3-substituted phthalide compounds, methods of making and uses thereof
By synthesizing 3-substituted phthalide compounds, the problems of uneven target activity and poor solubility of existing drugs have been solved, realizing the efficient treatment of neurological diseases with multi-target drugs. The compounds have significant AChE inhibitory and antioxidant activities, reduced toxic side effects, and enhanced the stability and efficacy of the compounds in vivo.
CN122234019APending Publication Date: 2026-06-19SICHUAN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SICHUAN UNIV
- Filing Date
- 2024-12-18
- Publication Date
- 2026-06-19
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Figure CN122234019A_ABST
Abstract
This invention discloses a class of 3-substituted phthalide compounds (I) and their pharmaceutically acceptable salts, their preparation methods, pharmaceutical compositions, and their use in the preparation of drugs for the treatment and / or prevention of neurological diseases, including but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion's disease, Lewy body dementia, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, hemorrhagic stroke, and neurological damage caused by traumatic brain injury;
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