Application of mt2a protein or its coding gene as a target in regulating iron death of osteoarthritis chondrocytes

Abstract

This invention relates to the field of biomedical technology, providing the application of MT2A protein or its encoding gene as a target in regulating ferroptosis in chondrocytes of osteoarthritis. This invention provides a novel target for regulating ferroptosis in chondrocytes of osteoarthritis, offering a new research direction and approach for the treatment of osteoarthritis. Knockdown of MT2A increases SLC7A11 expression, restores intracellular GSH levels, and reduces MDA accumulation, while affecting ACSL4 and GPX4 expression and intracellular Fe... 2+ The level was not significantly affected; the drug inhibited the use of system Xc. ‑ Treatment with the inhibitor erastin partially reversed the effects of MT2A knockdown, suggesting that targeting MT2A-mediated redox regulation may be a potential treatment strategy for osteoarthritis. This provides theoretical support for developing novel treatments that can effectively alter disease progression, and is expected to bring more effective treatment options to osteoarthritis patients, improve their quality of life, and reduce the economic and care burden on families and society.

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