20 by scheduling the reagent container carrier used to load the first reagent container 20.

[0031] In one embodiment where the scheduling device 500 drives the reagent container loading device 400 to move, the scheduling device 500 drives the reagent container loading device 400 to rotate, thereby moving the first reagent container 20, which contains the first reagent and is covered with a container lid 21, from the loading position 12 to the transfer position 13. The rotational motion performed by the scheduling device 500 driving the reagent container loading device 400 can be a horizontal arc reciprocating motion, or a clockwise or counterclockwise horizontal circular motion.

[0032] As a further embodiment of the first implementation where the scheduling device 500 drives the reagent container loading device 400 to move, the reagent container loading device 400 can be a sector-shaped loading device or a disc-shaped loading device. When the reagent container loading device 400 is a sector-shaped loading device, the rotational motion driven by the scheduling device 500 is a horizontal arc-shaped reciprocating motion. When the reagent container loading device 400 is a disc-shaped loading device, the rotational motion driven by the scheduling device 500 is a clockwise or counterclockwise horizontal circular motion. Of course, in specific applications, as an alternative implementation, when the scheduling device 500 drives the reagent container loading device 400 to rotate, the reagent container loading device 400 is not limited to a sector-shaped or disc-shaped loading device, but can also be a loading device of other shapes, such as a rectangular loading device or other irregularly shaped loading devices.

[0033] As a further embodiment of the first embodiment in which the scheduling device 500 drives the reagent container loading device 400 to move, the scheduling device 500 is a combination of a motor and a transmission mechanism.

[0034] In a second embodiment where the scheduling device 500 drives the reagent container loading device 400 to move, the scheduling device 500 schedules the first reagent container 20, which contains the first reagent and is covered with a container lid 21, from the loading position 12 to the transfer position 13 by driving the reagent container loading device 400 to move horizontally in a linear motion. The horizontal linear motion performed by the scheduling device 500 driving the reagent container loading device 400 is a horizontal linear reciprocating motion.

[0035] In a further embodiment of the second implementation where the scheduling device 500 drives the reagent container loading device 400 to move, the reagent container loading device 400 is a rectangular loading device. Of course, in specific applications, as an alternative implementation where the scheduling device 500 drives the reagent container loading device 400 to move horizontally in a straight line, the reagent container loading device 400 is not limited to a rectangular loading device; it can also be a loading device of other shapes, such as a fan-shaped loading device, a disc-shaped loading device, or other irregularly shaped loading devices.

[0036] As a further embodiment of the second implementation of the method of the scheduling device 500 driving the reagent container loading device 400 to move, the scheduling device 500 can be a combination of a motor and a transmission mechanism, or a cylinder or a hydraulic cylinder.

[0037] In one implementation, the first reagent includes magnetic beads, i.e., the first reagent is a magnetic bead reagent. The magnetic bead reagent is used to perform antigen and antibody binding reactions with the sample. The sample analysis device 10 also includes a magnetic separation device 103, which is used to perform magnetic separation and cleaning operations on the reaction solution prepared at least from the sample and the first reagent. During the magnetic separation and cleaning process, operations such as magnetic adsorption, liquid aspiration, addition of separation liquid, mixing, and incubation are performed. The magnetic separation and cleaning operation is mainly used to remove impurities in the reaction solution while retaining the part to be tested, so as to obtain a purified reaction solution. The liquid after being processed by the magnetic separation device 103 includes a clear liquid and a magnetic bead liquid. In some detection projects, the clear liquid is treated as waste liquid, and the magnetic bead liquid forms a reaction solution to prepare the test solution; in other detection projects, the magnetic bead liquid is treated as waste liquid, and the clear liquid forms a reaction solution to prepare the test solution. Of course, in specific applications, the above-mentioned scheme of the first capping device 100 and the second capping device can also be applied to other sample analysis devices 10 that do not use magnetic bead reagents.

[0038] In one implementation, the detection device 101 detects the test solution prepared based on at least the sample and the first reagent within the reaction container, including: the detection device 101 performs an immunoassay on the test solution prepared based on at least the sample and the first reagent within the reaction container. That is, the sample analysis device 10 described above is an immunoassay device. The sample is a blood sample. The sample analysis device 10 also includes a reaction device 104 and a magnetic separation device 103. The reaction device 104 is used to hold the reaction container to incubate the sample and reagents (including but not limited to the first reagent) within the reaction container. The reagent dispensing device 900 is used to dispense reagents into the reaction container of the reaction device 104. Of course, in specific applications, the type of sample analysis device 10 is not limited to this. For example, as an alternative implementation, the sample analysis device 10 employing the first and second opening devices described above can also be a biochemical analysis device or a coagulation analysis device, or other analytical devices.

[0039] In one implementation, the immunoassay device performs at least one immunoluminescence assay. The goal of immunoluminescence assay is to detect the content of a specific antigen or antibody in a sample. The reaction vessel is used to hold the sample and a first reagent to generate an antigen-antibody binding reaction. The detection device 101 is used to detect the light signal in the test solution. Because various impurities exist in the sample, some impurities, such as endogenous enzymes naturally present in blood samples, can affect the final detection system (i.e., the final test solution), thus affecting the accuracy of the detection results. Therefore, the immunoluminescence assay process requires first purifying the target antigen or antibody, and then obtaining the level (i.e., content) of the target antigen or antibody in the sample through the luminescence detection of the label. In order to detect the level of the target antigen or antibody in the sample, this embodiment converts the concentration of the target antigen or antibody into a luminescent physical quantity. Since the antigen or antibody itself does not have luminescent ability, the conversion to luminescence can be achieved using an antibody with a luminescent label or an antigen with a luminescent label.

[0040] As one implementation method, the immunoassay device can perform immunoassay on samples using either direct chemiluminescence or enzyme-catalyzed chemiluminescence. When the immunoassay device uses enzyme-catalyzed chemiluminescence to perform immunoassay on samples, the execution process of one detection item in the immunoassay device includes: adding the sample, adding magnetic bead reagent and labeling reagent to form a first mixture, mixing and incubating the first mixture to obtain a first reaction solution, magnetically separating and washing the first reaction solution to obtain a second reaction solution, adding a luminescent substrate reagent to the second reaction solution to obtain a second mixture, mixing and incubating the second mixture to obtain the test solution, and performing optical measurement on the test solution to obtain the detection result.

[0041] Reference Figure 1 and Figure 15 , Figure 19 As shown, in one embodiment, the sample analysis device 10 also includes a mixing device 107, which is used to perform a mixing action on the magnetic beads deposited in the first reagent container 20 from the reagent container loading device 400, so that the magnetic beads deposited in the first reagent container 20 are detached from their deposition positions. The magnetic bead reagent needs to be in a homogeneous state when participating in the reaction. Due to the long-term standing of the magnetic bead reagent before loading, the magnetic bead deposition may not be easily mixed and dispersed, so a pre-mixing action, i.e., a mixing action, is required. The mixing device 107 performs the mixing action on the first reagent container 20, which allows the magnetic bead reagent to be in a better mixed state after loading. In this embodiment, by setting the mixing device 107 in the sample analysis device 10 to automatically perform the mixing action on the first reagent container 20 loaded, without requiring the user to manually perform the mixing action, it is beneficial to further reduce the user's workload and reduce the user's workload.

[0042] In one embodiment, the mixing device 107 is used to perform a mixing action on the magnetic beads deposited at the bottom of the first reagent container 20 before the first opening device 100 performs a first opening action on the first reagent container 20 containing the first reagent and covered with the container cap 21. That is, the mixing action is performed before the first opening action.

[0043] In one implementation, the mixing device 107 is used to: during the process of the dispatching device 500 dispatching the first reagent container 20, which contains the first reagent and is covered with the container cap 21, from the loading position 12 to the transfer position 13, or after dispatching to the transfer position 13, perform a mixing action on the magnetic beads deposited at the bottom of the first reagent container 20, so that the magnetic beads deposited at the bottom of the first reagent container 20 detach from its bottom. That is, the mixing action can be performed during the process of dispatching the first reagent container 20 to the transfer position 13, or it can be performed after dispatching to the transfer position 13 and before performing the first cap-opening action.

[0044] In one embodiment, the mixing device 107 is located outside the reagent container storage device 200. The aforementioned control of the reagent container transfer device 300 to remove and transfer the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and is covered by a container cap 21, from the transfer position 13 to the first opening device 100 includes: controlling the reagent container transfer device 300 to remove and transfer the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and the magnetic beads in the first reagent, after the mixing action has been completed, from the transfer position 13 to the first opening device 100. In this embodiment, the sample analysis device 10 has a mixing position located outside the reagent container storage device 200. The mixing position is located between the loading position 12 and the transfer position 13, or at the transfer position 13, along the trajectory of the scheduling device 500 driving the reagent container loading device 400 to move the first reagent container 20. During or after the scheduling device 500 schedules the first reagent container 20 from the loading position 12 to the transfer position 13, the mixing device 107 performs a mixing action on the first reagent in the first reagent container 20. In this embodiment, by arranging the mixing device 107 along the path of the first reagent container 20 from the loading position 12 to the transfer position 13, the mixing action on the first reagent container 20 is automatically performed during the scheduling process. This ensures that the setting of the first opening device 100 does not affect the internal structure of the reagent container storage device 200, and that the mixing action is completed during the scheduling process of the first reagent container 20, i.e., the mixing action is completed at the same time as the scheduling of the first reagent container 20, thus combining the scheduling time and the mixing time into one, thereby reducing the waiting time for starting sample testing; furthermore, it eliminates the need for manual operation of the mixing action. Of course, in specific applications, as an alternative embodiment, the mixing device 107 can also be located inside the reagent container storage device 200.

[0045] In the above scheme, the first reagent container 20 performs the mixing action on the reagent container loading device 400. Of course, in specific applications, as an alternative implementation, the first reagent container 20 may also perform the mixing action outside the reagent container loading device 400. For example, as an alternative implementation, the above-described control reagent container transfer device 300 removes and transfers the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and is covered with a container cap 21, from the intermediate transfer position 13 to the first cap opening device 100, including: controlling the reagent container transfer device 300 to remove and transfer the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and is covered with a container cap 21, from the intermediate transfer position 13 to the mixing position, so that the mixing device 107 performs a mixing action on the magnetic beads deposited at the bottom of the first reagent container 20 located at the mixing position, thereby causing the magnetic beads deposited at the bottom of the first reagent container 20 to detach from its bottom; controlling the reagent container transfer device 300 to transfer the first reagent container 20, which is located at the mixing position and contains the first reagent and the magnetic beads in the first reagent, to the first cap opening device 100 after the mixing action is completed. In this alternative implementation, the sample analysis device 10 also has a mixing position located outside the reagent container storage device 200, but the mixing position is outside the trajectory along which the scheduling device 500 drives the reagent container loading device 400 to move the first reagent container 20. In this implementation, the mixing position is located in an independent position. The first reagent container 20 is taken from the reagent container loading device 400 by the reagent container transfer device 300 and transferred to the mixing position to perform the mixing action. After the mixing action is completed, the first reagent container 20 is transferred to the first capping device 100 to perform the first capping action. Using this scheme, the mixing action of the first reagent in the first reagent container 20 can also be performed before the first capping device 100 performs the first capping action on the first reagent container 20.

[0046] In one embodiment, the mixing device 107 is disposed on the reagent container loading device 400 or between the loading position 12 and the transfer position 13. The mixing device 107 is used to perform a mixing action on the first reagent container 20 before the scheduling device 500 schedules the reagent container loading device 400 containing the first reagent container 20 from the loading position 12 to the transfer position 13, or during the scheduling device 500's scheduling of the reagent container loading device 400 containing the first reagent container 20 from the loading position 12 to the transfer position 13; or, the mixing device 107 is used to perform a mixing action on the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13 during the scheduling device 500's scheduling of the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13. The mixing device 107 is used to perform a mixing action on the first reagent container 20 before the scheduling device 500 schedules the first reagent container 20 loaded in the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13; or, the mixing device 107 is used to perform a mixing action on the first reagent container 20 before the scheduling device 500 schedules the reagent container carrier loaded in the reagent container loading device 400 and loaded with the first reagent container 20 from the reagent container loading device 400 to the transfer position 13 or during the scheduling device 500 schedules the reagent container carrier loaded in the reagent container loading device 400 and loaded with the first reagent container 20 from the reagent container loading device 400 to the transfer position 13.

[0047] In one implementation, the mixing device 107 is a magnetic adsorption device, which can be an electromagnet or a permanent magnet. The magnetic adsorption device performs a mixing action on the first reagent container 20, adsorbing magnetic beads to a target position on the side wall of the first reagent container 20. This allows magnetic beads deposited in the first reagent container 20 to detach from their deposition position, and facilitates better mixing of the first reagent after it is loaded into the machine. Furthermore, using a magnetic adsorption device to perform the mixing action on the first reagent in the first reagent container 20 does not require contact with the first reagent, making it easy to implement and preventing contamination of the first reagent. Of course, in specific applications, the configuration of the mixing device 107 is not limited to this; for example, the mixing device 107 can also be an ultrasonic mixing device 1011, an oscillating mixing device 1011, or a stirring device, etc.

[0048] In one implementation, the mixing device 107 and the reagent container loading device 400 are independently arranged, and the mixing device 107 and the reagent container loading device 400 can move relative to each other. The scheduling device 500 can drive the reagent container loading device 400 to move to the side of the mixing device 107 so that the mixing device 107 can perform a mixing action on the first reagent in the first reagent container 20. Of course, in specific applications, as an alternative implementation, the mixing device 107 can also be configured to be connected to the reagent container loading device 400 and move together with the reagent container loading device 400.

[0049] Reference Figure 1 and Figure 16 , Figure 19 As shown, in one embodiment, the sample analysis device 10 further includes a magnetic bead aggregation detection device 108; before the control reagent container transfer device 300 transfers the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the reagent container loading device 400 to the first cap opening device 100, the controller 600 is further configured to: control the reagent container transfer device 300 to transfer the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the reagent container loading device 400 to the magnetic bead aggregation detection position, and control the magnetic bead aggregation detection device 108 to detect the magnetic bead aggregation at the magnetic bead aggregation detection position. The first reagent container 20 performs a magnetic bead aggregation detection action to obtain magnetic bead aggregation detection information; based on the magnetic bead aggregation detection information, it is determined whether there is aggregation of magnetic beads in the first reagent container 20; the aforementioned control reagent container transfer device 300 transfers the first reagent container 20, which comes from the reagent container loading device 400 and contains the first reagent and is covered with a container cap 21, to the first cap opening device 100, including: controlling the reagent container transfer device 300 to transfer the first reagent container 20, which is determined based on the magnetic bead aggregation detection information, to the first cap opening device 100. Inversion, lateral placement, and excessively high or low storage temperatures during the transportation and storage of the first reagent can all cause irreversible aggregation of the magnetic beads in the first reagent. If the first reagent used in the analyzer exhibits magnetic bead aggregation, it can lead to precipitation or rapid settling even after in-process mixing, resulting in an abnormal effective concentration of magnetic beads. Using a first reagent with irreversible magnetic bead aggregation can cause abnormal sample test results, leading to incorrect results for patients and healthcare professionals, potentially resulting in serious consequences. This implementation scheme uses a magnetic bead aggregation detection device 108 in the sample analysis device 10 to automatically perform magnetic bead aggregation detection on the first reagent container 20 before the first opening action. This determines whether magnetic beads aggregation exists in the first reagent container 20, thus preventing the use of a first reagent with irreversible magnetic bead aggregation for sample reaction testing and avoiding incorrect sample test results for patients and healthcare professionals, which could lead to misdiagnosis of the patient's condition. Furthermore, performing magnetic bead agglomeration detection on the first reagent in the first reagent container 20 before performing the first opening action can avoid performing an unnecessary first opening action on the first reagent container 20 where agglomeration occurs, and can also help avoid affecting the airtightness and transportation of the first reagent container 20 after performing the first opening action.

[0050] In one implementation, the magnetic bead aggregation detection device 108 is disposed outside the reagent container storage device 200, and the sample analysis device 10 also forms a magnetic bead aggregation detection position located outside the reagent container storage device 200. The magnetic bead aggregation detection device 108 is used to perform magnetic bead aggregation detection on the first reagent container 20 located at the magnetic bead aggregation detection position. In this embodiment, disposing of the magnetic bead aggregation detection device 108 outside the reagent container storage device 200 facilitates the installation and setting of the magnetic bead aggregation detection device 108, is easy to implement, and ensures that the setting of the magnetic bead aggregation detection device 108 does not affect the internal structure of the reagent container storage device 200. In addition, performing magnetic bead aggregation detection on the first reagent in the first reagent container 20 before the first reagent container 20 enters the reagent container storage device 200 avoids unnecessary loading of the first reagent container 20, which has aggregation phenomena, into the reagent container storage device 200.

[0051] As one implementation, after the aforementioned magnetic bead aggregation detection device 108 performs a magnetic bead aggregation detection action on the first reagent container 20 located at the magnetic bead aggregation detection position, the controller 600 is further configured to: when it is determined, based on the magnetic bead aggregation detection information, that magnetic beads in the first reagent container 20 exhibit aggregation, perform at least one of the following actions: a rollback action and output an alarm message. The rollback action involves returning the first reagent container 20 to the loading position 12. Performing the rollback process on the first reagent container 20 prevents the first reagent exhibiting magnetic bead aggregation from being used in subsequent sample testing, thereby avoiding erroneous sample test results due to the use of the first reagent with quality issues, and ensuring the accuracy and reliability of the sample test results output by the sample analysis device 10. The output alarm message is mainly used to remind the user to intervene and handle the first reagent exhibiting magnetic bead aggregation. In practical applications, users can directly discard the first reagent container 20 that has been returned to the loading container; or they can first observe and verify the first reagent in the first reagent container 20 that has been returned to the loading position 12 to confirm whether there is really an irreversible aggregation of magnetic beads, and can then perform other treatments on the abnormal first reagent.

[0052] In one implementation, the above-mentioned retraction action includes: controlling the reagent container transfer device 300 to transfer the first reagent container 20, which contains the first reagent and in which the magnetic beads in the first reagent exhibit agglomeration, from the magnetic bead agglomeration detection position to the transfer position 13 and place it on the reagent container loading device 400; and controlling the scheduling device 500 to schedule the reagent container loading device 400, which contains the first reagent container 20 and in which the magnetic beads in the first reagent container 20 exhibit agglomeration, from the transfer position 13 to the loading position 12. In this embodiment, before the reagent container transfer device 300 transfers the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the reagent container loading device 400 to the magnetic bead aggregation detection position, the controller 600 is further configured to: control the scheduling device 500 to drive the reagent container loading device 400 to move the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and is covered with a container cap 21, so as to schedule the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the loading position 12 to the transfer position 13. When performing the retraction action, the first reagent container 20 first retracts to the reagent container loading device 400 located at the transfer position 13, and then the reagent container loading device 400 drives the first reagent container 20 to retract to the loading position 12. In other alternative implementations, the rollback action may also include: controlling the reagent container transfer device 300 to transfer the first reagent container 20 from the magnetic bead aggregation detection position to the transfer position 13, and controlling the scheduling device 500 to transfer the first reagent container 20 from the transfer position 13 to the reagent container loading device 400 located at the loading position 12; or controlling the reagent container transfer device 300 to transfer the first reagent container 20 from the magnetic bead aggregation detection position to the reagent container carrier located at the transfer position 13, and controlling the scheduling device 500 to schedule the reagent container carrier loaded with the first reagent container 20 from the transfer position 13 to the reagent container loading device 400 located at the loading position 12. In this implementation, the rollback process for the first reagent container 20 is performed by rolling the first reagent container 20 back to the reagent container loading device 400 located at the loading position 12.

[0053] In one implementation, the sample analysis device 10 also includes an alarm device. The aforementioned output alarm information includes controlling the alarm device to issue an abnormality alert signal. The abnormality alert signal can remind the user to perform recovery or quality verification on the first reagent container 20 where magnetic beads agglomerate.

[0054] In one implementation, the alarm device can be an indicator light that emits a light signal, a speaker that emits a sound signal, a warning sign or prompt message displayed on the screen built into the sample analysis device 10, or an abnormality reminder message sent to a server or mobile terminal.

[0055] In one implementation, the magnetic bead aggregation detection device 108 is an image capturing device used to capture an image of the bottom of the first reagent container 20. Controlling the magnetic bead aggregation detection device 108 to perform a magnetic bead aggregation detection action on the first reagent container 20 located at the magnetic bead aggregation detection position to obtain magnetic bead aggregation detection information includes: controlling the image capturing device to capture an image of the bottom of the first reagent container 20 located at the magnetic bead aggregation detection position to obtain a target image. Determining whether there is aggregation of magnetic beads in the first reagent container 20 based on the magnetic bead aggregation detection information includes: performing grayscale comparison analysis on the target image to determine whether magnetic bead caking occurs in the first reagent container 20; if so, it is determined that there is aggregation of magnetic beads in the first reagent container 20. In this implementation, an image capturing device is used to acquire images for magnetic bead aggregation detection. This detection method does not require the aspiration of the first reagent for detection, i.e., it is a lossless detection. The amount of the first reagent is not lost due to magnetic bead aggregation detection, balancing the accuracy and cost of sample detection. Furthermore, in this embodiment, the controller 600 determines whether the magnetic bead reagent has agglomerated by performing grayscale comparison analysis on the image obtained from the bottom of the first reagent container 20 captured by the image capturing device. This method has better applicability than directly using a grayscale threshold to determine whether agglomeration has occurred. Specifically, in the method of directly using a grayscale threshold, a large number of tests are required to determine the corresponding grayscale threshold for different types of magnetic bead reagents, different concentrations of magnetic bead reagents, and different image acquisition conditions. In other words, the grayscale threshold to be set for different reagent images cannot be unified. However, by performing grayscale comparison analysis on the image obtained from the bottom of the first reagent container 20 captured by the image capturing device, the influence of different first reagent types, first reagent concentrations, image acquisition conditions, etc. can be eliminated, thus having better applicability.

[0056] As one implementation method, the above-mentioned grayscale comparison analysis of the target image to determine whether the magnetic beads in the first reagent container 20 have clumped together includes: determining whether the magnetic bead reagent has undergone irreversible magnetic bead aggregation based on the relative grayscale comparison of the pixel sampling points in the target image.

[0057] As one implementation method, the method of determining whether magnetic bead reagent has undergone magnetic bead aggregation based on the relative comparison of gray values ​​of pixel sampling points in the target image includes: determining the target area corresponding to the bottom of the first reagent container 20 based on the relative comparison of gray values ​​of each pixel point in the target image; and determining whether irreversible magnetic bead aggregation has occurred based on the degree of dispersion of gray values ​​of each pixel sampling point in the target area. Since the image captured by the image capturing device is obtained from the bottom of the first reagent container 20 containing magnetic bead reagent, and the shape of the image captured by the image capturing device is difficult to completely match the bottom of the first reagent container 20, the image captured by the image capturing device is often larger. Therefore, the image captured by the image capturing device will include the area corresponding to the bottom of the first reagent container 20 and other edge areas. The image captured by the image capturing device includes a circular area in the middle corresponding to the bottom of the first reagent container 20 and an outer peripheral area located outside the circular area. The outer peripheral area is often the image corresponding to the container seat 106 or other base used to place the first reagent container 20. It is not necessary to use it to determine whether the magnetic bead reagent has undergone irreversible magnetic bead aggregation. That is, the circular area corresponding to the bottom of the first reagent container 20 in the image captured by the image capturing device is the target area required for judgment. Furthermore, because the light transmittance of the container base 106 differs from that of the first reagent container 20, the grayscale values ​​of each pixel in the target area corresponding to the bottom of the first reagent container 20 and the outer area corresponding to the container base 106 or other base used to place the first reagent container 20 are different, with a significant difference in grayscale values. The target area and the outer area have a relatively clear boundary. For example, if the container base 106 or other base used to place the first reagent container 20 is made of transparent material, the image of the outer area is whiter and has a higher grayscale value; if the container base 106 or other base used to place the first reagent container 20 is made of opaque material, the image of the outer area is darker and has a lower grayscale value. Therefore, the target area is first determined based on the grayscale values, and then the grayscale values ​​of each pixel sampling point in the target area are further analyzed.

[0058] By using the dispersion of grayscale values ​​of each pixel sampling point in the target area, the presence of magnetic bead agglomeration is determined. This method has better applicability compared to other methods that directly use grayscale thresholds to determine whether magnetic bead agglomeration has occurred. Prior to this application, related technologies analyzed acquired images in various ways: one method segmented the acquired image into agglomerated and non-agglomerated parts based on the pixel grayscale values ​​of each pixel and a preset binarization threshold, and then determined abnormal magnetic bead reagents based on the area of ​​the agglomerated part. This is because when magnetic bead agglomeration occurs, there is a certain boundary between the agglomerated and non-agglomerated parts. By setting a binarization threshold and comparing the pixel grayscale values ​​of each pixel in the acquired image with the preset binarization threshold, the acquired image is segmented into agglomerated and non-agglomerated parts. Then, the area of ​​the agglomerated part is identified, and the size of this area can be used to determine whether the magnetic bead reagent is abnormal. In another approach, multiple target regions are divided from the acquired image. Abnormal magnetic bead reagents are identified based on the average grayscale value of each pixel in the multiple target regions and a preset grayscale threshold. This is because when magnetic beads aggregate, the grayscale value of each pixel in the aggregated part will be lower, thus reducing the average grayscale value of each pixel in each target region. By setting a preset grayscale threshold, when the average grayscale value of each pixel in the target region is less than the preset grayscale threshold, it can be considered that magnetic bead aggregation has occurred in the target region. In another method, abnormal magnetic bead reagents are identified based on the histogram of the pixel grayscale of each pixel in the acquired image. This is because for the first reagent container 20 containing normal magnetic bead reagents, the pixel grayscale distribution of each pixel in the acquired image of the bottom of the first reagent container 20 is uniform, and its histogram distribution range is relatively concentrated. When magnetic bead aggregation occurs, the pixel grayscale value of the pixel corresponding to the aggregation part decreases, and a peak will appear in the low grayscale value area of ​​the histogram. Therefore, by identifying the histogram distribution structure of the pixel grayscale of each pixel in the acquired image, it is possible to detect whether magnetic bead aggregation has occurred.However, all three methods have significant drawbacks. The first method uses a hard threshold for segmentation by setting a binarization threshold. Different concentrations and types of magnetic beads can interfere with the selection of the detection threshold, making it impossible to unify the detection threshold across different images. The second method compares a preset grayscale threshold with the average grayscale value of each pixel, also using a hard threshold for segmentation. Different concentrations and types of magnetic beads can interfere with the selection of the detection threshold, and this method is also greatly affected by lighting conditions, making it impossible to unify the detection threshold across different images. The third method is based on grayscale histogram features, detecting whether there are spikes in low grayscale regions of the histogram to detect the presence of magnetic bead aggregation. When only a small amount of aggregation occurs, this peak feature is not obvious, easily leading to missed detections. In this implementation scheme, for the first reagent container 20 containing normal magnetic bead reagent, the pixel grayscale distribution of each pixel in the reagent image at the bottom is uniform, and the discrete distribution of pixel grayscale is good, for example, the standard deviation, relative range, or coefficient of variation of pixel grayscale will be small. When magnetic bead aggregation occurs, the discrete distribution of pixel grayscale deteriorates, and the standard deviation, relative range, or coefficient of variation of pixel grayscale will increase. Therefore, by setting a discrete distribution threshold that characterizes the degree of dispersion, such as the standard deviation, relative range, or coefficient of variation of pixel grayscale, when the discrete index of pixel grayscale is greater than the discrete distribution threshold, it is determined that the magnetic bead reagent has aggregated, and it can be identified as abnormal magnetic bead reagent. Furthermore, the discrete index of pixel grayscale is obtained based on the relative comparison of the grayscale values ​​of each pixel in the reagent image. The type of magnetic bead reagent, the concentration of the magnetic bead reagent, and the illumination when acquiring the reagent image have the same impact on the grayscale values ​​of each pixel, which can eliminate the influence of different reagent types, reagent concentrations, image acquisition conditions, etc., and has better applicability.

[0059] In one implementation, the first capping position 11 and the magnetic bead aggregation detection position are two different locations. Of course, in specific applications, as an alternative implementation, the first capping position 11 and the magnetic bead aggregation detection position can also be the same location. The first capping device 100 and the magnetic bead aggregation detection device 108 are used to perform the first capping action and the magnetic bead aggregation detection action respectively on the first reagent container 20 at the same location. This allows the same container holder 106 to be reused for positioning the first reagent container 20 during both the first capping action and the magnetic bead aggregation detection action. This improves the structural compactness of the sample analysis device 10 and reduces its cost. Furthermore, it reduces the number of working positions on the first reagent container 20, thereby reducing the transfer time of the first reagent container 20.

[0060] In one embodiment, when the sample analysis device 10 includes the magnetic bead aggregation detection device 108 described above, the sample analysis device 10 further includes a mixing device 107 and / or a mixing device 1011; wherein, the mixing device 107 is used to: perform a mixing action on the magnetic beads deposited at the bottom of the first reagent container 20 before the reagent container transfer device 300 transfers the first reagent container 20, which is from the reagent container loading device 400 and contains the first reagent and is covered with a container cap 21, to the magnetic bead aggregation detection position, so that the magnetic beads deposited at the bottom of the first reagent container 20 detach from its bottom; the mixing device 1011 is used to: perform a mixing action on the first reagent in the first reagent container 20 before the magnetic bead aggregation detection device 108 performs a magnetic bead aggregation detection action on the first reagent container 20 located at the magnetic bead aggregation detection position. In this embodiment, before the magnetic bead aggregation detection device 108 performs the magnetic bead aggregation detection action on the first reagent container 20, a mixing action and / or a homogenizing action is performed on the first reagent in the first reagent container 20, which helps to ensure the accuracy and reliability of the magnetic bead aggregation detection results. Of course, in specific applications, as an alternative embodiment, if the sample analysis device 10 includes the above-mentioned magnetic bead aggregation detection device 108, the sample analysis device 10 may not include either the mixing device 107 or the homogenizing device 1011. For example, the mixing action and / or homogenizing action on the first reagent in the first reagent container 20 can be performed manually or by a mechanism independent of the sample analysis device 10, and then the first reagent container 20 can be loaded from the loading position 12 onto the reagent container loading device 400.

[0061] In one implementation, the sample analysis device 10 also includes a mixing device 1011 (see reference 1011). Figure 19 As shown, the mixing device 1011 is used to perform a mixing action on the first reagent in the first reagent container 20. The magnetic bead aggregation detection device 108 is used to perform a magnetic bead aggregation detection action on the first reagent container 20 after the mixing action is completed and it is located at the magnetic bead aggregation detection position. In this implementation scheme, the magnetic beads in the magnetic bead reagent are mixed by the mixing device 1011, which can improve the uniformity of the magnetic bead reagent. Then, before the magnetic bead reagent is used, that is, before the magnetic bead reagent is mixed with the sample, the magnetic bead aggregation detection device 108 detects the aggregation of the magnetic bead reagent in the first reagent container 20 after the mixing treatment. Then, the controller 600 identifies anomalies based on the magnetic bead aggregation detection information obtained by the magnetic bead aggregation detection device 108, and determines whether the magnetic bead reagent has an abnormal aggregation phenomenon. This avoids the use of abnormal magnetic bead reagent in subsequent sample tests, which would cause abnormal sample test results. Alternatively, it can prompt patients and medical staff to ignore the sample test results using abnormal magnetic bead reagent, so as to avoid patients and medical staff receiving incorrect sample test results and thus misjudging the condition.

[0062] In one implementation, the mixing device 1011 performs a mixing action on the first reagent in the first reagent container 20 by driving the first reagent container 20 to rotate. Of course, in specific applications, as an alternative implementation, the mixing device 1011 can also perform a mixing action on the first reagent in the first reagent container 20 in other ways, such as shaking mixing, inverting mixing, ultrasonic mixing, etc.

[0063] In one implementation, the sample analysis device 10 also includes a correction device 1010 (see reference 1010). Figure 19 (As shown); before the control reagent container transfer device 300 transfers the first reagent container 20, which is determined by the magnetic bead aggregation detection information to have no magnetic bead aggregation, to the first capping device 100, the controller 600 is further configured to: control the reagent container transfer device 300 to transfer the first reagent container 20, which is determined by the magnetic bead aggregation detection information to have no magnetic bead aggregation, to the correction position, and control the correction device 1010 to perform a correction action on the container cap 21 of the first reagent container 20 located at the correction position; the above-mentioned control reagent container transfer device 300 to transfer the first reagent container 20, which is determined by the magnetic bead aggregation detection information to have no magnetic bead aggregation, to the first capping device 100 includes: controlling the reagent container transfer device 300 to transfer the first reagent container 20, which is determined by the magnetic bead aggregation detection information to have no magnetic bead aggregation, and the correction device 1010 has completed the correction action, from the correction position to the first capping device 100. The setting of the correction device 1010 is mainly used to ensure that the container cap 21 of each first reagent container 20 that is delivered to the first cap opening device 100 is facing the same direction, thereby facilitating the smooth execution of the first cap opening action.

[0064] In one implementation, the sample analysis device 10 further includes a deflection detection device 101. The aforementioned control and correction device 1010 performs a correction action on the container cap 21 of the first reagent container 20 located at the correction position, including: controlling the deflection detection device 101 to perform a deflection angle detection action on the container cap 21 of the first reagent container 20 located at the correction position to obtain deflection angle detection information; determining whether the container cap 21 has a deflection phenomenon and determining the deflection angle of the container cap 21 based on the deflection angle of the container cap 21; and controlling the correction device 1010 to perform a correction action on the container cap 21 of the first reagent container 20 located at the correction position based on the deflection angle of the container cap 21. In this embodiment, before performing the correction action, the deflection angle of the container cap 21 is detected first, which facilitates accurate correction of the container cap 21, thereby facilitating the correction device 1010 to drive the container cap 21 to rotate back by the deflection angle. Of course, in specific applications, as an alternative implementation, the deflection detection device 101 may not be set up, and other methods may be used to determine the deflection angle of the container lid 21, such as determining it based on the working parameters of the mixing device 1011.

[0065] In one implementation, the deflection detection device 101 is a camera device used to capture an image of the container cap 21 from above the first reagent container 20. The controller 600 is configured to determine whether the container cap 21 is deflected and to determine the deflection angle of the container cap 21 based on the image captured by the camera device.

[0066] Reference Figure 1 , Figure 2 , Figure 15 , Figure 16 and Figure 18 , Figure 19As shown, in one embodiment, when the sample analysis device 10 includes the aforementioned magnetic bead aggregation detection device 108, the sample analysis device 10 includes a mixing device 107 and a homogenizing device 1011. The controller 600 is further configured to: acquire information that a user places a first reagent container 20 containing the first reagent and covered with a container cap 21 from the loading position 12 onto the reagent container loading device 400; control the scheduling device 500 to drive the reagent container loading device 400 to move the first reagent container 20 loaded on the reagent container loading device 400, thereby scheduling the first reagent container 20 from the loading position 12 to the transfer position 13, wherein the scheduling device 500 schedules the first reagent container 20 from the loading position 12 to the transfer position 13... During the process or after being dispatched to the transfer station 13, the mixing device 107 performs a mixing action on the magnetic beads deposited at the bottom of the first reagent container 20; the reagent container transfer device 300 is controlled to remove the first reagent container 20, which is loaded on the reagent container loading device 400 and contains the first reagent and the magnetic beads in the first reagent, from the transfer station 13 after the mixing action is completed, and transfer it to the magnetic bead aggregation detection station; the mixing device 1011 is controlled to perform a mixing action on the first reagent in the first reagent container 20 located at the magnetic bead aggregation detection station; the magnetic bead aggregation detector is controlled. After the mixing process is completed, the first reagent container 20 located at the magnetic bead aggregation detection position performs a magnetic bead aggregation detection action to obtain magnetic bead aggregation detection information. When the magnetic bead aggregation detection information determines that there is no aggregation of magnetic beads in the first reagent container 20, the reagent container transfer device 300 is controlled to transfer the first reagent container 20 from the magnetic bead aggregation detection position to the correction position. The deflection detection device 101 is then controlled to perform a deflection angle detection action on the container cap 21 of the first reagent container 20 located at the correction position to obtain the deflection angle of the container cap 21. Angle; based on the deflection angle of the container cap 21, control the correction device 1010 to perform a correction action on the container cap 21 of the first reagent container 20 located in the correction position, control the reagent container transfer device 300 to transfer the first reagent container 20 after the correction action completed by the correction device 1010 from the correction position to the first cap opening device 100, control the first cap opening device 100 to perform a first cap opening action on the first reagent container 20; when it is determined that there is agglomeration of magnetic beads in the first reagent container 20 based on the magnetic bead agglomeration detection information, execute a retraction action.In this embodiment, after the first reagent container 20 is loaded into the reagent container loading device 400, it first performs a mixing action; after the mixing action is completed, it performs a homogenization action; after the homogenization action is completed, it performs a magnetic bead aggregation detection action; if the magnetic bead aggregation detection information obtained from the magnetic bead aggregation detection action determines that there is aggregation of magnetic beads in the first reagent container 20, the first reagent container 20 is retracted; if the magnetic bead aggregation detection information obtained from the magnetic bead aggregation detection action determines that there is no aggregation of magnetic beads in the first reagent container 20, the container lid 21 of the first reagent container 20 is corrected; after the correction action is completed, the first lid opening action is performed, and then the reagent container storage device 200 is placed in; then the second lid opening action and reagent suction action are performed on the first reagent container 20. Of course, in specific applications, as an alternative embodiment, after the mixing action is completed, the first lid opening action can also be performed first; after the first lid opening action is completed, the homogenization action and the magnetic bead aggregation detection action can be performed.

[0067] In one embodiment, the reagent container storage device 200 has a reagent container interaction port 210, which is at least used by the reagent container transfer device 300 to place the first reagent container 20 after the first opening action into the reagent container storage device 200.

[0068] like Figure 2 As shown, in a further embodiment of the first embodiment where the first opening device 100 is located outside the reagent container storage device 200, the first opening position 11 is located on the side of the reagent container interaction port 210 away from the loading position 12. The sample analysis device 10 also includes a container seat 106, which is located at the first opening position 11 and is used to carry the first reagent container 20 to perform the first opening action. The reagent container transfer device 300 is used to transfer the first reagent container 20, which is loaded with the first reagent and has a container cap 21, to the container seat 106 located at the first opening position 11, and to transfer the first reagent container 20, after the first opening action is completed, from the container seat 106 located at the first opening position 11 to the reagent container storage device 200. The above-mentioned control of the first opening device 100 to perform the first opening action on the first reagent container 20 loaded with the first reagent and having a container cap 21 includes: controlling the reagent container transfer device 300 to transfer the first reagent container 20 loaded with the first reagent and having a container cap 21 to the container seat 106, and controlling the first opening device 100 to perform the first opening action on the first reagent container 20 located in the container seat 106. Reference Figure 3As shown, in a second embodiment where the first opening device 100 is located outside the reagent container storage device 200, the first opening position 11 is located at the loading position 12. The first opening device 100 can perform a first opening action on the first reagent container 20 located at the loading position 12 from the side of the loading position 12.

[0069] As a third embodiment where the first opening device 100 is located outside the reagent container storage device 200, the first opening position 11 is located directly above or directly below the reagent container interaction port 210.

[0070] In one implementation, the transfer position 13, the magnetic bead agglomeration detection position, the correction position, and the first capping device 100 are all located at positions that are horizontally offset from the reagent container interaction port 210 and horizontally offset from the loading position 12. The transfer position 13 is located between the loading position 12 and the reagent container interaction port 210, the reagent container interaction port 210 is located between the transfer position 13 and the magnetic bead agglomeration detection position, and the correction position is located between the magnetic bead agglomeration detection position and the first capping device 100.

[0071] Reference Figures 1 to 4 and Figure 17As shown, in one embodiment, the above-mentioned control of the first opening device 100 to perform a first opening action on the first reagent container 20 loaded with the first reagent and having a container cap 21, and the above-mentioned control of the second opening device to perform a second opening action on the first reagent container 20 after the first opening action is completed, includes: when information is obtained that the first reagent container 20 is placed in the reagent container loading device 400, determining whether there is a test item to be performed that requires the use of the first reagent in the first reagent container 20; if it is determined that there is a test item that requires the use of the first reagent in the first reagent container 20, controlling the first opening device 100 to perform a first opening action on the first reagent container 20 located at the first opening position 11, controlling the reagent container transfer device 300 to transfer the first reagent container 20 after the first opening action is completed to the reagent container interaction port 210 and place it into the reagent container storage device 200 through the reagent container interaction port 210, and controlling the second opening device to perform a second opening action on the first reagent container 20 placed in the reagent container storage device 200 and after the first opening action is completed. In a specific application, when a user places a newly loaded first reagent container 20 into the reagent container loading device 400, the controller 600 receives information that the first reagent container 20 is placed in the reagent container loading device 400. It then determines whether any of the tests to be performed require the use of the first reagent in the first reagent container 20, which is equivalent to determining whether the first reagent in the first reagent container 20 should be used immediately. In this implementation scheme, when the first reagent is loaded, it first determines whether the first reagent needs to be used. If so, it first performs a first opening action on the first reagent container 20 containing the first reagent to relieve part of the sealing force of the container cap 21. Then, it places the first reagent container 20 into the reagent container storage device 200, and then performs a second opening action on the first reagent container 20 to completely open the container cap 21. This allows the reagent dispensing device 900 to draw the first reagent from the first reagent container 20 containing the first reagent and dispense it into the reaction container, thereby enabling the first reagent to react with the sample in the reaction container to form a test solution for detection by the detection device 101.

[0072] As one implementation, when the first opening position 11 is independent of the loading position 12 (i.e., the first opening position 11 is not located at the loading position 12), before controlling the first opening device 100 to perform the first opening action on the first reagent container 20, it is necessary to first control the reagent container transfer device 300 and / or the scheduling device 500 to transfer the first reagent container 20 to the first opening position 11. For example, when the first opening position 11 is located in the horizontal direction on the side of the transfer position 13 away from the loading position 12 and is horizontally offset from the reagent container interaction port 210, the above-mentioned control of the first opening device 100 to perform the first opening action on the first reagent container 20 loaded with the first reagent and having a container cap 21, and the above-mentioned control of the second opening device to perform the second opening action on the first reagent container 20 after the first opening action is completed, includes: when information is obtained that the first reagent container 20 is placed on the reagent container loading device 400, controlling the first opening device 100 to perform the first opening action on the first reagent container 20, and controlling the second opening device to perform the second opening action on the first reagent container 20 after the first opening action is completed, including: when information is obtained that the first reagent container 20 is placed on the reagent container loading device 400, controlling the first opening device 100 to perform the first opening action on the first reagent container 20, and controlling the second opening device to perform the second opening action on the first reagent container 20 after the first opening action is completed ... The scheduling device 500 schedules the reagent container loading device 400, which is loaded with the first reagent container 20, from the loading position 12 to the transfer position 13; or the scheduling device 500 schedules the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13; or the scheduling device 500 schedules the reagent container carrier loaded on the reagent container loading device 400 and loaded with the first reagent container 20 from the reagent container loading device 400 to the transfer position 13; and determines whether the test item to be performed is... If a test requires the use of the first reagent in the first reagent container 20, and if it is determined that a test requires the use of the first reagent in the first reagent container 20, the reagent container transfer device 300 is controlled to remove the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and transfer the first reagent container 20 to the first opening position 11, or to transfer the first reagent container 20 from the transfer position 13 to the first opening position 11, or to remove the first reagent container 20 from the reagent container carrier located at the transfer position 13 and transfer the first reagent container 20 to the first opening position 11. Move to the first opening position 11, control the first opening device 100 to perform the first opening action on the first reagent container 20 located at the first opening position 11, control the reagent container transfer device 300 to transfer the first reagent container 20 after completing the first opening action from the first opening position 11 to the reagent container interaction port 210 and put it into the reagent container storage device 200 through the reagent container interaction port 210, and control the second opening device to perform the second opening action on the first reagent container 20 after it has been put into the reagent container storage device 200 and completed the first opening action.

[0073] In one implementation, when the first opening position 11 is located at the loading position 12, before controlling the first opening device 100 to perform the first opening action on the first reagent container 20, it is not necessary to control the reagent container transfer device 300 and / or the scheduling device 500 to transfer the first reagent container 20 to the first opening position 11, and the first opening action can be performed at the loading position 12. The aforementioned control reagent container transfer device 300 transfers the first reagent container 20, after completing the first opening action, to the reagent container interface 210 and then places it into the reagent container storage device 200 from the reagent container interface 210. This includes: the control scheduling device 500 scheduling the reagent container loading device 400, which is loaded with the first reagent container 20 after completing the first opening action and is in the first open state, from the loading position 12 to the transfer position 13; the control reagent container transfer device 300 removing the first reagent container 20, after completing the first opening action, from the reagent container loading device 400 located at the transfer position 13 and transferring it to the reagent container interface 210 and placing it into the reagent container storage device 200 through the reagent container interface 210; or, the control scheduling device 500 removing the first reagent container 20, after completing the first opening action and being in the first open state, from the reagent container loading device 400 located at the transfer position 13 and transferring it to the reagent container interface 210 and placing it into the reagent container storage device 200 through the reagent container interface 210; or, the control scheduling device 500 removing the first reagent container 20, after completing the first opening action and being in the first open state, from the reagent container loading device 400 located at the transfer position 13 and transferring it to the reagent container interface 210 and placing it into the reagent container storage device 200 through the reagent container interface 210. The reagent container loading device 400 located at loading position 12 is taken out and dispatched to transfer position 13. The reagent container transfer device 300 is controlled to transfer the first reagent container 20, which has completed the first opening action, from transfer position 13 to reagent container interaction port 210 and then put into reagent container storage device 200 through reagent container interaction port 210; or, the control dispatch device 500 takes out the reagent container carrier containing the first reagent container 20, which has completed the first opening action and is in the first open state, from the reagent container loading device 400 located at loading position 12 and dispatches it to transfer position 13. The control reagent container transfer device 300 takes out the first reagent container 20, which has completed the first opening action, from the reagent container carrier located at transfer position 13, transfers it to reagent container interaction port 210 and then puts it into reagent container storage device 200 through reagent container interaction port 210.

[0074] Reference Figures 1 to 4 and Figure 17As shown, in one implementation, after determining whether any of the tests to be performed require the use of the first reagent in the first reagent container 20, the controller 600 is further configured to: if it is determined that no test requires the use of the first reagent in the first reagent container 20, control the reagent container transfer device 300 to remove the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and place the first reagent container 20 into the reagent container storage device 200 through the reagent container interaction port 210; or control the reagent container transfer device 300 to place the first reagent container 20 from the transfer position 13 into the reagent container storage device 200 through the reagent container interaction port 210; or control the reagent container transfer device 300 to remove the first reagent container 20 from the reagent container carrier located at the transfer position 13 and place the first reagent container 20 into the reagent container storage device 200 through the reagent container interaction port 210. The reagent container is placed into the reagent container storage device 200 through the reagent container interface 210. When a test item requires the use of the first reagent in the first reagent container 20, the reagent container transfer device 300 is controlled to remove the first reagent container 20 from the reagent container storage device 200 through the reagent container interface 210 and transfer it to the first opening position 11. The first opening device 100 is controlled to perform a first opening action on the first reagent container 20 located at the first opening position 11. The reagent container transfer device 300 is controlled to transfer the first reagent container 20 after the first opening action is completed from the first opening position 11 to the reagent container interface 210 and place it into the reagent container storage device 200 through the reagent container interface 210. The second opening device is controlled to perform a second opening action on the first reagent container 20 after it has been placed into the reagent container storage device 200 and completed the first opening action. In this embodiment, when the first reagent is being fed, if it is determined that the first reagent is not currently needed, the first reagent container 20 containing the first reagent is first placed in the reagent container storage device 200 for storage. When the first reagent is needed, the first reagent container 20 containing the first reagent is then removed from the reagent container storage device 200 and placed in the first opening position 11 to perform the first opening action. After removing part of the sealing force of the container cap 21, the first reagent container 20 after the first opening action is completed is placed back into the reagent container storage device 200. Then, the first reagent container 20 is subjected to the second opening action to fully open the container cap 21, thereby facilitating the reagent dispensing device 900 to draw the first reagent from the first reagent container 20 containing the first reagent and dispense it into the reaction container. This allows the first reagent to react with the sample in the reaction container to form a test solution for detection by the detection device 101.

[0075] Reference Figures 3 to 5As shown, in one embodiment, when the first opening device 100 is located inside the reagent container storage device 200, or at the loading position 12, or between the transfer position 13 and the loading position 12, the sample analysis device 10 also forms a buffer position 15 outside the reagent container storage device 200. The buffer position 15 is used to buffer the first reagent container 20 from the reagent container loading device 400 when the reagent container storage device 200 is full, or to buffer the first reagent container 20 from the reagent container storage device 200 awaiting recycling when the reagent container loading device 400 is full, or to buffer the first reagent container 20 when the sample analysis device 10 is malfunctioning, or to buffer an abnormal first reagent container 20. The reagent container transfer device 300 is used at least to transfer the first reagent container 20 between the transfer position 13, the reagent container storage device 200, and the buffer position 15. Specifically, the reagent container transfer device 300 is used to transfer the first reagent container 20 between the transfer position 13, the reagent container interaction port 210, and the buffer position 15. "Reagent container storage device 200 in full load condition" means that the reagent container storage device 200 is filled with reagent containers, that is, each of the reagent container storage devices 200's accommodating slots is filled with reagent containers. "Reagent container loading device 400 in full load condition" means that the reagent container loading device 400 is filled with reagent containers, that is, each of the reagent container loading devices 400's slots or locators is filled with reagent containers. "Sample analysis device 10 in malfunction condition" means that the sample analysis device 10 is malfunctioning due to a mechanical component, circuit, or software program failure. Abnormal first reagent containers 20 include, but are not limited to, first reagent containers 20 that cannot be scanned or whose loaded first reagent is expired, first reagent containers 20 where magnetic beads have agglomerated, and first reagent containers 20 where the loaded first reagent has other quality abnormalities. In this embodiment, during the process of loading reagent containers into the reagent container storage device 200, if the number of reagent containers loaded exceeds the number of remaining empty slots in the reagent container storage device 200, the excess reagent containers can be placed in the buffer position 15. During the process of dispatching reagent containers to the reagent container loading device 400 for retrieval, if the number of reagent containers to be retrieved exceeds the number of remaining empty slots or compartments in the reagent container loading device 400, the excess reagent containers can be placed in the buffer position 15. When the sample analysis device 10 malfunctions, the nearest reagent container can be placed in the buffer position 15. When the first reagent container 20 is determined to be abnormal, the first reagent container 20 can be placed in the buffer position 15. This embodiment, by setting up a buffer position 15 outside the reagent container storage device 200 to buffer reagent containers, helps to improve the continuous stability of the sample analysis device 10's operation.Of course, in specific applications, as an alternative implementation, the sample analysis device 10 may not have a cache bit 15.

[0076] In one embodiment, the sample analysis device 10 further includes a reagent container storage device 200 and a reagent container transfer device 300. The reagent container storage device 200 is used to store a first reagent container 20. The reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 with its container cap 21 in a second open state, and to dispense all or part of the drawn first reagent into a reaction vessel. A first cap-opening device 100 is located outside the reagent container storage device 200. The sample analysis device 10 also includes a container seat 106, located outside the reagent container storage device 200 and used to support the first reagent container 20 to perform a first cap-opening action. The reagent container transfer device 300 is used to transfer the first reagent container 20, which contains the first reagent and has a container cap 21, to the container seat 106, and to transfer the first reagent container 20 from the container seat 106 to the reagent container storage device 200 after the first cap-opening action has been completed. The above-mentioned control of the first opening device 100 to perform the first opening action on the first reagent container 20 loaded with the first reagent and having a container cap 21 includes: controlling the reagent container transfer device 300 to transfer the first reagent container 20 loaded with the first reagent and having a container cap 21 to the container seat 106, and controlling the first opening device 100 to perform the first opening action on the first reagent container 20 located in the container seat 106.

[0077] In the above scheme, the first opening device 100 is located outside the reagent container storage device 200. Of course, in specific applications, as an alternative implementation, the first opening device 100 can also be located inside the reagent container storage device 200. (Refer to...) Figure 5As shown, in this alternative embodiment, the first opening device 100 is located inside the reagent container storage device 200; the reagent container storage device 200 has a reagent container interaction port 210; and a second opening position 14 is formed inside the reagent container storage device 200. The sample analysis device 10 also includes a reagent container loading device 400, a reagent container transfer device 300, and a scheduling device 500. The sample analysis device 10 also has a loading position 12 located outside the reagent container storage device 200, which is used to accommodate the reagent container loading device 400 containing the first reagent container 20 to realize the loading of the first reagent. The sample analysis device 10 also includes a transfer station 13 located outside the reagent container storage device 200. A scheduling device 500 is used to schedule the reagent container loading device 400, which contains the first reagent container 20, from the loading station 12 to the transfer station 13; or the scheduling device 500 is used to schedule the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer station 13; or the scheduling device 500 is used to schedule a reagent container carrier loaded on the reagent container loading device 400 and containing the first reagent container 20 from the reagent container loading device 400 to the transfer station 13. A reagent container transfer device 300 is used to place the first reagent container 20 located at the transfer station 13 into the reagent container storage device 200 through the reagent container interface 210.The aforementioned control of the first opening device 100 to perform a first opening action on the first reagent container 20 loaded with the first reagent and having a container cap 21, and the control of the second opening device to perform a second opening action on the first reagent container 20 after the first opening action is completed, includes: when information is obtained that the first reagent container 20 is placed in the reagent container loading device 400, the control scheduling device 500 schedules the reagent container loading device 400 loaded with the first reagent container 20 from the loading position 12 to the transfer position 13, or the control scheduling device 500 schedules the reagent container carrier loaded in the reagent container loading device 400 and loaded with the first reagent container 20 from the reagent container loading device 400 to the transfer position 13, or the control scheduling device 500 schedules the first reagent container 20 located in the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13; the control of the reagent container transfer device 300 to transfer the first reagent container 20 from the reagent container loading device 400 located in the transfer position 13 or the reagent container The first reagent container 20 is taken out of the carrier and placed into the reagent container storage device 200 through the reagent container interaction port 210, or the first reagent container 20 located at the transfer position 13 is placed into the reagent container storage device 200 through the reagent container interaction port 210. The first reagent container 20 is taken out of the reagent container carrier located at the transfer position 13 and placed into the reagent container storage device 200 through the reagent container interaction port 210. It is determined whether there is a test item that requires the use of the first reagent in the first reagent container 20. If it is determined that there is a test item that requires the use of the first reagent in the first reagent container 20, the reagent container storage device 200 is controlled to transfer the first reagent container 20 to the second opening position 14, the first opening device 100 is controlled to perform a first opening action on the first reagent container 20 located at the second opening position 14, and the second opening device is controlled to perform a second opening action on the first reagent container 20 in the reagent container storage device 200 after the first opening action is completed. In this embodiment, after the first reagent container 20 enters the sample analysis device 10, it is first stored in the reagent container storage device 200. Then, it is determined whether the first reagent in the first reagent container 20 needs to be used. If the first reagent needs to be used, the reagent container storage device 200 moves the first reagent container 20 to the second opening position 14, and the first opening device 100 performs the first opening action on the reagent container located at the second opening position 14. If the first reagent does not need to be used, the first reagent container 20 remains stored in the reagent container storage device 200. The movement of the first reagent container 20 to the second opening position 14 by the reagent container storage device 200 can be, for example, by the reagent container storage device 200 having a disc-shaped structure, where the rotation of the reagent container storage device 200 moves the first reagent container 20 to the second opening position 14.

[0078] In the above scheme, the first reagent container 20 is automatically loaded into the reagent container storage device 200. However, in specific applications, as an alternative implementation, the first reagent container 20 can also be manually loaded into the reagent container storage device 200. Specifically, in this alternative implementation, the reagent container storage device 200 is also used to store the first reagent container 20 containing the first reagent and having a container lid 21 for feeding the first reagent; that is, the reagent container storage device 200 is used to place the first reagent container 20 containing the first reagent and having a container lid 21 for feeding the first reagent, and to store the first reagent container 20. The reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 located inside the reagent container storage device 200 and in a second open state, and to dispense all or part of the drawn first reagent into the reaction vessel. The first lid-opening device 100 is located inside or outside the reagent container storage device 200. When the first opening device 100 is located inside the reagent container storage device 200, the sample analysis device 10 does not have the reagent container loading device 400, the scheduling device 500, or the reagent container transfer device 300; when the first opening device 100 is located outside the reagent container storage device 200, the sample analysis device 10 does not have the reagent container loading device 400 or the scheduling device 500. The first reagent is fed by the user manually placing the first reagent container 20 containing the first reagent into the reagent container storage device 200.

[0079] In one implementation, the reagent container storage device 200 does not have a refrigeration function, which simplifies the structure of the reagent container storage device 200 and reduces its cost. Of course, in specific applications, as an alternative implementation, the reagent container storage device 200 can also have a refrigeration function, and the first reagent container 20 can be refrigerated inside the reagent container storage device 200, thereby preventing the first reagent inside the first reagent container 20 from deteriorating.

[0080] In one implementation, the reagent container storage device 200 is a reagent tray. The reagent tray is disc-shaped. At least one ring of receiving grooves is formed around the circumference of the reagent tray, each receiving groove being used to store a reagent container (the first reagent container 20 or other reagent containers). In this embodiment, configuring the scheduling device 500 to drive the reagent container loading device 400 to rotate facilitates better matching of the disc contour of the reagent container storage device 200, thereby facilitating better installation and movement of the reagent container loading device 400. Of course, in specific applications, the reagent container storage device 200 can also be of other shapes.

[0081] In one embodiment, the reagent container storage device 200 has a reagent container interaction port 210; the reagent container transfer device 300 is used to place the first reagent container 20, after the first opening action is completed, from the first opening device 100 through the reagent container interaction port 210 into the reagent container storage device 200.

[0082] In one embodiment, the reagent tray can rotate the reagent container on it so that each container and reagent container can rotate to a different station, such as the reagent aspiration station. The reagent dispensing device 900 is used to aspirate at least a portion of the reagent from the reagent container located at the reagent aspiration station and in the second open state, and to dispense all or part of the aspirated reagent into the reaction vessel.

[0083] In one implementation, the first capping device 100 and the second capping device are two different capping devices; the first capping device 100 is located outside the reagent container storage device 200; the second capping device is located inside the reagent container storage device 200. The first capping device 100 is used to perform a first capping action on the first reagent container 20 from outside the reagent container storage device 200, and the second capping device is used to perform a second capping action on the first reagent container 20 from inside the reagent container storage device 200. This ensures that the placement of the first capping device 100 does not affect the internal structure of the reagent container storage device 200, thereby reducing the difficulty of improving the sample analysis device 10. Of course, in specific applications, the placement of the first capping device 100 and the second capping device is not limited to this. For example, as an alternative implementation, the first capping device 100 may also be located inside the reagent container storage device 200; or, as another alternative implementation, the first capping device 100 and the second capping device may be the same capping device.

[0084] Reference Figures 1 to 4 As shown, in one embodiment, when the first opening device 100 is located outside the reagent container storage device 200, the sample analysis device 10 has a first opening position 11 located outside the reagent container storage device 200. The first opening device 100 is used to perform a first opening action on the first reagent container 20 located at the first opening position 11. The first opening position 11 is used to provide a accommodating space for the first reagent container 20 to allow the first opening device 100 to perform the first opening action.

[0085] In one embodiment, the reagent container transfer device 300 includes a clamping member and a motion driving member for driving the clamping member to move. The clamping member is used to clamp or release the first reagent container 20, and the motion driving member is connected to the clamping member to drive the clamping member to move.

[0086] Reference Figure 1 , Figure 2 and Figure 6As shown, in one embodiment, the sample analysis device 10 includes a reagent container storage device 200 and a reagent container transfer device 300. The reagent container storage device 200 is used to store a first reagent container 20. The reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 with its container cap 21 in a second open state, and to dispense all or part of the drawn first reagent into a reaction vessel. A first cap opening device 100 is located outside the reagent container storage device 200. The sample analysis device 10 also includes a container seat 106, located outside the reagent container storage device 200 and used to support the first reagent container 20 to perform a first cap opening action. The reagent container transfer device 300 is used to transfer the first reagent container 20, which contains the first reagent and has a container cap 21, to the container seat 106, and to transfer the first reagent container 20 from the container seat 106 to the reagent container storage device 200 after the first cap opening action has been completed. The aforementioned control of the first opening device 100 to perform a first opening action on the first reagent container 20 containing the first reagent and having a container cap 21 includes: controlling the reagent container transfer device 300 to transfer the first reagent container 20 containing the first reagent and having a container cap 21 to the container seat 106, and controlling the first opening device 100 to perform a first opening action on the first reagent container 20 located in the container seat 106. In this embodiment, a container seat 106 is separately provided outside the reagent container storage device 200 for accommodating the first reagent container 20. Before performing the first opening action on the first reagent container 20, the first reagent container 20 is first transferred to the container seat 106 by the reagent container transfer device 300, and then the first opening device 100 performs the first opening action on the first reagent container 20 located in the container seat 106. The container seat 106 can be used to position the first reagent container 20, thereby facilitating the first opening device 100 to smoothly perform the first opening action on the first reagent container 20. Reference Figures 1 to 4As shown, in one embodiment, the sample analysis device 10 also has a loading position 12 located outside the reagent container storage device 200. The loading position 12 is used to accommodate the reagent container loading device 400 containing the first reagent container 20 to realize the loading of the first reagent. The reagent container loading device 400 can be a movable device or a fixed device. When the reagent container loading device 400 is a movable device, such as a drawer-type loading device, the reagent container loading device 400 can be at least partially pulled out of the sample analysis device 10. The user or an automated operating device such as a robotic arm can load the reagent container (including but not limited to the first reagent container 20 containing the first reagent) into the reagent container loading device 400. After loading the reagent container, the reagent container loading device 400 containing the reagent container is pushed back into the loading position 12 inside the sample analysis device 10, thereby realizing the loading of the reagent. When the reagent container loading device 400 is a fixed device, such as a reagent compartment, a reagent placement platform, or multiple storage channels arranged side by side, the user or an automated operating device such as a robotic arm can place the reagent container carrier containing the reagent into the reagent container loading device 400 located within the sample analysis device 10. Alternatively, the user or an automated operating device such as a robotic arm can directly place the reagent container containing the reagent into the reagent container loading device 400 located within the sample analysis device 10, thereby realizing the loading of reagents.

[0087] In one implementation, the reagent container loading device 400 is also used to hold reagent containers to be recycled (including but not limited to the first reagent container 20 containing the first reagent). Reagent containers with insufficient reagent remaining, expired reagent, or abnormal reagent can be transferred to the reagent container loading device 400 for placement to await recycling. In this implementation, reagent containers share the same reagent container loading device 400 for loading and recycling, which simplifies the structure of the sample analysis device 10. Of course, in specific applications, as an alternative implementation, reagent containers may not be recycled in the reagent container loading device 400, but may be recycled in other devices or other locations outside the reagent container loading device 400, such as directly from the reagent container storage device 200.

[0088] Reference Figures 1 to 5As shown, in one embodiment, the reagent container storage device 200 has a reagent container interface 210. The reagent container transfer device 300 transfers a first reagent container 20 from the reagent container loading device 400 to the reagent container storage device 200, including: the reagent container transfer device 300 placing the first reagent container 20 from the reagent container loading device 400 into the reagent container storage device 200 through the reagent container interface 210. The reagent container interface 210 can be used to allow the first reagent container 20 to enter and exit the reagent container storage device 200. The reagent container transfer device 300 places the first reagent container 20 into the reagent container storage device 200 and removes the first reagent container 20 from the reagent container storage device 200 through the reagent container interface 210.

[0089] In one implementation, the first opening position 11 is located in one of the following positions: directly above or below the reagent container interface 210, at the loading position 12, or horizontally offset from both the reagent container interface 210 and the loading position 12. The position horizontally offset from both the reagent container interface 210 and the loading position 12 includes: diagonally above the reagent container interface 210, diagonally below the reagent container interface 210, diagonally above the loading position 12, diagonally below the loading position 12, horizontally to the side of the reagent container interface 210, and horizontally to the side of the loading position 12. Specifically, when the first opening position 11 is located outside the reagent container storage device 200, the first opening position 11 can be in the same position as the reagent container interface 210 or the loading position 12, or it can be in a different position from both the reagent container interface 210 and the loading position 12.

[0090] Reference Figures 1 to 5As shown, in one embodiment, the sample analysis device 10 further includes a scheduling device 500. The sample analysis device 10 also forms a transfer position 13 located outside the reagent container storage device 200. The scheduling device 500 is used to schedule the first reagent container 20 from the loading position 12 to the transfer position 13. The reagent container transfer device 300 is used to transfer the first reagent container 20 from the transfer position 13 to the reagent container interaction port 210 or the first opening position 11. The loading position 12 is the initial position for loading the first reagent container 20, and the transfer position 13 is a transfer position 13 before the first reagent container 20 is loaded into the reagent container storage device 200. The scheduling device 500 is used to schedule the first reagent container 20 between the loading position 12 and the transfer position 13. The reagent container transfer device 300 is used to schedule the first reagent container 20 between the transfer position 13, the reagent container interaction port 210, the reagent container storage device 200, and the first opening position 11. In this embodiment, the first reagent container 20 is first moved from the loading position 12 to the transfer position 13 by the scheduling device 500, and then the first reagent container 20 is transferred from the transfer position 13 to the reagent container interaction port 210 by the reagent container transfer device 300, and then placed into the reagent container storage device 200 through the reagent container interaction port 210. This way, the travel distance of the reagent container transfer device 300 does not need to be extended to the loading position 12, which helps to shorten the travel distance of the reagent container transfer device 300. Of course, in specific applications, as an alternative embodiment, the scheduling device 500 may not be provided, and the reagent container transfer device 300 can directly transfer the first reagent container 20 from the loading position 12 to the reagent container interaction port 210 or the first opening position 11.

[0091] In one implementation, the reagent container transfer device 300 places the first reagent container 20 from the reagent container loading device 400 into the reagent container storage device 200 through the reagent container interaction port 210. This includes: the reagent container transfer device 300 placing the first reagent container 20 located at the intermediate transfer position 13 into the reagent container storage device 200 through the reagent container interaction port 210; or, the reagent container transfer device 300 placing the first reagent container 20 located at the first opening position 11 into the reagent container storage device 200 through the reagent container interaction port 210. In this implementation, the reagent container transfer device 300 can directly place the first reagent container 20 from the intermediate transfer position 13 into the reagent container storage device 200 through the reagent container interaction port 210; alternatively, it can first transfer the first reagent container 20 from the intermediate transfer position 13 to the first opening position 11 to perform a first opening action, and then place the first reagent container 20 in the first open state from the first opening position 11 into the reagent container storage device 200 through the reagent container interaction port 210.

[0092] In one implementation, when the scheduling device 500 is used to schedule the reagent container loading device 400 containing the first reagent container 20 from the loading position 12 to the transfer position 13, the reagent container transfer device 300 places the first reagent container 20 from the reagent container loading device 400 into the reagent container storage device 200 through the reagent container interaction port 210, including: the reagent container transfer device 300 taking the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and placing it into the reagent container storage device 200 through the reagent container interaction port 210; or, the reagent container transfer device 300 placing the first reagent container 20 in the first open state from the first opening position 11 into the reagent container storage device 200 through the reagent container interaction port 210. In this embodiment, the reagent container transfer device 300 can directly remove the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and place it into the reagent container storage device 200 through the reagent container interaction port 210; alternatively, the first reagent container 20 can be removed from the reagent container loading device 400 located at the transfer position 13 and transferred to the first opening position 11 to perform the first opening action, and then the first reagent container 20, which is in the first open state after the first opening action is completed, can be placed into the reagent container storage device 200 from the first opening position 11 through the reagent container interaction port 210.

[0093] In one implementation, when the scheduling device 500 is used to schedule the first reagent container 20 loaded in the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13, the reagent container transfer device 300 places the first reagent container 20 from the reagent container loading device 400 into the reagent container storage device 200 through the reagent container interaction port 210, including: the reagent container transfer device 300 transfers the reagent container from the transfer position 13 to the reagent container interaction port 210 and places it into the reagent container storage device 200 through the reagent container interaction port 210; or, the reagent container transfer device 300 places the first reagent container 20, which has completed the first opening action and is in the first open state, from the first opening position 11 into the reagent container storage device 200 through the reagent container interaction port 210. In this embodiment, the reagent container transfer device 300 can directly transfer the first reagent container 20 from the transfer position 13 to the reagent container interaction port 210 and place it in the reagent container storage device 200 through the reagent container interaction port 210; alternatively, it can first transfer the first reagent container 20 from the transfer position 13 to the first opening position 11 to perform the first opening action, and then place the first reagent container 20, which is in the first open state after the first opening action is completed, from the first opening position 11 through the reagent container interaction port 210 into the reagent container storage device 200.

[0094] In one implementation, when the scheduling device 500 is used to schedule a reagent container carrier loaded in the reagent container loading device 400 and carrying the first reagent container 20 from the reagent container loading device 400 to the transfer position 13, the aforementioned reagent container transfer device 300 places the reagent container from the reagent container loading device 400 into the reagent container storage device 200 through the reagent container interaction port 210, including: the reagent container transfer device 300 taking the first reagent container 20 from the reagent container carrier located in the transfer position 13 and placing it into the reagent container storage device 200 through the reagent container interaction port 210; or, the reagent container transfer device 300 placing the first reagent container 20, which has completed the first opening action and is in the first open state, from the first opening position 11 into the reagent container storage device 200 through the reagent container interaction port 210. In this embodiment, the reagent container transfer device 300 can directly remove the first reagent container 20 from the reagent container carrier located at the transfer position 13 and place it into the reagent container storage device 200 through the reagent container interaction port 210; alternatively, the first reagent container 20 can be removed from the reagent container carrier located at the transfer position 13 and transferred to the first opening position 11 to perform the first opening action. After the first opening action is completed and the first reagent container 20 is in the first open state, it is placed into the reagent container storage device 200 from the first opening position 11 through the reagent container interaction port 210.

[0095] In one implementation, the transfer position 13 is located directly above the reagent container interaction port 210. In a specific application, when the scheduling device 500 drives the reagent container loading device 400 to move the first reagent container 20 to the transfer position 13, the reagent container loading device 400 is located directly above the reagent container interaction port 210, and the reagent container interaction port 210 is blocked by the reagent container loading device 400. After the reagent container transfer device 300 grabs the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and rises, the scheduling device 500 drives the reagent container loading device 400 to retract to expose the reagent container interaction port 210. The reagent container transfer device 300 then transfers the grabbed first reagent container 20 to the first opening position 11 to perform the first opening action or transfers it to the reagent container interaction port 210 and places it into the reagent container storage device 200 through the reagent container interaction port 210. In this embodiment, the transfer position 13 is located directly above the reagent container interface 210, so that the reagent container transfer device 300 can share a single horizontal working position when grasping the first reagent container 20 at the transfer position 13 and placing the first reagent container 20 through the reagent container interface 210 into the reagent container storage device 200. This helps to reduce the horizontal travel distance of the reagent container transfer device 300. Of course, in specific applications, the location of the transfer position 13 is not limited to this. For example, as an alternative implementation, the transfer position 13 is located directly below the reagent container interface 210. In this alternative implementation, the transfer position 13 is located below the reagent container storage device 200. Alternatively, as another alternative implementation, the transfer position 13 is horizontally offset from the reagent container interface 210 and horizontally offset from the loading position 12, that is, horizontally, the transfer position 13 is located between the loading position 12 and the reagent container interface 210.

[0096] In one implementation, the first opening position 11 is located at a position that is horizontally offset from the reagent container interface 210 and horizontally offset from the loading position 12, including: the first opening position 11 is located horizontally on the side of the transfer position 13 away from the loading position 12 and is horizontally offset from the reagent container interface 210; the first opening position 11 is located horizontally between the transfer position 13 and the loading position 12. That is, when the first opening position 11 is set independently of the reagent container interface 210 and independently of the loading position 12, the first opening position 11 can be located outside the transfer position 13 and the loading position 12, or it can be located between the transfer position 13 and the loading position 12.

[0097] like Figure 2 and Figure 4As shown, in a first embodiment where the first opening device 100 is located outside the reagent container storage device 200, the first opening position 11 is located at a position that is horizontally offset from the reagent container interaction port 210 and horizontally offset from the loading position 12. The first opening position 11 is set independently of the reagent container interaction port 210 and independently of the loading position 12.

[0098] As a further embodiment of the first embodiment in which the first opening device 100 is located outside the reagent container storage device 200, the first opening position 11 is located on the side of the reagent container interaction port 210 away from the loading position 12 (e.g., Figure 2 (as shown), or, the first opening position 11 is located between the reagent container interaction port 210 and the loading position 12 (as shown). Figure 4 (As shown).

[0099] In one embodiment, the container body 22 has multiple reagent chambers, each forming a container opening, and each container opening is provided with a container cap 21. Each reagent chamber can be used to hold one reagent (including but not limited to a first reagent), and the multiple reagent chambers of the same container body 22 can be used to hold different types of reagents or to hold the same type of reagent. The container body 22 can be a one-piece molded component with multiple reagent chambers, or it can be formed by assembling multiple separate components. Of course, in specific applications, as an alternative embodiment, the container body 22 can also have only one reagent chamber, and the number of container caps 21 for each reagent container is only one.

[0100] In one implementation, after the reagent dispensing device 900 draws at least a portion of the reagent from the first reagent container 20, the container cap 21 needs to be closed onto the container body 22 of the first reagent container 20. When it is necessary to draw the first reagent loaded in the first reagent container 20 again, the cap opening action (which can be the second cap opening action described above or other cap opening actions) needs to be performed again to open the container cap 21.

[0101] In one implementation, the second capping device is also used to perform a capping action on the first reagent container 20 after the reagent dispensing device 900 has drawn at least a portion of the first reagent from the first reagent container 20. After the reagent dispensing device 900 draws at least a portion of the first reagent from the first reagent container 20 located in the reagent container storage device 200 with the container cap 21 in a second open state, the controller 600 is further configured to: control the second capping device to perform a capping action on the first reagent container 20, so that the container cap 21 is in a closed state. The second capping device performing the capping action on the first reagent container 20 specifically includes: covering the container cap 21 onto the container body 22 so that the container cap 21 covers the container opening, but does not need to force the container cap 21 to seal it completely. When the reagent dispensing device 900 has finished drawing the first reagent from the first reagent container 20, and there are no test items in the test that require the use of the first reagent, the second capping device closes the container cap 21 onto the container body 22, thereby helping to reduce the volatilization and deterioration of the first reagent in the first reagent container 20. In this embodiment, the second opening device is time-division multiplexed to perform the second opening action and the closing action, which can help simplify the structure of the sample analysis device 10 and reduce the cost of the sample analysis device 10.

[0102] Of course, in specific applications, the method of closing the first reagent container 20 is not limited to the above-described scheme. For example, as an alternative implementation, the sample analysis device 10 also includes a closing device, which is used to close the first reagent container 20 after the reagent dispensing device 900 draws at least a portion of the first reagent from the first reagent container 20. After the reagent dispensing device 900 draws at least a portion of the first reagent from the first reagent container 20 located in the reagent container storage device 200 with the container lid 21 in a second open state, the controller 600 is further configured to control the closing device to perform a closing action on the first reagent container 20, so that the container lid 21 is in a closed state. The closing device and the second opening device are two different devices, that is, the closing device and the second opening device are not the same device.

[0103] Reference Figure 1 , Figure 2 and Figures 9 to 11 As shown, in one embodiment, the controller 600 is further configured to: when it receives information that no test item requires the use of the first reagent in the first reagent container 20, control the second opening device or closing device to perform a closing action on the first reagent container 20 so that the container lid 21 is in a closed state; when it receives information that a test item requires the use of the first reagent in the first reagent container 20, control the second opening device to perform a second opening action on the first reagent container 20 after the closing action is completed and the container lid 21 is in a closed state, so that the container lid 21 is in a second open state; The reagent dispensing device 900 draws at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200, after completing the second opening action and with the container lid 21 in the second open state, and dispenses all or part of the drawn first reagent into the reaction vessel. In this embodiment, after the reagent dispensing device 900 has finished drawing the first reagent from the first reagent container 20, and there are no test items requiring the use of the first reagent, the container lid 21 is closed to the container body 22 by the second opening device or closing device. When a test item requires the use of the first reagent in the first reagent container 20 again, only the second opening device needs to perform the second opening action on the first reagent container 20, without the first opening device 100 needing to perform the first opening action. This not only helps to reduce the volatilization and deterioration of the first reagent in the first reagent container 20 when the first reagent is not in use, but also allows for quick opening of the container lid 21 of the first reagent container 20 when the first reagent is used again.

[0104] In the above scheme, the first opening device 100 performs the first opening action, which only relieves part of the sealing force of the container lid 21 and does not completely open the container lid 21. At this time, the reagent dispensing device 900 cannot pass into the first reagent container 20 to draw the first reagent without obstruction. The second opening device needs to perform the second opening action on the first reagent container 20 to completely open the container lid 21 before the reagent dispensing device 900 can enter the first reagent container 20 to draw the first reagent without obstruction. The second opening device is reused to perform the closing action on the container lid 21 after the reagent dispensing device 900 draws the first reagent. Of course, in specific applications, the opening and closing methods of the container lid 21 are not limited to this. For example, as an alternative implementation, the first opening device 100 performs the first opening action to fully open the container lid 21. At this time, the reagent dispensing device 900 can enter the first reagent container 20 without hindrance to draw the first reagent. The second opening device is used to perform the closing action on the container lid 21 after the reagent dispensing device 900 draws the first reagent, and to perform the second opening action on the container lid 21 to open the container lid 21 again when the first reagent in the first reagent container 20 needs to be used again, so that the reagent dispensing device 900 can enter the first reagent container 20 without hindrance to draw the first reagent. Alternatively, as another alternative implementation, the second opening device is not provided. The first opening device 100 performs the first opening action, which can fully open the container lid 21. At this time, the reagent dispensing device 900 can enter the first reagent container 20 without obstruction to draw the first reagent. The first opening device 100 is also used to perform the closing action on the container lid 21 after the reagent dispensing device 900 draws the first reagent, and to perform the third opening action on the container lid 21 to open the container lid 21 again when the first reagent in the first reagent container 20 needs to be used again, so that the reagent dispensing device 900 can enter the first reagent container 20 without obstruction to draw the first reagent.

[0105] Reference Figure 1 , Figure 2 , Figure 10 and Figure 11 As shown, in the first embodiment of the above-mentioned opening degree, the opening degree includes the opening angle of the container lid 21 of the first reagent container 20. The opening degree of the container lid 21 in the first open state is less than the opening degree of the container lid 21 in the second open state, including: the opening angle of the container lid 21 in the first open state is less than the opening angle of the container lid 21 in the second open state. The opening angle of the container lid 21 in the first open state is the first opening angle A1, and the opening angle of the container lid 21 in the second open state is the second opening angle A2. The first opening angle A1 is less than the second opening angle A2. In this embodiment, the container lid 21 is sealed to the container opening by a flip connection, and the container opening is opened by flipping. The opening angle of the container lid 21 is the angle of the container lid 21 relative to the top surface of the container opening, that is: when the central axis of the container opening is vertical, the angle of the container lid 21 relative to the horizontal plane (the plane perpendicular to the central axis). With the container lid 21 closed and sealing the container opening, the lid 21 is pressed tightly against the top surface of the container opening, and the opening angle of the lid 21 is 0° (i.e., not opened). A larger opening angle corresponds to a greater degree of opening. When the container lid 21 is connected to the container body 22 by flipping, by setting the opening angle of the lid 21 in the first open state to be smaller than the opening angle in the second open state, the degree of opening of the lid 21 in the first open state can be less than the degree of opening in the second open state. In the first open state, the lid 21 is not fully open, and at this time, the lid 21 is in a state that would prevent the reagent dispensing device 900 from entering the container opening to draw in the first reagent. In the second open state, the lid 21 is fully open, and at this time, the lid 21 is in a state that at least does not prevent the reagent dispensing device 900 from entering the container opening to draw in the first reagent.

[0106] As a further embodiment of the first implementation of the above-described opening degree, when the opening degree includes the opening angle of the container lid 21 of the first reagent container 20, the opening angle of the container lid 21 in the first open state is greater than 0° and less than 90°, that is, the first opening angle A1 is greater than 0° and less than 90°. The opening angle of the container lid 21 is the opening angle or flipping angle of the container lid 21. In this embodiment, after the first opening action is completed, since the opening angle of the container lid 21 is less than 90°, the container lid 21 still at least partially covers the top of the container opening, and is not completely exposed, which helps to reduce the volatilization and deterioration of the first reagent.

[0107] As a further embodiment of the first embodiment of the opening degree described above, the opening angle of the container lid 21 in the first open state is greater than 0° and less than or equal to 45°, that is, the first opening angle A1 is greater than 0° and less than or equal to 45°. This is more conducive to reducing the volatilization and deterioration of the first reagent, and also helps to prevent the reagent dispensing device 900 from entering the first reagent container 20 and absorbing the first reagent in this state.

[0108] As a further embodiment of the first implementation of the opening degree described above, the container lid 21 has an opening angle greater than 0° and less than or equal to 30° in the first open state, that is, the first opening angle A1 is greater than 0° and less than or equal to 30°. In this way, after the first opening action is completed, a large portion of the container lid 21 still covers the top of the container opening, which helps to further reduce the volatilization and deterioration of the first reagent, and also helps to prevent the reagent dispensing device 900 from entering the first reagent container 20 and drawing in the first reagent in this state.

[0109] As a further embodiment of the first implementation of the opening degree described above, when the opening degree includes the opening angle of the container lid 21 of the first reagent container 20, the opening angle of the container lid 21 in the second open state is greater than or equal to 90°, that is, the second opening angle A2 is greater than or equal to 90°. In this embodiment, after the second opening action is completed, since the opening angle of the container lid 21 is greater than or equal to 90°, the container lid 21 does not block the container opening, and the container opening is fully exposed, so that the reagent dispensing device 900 can enter the first reagent container 20 without obstruction and draw the first reagent in this case.

[0110] As a further embodiment of the first embodiment of the above-described opening degree, the container lid 21 in the second open state has an opening angle greater than or equal to 90° and less than 180°.

[0111] As a further embodiment of the first embodiment of the above-described opening degree, the container lid 21 in the second open state has an opening angle greater than or equal to 90° and less than or equal to 135°.

[0112] As a second embodiment of the aforementioned opening degree, the opening degree includes the degree of loosening. The opening degree of the container lid 21 in the first open state is less than the opening degree of the container lid 21 in the second open state, including: the degree of loosening of the container lid 21 in the first open state is less than the degree of loosening of the container lid 21 in the second open state. In this embodiment, the container lid 21 is sealed to the container opening by a screw connection and opened by a reverse screw rotation, that is, the container lid 21 is threaded to the container body 22. The degree of loosening of the container lid 21 is the number of screw turns between the container lid 21 and the container body 22. The smaller the number of screw turns, the greater the degree of loosening. When the container lid 21 is connected to the container body 22 by a screw connection, by setting the loosening angle of the container lid 21 in the first open state to be less than the loosening angle of the container lid 21 in the second open state, it is also possible to achieve the effect that the opening degree of the container lid 21 in the first open state is less than the opening degree of the container lid 21 in the second open state. In the first open state, the container lid 21 is not fully open, and is still loosely screwed onto the container body 22. In the second open state, the container lid 21 is fully open, and is loosely screwed off the container opening.

[0113] As a third embodiment of the aforementioned opening degree, the opening degree includes the pull-out degree, where the opening degree of the container lid 21 in the first open state is less than the opening degree of the container lid 21 in the second open state. This includes: the pull-out degree of the container lid 21 in the first open state is less than the pull-out degree of the container lid 21 in the second open state. In this embodiment, the container lid 21 seals the container opening by insertion and opens the container opening by pulling out the container lid 21; that is, the container lid 21 is a plug that is at least partially inserted into the container opening. The pull-out degree of the container lid 21 refers to the length by which the container lid 21 is pulled out of the container opening. The greater the pull-out length, the greater the pull-out degree, and the greater the corresponding opening degree. When the container lid 21 is connected to the container body 22 by insertion and removal, by setting the pull-out degree of the container lid 21 in the first open state to be less than the pull-out degree of the container lid 21 in the second open state, it is also possible to achieve the effect that the opening degree of the container lid 21 in the first open state is less than the opening degree of the container lid 21 in the second open state. In the first open state, the container lid 21 is not fully open, and is still at least partially inserted into the container opening. In the second open state, the container lid 21 is fully open, and is completely pulled out of the container opening.

[0114] As a third embodiment of the above-mentioned opening degree, the opening degree includes the degree to which the container lid 21 of the first reagent container 20 is slid open, and the degree to which the container lid 21 is slid open in the first open state is less than the degree to which the container lid 21 is slid open in the second open state, including: the degree to which the container lid 21 of the first reagent container 20 is slid open in the first open state is less than the degree to which the container lid 21 is slid open in the second open state.

[0115] Reference Figure 2 , Figure 6 and Figure 7 As shown, in one embodiment, the first opening device 100 includes a container base 106 and an opening component 109. The container base 106 is located outside the reagent container storage device 200. The above-mentioned control of the reagent container transfer device 300 to transfer the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the reagent container loading device 400 to the first opening device 100 includes: controlling the reagent container transfer device 300 to transfer the first reagent container 20, which contains the first reagent and is covered with a container cap 21, from the reagent container loading device 400 to the container base 106. The above-mentioned control of the first opening device 100 to perform a first opening action on the first reagent container 20, which is covered with a container cap 21, from the reagent container loading device 400 includes: controlling the opening component 109 to perform a first opening action on the first reagent container 20, which is located in the container base 106 and is covered with a container cap 21. In this embodiment, a separate container holder 106 is provided for placing and positioning the first reagent container 20, which helps to ensure that the position of each first reagent container 20 is fixed when performing the first opening action. Of course, in specific applications, the container holder 106 may not be provided, and the inherent structure of the sample analysis device 10 (such as the reagent container loading device 400 or the reagent container storage device 200) may be used to position the first reagent container 20 when performing the first opening action.

[0116] Reference Figure 2 , Figure 6 , Figure 7 and Figure 8As shown, in a first embodiment of the first opening device 100, the opening component 109 includes at least one abutting component 110 and a first driving component 120. Controlling the opening component 109 to perform a first opening action on the first reagent container 20 located on the container base 106 and covered with a container lid 21 includes: controlling the first driving component 120 to drive one of the at least one abutting component 110 and the container base 106 to move relative to the other along a first horizontal direction X, so that the at least one abutting component 110 contacts the bottom of the container lid 21 located on the container base 106 and abuts the container lid 21 upwards, thereby flipping the container lid 21 to a first open state. The first reagent container 20 is placed on the container base 106, and during the first opening action, the first reagent container 20 and the container base 106 remain relatively stationary; that is, the first reagent container 20 does not move relative to the container base 106 during the first opening action. In this embodiment, the first opening device 100 is suitable for situations where the container lid 21 is connected to the container body 22 by flipping. The opening principle is as follows: during the horizontal movement of the abutting component 110 and the container seat 106, the abutting component 110 pushes the container cover 21 upward to make the container cover 21 flip upward.

[0117] In one implementation, the first driving component 120 is driveably connected to the abutting component 110 to drive the abutting component 110 to move relative to the container seat 106 along a first horizontal direction X. In this embodiment, during the first opening action, the abutting component 110 moves horizontally, while the container seat 106 and the first reagent container 20 do not move horizontally. Of course, in specific applications, as an alternative implementation, during the first opening action, the first driving component 120 drives the container seat 106 to move the first reagent container 20 horizontally, while the abutting component 110 does not move horizontally.

[0118] Reference Figure 2 , Figure 6 , Figure 7 and Figure 8As shown, in one embodiment, the opening component 109 further includes a bracket 130, a connecting seat 140, and an elastic component 150. The connecting seat 140 is mounted on the bracket 130 in a way that allows it to float up and down via the elastic component 150. At least one abutting component 110 is mounted on or integrally formed with the connecting seat 140. The first driving component 120 is connected to the bracket 130 for driving the bracket 130 to move the connecting seat 140, at least one abutting component 110, and the elastic component 150 along the first horizontal direction X. The elastic component 150 allows the contact between the abutting component 110 and the container lid 21 to have a certain vertical floating space. This helps to avoid the adverse phenomenon that the container lid 21 or the container body 22 may be damaged due to the instantaneous excessive force applied by the abutting component 110 to the container lid 21, and also helps to ensure that the abutting component 110 maintains contact with the bottom of the container lid 21.

[0119] Reference Figure 2 , Figure 6 , Figure 7 and Figure 8 As shown, in one embodiment, the opening component 109 further includes a limiting structure 160. The limiting structure 160 is integrally formed or installed on the connecting seat 140. The limiting structure 160 is used to press down on the container body 22 of the first reagent container 20 when at least one abutting component 110 abuts the container cap 21 upwards, to prevent the first reagent container 20 from detaching from the container seat 106 when at least one abutting component 110 abuts the container cap 21 upwards. The limiting structure 160 is mainly used to limit the upward displacement of the container body 22 during the first opening action, so that when the first abutting component 110 abuts the container cap 21 upwards, the container cap 21 cannot drive the container body 22 upwards under the abutting action of the first abutting component 110, so that the container cap 21 can only flip upwards relative to the container body 22 by force alone, thereby helping to ensure the reliability and safety of the first opening device 100 performing the first opening action on the container cap 21.

[0120] Reference Figure 2 , Figure 6 , Figure 7 and Figure 8 As shown, in one embodiment, the limiting structure 160 is a rib provided at the bottom end of the connecting seat 140. The container body 22 forms a limiting boss 2201. During the execution of the first opening action, the rib presses against the limiting boss 2201, thereby preventing the container body 22 from disengaging from the container seat 106 when at least one abutting member 110 pushes the container lid 21 upwards, thus ensuring the reliability and safety of the first opening device 100 in performing the first opening action on the container lid 21.

[0121] Reference Figure 6 , Figure 7 and Figure 8 As shown, in one embodiment, the at least one abutting component 110 includes at least two abutting components 110. Any two abutting components 110 are staggered in the first horizontal direction X and the vertical direction, that is, any two abutting components 110 do not overlap at least partially in the top view projection and the front view projection. In this way, during the relative horizontal movement of the abutting component 110 and the first reagent container 20, the container lid 21 contacts the at least two abutting components 110 in sequence, and the at least two abutting components 110 successively push the container lid 21 upward and flip it to different angles.

[0122] Reference Figure 6 , Figure 7 and Figure 8 As shown, in one embodiment, the tops of the at least two abutting members 110 are sequentially spaced along an inclined trajectory. The inclined trajectory is set at an angle A3 greater than 0° and less than 90° relative to the first horizontal direction X. The at least two abutting members 110 are used to sequentially contact the bottom of the container lid 21 under the drive of the first driving member 120 to push the container lid 21 upward, thereby opening the container lid 21 to the first open state. During the execution of the first opening action, the top of the abutting member 110 is used to contact the bottom of the container lid 21 to push the container lid 21 upward.

[0123] In one implementation, at least two abutting components 110 are sequentially spaced along an inclined trajectory. The inclined trajectory is set at an angle A3 greater than 0° and less than 90° relative to the first horizontal direction X. The at least two abutting components 110 are used to sequentially contact the bottom of the container lid 21 under the drive of the first driving component 120 to push the container lid 21 upward, thereby opening the container lid 21 to the first open state. In this embodiment, by setting the at least two abutting components 110 as a whole to be spaced along the inclined trajectory, during the first opening action, the at least two abutting components 110 will gradually push and flip the container lid 21 upward to different angles, thereby ensuring the smoothness of the relative horizontal movement of the abutting components 110 and the first reagent container 20, and avoiding the adverse phenomenon of damage to the container lid 21 or the container body 22 due to excessively large flipping angles at one time. Of course, in specific applications, as an alternative implementation, it is also possible that the tops of at least two abutting components 110 are distributed sequentially and alternately along an inclined trajectory, while the bottoms or other parts of at least two abutting components 110 may not be distributed sequentially and alternately along an inclined trajectory. For example, when at least two abutting components 110 are components of different shapes and / or sizes, it is only necessary to ensure that the tops of at least two abutting components 110 are distributed sequentially and alternately along an inclined trajectory, without limiting the distribution of the bottoms of at least two abutting components 110.

[0124] As one implementation, the tilt trajectory is set at a tilt angle A3 of greater than 0° and less than or equal to 45° relative to the first horizontal direction X.

[0125] As one implementation, the tilt trajectory is set at a tilt angle A3 of greater than 0° and less than or equal to 30° relative to the first horizontal direction X.

[0126] In one embodiment, the abutting member 110 is a rotatable abutting member 110, that is, the abutting member 110 can rotate freely around its central axis under the action of external force. Specifically, at least two abutting members 110 include at least two rotatable abutting members 110, which are distributed sequentially at intervals along an inclined trajectory. The at least two rotatable abutting members 110 are used to sequentially contact the bottom of the container lid 21 under the drive of the first driving member 120 to push the container lid 21 upward, thereby opening the container lid 21 to the first open state. In this embodiment, the abutting component 110 is configured to be a component that can rotate freely around its own central axis. In this way, during the relative horizontal movement of the abutting component 110 and the first reagent container 20, the abutting component 110 will rotate freely under the action of the container lid 21, thereby reducing the frictional force during the relative horizontal movement of the abutting component 110 and the first reagent container 20. This helps to ensure the smoothness of the relative horizontal movement of the abutting component 110 and the first reagent container 20, and also helps to reduce the difficulty of opening the container lid 21 to the first open state.

[0127] In one embodiment, each rotatable abutment component 110 includes at least one of a rotatable bearing, a rotatable roller, or a rotatable spherical component. That is, the abutment component 110 can be a bearing, a roller, a spherical component, a combination of a roller and a bearing, or a combination of a roller, a bearing, and a spherical component, etc. The central axis of the rotatable abutment component 110 is arranged along a second horizontal direction, which is perpendicular to the first horizontal direction X. When the abutment component 110 is a bearing, the bearing is rotatably mounted on a fixed shaft arranged along the second horizontal direction; when the abutment component 110 is a roller, the roller is rotatably mounted on a fixed shaft arranged along the second horizontal direction; when the abutment component 110 is a combination of a roller and a bearing, the roller is rotatably mounted on a fixed shaft arranged along the second horizontal direction via the bearing. The outer peripheral surface of the rotatable abutment component 110 is used to contact the container lid 21. The outer circumferential surface of the bearing and the outer circumferential surface of the roller are in contact with the bottom of the container cover 21, which helps to prevent the abutting component 110 from scratching the container cover 21.

[0128] Reference Figure 6 , Figure 7 and Figure 8As shown, in one embodiment, the bottom of the container lid 21 is provided with a protrusion 2101, and the abutting member 110 is used to abut the container lid 21 upward by contacting the protrusion 2101.

[0129] As one implementation, the bottom surface of the protrusion 2101 is arc-shaped, which helps to further improve the smoothness of the abutment member 110 in performing the first opening action on the container lid 21 and better prevent the abutment member 110 from scratching the container lid 21. In one embodiment, the end of the container lid 21 away from the protrusion 2101 is rotatably connected to the container body 22, so that the container lid 21 remains connected to the container body 22 when the container lid 21 is opened to the first open state and the second open state.

[0130] In the above scheme, the abutting component 110 is a rotatable abutting component 110. Of course, in specific applications, as an alternative implementation, the abutting component 110 can also be fixed. Specifically, in this alternative implementation, at least two abutting components 110 include at least two abutting components 110 with a first inclined surface. The at least two abutting components 110 with a first inclined surface are distributed sequentially at intervals along an inclined trajectory. The inclined trajectory is set at an angle A3 greater than 0° and less than 90° relative to the first horizontal direction X. The at least two abutting components 110 with a first inclined surface are used to make the first inclined surface contact the bottom of the container lid 21 sequentially under the drive of the first driving component 120, so as to push the container lid 21 upward, thereby opening the container lid 21 to the first open state. During the execution of the first opening action, at least two first inclined surfaces will contact the bottom of the container lid 21 sequentially and gradually push the container lid 21 upward and flip it to different angles, which also helps to ensure the smoothness of the first opening device 100 performing the first opening action on the container lid 21.

[0131] In the above scheme, the number of abutting components 110 is at least two. Of course, in specific applications, as an alternative implementation, the number of abutting components 110 can also be one. For example, the above-mentioned at least one abutting component 110 is an abutting component 110 with a second inclined surface. The second inclined surface is set at an angle A3 greater than 0° and less than 90° relative to the first horizontal direction X. An abutting component 110 with a second inclined surface is used to continuously contact the bottom of the container lid 21 under the drive of the first driving component 120, so as to push the container lid 21 upward, thereby opening the container lid 21 to the first open state. During the execution of the first opening action, different parts of the second inclined surface will successively contact the bottom of the container lid 21 and gradually push the container lid 21 upward and flip it to different angles, which also helps to ensure the smoothness of the first opening device 100 performing the first opening action on the container lid 21.

[0132] In the first embodiment of the first opening device 100 described above, the first opening device 100 opens the container lid 21 by flipping it upwards and pressing against the bottom of the container lid 21. Of course, in specific applications, the configuration of the first opening device 100 is not limited to this.

[0133] For example, refer to Figure 2 and Figure 12 As shown, in a second embodiment of the first opening device 100, the first opening device 100 includes a hook 170 and a second driving component 180. A hook position is formed on the container lid 21. The second driving component 180 is used to drive the hook 170 to move up and down so that the hook 170 is hooked at the hook position, and when the hook 170 is hooked at the hook position, it drives the hook 170 to pull the container lid 21 upwards to open the container lid 21 to a first open state. The second driving component 180 is tractively connected to the hook 170 to drive the hook 170 to move. In this embodiment, the first opening device 100 is suitable for situations where the container lid 21 is connected to the container body 22 by flipping. Its opening principle is as follows: the second driving component 180 drives the hook 170 to move to the hook position on the container lid 21, and then drives the hook 170 to pull the container lid 21 to open or pull it out to the first open state.

[0134] Or, refer to Figure 2 and Figure 13 As shown, in a third embodiment of the first opening device 100, the first opening device 100 includes a pressing member 190 and a third driving member 1001. A cantilevered portion 2102 is formed at the top of the container lid 21. The third driving member 1001 drives the pressing member 190 to move up and down, pressing the pressing member 190 against the cantilevered portion 2102, thereby driving the end of the container lid 21 away from the cantilevered portion 2102 to swing upwards, causing the container lid 21 to open to a first open state. The third driving member 1001 is driveably connected to the pressing member 190 to drive the pressing member 190 to move. In this embodiment, the first opening device 100 is suitable for situations where the container lid 21 is connected to the container body 22 by flipping. The opening principle is as follows: the third driving component 1001 drives the pressing component 190 to move so that the pressing component 190 abuts against the top of the suspended part 2102, and then drives the pressing component 190 to press down on the suspended part 2102 so that the part of the container lid 21 away from the suspended part 2102 flips upward to the first open state.

[0135] It should be noted that when the reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 after the first opening action is completed and to dispense all or part of the drawn first reagent into the reaction vessel, the first opening device 100 performs the first opening action. For example, the pressing member 190 of the first opening device 100 can press down on the suspended part 2102 to directly open the container lid 21 until the reagent dispensing device 900 can enter the first reagent container 20 without obstruction to draw the first reagent.

[0136] Or, refer to Figure 2 and Figure 14 As shown, in a fourth embodiment of the first cap-opening device 100, the first cap-opening device 100 includes a gripper 1002 and a fourth driving component 1003. The container cap 21 is threadedly connected to the top of the container body 22 of the first reagent container 20. The fourth driving component 1003 is used to drive the gripper 1002 to move so that the gripper 1002 grips the outer side of the container cap 21, and to drive the gripper 1002 to rotate when it grips the container cap 21, so as to loosen the container cap 21 to a first open state. The fourth driving component 1003 is drivenly connected to the gripper 1002 to drive the gripper 1002 to move. In this embodiment, the first cap-opening device 100 is suitable for situations where the container cap 21 is connected to the container body 22 by a screw-on connection. The opening principle is as follows: the fourth driving component 1003 drives the gripper 1002 to move so that the gripper 1002 grips the outer side of the container lid 21, and then drives the gripper 1002 to rotate the container lid 21 so that the gripper 1002 rotates the container lid 21 in the loosening direction to the first open state.

[0137] Alternatively, as a fifth embodiment of the first opening device 100, the first opening device 100 includes a pusher and a fifth driving component. The container lid 21 is slidably connected to the top of the container body 22 of the first reagent container 20. The fifth driving component is used to drive the pusher to move so that the pusher pushes the container lid 21 to slide to the first open state.

[0138] In the above scheme, the first cap-opening device 100 and the second cap-opening device are two different cap-opening devices. Of course, in specific applications, as an alternative implementation, the first cap-opening device 100 and the second cap-opening device can also be the same cap-opening device; that is, the first cap-opening device 100 and the second cap-opening device are not two cap-opening devices, and the first cap-opening action and the second cap-opening action are executed sequentially by the same cap-opening device. In this alternative implementation, the same cap-opening device is used to execute the first cap-opening action with a first output force, and the same cap-opening device is also used to execute the second cap-opening action with a second output force, where the first output force is greater than the second output force. The first cap-opening action requires a larger opening force, while the second cap-opening action requires a smaller opening force. Therefore, by setting the same cap-opening device to have two output forces, and using the larger output force to execute the first cap-opening action, and using the smaller output force to execute the second cap-opening action, one cap-opening device can simultaneously meet the requirements of the first and second cap-opening actions.

[0139] In one implementation, when the first capping device 100 and the second capping device are the same capping device, the aforementioned control of the first capping device 100 to perform a first capping action on the first reagent container 20 containing the first reagent and having a container cap 21, and control of the second capping device to perform a second capping action on the first reagent container 20 after the first capping action has been completed, includes: controlling the same capping device to perform the first capping action on the first reagent container 20 containing the first reagent and having a container cap 21 in a first working mode, and controlling the same capping device to perform the second capping action on the first reagent container 20 after the first capping action has been completed in a second working mode, wherein the first working mode is different from the second working mode. In the first working mode and the second working mode, at least one of the output force magnitude, output force direction, and motion trajectory of the same capping device is different. In this implementation, by setting the same capping device to have two working modes, and using one working mode to perform the first capping action and using the other working mode to perform the second capping action, one capping device can simultaneously satisfy the requirements of the first capping action and the second capping action.

[0140] In one embodiment, the reagent container storage device 200 further includes a first cover for opening and closing the reagent container interface 210.

[0141] In one embodiment, the reagent container storage device 200 is also used to store a second reagent container loaded with a second reagent; the reagent container storage device 200 is also formed with a reagent container loading port, which is set independently of the reagent container interaction port 210; the reagent container loading port is used to allow the second reagent container loaded with the second reagent to be placed into the reagent container storage device 200 so as to realize the feeding of the second reagent.

[0142] In one embodiment, the reagent container storage device 200 also includes a second cover for opening and closing the reagent container loading port.

[0143] Reference Figures 2 to 5 As shown, in one embodiment, the sample analysis device 10 also includes a support component 700, which supports the reagent container loading device 400, the scheduling device 500, the reagent container transfer device 300, the first cap opening device 100, the magnetic bead aggregation detection device 108, the mixing device 1011, the correction device 1010, and the deflection detection device 101. The support component 700 mainly provides an installation location for the reagent container loading device 400, the scheduling device 500, the reagent container transfer device 300, the first cap opening device 100, the magnetic bead aggregation detection device 108, the mixing device 1011, the correction device 1010, and the deflection detection device 101, which are located outside the reagent container storage device 200.

[0144] In one embodiment, the reagent dispensing device 900 includes a reagent needle, a first suction / dispensing power source for driving the suction / dispensing action of the reagent needle, and a first motion power source for driving the reagent needle to perform spatial motion.

[0145] In one implementation, the controller 600 is further configured to: control the sample dispensing device 800 to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container. The sample dispensing action can be performed before, after, or in parallel with the reagent dispensing action. That is, controlling the sample dispensing device 800 to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container can be performed before or after the control of the reagent dispensing device 900 to draw at least a portion of the first reagent from the first reagent container 20 after the second opening action is completed and the container lid 21 is in the second open state, and to dispense all or part of the drawn first reagent into the reaction container; it can also be performed in parallel with the control of the reagent dispensing device 900 to draw at least a portion of the first reagent from the first reagent container 20 after the second opening action is completed and the container lid 21 is in the second open state, and to dispense all or part of the drawn first reagent into the reaction container.

[0146] In one implementation, the sample dispensing device 800 includes a sample needle, a second suction / dispensing power source for driving the sample needle suction / dispensing action, and a second motion power source for driving the sample needle to perform spatial motion.

[0147] Reference Figure 1As shown, in one embodiment, the sample analyzer also includes a reaction vessel providing device 102, a reaction vessel transferring device 105, and a reaction vessel recycling device. The reaction vessel providing device 102 is used to provide the reaction vessel, and the reaction vessel recycling device is used to recycle the reaction vessel. The sample analysis device 10 also forms a recycling position, with the reaction vessel recycling device located below, above, or otherwise close to the recycling position. The reaction vessel transferring device 105 is used at least to transfer the reaction vessel from the detection position to the recycling position for recycling. In this embodiment, the reaction vessel is a disposable container, meaning that a reaction vessel is recycled after completing one test item. Of course, in specific applications, the reaction vessel can also be a reusable container, meaning that after completing one test item, the reaction vessel can be cleaned within the sample analysis device 10 and reused for other test items.

[0148] In one embodiment, the reaction device 104 is disc-shaped, that is, the reaction device 104 is a reaction disk, and the reaction disk can carry multiple reaction containers for rotation.

[0149] In one implementation, the sample analysis device 10 is a standalone sample analyzer. This standalone sample analyzer can independently complete the testing of samples.

[0150] Alternatively, as another implementation, the sample analysis device 10 is a sample analysis pipeline. The sample analysis device 10 further includes a reagent container storage device 200, a reagent container loading device 400, a reagent container storage freezer, a reagent container conveying device, and a reagent container transfer device 300. The reagent container storage freezer is used to store a first reagent container 20 containing a first reagent. The reagent container conveying device is used to convey the first reagent container 20 from the reagent container storage freezer to the reagent container loading device 400. The reagent container transfer device 300 is used to transfer the first reagent container 20 from the reagent container loading device 400 to the reagent container storage device 200. The controller 600 is also configured to: control the reagent container conveying device to convey the first reagent container 20 from the reagent container storage freezer to the reagent container loading device 400, and control the reagent container transfer device 300 to transfer the first reagent container 20 from the reagent container loading device 400 to the reagent container storage device 200. The sample analysis pipeline includes a transport track and multiple or individual sample analyzers that interact with the transport track. The transport track can transport reagent containers (including but not limited to the first reagent container 20 mentioned above) to different sample analyzers or to a single sample analyzer. A reagent storage freezer can be used to store a large number of reagent containers. The sample analysis device 10 of this embodiment can automatically transport the first reagent container 20 from the reagent storage freezer to the reagent container loading device 400 of the sample analyzer. This implementation scheme, by setting up a reagent container loading device 400, a reagent container storage refrigerator, and a reagent container conveying device, uses a controller 600 to control the reagent container conveying device to transport the first reagent container 20 from the reagent container storage refrigerator to the reagent container loading device 400. This works in conjunction with a first capping device 100, a reagent container transfer device 300, a scheduling device 500, a reagent container storage device 200, a second capping device, and a reagent dispensing device 900 to achieve automatic loading of the first reagent container 20 within the sample analyzer and automatic pre-capping and full capping of the first reagent container 20, thus achieving full automation of the loading and capping process of the first reagent container 20. When a detection action is required, the controller 600 controls the reagent dispensing device 900 to directly draw the reagent from the first reagent container 20 located in the reagent container storage device 200 and dispense it into the reaction vessel.

[0151] In one implementation, the reagent container conveying device includes a transport track, which can be the same track as the aforementioned transport track or a different track. When the first reagent in the first reagent container 20 located in the reagent container storage device 200 is consumed, the controller 600 automatically controls the first reagent container 20 stored in the reagent container storage freezer to be automatically loaded into the transport track. For example, the door of the reagent container storage freezer or the reagent container outlet automatically opens, and the first reagent container 20 enters the transport track. The controller 600 automatically controls the transport track to transport the first reagent container 20 to the reagent container loading device 400, and the automatic control scheduling device 500 schedules the reagent container loading device 400 and controls the reagent container transfer device 300 to transfer the first reagent container 20 from the reagent container loading device 400 to the first cap opening device 100 to perform the first cap opening action, and then transfer it to the reagent container storage device 200. After controlling the second cap opening device to perform the second cap opening action on the first reagent container 20 placed in the reagent container storage device 200, the controller then controls the reagent dispensing device 900 to draw the first reagent from the first reagent container 20 and dispense it into the reaction container to participate in the reaction and then perform detection. Adopting an automatic control scheme helps ensure the smooth progress of project testing, avoids testing stagnation caused by the inability to replenish or replace the first reagent container 20 in a timely manner when abnormalities such as the first reagent in the first reagent container 20 are exhausted; and can improve the testing throughput by timely supply of the first reagent container 20.

[0152] As one implementation method, the determination that the first reagent in the first reagent container 20 has been consumed can be based on the number of times the item is tested or the number of times the reagent dispensing device 900 draws the first reagent from the first reagent container 20.

[0153] A second aspect of the present invention provides a sample analysis device 10, the sample analysis device 10 comprising: The sample dispensing device 800 is used to aspirate at least a portion of a sample from a sample container and dispense all or part of the aspirated sample into a reaction container. A reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 and dispense all or part of the drawn first reagent into the reaction container. The first opening device 100 is used to perform a first opening action on a first reagent container 20 containing a first reagent and having a container lid 21, so that the container lid 21 is in a first open state. The detection device 101 is used to detect a test solution prepared from at least a sample dispensed into a reaction vessel and a first reagent to obtain sample detection information. The controller 600 is configured to process sample detection information to obtain the sample detection result. When the container lid 21 is in the first open state, the reagent dispensing device 900 is unable to draw at least a portion of the first reagent from the first reagent container 20 and dispense all or part of the drawn first reagent into the reaction container.

[0154] The first aspect and the second aspect of the embodiments of the present invention respectively illustrate from different perspectives that the first opening action performed by the first opening device 100 on the first reagent container 20 is a pre-opening action, which only relieves part of the sealing force of the container cap 21; but does not completely open the container cap 21. Specifically, the second aspect of the embodiments of the present invention focuses on illustrating from the following perspective that the first opening action performed by the first opening device 100 on the first reagent container 20 is a pre-opening action: after the first opening device 100 completes the first opening action on the first reagent container 20 to put the container cap 21 in the first open state, the reagent dispensing device 900 cannot draw the first reagent from the first reagent container 20 with the container cap 21 in the first open state. The first aspect of the above-described embodiments of the present invention focuses on the first opening action performed by the first opening device 100 on the first reagent container 20 as a pre-opening action: after the first opening device 100 completes the first opening action on the first reagent container 20 to put the container lid 21 in the first open state, the second opening device needs to perform a second opening action on the first reagent container 20 after the first opening action is completed, and the reagent dispensing device 900 draws the first reagent from the first reagent container 20 after the second opening action is completed and the container lid 21 is in the second open state.

[0155] The sample analysis device 10 provided in the second aspect of the present invention can automatically perform a pre-opening action on the first reagent container 20 after the first reagent container 20 enters the sample analysis device 10, without requiring manual operation by the user. Therefore, it can save the user time and effort in performing the pre-opening action, thereby effectively reducing the user's workload and reducing the user's workload.

[0156] In one implementation, the container lid 21 is opened at an angle greater than 0° and less than 90° in the first open state.

[0157] In one embodiment, the container lid 21 is opened at an angle greater than 0° and less than or equal to 45° in the first open state.

[0158] In one embodiment, the container lid 21 is opened at an angle greater than 0° and less than or equal to 30° in the first open state.

[0159] In one embodiment, the sample analysis device 10 further includes a reagent container storage device 200 for storing a first reagent container 20; a reagent dispensing device 900 for drawing at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 and dispensing all or part of the drawn first reagent into a reaction vessel. A first opening device 100 is located outside the reagent container storage device 200.

[0160] Apart from the above, other parts and principles of the sample analysis device 10 provided in the second aspect of the present invention can be referred to the sample analysis device 10 provided in the first aspect above, and will not be described in detail here.

[0161] A third aspect of the present invention provides a sample analysis device 10, which includes a sample dispensing device 800, a first opening device 100, a reagent dispensing device 900, a closing device, a detection device 101, and a controller 600. The sample dispensing device 800 is used to draw at least a portion of a sample from a sample container and dispense all or part of the drawn sample into a reaction container. The first opening device 100 is used to perform a first opening action on a first reagent container 20 containing a first reagent and having a container cap 21, so that the container cap 21 is in a first open state. The reagent dispensing device 900 is used to draw at least a portion of the first reagent from the first reagent container 20 after the first opening action is completed and dispense all or part of the drawn first reagent into the reaction container. The closing device is used to perform a closing action on the first reagent container 20 after the reagent dispensing device 900 draws at least a portion of the first reagent from the first reagent container 20, so that the container cap 21 is in a closed state. The detection device 101 is used to detect a test solution prepared from at least the sample dispensed into the reaction container and the first reagent to obtain sample detection information. The controller 600 is configured to process sample detection information to obtain the sample detection result. The first opening device 100 and the closing device are either two different devices or the same device. In this embodiment, after the reagent dispensing device 900 draws at least a portion of the reagent from the first reagent container 20 after completing the first opening action, the closing device closes the container lid 21 onto the container body 22 of the first reagent container 20. When it is necessary to draw the first reagent from the first reagent container 20 again, the opening action (which can be the aforementioned first opening action or other opening actions) must be performed again to open the container lid 21.

[0162] In one implementation, the first opening device 100 performs a first opening action on the first reagent container 20, which can completely open the container lid 21. At this time, the reagent dispensing device 900 can enter the first reagent container 20 without obstruction to draw the first reagent. Of course, in specific applications, as an alternative implementation, the first opening device 100 performing the first opening action on the first reagent container 20 can also be a pre-opening action. In this case, the reagent dispensing device 900 cannot enter the first reagent container 20 without obstruction to draw the first reagent; a closing device or the second opening device mentioned in the first aspect needs to perform a further opening action on the first reagent container 20 to completely open the container lid 21 so that the reagent dispensing device 900 can enter the first reagent container 20 without obstruction to draw the first reagent.

[0163] In one embodiment of the connection between the container lid 21 and the container body 22, the container lid 21 is connected to the container body 22 by flipping. When the first opening device 100 performs a first opening action on the first reagent container 20 and can fully open the container lid 21, the opening angle of the container lid 21 in the first open state is greater than or equal to 90°. In an alternative embodiment, when the first opening device 100 performs a first opening action on the first reagent container 20 but cannot fully open the container lid 21, the opening angle of the container lid 21 in the first open state is 0° and less than 90°. A closing device or the second opening device mentioned in the first aspect needs to perform a further opening action on the first reagent container 20 to make the opening angle of the container lid 21 greater than or equal to 90°.

[0164] As a further embodiment of the connection between the container lid 21 and the container body 22 described above, the first opening device 100 includes a pressing member 190 and a third driving member 1001. The top of the container lid 21 has a cantilevered portion 2102. The third driving member 1001 drives the pressing member 190 to move up and down, pressing it against the cantilevered portion 2102, thereby driving the end of the container lid 21 away from the cantilevered portion 2102 to swing upwards, opening the container lid 21 to a first open state. The third driving member 1001 is connected to the pressing member 190 to drive the pressing member 190 to move. When the first opening device 100 performs the first opening action on the first reagent container 20 and can fully open the container lid 21, the first opening device 100 performs the first opening action. For example, the pressing member 190 of the first opening device 100 can press down on the suspended part 2102 to directly open the container lid 21 until the reagent dispensing device 900 can enter the first reagent container 20 without obstruction to draw the first reagent.

[0165] In another embodiment of the connection between the container cap 21 and the container body 22, the container cap 21 is spirally connected to the container body 22. When the first capping device 100 performs a first capping action on the first reagent container 20 and can fully open the container cap 21, the container cap 21 is completely rotated away from the container body 22 in the first open state. In an alternative embodiment, when the first capping device 100 performs a first capping action on the first reagent container 20 but cannot fully open the container cap 21, the container cap 21 remains screwed onto the container body 22 in the first open state. A capping device or the second capping device mentioned in the first aspect needs to perform a further capping action on the first reagent container 20 to completely rotate the container cap 21 away from the container body 22. The first capping device 100 can be configured, for example, using the gripping member 1002 and the fourth driving member 1003 mentioned in the first aspect, which will not be described in detail here.

[0166] In one implementation, the closing device and the first opening device 100 are two different devices. Besides performing the closing action, the closing device is also used to perform a fourth opening action on the container lid 21 when the first reagent in the first reagent container 20 needs to be used again, so that the reagent dispensing device 900 can unimpededly enter the first reagent container 20 to draw the first reagent. After the closing device performs the closing action on the first reagent container 20 to close the container lid 21, when it is necessary to draw the first reagent from the first reagent container 20 again, the closing device first performs a fourth opening action on the first reagent container 20 to fully open the container lid 21, so that the reagent dispensing device 900 can unimpededly enter the first reagent container 20 to draw the first reagent.

[0167] Of course, in specific applications, the configuration of the closing device is not limited to the above scheme. For example, as an alternative implementation, the closing device and the first opening device 100 are the same device. In addition to performing the first opening action, the first opening device 100 is also used to perform a closing action on the container lid 21 after the reagent dispensing device 900 has absorbed the first reagent; and to perform a third opening action on the container lid 21 when the first reagent in the first reagent container 20 needs to be used again, so that the reagent dispensing device 900 can unimpededly enter the first reagent container 20 to absorb the first reagent. After the first opening device 100 performs a closing action on the first reagent container 20 to close the container lid 21, when it is necessary to absorb the first reagent loaded in the first reagent container 20 again, the first opening device 100 first performs a third opening action on the first reagent container 20 to fully open the container lid 21, so that the reagent dispensing device 900 can unimpededly enter the first reagent container 20 to absorb the first reagent.

[0168] Alternatively, as an alternative implementation, the closing device and the first opening device 100 are two different devices. The first opening device 100, in addition to performing the first opening action, is also used to perform a third opening action on the container lid 21 when the first reagent in the first reagent container 20 needs to be used again, so as to reopen the container lid 21 and allow the reagent dispensing device 900 to unobstructedly enter the first reagent container 20 to draw the first reagent. After the closing device performs a closing action on the first reagent container 20 to close the container lid 21, when it is necessary to draw the first reagent from the first reagent container 20 again, the first opening device 100 first performs a third opening action on the first reagent container 20 to fully open the container lid 21, allowing the reagent dispensing device 900 to unobstructedly enter the first reagent container 20 to draw the first reagent.

[0169] Alternatively, as another alternative implementation, the closing device and the first opening device 100 are two different devices. The sample analysis device 10 also includes a second opening device, which is used to perform a second opening action on the container lid 21 after the closing device has closed the first reagent container 20 and when the first reagent in the first reagent container 20 needs to be used again, so that the container lid 21 is in a second open state, allowing the reagent dispensing device 900 to enter the first reagent container 20 without obstruction to draw the first reagent. After the closing device has closed the first reagent container 20 to close the container lid 21, when it is necessary to draw the first reagent loaded in the first reagent container 20 again, the second opening device first performs a second opening action on the first reagent container 20 to fully open the container lid 21, allowing the reagent dispensing device 900 to enter the first reagent container 20 without obstruction to draw the first reagent.

[0170] In one embodiment, the sample analysis device 10 further includes a reagent container storage device 200 for storing a first reagent container 20; a reagent dispensing device 900 for drawing at least a portion of the first reagent from the first reagent container 20 located within the reagent container storage device 200 and dispensing all or part of the drawn first reagent into a reaction vessel. A first opening device 100 is located outside the reagent container storage device 200.

[0171] Apart from the above, other parts and principles of the sample analysis device 10 provided in the third aspect of the present invention can be referred to the sample analysis device 10 provided in the first and second aspects above, and will not be described in detail here.

[0172] A fourth aspect of the present invention provides a control method for a sample analysis device 10, the control method comprising: The reagent container transfer device 300 transfers a first reagent container 20, which is contained in the first reagent and has a container cap 21 closed, from the reagent container loading device 400 to the first cap opening device 100. The first opening device 100 controls the first reagent container 20, which is from the reagent container loading device 400 and has the container lid 21 closed, to perform a first opening action, so that the container lid 21 is in a first open state. The reagent container transfer device 300 controls the first reagent container 20, after the first opening action is completed, to be placed into the reagent container storage device 200; The second opening device controls the first reagent container 20 located inside the reagent container storage device 200 and after the first opening action has been completed to perform a second opening action, so that the container lid 21 is in a second open state, wherein the degree of opening of the container lid 21 in the first open state is less than the degree of opening of the container lid 21 in the second open state. The sample dispensing device 800 controls the aspirating of at least a portion of the sample from the sample container and dispenses all or part of the aspirated sample into the reaction container; The reagent dispensing device 900 draws at least a portion of the first reagent from the first reagent container 20 located inside the reagent container storage device 200 with the container lid 21 in a second open state, and dispenses all or part of the drawn first reagent into the reaction container. The control detection device 101 detects at least a test solution prepared based on the sample dispensed into the reaction vessel and the first reagent to obtain the test result of the sample.

[0173] In one implementation, the first opening device 100 controls the first reagent container 20, which contains the first reagent and has a container cap 21, to perform a first opening action, so that the container cap 21 is in a first open state. The second opening device controls the first reagent container 20 to perform a second opening action after the first opening action is completed. This includes: when information is obtained that the first reagent container 20 is placed on the reagent container loading device 400, controlling the scheduling device 500 to schedule the reagent container loading device 400 containing the first reagent container 20 from the loading position 12 to the transfer position 13, or to schedule the first reagent container 20 loaded on the reagent container loading device 400 from the reagent container loading device 400 to the transfer position 13; determining whether any of the tests to be performed requires the use of the first reagent in the first reagent container 20; and if a test is determined to be performed... When the first reagent in the first reagent container 20 is needed, the reagent container transfer device 300 is controlled to remove the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and transfer the first reagent container 20 to the first opening position 11, or to transfer the first reagent container 20 from the transfer position 13 to the first opening position 11. The first opening device 100 is controlled to perform a first opening action on the first reagent container 20 located at the first opening position 11. The reagent container transfer device 300 is controlled to transfer the first reagent container 20 after the first opening action is completed from the first opening position 11 to the reagent container interaction port 210 and put it into the reagent container storage device 200 through the reagent container interaction port 210. The second opening device is controlled to perform a second opening action on the first reagent container 20 after it has been put into the reagent container storage device 200 and the first opening action is completed.

[0174] As one implementation, after determining whether any of the tests to be performed require the use of the first reagent in the first reagent container 20, the control method further includes: if it is determined that no test requires the use of the first reagent in the first reagent container 20, controlling the reagent container transfer device 300 to remove the first reagent container 20 from the reagent container loading device 400 located at the transfer position 13 and place the first reagent container 20 into the reagent container storage device 200 through the reagent container interaction port 210, or to place the first reagent container 20 from the transfer position 13 into the reagent container storage device 200 through the reagent container interaction port 210; when it is determined that a test requires the use of the first reagent in the first reagent container 20... When the first reagent is applied, the reagent container transfer device 300 is controlled to remove the first reagent container 20 from the reagent container storage device 200 through the reagent container interaction port 210 and transfer it to the first opening position 11. The first opening device 100 is controlled to perform a first opening action on the first reagent container 20 located at the first opening position 11. The reagent container transfer device 300 is controlled to transfer the first reagent container 20, after completing the first opening action, from the first opening position 11 to the reagent container interaction port 210 and place it into the reagent container storage device 200 through the reagent container interaction port 210. The second opening device is controlled to perform a second opening action on the first reagent container 20, which has been placed into the reagent container storage device 200 and completed the first opening action.

[0175] In addition to the above, other parts and principles of the control method of the sample analysis device 10 provided in the fourth aspect of the present invention can be referred to the control method and principle of the controller 600 in the sample analysis device 10 provided in the first, second and third aspects above, and will not be described in detail here.

[0176] A fifth aspect of this invention provides a computer-readable storage medium storing a computer program. When the computer program is executed by a processor (e.g., the controller 600 described above), it causes the processor to implement the steps of the control method for the sample analysis device 10 described above. The computer-readable storage medium may be an internal storage unit of the sample analysis device 10, such as a hard disk or memory of the sample analysis device 10; or it may be an external storage device of the sample analysis device 10, such as a pluggable hard disk, smart media card (SMC), secure digital (SD) card, flash card, etc., provided on the sample analysis device 10.

[0177] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A sample analysis device, characterized in that: It includes a reagent container transfer device, a reagent container loading device, a first cap opening device, a reagent container storage device, a second cap opening device, a sample dispensing device, a reagent dispensing device, a detection device, and a controller; The controller is configured to: The reagent container transfer device controls the transfer of a first reagent container, which is from the reagent container loading device and contains a first reagent and has a container cap closed, to the first cap opening device. The first cap-opening device is controlled to perform a first cap-opening action on the first reagent container from the reagent container loading device and which is covered by the container cap, so that the container cap is in a first open state. The reagent container transfer device is controlled to place the first reagent container, after the first opening action is completed, into the reagent container storage device; The second opening device is controlled to perform a second opening action on the first reagent container located inside the reagent container storage device after the first opening action has been completed, so that the container lid is in a second open state, wherein the degree of opening of the container lid in the first open state is less than the degree of opening of the container lid in the second open state; The sample dispensing device is controlled to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container; The reagent dispensing device is controlled to draw at least a portion of the first reagent from the first reagent container located inside the reagent container storage device and with the container lid in the second open state, and to dispense all or part of the drawn first reagent into the reaction vessel; The detection device is controlled to detect a test solution prepared based at least on the sample dispensed into the reaction vessel and the first reagent, in order to obtain a detection result for the sample.

2. The sample analysis device as described in claim 1, characterized in that: The sample analysis device also includes a scheduling device; Before the reagent container transfer device transfers the first reagent container, which contains the first reagent and has its lid closed, from the reagent container loading device to the first lid opening device, the controller is further configured to: control the scheduling device to drive the reagent container loading device to move the first reagent container, which contains the first reagent and has its lid closed, loaded on the reagent container loading device, so as to schedule the first reagent container, which contains the first reagent and has its lid closed, from the loading position to the transfer position, wherein the loading position is used for the user to place the first reagent container, which contains the first reagent and has its lid closed, on the reagent container loading device; The method of controlling the reagent container transfer device to transfer the first reagent container, which is loaded from the reagent container loading device and contains the first reagent and is covered with a container cap, to the first cap opening device includes: controlling the reagent container transfer device to remove the first reagent container, which is loaded on the reagent container loading device and contains the first reagent and is covered with the container cap, from the intermediate position and transfer it to the first cap opening device.

3. The sample analysis device as described in claim 2, characterized in that: The first reagent includes magnetic beads, and the sample analysis device further includes a mixing device, wherein: The mixing device is used to: during the process of the dispatching device dispatching the first reagent container, containing the first reagent and covered by the container lid, from the loading position to the transfer position, or after dispatching to the transfer position, perform a mixing action on the magnetic beads deposited at the bottom of the first reagent container, so that the magnetic beads deposited at the bottom of the first reagent container detach from its bottom; and The method of controlling the reagent container transfer device to remove and transfer the first reagent container, which is loaded on the reagent container loading device and contains the first reagent and is covered by the container cap, from the intermediate transfer position to the first cap opening device includes: controlling the reagent container transfer device to remove and transfer the first reagent container, which is loaded on the reagent container loading device and contains the first reagent and the magnetic beads in the first reagent, after the mixing action has been completed, from the intermediate transfer position to the first cap opening device; Alternatively, controlling the reagent container transfer device to remove the first reagent container, which is loaded on the reagent container loading device and contains the first reagent and has the container cap closed, from the intermediate transfer position and transfer it to the first cap opening device includes: controlling the reagent container transfer device to remove the first reagent container, which is loaded on the reagent container loading device and contains the first reagent and has the container cap closed, from the intermediate transfer position and transfer it to the mixing position, so that the mixing device performs a mixing action on the magnetic beads deposited at the bottom of the first reagent container located at the mixing position, thereby causing the magnetic beads deposited at the bottom of the first reagent container to detach from its bottom; controlling the reagent container transfer device to transfer the first reagent container, which is located at the mixing position and contains the first reagent and the magnetic beads in the first reagent, to the first cap opening device after the mixing action is completed.

4. The sample analysis device as described in claim 2 or 3, characterized in that: The scheduling device drives the reagent container loading device to rotate, and schedules the first reagent container containing the first reagent and the container lid closed from the loading position to the transfer position. Alternatively, the scheduling device can move the reagent container, which contains the first reagent and is covered by the container lid, from the loading position to the transfer position by driving the reagent container loading device to move horizontally in a straight line.

5. The sample analysis device according to any one of claims 1 to 3, characterized in that: The sample analysis device is equipped with a first reagent loading mode and a second reagent loading mode; In the first reagent loading mode, the controller is configured to: first control the reagent container transfer device to transfer the first reagent container, which is contained in the first reagent and has a container cap, from the reagent container loading device to the first cap opening device; then control the first cap opening device to perform the first cap opening action on the first reagent container, which is contained in the reagent container loading device and has the container cap; and then control the reagent container transfer device to place the first reagent container, which has completed the first cap opening action, into the reagent container storage device. In the second reagent loading mode, the controller is configured to: control the reagent container transfer device to place the first reagent container from the reagent container loading device, which has not undergone the first opening action by the first opening device, into the reagent container storage device; when a preset condition is met, control the reagent container transfer device to remove the first reagent container located in the reagent container storage device, which has not undergone the first opening action by the first opening device, and transfer it to the first opening device; control the first opening device to perform the first opening action on the first reagent container; and control the reagent container transfer device to place the first reagent container after completing the first opening action into the reagent container storage device.

6. The sample analysis device as described in claim 5, characterized in that: The sample analysis equipment also includes a human-computer interaction device; The controller is further configured to: determine, based on preset rules and / or information input by the user through the human-computer interaction device, that the first reagent needs to be loaded in the second reagent loading mode, and switch the first reagent loading mode to the second reagent loading mode; wherein, the preset rules include: obtaining information that the number of the first reagent containers to be loaded is greater than the number of the first reagent containers that the reagent container loading device can load at one time; And / or, satisfying the preset conditions includes satisfying at least one of the following preset conditions: The system obtains information indicating that no test item requires the reagent dispensing device to perform a reagent dispensing action. Information was obtained that the reagent dispensing device had started performing a reagent needle cleaning action; The information obtained indicates that no test items require the sample analysis equipment to perform tests; Information is obtained that a test item requires the use of the first reagent in the first reagent container located in the reagent container storage device and which has not yet undergone the first opening action by the first opening device.

7. The sample analysis device according to any one of claims 1 to 3, characterized in that: The first reagent contains magnetic beads; The sample analysis equipment also includes a magnetic bead aggregation detection device; Before the controller transfers the reagent container from the reagent container loading device, containing the first reagent and with the container cap closed, to the first cap opening device, the controller is further configured to: control the reagent container transfer device to transfer the reagent container from the reagent container loading device, containing the first reagent and with the container cap closed, to the magnetic bead aggregation detection position; control the magnetic bead aggregation detection device to perform a magnetic bead aggregation detection action on the first reagent container located at the magnetic bead aggregation detection position to obtain magnetic bead aggregation detection information; and determine whether the magnetic beads in the first reagent container exhibit aggregation based on the magnetic bead aggregation detection information. The method of controlling the reagent container transfer device to transfer a first reagent container, which is from the reagent container loading device and contains a first reagent and has a container cap closed, to the first cap opening device includes: controlling the reagent container transfer device to transfer a first reagent container, which is determined based on the magnetic bead aggregation detection information, to the first cap opening device, where the magnetic beads in the first reagent container do not exhibit aggregation.

8. The sample analysis device as described in claim 7, characterized in that: The sample analysis device also includes a scheduling device; Before the control device transfers the reagent container from the reagent container loading device, which contains the first reagent and has its lid closed, to the magnetic bead aggregation detection position, the controller is further configured to: control the scheduling device to drive the reagent container loading device to move the first reagent container loaded on the reagent container loading device, which contains the first reagent and has its lid closed, so as to schedule the first reagent container containing the first reagent and having its lid closed from the loading position to the transfer position, wherein the loading position is used for the user to place the first reagent container containing the first reagent and having its lid closed on the reagent container loading device; After the controller controls the magnetic bead aggregation detection device to perform a magnetic bead aggregation detection action on the first reagent container located at the magnetic bead aggregation detection position, the controller is further configured to: when it is determined, based on the magnetic bead aggregation detection information, that there is aggregation of the magnetic beads in the first reagent container, perform at least one of the following actions: a rollback action, outputting alarm information; The retraction action includes: controlling the reagent container transfer device to transfer the first reagent container, which contains the first reagent and in which the magnetic beads in the first reagent exhibit agglomeration, from the magnetic bead agglomeration detection position to the transfer position and place it on the reagent container loading device; and controlling the scheduling device to schedule the reagent container loading device, which contains the first reagent container and in which the magnetic beads in the first reagent container exhibit agglomeration, from the transfer position to the loading position.

9. The sample analysis device as described in claim 8, characterized in that: The sample analysis device also includes a mixing device and / or a homogenizing device; The mixing device is used to: perform a mixing action on the magnetic beads deposited at the bottom of the first reagent container before the reagent container transfer device transfers the first reagent container, which is from the reagent container loading device and contains the first reagent and is covered with a container cap, to the magnetic bead aggregation detection position, so that the magnetic beads deposited at the bottom of the first reagent container detach from its bottom. The mixing device is used to: mix the first reagent in the first reagent container before the magnetic bead aggregation detection device performs the magnetic bead aggregation detection action on the first reagent container located at the magnetic bead aggregation detection position.

10. The sample analysis device as described in claim 9, characterized in that: The sample analysis equipment also includes a correction device; Before the reagent container transfer device transfers the first reagent container, which is determined by the magnetic bead aggregation detection information to have no magnetic beads agglomeration, to the first cap opening device, the controller is further configured to: control the reagent container transfer device to transfer the first reagent container, which is determined by the magnetic bead aggregation detection information to have no magnetic beads agglomeration, to the correction position, and control the correction device to perform a correction action on the container cap of the first reagent container located at the correction position; The method of controlling the reagent container transfer device to transfer the first reagent container, which determines that the magnetic beads in the first reagent container do not exhibit agglomeration based on the magnetic bead agglomeration detection information, to the first cap opening device includes: controlling the reagent container transfer device to transfer the first reagent container, which has been determined that the magnetic beads in the first reagent container do not exhibit agglomeration based on the magnetic bead agglomeration detection information and has undergone the correction action by the correction device, from the correction position to the first cap opening device.

11. The sample analysis device as described in claim 10, characterized in that: The sample analysis equipment also includes a deflection detection device; The step of controlling the correction device to perform a correction action on the container cap of the first reagent container located at the correction position includes: controlling the deflection detection device to perform a deflection angle detection action on the container cap of the first reagent container located at the correction position to obtain deflection angle detection information; determining whether the container cap has a deflection phenomenon and determining the deflection angle of the container cap based on the deflection angle detection information; and controlling the correction device to perform the correction action on the container cap of the first reagent container located at the correction position based on the deflection angle of the container cap.

12. The sample analysis device as described in claim 11, characterized in that: The sample analysis device includes the mixing device and the homogenizing device; The controller is also configured to: The information obtained is that the user places the first reagent container, which contains the first reagent and is covered by the container cap, onto the reagent container loading device from the loading position; The scheduling device controls the reagent container loading device to move the first reagent container loaded on the reagent container loading device, so as to schedule the first reagent container from the loading position to the transfer position. During or after the scheduling device schedules the first reagent container from the loading position to the transfer position, the mixing device performs the mixing action on the magnetic beads deposited at the bottom of the first reagent container. The reagent container transfer device is controlled to remove the first reagent container, which is loaded on the reagent container loading device and contains the first reagent and the magnetic beads in the first reagent, after the mixing action has been completed, from the intermediate transfer position and transfer it to the magnetic bead aggregation detection position. The mixing device is controlled to perform the mixing action on the first reagent in the first reagent container located at the magnetic bead aggregation detection position; The magnetic bead aggregation detection device is controlled to perform the magnetic bead aggregation detection action on the first reagent container located at the magnetic bead aggregation detection position after the mixing action is completed, so as to obtain the magnetic bead aggregation detection information. When it is determined, based on the magnetic bead aggregation detection information, that there is no aggregation of the magnetic beads in the first reagent container, the reagent container transfer device is controlled to transfer the first reagent container from the magnetic bead aggregation detection position to the correction position. The deflection detection device is controlled to perform a deflection angle detection action on the container cap of the first reagent container located at the correction position to obtain the deflection angle of the container cap. Based on the deflection angle of the container cap, the correction device is controlled to perform a correction action on the container cap of the first reagent container located at the correction position. The reagent container transfer device is controlled to transfer the first reagent container, after the correction action has been completed by the correction device, from the correction position to the first cap opening device. The first cap opening device is controlled to perform the first cap opening action on the first reagent container. When it is determined, based on the magnetic bead aggregation detection information, that the magnetic beads in the first reagent container exhibit aggregation, the rollback action is executed.

13. The sample analysis device as described in claim 12, characterized in that: The reagent container storage device has a reagent container interaction port. The reagent container interaction port is at least used by the reagent container transfer device to place the first reagent container, after completing the first opening action, into the reagent container storage device. The transfer position, the magnetic bead aggregation detection position, the correction position, and the first opening device are all located at positions that are horizontally offset from the reagent container interaction port and horizontally offset from the loading position. The transfer position is located between the loading position and the reagent container interaction port, the reagent container interaction port is located between the transfer position and the magnetic bead aggregation detection position, and the correction position is located between the magnetic bead aggregation detection position and the first opening device.

14. The sample analysis device as described in claim 7, characterized in that: The magnetic bead aggregation detection device is an image capturing device, which is used to capture an image of the bottom of the first reagent container; The step of controlling the magnetic bead aggregation detection device to perform a magnetic bead aggregation detection action on the first reagent container located at the magnetic bead aggregation detection position to obtain magnetic bead aggregation detection information includes: controlling the image capturing device to capture an image of the bottom of the first reagent container located at the magnetic bead aggregation detection position to obtain a target image; The step of determining whether the magnetic beads in the first reagent container have agglomeration based on the magnetic bead agglomeration detection information includes: performing grayscale comparison analysis on the target image to determine whether the magnetic beads in the first reagent container have agglomeration; if so, it is determined that the magnetic beads in the first reagent container have agglomeration.

15. The sample analysis device as described in claim 1, characterized in that: The degree of opening includes the opening angle of the container lid of the first reagent container. The degree of opening of the container lid in the first open state is less than the degree of opening of the container lid in the second open state, including: the opening angle of the container lid of the first reagent container in the first open state is less than the opening angle of the container lid in the second open state. Alternatively, the degree of opening includes the degree to which the lid of the first reagent container is slid open, wherein the degree of opening of the lid in the first open state is less than the degree of opening of the lid in the second open state, including: the degree of sliding of the lid of the first reagent container in the first open state is less than the degree of sliding of the lid in the second open state.

16. The sample analysis device as described in claim 15, characterized in that: When the degree of opening includes the opening angle of the container lid of the first reagent container, the opening angle of the container lid in the first open state is greater than 0° and less than 90°; And / or, when the degree of opening includes the opening angle of the container lid of the first reagent container, the opening angle of the container lid in the second open state is greater than or equal to 90°.

17. The sample analysis apparatus as described in any one of claims 1 to 3, or 15 or 16, characterized in that: The first opening device includes a container seat and an opening component, wherein the container seat is located outside the reagent container storage device; The method of controlling the reagent container transfer device to transfer the first reagent container, which is contained in the first reagent and has a container cap closed, from the reagent container loading device to the first cap opening device includes: controlling the reagent container transfer device to transfer the first reagent container, which is contained in the first reagent and has a container cap closed, from the reagent container loading device to the container seat. The control of the first opening device to perform the first opening action on the first reagent container from the reagent container loading device and covered with the container lid includes: controlling the opening component to perform the first opening action on the first reagent container located on the container seat and covered with the container lid.

18. The sample analysis device as described in claim 17, characterized in that: The opening component includes at least one abutting component and a first driving component; The method of controlling the opening component to perform the first opening action on the first reagent container located on the container seat and covered by the container cap includes: controlling the first driving component to drive one of the at least one abutting component and the container seat to move relative to the other in a first horizontal direction, so that the at least one abutting component contacts the bottom of the container cap located on the container seat and abuts the container cap upward, thereby opening the container cap to the first open state.

19. The sample analysis device as described in claim 18, characterized in that: The at least one abutting component includes at least two abutting components, and any two of the at least two abutting components are staggered in the first horizontal direction and the first vertical direction.

20. The sample analysis device as described in claim 19, characterized in that: The at least two abutting components include at least two rotatable abutting components, which are sequentially spaced along an inclined trajectory. The inclined trajectory is set at an angle greater than 0° and less than 90° relative to the first horizontal direction. The at least two rotatable abutting components are used to sequentially contact the bottom of the container lid located on the container seat under the drive of the first driving component, so as to push the container lid upward, thereby opening the container lid to the first open state. Each rotatable abutting component includes at least one of a rotatable bearing, a rotatable roller, and a rotatable spherical component. Alternatively, the at least two abutting components include at least two abutting components with a first inclined surface. The at least two abutting components with the first inclined surface are distributed sequentially at intervals along an inclined trajectory. The inclined trajectory is set at an angle greater than 0° and less than 90° relative to the first horizontal direction. The at least two abutting components with the first inclined surface are used to make the first inclined surface contact the bottom of the container lid located on the container seat in sequence under the drive of the first driving component, so as to push the container lid upward and open the container lid to the first open state.

21. The sample analysis device as described in claim 18, characterized in that: The at least one abutting component is an abutting component with a second inclined surface. The second inclined surface is set at an angle greater than 0° and less than 90° relative to the first horizontal direction. The abutting component with the second inclined surface is used to continuously contact the bottom of the container lid located on the container seat under the drive of the first driving component, so as to push the container lid upward and open the container lid to the first open state.

22. The sample analysis device as described in claim 18, characterized in that: The opening component further includes a bracket, a connecting seat, and an elastic component. The connecting seat is mounted on the bracket by means of the elastic component, and the at least one abutting component is mounted on or integrally formed with the connecting seat. The first driving component is connected to the bracket for driving the bracket to move the connecting seat, the at least one abutting component, and the elastic component along the first horizontal direction.

23. The sample analysis device as described in claim 22, characterized in that: The opening component also includes a limiting structure, which is integrally formed or installed on the connecting seat. The limiting structure is used to press down on the container body of the first reagent container when the at least one abutting component abuts the container cap upward, so as to prevent the first reagent container from detaching from the container seat when the at least one abutting component abuts the container cap upward.

24. The sample analysis apparatus as described in any one of claims 1 to 3, or 15 or 16, characterized in that: The first opening device includes a hook and a second driving component. A hook position is formed on the container lid. The second driving component is used to drive the hook to move up and down so that the hook is hooked at the hook position. When the hook is hooked at the hook position, the second driving component is used to drive the hook to pull the container lid upward to open the container lid to the first open state. Alternatively, the first opening device includes a pressing member and a third driving member. The top of the container lid has a cantilevered portion. The third driving member is used to drive the pressing member to move up and down so that the pressing member presses against the cantilevered portion, thereby driving the end of the container lid away from the cantilevered portion to swing upward so that the container lid is opened to the first open state.

25. The sample analysis apparatus as described in any one of claims 1 to 3, or 15 or 16, characterized in that: After the controller controls the reagent dispensing device to draw at least a portion of the first reagent from the first reagent container located within the reagent container storage device and with the container lid in the second open state, the controller is further configured to: control the second lid opening device to perform a lid closing action on the first reagent container to bring the container lid into a closed state; Alternatively, the sample analysis device further includes a capping device, wherein after the controller controls the reagent dispensing device to draw at least a portion of the first reagent from the first reagent container located within the reagent container storage device and with the container cap in the second open state, the controller is further configured to control the capping device to perform a capping action on the first reagent container to bring the container cap into a closed state.

26. The sample analysis device as described in claim 25, characterized in that: The controller is also configured to: When information is received that there is no test item that requires the use of the first reagent in the first reagent container, the second opening device or the closing device is controlled to perform the closing action on the first reagent container so that the container lid is in the closed state. When it is determined that a test item requires the use of the first reagent in the first reagent container, the second opening device is controlled to perform the second opening action on the first reagent container after the closing action is completed and the container lid is in the closed state, so that the container lid is in the second open state. The reagent dispensing device is controlled to draw at least a portion of the first reagent from the first reagent container located inside the reagent container storage device, after the second opening action is completed and the container lid is in the second open state, and to dispense all or part of the drawn first reagent into the reaction container.

27. A control method for a sample analysis device, characterized in that: include: The reagent container transfer device controls the transfer of a first reagent container, which is from the reagent container loading device and contains a first reagent and has its lid closed, to a first lid opening device. The first capping device is controlled to perform a first capping action on the first reagent container from the reagent container loading device and which is covered by the container cap, so that the container cap is in a first open state. The reagent container transfer device controls the placement of the first reagent container, after the first opening action is completed, into the reagent container storage device; The second capping device is controlled to perform a second capping action on the first reagent container located inside the reagent container storage device after the first capping action has been completed, so that the container cap is in a second open state, wherein the degree of opening of the container cap in the first open state is less than the degree of opening of the container cap in the second open state; The sample dispensing device is controlled to draw at least a portion of the sample from the sample container and dispense all or part of the drawn sample into the reaction container; The control reagent dispensing device draws at least a portion of the first reagent from the first reagent container located within the reagent container storage device with the container lid in the second open state, and dispenses all or part of the drawn first reagent into the reaction vessel; The control detection device detects at least a test solution prepared based on the sample dispensed into the reaction vessel and the first reagent to obtain a test result for the sample.

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