A traditional Chinese medicine composition for treating cerebral infarction, a preparation method and application thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating cerebral infarction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is composed of Chuanxiong Rhizoma, processed Southern Starwort Rhizome, Nine-Sectioned Lily Bulb, Gastrodia Elata Blume, Uncaria, Rhodiola, Leech, Earthworm and Polygonatum. The application follows the compatibility principle of monarch, minister, assistant and messenger in traditional Chinese medicine, and the medicinal materials synergistically act according to precise weight proportions, and the compatibility is scientific and the dosage is clear. The traditional Chinese medicine composition has the effects of activating blood circulation to dissipate blood stasis, dissipating phlegm to open the orifices, calming liver wind and benefiting qi and nourishing yin, can effectively improve blood circulation in the brain, has definite curative effect and small side effect, has simple preparation process and low cost, and is suitable for large-scale production and clinical popularization and application.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and more specifically, relates to a traditional Chinese medicine composition for treating cerebral infarction, its preparation method, and its application. Background Technology

[0002] Cerebral infarction is a common cerebrovascular disease characterized by high incidence, high disability rate, high recurrence rate, and high mortality rate. It is mainly caused by impaired cerebral blood circulation, with thrombi blocking cerebral blood vessels, leading to temporary or permanent obstruction of cerebral blood flow, resulting in ischemia, hypoxia, and necrosis of brain tissue. This leads to neurological deficits, producing a series of clinical syndromes including hemiplegia, aphasia, and impaired cognitive and learning abilities, seriously threatening human health. While modern medical treatments have some efficacy, they also have certain limitations and risks.

[0003] In Traditional Chinese Medicine (TCM) theory, cerebral infarction falls under the category of "stroke." Its core pathogenesis is often characterized by deficiency of the root and excess of the branch, specifically qi deficiency and blood stasis, phlegm and blood stasis obstructing the collaterals, and liver yang hyperactivity. This means that the body's internal organs are imbalanced in yin and yang, resulting in internal deficiency of qi and blood. Combined with overwork, internal injury, and the accumulation of phlegm and heat, this leads to the mutual binding of phlegm and blood stasis, obstruction of the cerebral vessels, poor circulation of qi and blood, and malnourishment of the brain tissue, ultimately causing the disease. Phlegm and blood stasis are both the cause and the pathological product, persisting throughout the entire course of the disease. Therefore, treatment should focus on promoting blood circulation and removing blood stasis, clearing phlegm and opening the orifices, tonifying qi and unblocking the collaterals, and calming the liver and extinguishing wind.

[0004] Currently, there are many types of traditional Chinese medicine formulas for treating cerebral infarction, but many of them suffer from problems such as imprecise formulation, weak targeting, and unstable efficacy. Some formulas focus on promoting blood circulation and removing blood stasis while neglecting to resolve phlegm and open the orifices, or focus on tonifying deficiency while lacking the power to unblock the meridians. They are unable to take into account the pathological relationship between "phlegm, blood stasis, and deficiency" and cannot fully achieve the therapeutic effect of improving cerebral blood circulation and repairing nerve function.

[0005] Therefore, it is of great significance to develop a traditional Chinese medicine preparation that can simultaneously target the four major pathological factors of "phlegm, blood stasis, deficiency, and wind," with more precise formulation and stable efficacy. Summary of the Invention

[0006] To address the aforementioned problems in existing technologies, the technical problem this invention aims to solve is to provide a traditional Chinese medicine composition for treating cerebral infarction. This composition is scientifically formulated and precisely dosed, possessing the effects of promoting blood circulation, removing blood stasis, clearing phlegm, calming the liver and extinguishing wind, and nourishing qi and yin. It can effectively improve cerebral blood circulation and treat cerebral infarction. Another technical problem this invention aims to solve is to provide a preparation method for the above-mentioned traditional Chinese medicine composition. This method is simple, convenient, and can maximize the retention of the effective components of the medicinal materials, ensuring the stability and efficacy of the preparation. A further technical problem this invention aims to solve is to provide the application of the above-mentioned traditional Chinese medicine composition in the preparation of drugs for improving blood circulation or treating cerebral infarction.

[0007] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows:

[0008] A traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 5-15 parts of Ligusticum chuanxiong, 5-15 parts of processed Arisaema heterophyllum, 5-15 parts of Acorus tatarinowii, 5-15 parts of Gastrodia elata, 20-40 parts of Uncaria rhynchophylla, 10-20 parts of Rhodiola rosea, 3-8 parts of Hirudo medicinalis, 5-15 parts of Pheretima aspergillum, and 10-20 parts of Polygonatum sibiricum.

[0009] Preferably, the traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 8-12 parts of Ligusticum chuanxiong, 8-12 parts of processed Arisaema heterophyllum, 8-12 parts of Acorus tatarinowii, 8-12 parts of Gastrodia elata, 25-35 parts of Uncaria rhynchophylla, 12-18 parts of Rhodiola rosea, 4-6 parts of Hirudo medicinalis, 8-12 parts of Pheretima aspergillum, and 12-18 parts of Polygonatum sibiricum.

[0010] Preferably, the traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 30 parts of Uncaria rhynchophylla, 15 parts of Rhodiola rosea, 5 parts of Hirudo medicinalis, 10 parts of Pheretima aspergillum, and 15 parts of Polygonatum sibiricum.

[0011] A method for preparing the traditional Chinese medicine composition for treating cerebral infarction includes the following steps:

[0012] 1) Weigh the raw materials according to the weight proportions, remove impurities and mud, wash and dry them; crush the leeches and earthworms into coarse powder, and slice the Sichuan lovage rhizome, prepared arisaema, acorus calamus, gastrodia elata, uncaria rhizome, rhodiola rosea and polygonatum rhizome into thin slices for later use;

[0013] 2) Place all the Chinese medicinal herbs that have been pretreated in step 1) into a decoction container and add distilled water to soak them;

[0014] 3) Heat the soaked herbs and soaking liquid from step 2) together, bring to a boil over high heat, then reduce to low heat and simmer, stirring occasionally. After simmering, filter the liquid through gauze while it is still hot and collect the first decoction. Add distilled water to the dregs, bring to a boil over high heat, then simmer over low heat, filter, and collect the second decoction.

[0015] 4) Combine the two decoctions from step 3), put them into a concentration container, heat over low heat to concentrate, stir evenly, and let cool to room temperature to obtain an oral decoction.

[0016] Preferably, in step 1), the particle size of the coarse powder is 2-4 mm and the thickness of the sheet is 2-3 mm.

[0017] Preferably, in step 2), the amount of water added is 8 to 10 times the total weight of the medicinal materials, and the soaking time is 30 to 60 minutes.

[0018] Preferably, in step 3), the first simmering time is 30-40 minutes, with stirring 1-3 times; the amount of water added to the dregs is 5-6 times the total weight of the medicinal materials, and the second simmering time is 20-30 minutes.

[0019] Preferably, in step 4), the decoction is concentrated to 200-300 mL.

[0020] The use of the aforementioned traditional Chinese medicine composition in the preparation of a medicament for improving cerebral blood circulation or treating cerebral infarction.

[0021] Preferably, when the traditional Chinese medicine composition is prepared as an oral decoction, the dosage is one dose per day, taken twice a day, morning and evening, with each dose being 100-150 mL.

[0022] Beneficial effects: Compared with the prior art, the present invention has the following advantages:

[0023] 1) This invention breaks through the conventional single treatment method of promoting blood circulation and removing blood stasis or invigorating qi and promoting blood circulation. Based on the pathogenesis characteristics of the mutual combination of "phlegm, blood stasis, deficiency and wind", it creatively integrates four methods: calming the liver and extinguishing wind (Uncaria rhynchophylla, Gastrodia elata), resolving phlegm and opening the orifices (processed Arisaema heterophyllum, Acorus tatarinowii), breaking blood stasis and removing blood stasis (Hirudo medicinalis, Pheretima aspergillum, Ligusticum chuanxiong), and invigorating qi and nourishing yin (Rhodiola rosea, Polygonatum sibiricum). Through specific selection of medicinal ingredients and dosage ratio, the various medicines produce synergistic effects under the framework of "principal, assistant, adjuvant and guide", realizing comprehensive intervention on the complex pathogenesis of cerebral infarction.

[0024] 2) The traditional Chinese medicine composition of the present invention is strictly formulated, with Polygonatum sibiricum as the guiding herb to harmonize the medicinal properties and support the body's vital energy, thus avoiding the harm caused by strong drugs; no obvious adverse reactions have been observed in clinical application, and the safety is high.

[0025] 3) The preparation method of this invention is easy to operate, the process parameters are clear, and it is convenient for large-scale production and promotion. Attached Figure Description

[0026] Figure 1 The images show laser speckle patterns in the brains of mice after treatment with the oral decoction of Example 1; where a and c are before administration, and b and d are after administration. Detailed Implementation

[0027] To make the objectives, technical solutions, and advantages of this invention clearer, the invention is further described below with reference to specific embodiments. Unless otherwise specified, the technical means used in the following embodiments are all conventional means well known to those skilled in the art. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer are followed. Where the manufacturers of reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0028] Example 1

[0029] A traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 30 parts of Uncaria rhynchophylla, 15 parts of Rhodiola rosea, 5 parts of Hirudo medicinalis, 10 parts of Pheretima aspergillum, and 15 parts of Polygonatum sibiricum.

[0030] The method for preparing an oral decoction using the above-mentioned traditional Chinese medicine composition, per 1g serving, includes the following steps:

[0031] 1) Weigh each Chinese medicinal material according to the above weight proportions, remove impurities and mud, wash and dry them; crush leeches and earthworms into coarse powder with a particle size of 3mm, and cut chuanxiong, prepared arisaema, acorus tatarinowii, gastrodia elata, uncaria, rhodiola rosea and polygonatum into thin slices with a thickness of 2.5mm for later use.

[0032] 2) Place all the Chinese medicinal materials that have been pretreated in step 1) into a ceramic decoction pot, add distilled water, the amount of water being 9 times the total weight of the medicinal materials, and soak for 45 minutes;

[0033] 3) Heat the soaked herbs and soaking liquid from step 2) together, bring to a boil over high heat, then simmer over low heat for 35 minutes, stirring twice during the process; after simmering, filter the liquid through gauze while it is still hot and collect the first decoction; add distilled water to the dregs, the amount of water being 5.5 times the total weight of the herbs, bring to a boil over high heat, then simmer over low heat for 25 minutes, filter, and collect the second decoction;

[0034] 4) Combine the two decoctions from step 3), put them into a ceramic concentrator, heat over low heat to concentrate to 250mL, stir well, and let cool to room temperature to obtain the oral decoction.

[0035] Dosage and administration: One dose per day, taken twice daily, morning and evening, 125 mL each time.

[0036] Example 2

[0037] A traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 8 parts of Ligusticum chuanxiong, 8 parts of processed Arisaema heterophyllum, 8 parts of Acorus tatarinowii, 8 parts of Gastrodia elata, 25 parts of Uncaria rhynchophylla, 12 parts of Rhodiola rosea, 4 parts of Hirudo medicinalis, 8 parts of Pheretima aspergillum, and 12 parts of Polygonatum sibiricum.

[0038] Each dose is calculated as 1g. The method for preparing oral decoctions using the above-mentioned traditional Chinese medicine composition is the same as in Example 1.

[0039] Example 3

[0040] A traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 12 parts of Ligusticum chuanxiong, 12 parts of processed Arisaema heterophyllum, 12 parts of Acorus tatarinowii, 12 parts of Gastrodia elata, 35 parts of Uncaria rhynchophylla, 18 parts of Rhodiola rosea, 6 parts of Hirudo medicinalis, 12 parts of Pheretima aspergillum, and 18 parts of Polygonatum sibiricum.

[0041] Each dose is calculated as 1g. The method for preparing oral decoctions using the above-mentioned traditional Chinese medicine composition is the same as in Example 1.

[0042] Example 4

[0043] A traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 5 parts of Ligusticum chuanxiong, 15 parts of processed Arisaema heterophyllum, 5 parts of Acorus tatarinowii, 15 parts of Gastrodia elata, 20 parts of Uncaria rhynchophylla, 20 parts of Rhodiola rosea, 3 parts of Hirudo medicinalis, 15 parts of Pheretima aspergillum, and 10 parts of Polygonatum sibiricum.

[0044] Each dose is calculated as 1g. The method for preparing oral decoctions using the above-mentioned traditional Chinese medicine composition is the same as in Example 1.

[0045] Example 5

[0046] A traditional Chinese medicine composition for treating cerebral infarction is made from the following raw materials in parts by weight: 15 parts of Ligusticum chuanxiong, 5 parts of processed Arisaema heterophyllum, 15 parts of Acorus tatarinowii, 5 parts of Gastrodia elata, 40 parts of Uncaria rhynchophylla, 10 parts of Rhodiola rosea, 8 parts of Hirudo medicinalis, 5 parts of Pheretima aspergillum, and 20 parts of Polygonatum sibiricum.

[0047] Each dose is calculated as 1g. The method for preparing oral decoctions using the above-mentioned traditional Chinese medicine composition is the same as in Example 1.

[0048] Comparative Example 1

[0049] An oral decoction is made from the following ingredients in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 15 parts of Rhodiola rosea, 5 parts of Hirudo medicinalis, 10 parts of Pheretima aspergillum, and 15 parts of Polygonatum sibiricum; the preparation method is the same as in Example 1.

[0050] Comparative Example 2

[0051] An oral decoction is made from the following ingredients in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 30 parts of Uncaria rhynchophylla, 15 parts of Rhodiola rosea, and 15 parts of Polygonatum sibiricum; the preparation method is the same as in Example 1.

[0052] Comparative Example 3

[0053] An oral decoction is made from the following ingredients in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 30 parts of Uncaria rhynchophylla, 15 parts of Salvia miltiorrhiza, 10 parts of Angelica sinensis, 15 parts of Rhodiola rosea, and 15 parts of Polygonatum sibiricum; the preparation method is the same as in Example 1.

[0054] Comparative Example 4

[0055] An oral decoction is made from the following ingredients in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 10 parts of Uncaria rhynchophylla, 15 parts of Rhodiola rosea, 5 parts of Hirudo medicinalis, 10 parts of Pheretima aspergillum, and 15 parts of Polygonatum sibiricum; the preparation method is the same as in Example 1.

[0056] Example 6

[0057] Animal experiments were conducted on the traditional Chinese medicine compositions prepared in Examples 1-5 and Comparative Examples 1-4, as follows:

[0058] 1. Experimental animals: SPF-grade male C57 mice, 6-8 weeks old, weighing 18-25g, purchased from Shanghai Slack Laboratory Animal Co., Ltd.

[0059] 2. Experimental Methods

[0060] 1) Preparation of cerebral infarction model: AIS mouse model was prepared by MCAO method; after anesthetizing the mice, the right common carotid artery, internal carotid artery and external carotid artery were separated, and the suture was inserted into the internal carotid artery through the external carotid artery to block the origin of the middle cerebral artery and the incision was sutured; the criteria for judging the success of the model: the mice showed obvious hemiplegia, body tilting and crawling rotation after the operation.

[0061] 2) Animal grouping and administration: Mice with successfully established models were randomly divided into three groups (model group, Examples 1-5, and Comparative Examples 1-4), with 10 mice in each group. Examples and comparative examples were administered the corresponding extract concentrate via gavage at a dose of 18 g / kg daily. The sham-operated group and model group were administered the same dose of physiological saline via gavage. Administration was repeated once daily for 14 consecutive days. After administration, mice were anesthetized and euthanized to collect samples for relevant experimental indicators.

[0062] 3. Detection Indicators and Methods

[0063] 1) Laser speckle contrast imaging experiment: After anesthetizing mice, fix their heads, expose the skull, and use a laser speckle system to scan the blood flow in the brain. Record the images or data of the laser speckle and perform statistical analysis.

[0064] 2) Detection of nerve cell damage: The LDH detection kit produced by Biosharp was used to detect the damage of nerve cells. The absorbance value of each group of samples was detected by an ELISA reader. The LDH content in the sample was calculated according to the standard curve: y=0.1011x-0.0022, where x is the molar mass of NADH (nmol) and y is the absorbance value.

[0065] 3) Detection of cytokine expression in brain tissue samples: Mice were sacrificed after laser speckle contrast imaging experiment, and brain tissue was collected. 200 mg of tissue was added to PBS buffer containing PMSF, and the expression of cytokines in mouse brain tissue samples was detected using a dedicated ELISA kit.

[0066] 4) Detection of cerebral infarction volume: After euthanizing mice, brain tissue was taken and cut into 2 mm thick coronal sections. The sections were then stained in TTC staining solution at 37°C in the dark for 30 min. Normal brain tissue was stained red, while infarcted brain tissue was stained white. The percentage of cerebral infarction volume to total brain volume was calculated using an image analysis system.

[0067] 4. Experimental Results

[0068] Depend on Figure 1 It can be seen that after treatment with the oral decoction of Example 1, the clarity of the laser speckle pattern in the mouse brain tissue was significantly enhanced.

[0069] Table 1. Results of cerebral blood flow perfusion, LDH content, IL-1β content, and cerebral infarction volume in mice of each group.

[0070] Group Cerebral blood perfusion (PU) LDH content (nmol / mg) IL-1β content (pg / mg) Cerebral infarction volume (%) Sham surgery group 1002.5±35.6 48.6±5.2 14.8±2.1 0.00±0.00 Model group 301.8±28.4 352.4±28.6 121.5±10.3 28.65±2.31 Example 1 896.7±38.5 78.5±8.4 26.8±3.5 5.21±0.68 Example 2 825.4±40.2 96.2±9.1 32.5±4.1 6.15±0.75 Example 3 856.2±39.8 87.3±8.6 29.3±3.8 5.82±0.71 Example 4 758.3±41.5 125.4±11.3 41.6±5.2 7.56±0.82 Example 5 742.6±42.3 132.6±12.1 44.2±5.6 7.21±0.78 Comparative Example 1 485.2±35.6 256.8±22.4 82.3±8.5 18.65±1.92 Comparative Example 2 452.7±36.8 278.5±23.6 89.6±9.2 20.15±2.05 Comparative Example 3 526.8±37.2 224.3±20.5 72.5±7.8 17.52±1.85 Comparative Example 4 501.5±36.4 241.6±21.7 78.4±8.3 18.21±1.89

[0071] Table 1 shows that the formulation of this invention has a clear synergistic effect, significantly improving cerebral blood flow, protecting nerves, and promoting anti-inflammatory and repair effects. Compared with the model group, all example groups significantly improved cerebral blood perfusion (P<0.01). The blood flow recovery effect of Example 1 group was the best, approaching the level of the sham-operated group and significantly better than each comparative group, indicating that the composition of this invention can effectively improve cerebral blood circulation. LDH is a marker of nerve cell damage. The LDH content in the brain tissue of mice in Examples 1-5 groups was significantly lower than that in the model group (P<0.01) and the comparative group, indicating that the composition of this invention can effectively reduce nerve cell damage after cerebral ischemia.

[0072] Examples 1-5 all significantly reduced the volume of cerebral infarction (P<0.01), with Example 1 showing the best effect. Although Comparative Examples 1-4 also had some effect, the infarct volume was significantly larger than that of the Example groups, indicating that the combination of Uncaria rhynchophylla, leech, and earthworm, as well as the specific dosage ratio, are crucial for achieving the best therapeutic effect, thus confirming the scientific nature and rationality of the formulation of this invention.

[0073] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating cerebral infarction, characterized in that, It is made from the following raw materials in parts by weight: 5-15 parts of Ligusticum chuanxiong, 5-15 parts of processed Arisaema heterophyllum, 5-15 parts of Acorus tatarinowii, 5-15 parts of Gastrodia elata, 20-40 parts of Uncaria rhynchophylla, 10-20 parts of Rhodiola rosea, 3-8 parts of Hirudo medicinalis, 5-15 parts of Pheretima aspergillum, and 10-20 parts of Polygonatum sibiricum.

2. The traditional Chinese medicine composition for treating cerebral infarction according to claim 1, characterized in that, It is made from the following raw materials in parts by weight: 8-12 parts of Ligusticum chuanxiong, 8-12 parts of processed Arisaema heterophyllum, 8-12 parts of Acorus tatarinowii, 8-12 parts of Gastrodia elata, 25-35 parts of Uncaria rhynchophylla, 12-18 parts of Rhodiola rosea, 4-6 parts of Hirudo medicinalis, 8-12 parts of Pheretima aspergillum, and 12-18 parts of Polygonatum sibiricum.

3. The traditional Chinese medicine composition for treating cerebral infarction according to claim 2, characterized in that, It is made from the following ingredients in parts by weight: 10 parts of Ligusticum chuanxiong, 10 parts of processed Arisaema heterophyllum, 10 parts of Acorus tatarinowii, 10 parts of Gastrodia elata, 30 parts of Uncaria rhynchophylla, 15 parts of Rhodiola rosea, 5 parts of Hirudo medicinalis, 10 parts of Pheretima aspergillum, and 15 parts of Polygonatum sibiricum.

4. A method for preparing a traditional Chinese medicine composition for treating cerebral infarction as described in claim 1, characterized in that, Includes the following steps: 1) Weigh the raw materials according to the weight proportions, remove impurities and mud, wash and dry them; crush the leeches and earthworms into coarse powder, and slice the Sichuan lovage rhizome, prepared arisaema, acorus calamus, gastrodia elata, uncaria rhizome, rhodiola rosea and polygonatum rhizome into thin slices for later use; 2) Place all the Chinese medicinal herbs that have been pretreated in step 1) into a decoction container and add distilled water to soak them; 3) Heat the soaked herbs and soaking liquid from step 2) together, bring to a boil over high heat, then reduce to low heat and simmer, stirring occasionally. After simmering, filter the liquid through gauze while it is still hot and collect the first decoction. Add distilled water to the dregs, bring to a boil over high heat, then simmer over low heat, filter, and collect the second decoction. 4) Combine the two decoctions from step 3), put them into a concentration container, heat over low heat to concentrate, stir evenly, and let cool to room temperature to obtain an oral decoction.

5. The method for preparing the traditional Chinese medicine composition for treating cerebral infarction according to claim 4, characterized in that, In step 1), the particle size of the coarse powder is 2-4 mm, and the thickness of the thin sheet is 2-3 mm.

6. The method for preparing the traditional Chinese medicine composition for treating cerebral infarction according to claim 4, characterized in that, In step 2), the amount of water added is 8 to 10 times the total weight of the medicinal materials, and the soaking time is 30 to 60 minutes.

7. The method for preparing the traditional Chinese medicine composition for treating cerebral infarction according to claim 4, characterized in that, In step 3), the first simmering time is 30-40 minutes, with stirring 1-3 times; the amount of water added to the dregs is 5-6 times the total weight of the medicinal materials, and the second simmering time is 20-30 minutes.

8. The method for preparing the traditional Chinese medicine composition for treating cerebral infarction according to claim 4, characterized in that, In step 4), the decoction is concentrated to 200-300 mL.

9. The use of a traditional Chinese medicine composition as described in any one of claims 1 to 3 in the preparation of a medicament for improving cerebral blood circulation or treating cerebral infarction.

10. The application according to claim 9, characterized in that, When the traditional Chinese medicine composition is prepared as an oral decoction, the dosage is one dose per day, taken twice a day, morning and evening, with each dose being 100-150 mL.

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