A kind of food-medicines identical composition for relieving fatigue and its preparation method and application

Abstract

The application belongs to the technical field of food, and particularly relates to a kind of medicine-food homologous composition for relieving fatigue and its preparation method and application.The medicine-food homologous composition includes the following raw materials in weight fraction: 15-25 parts of ginseng powder, 10-20 parts of maca powder, 1-10 parts of yellow milkvetch powder, 5-10 parts of medlar powder, 5-10 parts of ginger powder and 1-10 parts of eucommia male flower powder.The medicine-food homologous composition prepared by the application can significantly improve body exercise endurance and explosive force, and relieve fatigue.

Description

Technical Field

[0001] This invention belongs to the field of food technology, specifically relating to a medicinal and edible composition for relieving fatigue, its preparation method, and its application. Background Technology

[0002] The increasingly deteriorating environment of modern life, including the tension and pressure brought about by the ever-accelerating pace of life, the formation of unhealthy lifestyles and habits, the adverse effects of environmental pollution, and the stimulation of negative mental and psychological factors, has led to widespread social concern about the psychological and physiological problems of adults. Currently, physiological problems manifest as physical weakness, malnutrition, lethargy, fatigue, loss of appetite, sleep disorders, and soreness in the lower back and knees.

[0003] The usual methods for improving this problem are drug treatment, mainly including Western medicine, single-herb Chinese herbal extracts, and simple compound preparations. Western medicine treatment: Phosphodiesterase-5 inhibitors (such as sildenafil) are representative. Although they have a rapid onset of action, they often target single symptoms and have side effects such as headaches, facial flushing, and visual abnormalities. They are not suitable for long-term use and cannot fundamentally regulate the body's constitution. Application of single-herb Chinese medicine or extracts: Commonly used are single herbs such as ginseng, wolfberry, or polygonatum, or their extracts. For example, ginsenosides are used to combat fatigue, and wolfberry polysaccharides are used to improve immunity. However, the effects of single herbs are limited, making it difficult to address multiple pathogenesis factors such as kidney essence deficiency and liver and kidney insufficiency, resulting in incomplete improvement. Long-term use of single components can easily lead to tolerance or imbalance. Simple compound preparations or traditional decoctions: Some combinations use a simple combination of two herbs (such as ginseng with wolfberry), or modifications to traditional formulas. While these methods have some conditioning effects, they mostly rely on empirical formulation, the proportions and synergistic mechanisms between the components are unclear, the utilization rate of active ingredients is low, and the formulations are traditional (such as decoctions and powders), which are not portable and have poor taste, making it difficult to meet the needs of modern consumers.

[0004] However, with the increasing pursuit of a healthy life, more and more people are choosing to develop foods that can relieve physical fatigue and improve physical endurance and explosive power by utilizing "food and medicine homology" substances, which has become an important research direction.

[0005] Relevant patent documents retrieved:

[0006] For example, Chinese patent CN103816378A, published on April 20, 2016, discloses an oral composition that can improve male vitality and its preparation method, belonging to the field of food processing technology. Each unit of this oral composition is prepared from 6-10 parts by weight of donkey penis powder, 8-12 parts by weight of ox kidney powder, 6-10 parts by weight of male silkworm pupa powder, 4-6 parts by weight of sea cucumber powder, 2-4 parts by weight of areca nut powder, 8-10 parts by weight of wax apple powder, 7-9 parts by weight of miracle fruit powder, 5-7 parts by weight of raspberry powder, 0.5-1.5 parts by weight of polygonatum powder, 1-3 parts by weight of wolfberry powder, 20-22 parts by weight of yam powder, 1-3 parts by weight of gorgon fruit powder, and 46-50 parts by weight of isomaltooligosaccharide. These components, combined with wolfberry, gorgon fruit, yam, and isomaltooligosaccharide, exhibit excellent synergistic and promoting effects, effectively activating male hormones, enhancing testosterone secretion, improving male kidney vitality, and strengthening male kidney function, making it a top choice for men's health. However, this invention fails to fully utilize the active ingredients in the oral composition.

[0007] Relevant non-patent literature retrieved: The journal title is *Heilongjiang University of Traditional Chinese Medicine*, and the article title is "Research and Development of Compound Polygonatum Ointment and Its Immunomodulatory Effects," volume number 2024000281. This study combines traditional Chinese medicine theory with modern scientific research results, using four medicinal and edible herbs—Polygonatum, Lycium barbarum, Ginseng, and Cordyceps militaris—as main raw materials to develop a health product—Compound Polygonatum Ointment—that helps enhance immunity. The extraction process of the active ingredients and the dosage of excipients in the Compound Polygonatum Ointment were optimized, quality standards were established, and its health benefits were verified through animal experiments. However, the anti-fatigue efficacy of this study still needs improvement.

[0008] Therefore, there is an urgent need to study a composition that can fully exert the effects of effective active ingredients and relieve fatigue. Summary of the Invention

[0009] The purpose of this invention is to provide a medicinal and edible composition for relieving fatigue, its preparation method and application, and related technologies, in order to solve technical problems such as low utilization rate of effective active ingredients in the composition and insignificant anti-fatigue effect, or a combination thereof.

[0010] Terminology Explanation: Unless otherwise defined, all technical terms in this document have the same meanings as commonly understood by one of ordinary skill in the art to which the subject matter of the claims pertains. Unless otherwise stated, all patents, patent inventions, and publications cited in this document are incorporated herein by reference in their entirety. If multiple definitions exist for terms in this document, the definitions in this chapter shall prevail.

[0011] It should be understood that the above brief description and the following detailed description are exemplary and for illustrative purposes only, and do not limit the subject matter of the invention in any way. In this invention, the singular is used in conjunction with the plural unless otherwise specifically stated. It should also be noted that, unless otherwise stated, the use of “or” or “or” means “and / or”. Furthermore, the use of the term “comprising” and other forms such as “including,” “containing,” and “contains” are not limiting.

[0012] The definition of the standard terminology can be found in the reference "Pharmacopoeia of the People's Republic of China (2020 Edition), China Medical Science and Technology Press, May 2020".

[0013] Unless specifically defined herein, the use of all commercially available products herein employs standard techniques. For example, it may be carried out using the manufacturer's instructions for use with the kit, or in accordance with methods known in the art or the description of this invention. The techniques and methods described herein can generally be implemented according to conventional methods well known in the art, based on the descriptions in the various summary and more specific documents cited and discussed in this specification.

[0014] On the one hand, the present invention provides a medicinal and edible composition for relieving fatigue, comprising the following raw materials by weight: 15-25 parts ginseng powder, 10-20 parts maca powder, 1-10 parts polygonatum powder, 5-10 parts wolfberry powder, 5-10 parts ginger powder and 1-10 parts eucommia male flower pollen.

[0015] Preferably, the composition comprises, by weight, the following raw materials: 15-20 parts ginseng powder, 10-15 parts maca powder, 5-10 parts polygonatum powder, 5-10 parts wolfberry powder, 8-10 parts ginger powder, and 1-5 parts eucommia male flower pollen.

[0016] More preferably, the composition comprises, by weight, the following ingredients: 20 parts ginseng powder, 15 parts maca powder, 5 parts polygonatum powder, 5 parts wolfberry powder, 8 parts ginger powder, and 5 parts eucommia male flower pollen.

[0017] On the other hand, the present invention also provides a method for preparing the above-mentioned food-medicine homology composition, comprising the following steps: (1) Mix ginseng powder, polygonatum powder, wolfberry powder and ginger powder, add water, decoct and filter; add Aspergillus oryzae to the filtrate, ferment and inactivate to obtain filtrate A; (2) Add water to maca powder and Eucommia ulmoides male pollen, decoct and filter; add Bacillus subtilis to the filtrate, ferment and inactivate to obtain filtrate B; (3) Mix filtrate A and filtrate B, concentrate and dry to obtain the final product.

[0018] Preferably, the amount of water added in step (1) is 10-20 times the total weight of ginseng powder, polygonatum powder, wolfberry powder and ginger powder, more preferably 15 times.

[0019] Preferably, the simmering time in step (1) is 1-2 hours, more preferably 1.5 hours.

[0020] Preferably, the amount of Aspergillus oryzae added in step (1) is 0.5-1.5% of the total weight of ginseng powder, Polygonatum powder, wolfberry powder and ginger powder, more preferably 1%.

[0021] Preferably, the viable count of Aspergillus oryzae in step (1) is 1 × 10⁻⁶. 11 -1×10 12 CFU / g.

[0022] Preferably, the amount of water added in step (2) is 5-10 times the weight of maca powder and Eucommia ulmoides male pollen, more preferably 8 times.

[0023] Preferably, the simmering time in step (2) is 1-3 hours, more preferably 2 hours.

[0024] Preferably, the amount of Bacillus subtilis added in step (2) is 0.2-0.5% of the weight of maca powder and Eucommia ulmoides male pollen, more preferably 0.3%.

[0025] Preferably, the viable count of Bacillus subtilis in step (2) is 1 × 10⁻⁶. 11 -1×10 12 CFU / g.

[0026] Preferably, the fermentation in steps (1) and (2) is carried out at 30-37°C for 24-48 hours.

[0027] More preferably, the fermentation described in steps (1) and (2) is carried out at 35°C for 48 hours.

[0028] Preferably, the inactivation conditions described in steps (1) and (2) are inactivation at 100-120℃ for 10-20 minutes.

[0029] More preferably, the inactivation conditions described in steps (1) and (2) are inactivation at 110°C for 15 min.

[0030] Preferably, the concentration in step (3) is vacuum concentration, concentrated to a solid content of 70-80%, more preferably 75%.

[0031] Preferably, the drying in step (3) is spray drying, and the drying time is 12-24 hours.

[0032] Finally, the present invention also provides the application of the above-mentioned food-medicine homology composition in the preparation of food for relieving fatigue.

[0033] Specifically, the food product is in the form of a solid beverage, liquid beverage, tablet, or tea paste.

[0034] Specifically, the food also includes acceptable food additives.

[0035] The present invention has the following beneficial effects: (1) This invention scientifically combines ginseng, polygonatum, wolfberry, maca, eucommia male flowers and ginger; each component has the effects of replenishing qi and strengthening the body, nourishing yin and tonifying the kidney, and benefiting essence and strengthening will.

[0036] (2) The food-medicine composition provided by the present invention has anti-fatigue ability and enhances energy and endurance; testosterone is a key hormone for maintaining male libido, muscle strength, bone health and mental state. Compared with the model group, the composition provided by the present invention helps to promote the increase of testosterone level in mice and helps to promote endogenous testosterone secretion, providing a key endocrine basis for improving male sexual function, enhancing muscle strength and improving mood. Detailed Implementation

[0037] The technical solution of the present invention will be clearly and completely described below with reference to specific embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention. Unless otherwise specified, the materials and reagents used are commercially available.

[0038] Table 1 below lists the manufacturers and models of the strains used in this invention: Table 1 Manufacturers and models of the strains

[0039] Example 1: A composition for relieving physical fatigue By weight, it consists of the following raw materials: 20 parts ginseng powder, 15 parts maca powder, 5 parts polygonatum powder, 5 parts wolfberry powder, 8 parts ginger powder, and 5 parts eucommia male flower powder.

[0040] Prepare according to the following method: (1) Mix ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, add water at 15 times the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, decoct for 1.5 hours, and filter; add 1% Aspergillus oryzae as a live bacteria of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder to the filtrate, with a live bacteria count of 1×10⁻⁶. 11CFU / g, fermented at 35℃ for 48h, then inactivated at 110℃ for 15min, to obtain filtrate A; (2) Mix maca powder and Eucommia ulmoides male pollen, add water at 8 times the total weight of the maca powder and Eucommia ulmoides male pollen, decoct for 2 hours, and filter; add Bacillus subtilis at 0.3% of the total weight of the maca powder and Eucommia ulmoides male pollen to the filtrate, with a viable count of 1×10⁻⁶. 11 CFU / g, fermented at 35℃ for 48h, then inactivated at 110℃ for 15min, to obtain filtrate B; (3) Mix filtrate A and filtrate B, concentrate under reduced pressure until the solid content is 75%, and spray dry for 24 hours to obtain the composition.

[0041] Example 2: A composition for relieving physical fatigue By weight, it consists of the following raw materials: 15 parts ginseng powder, 10 parts maca powder, 10 parts polygonatum powder, 10 parts wolfberry powder, 10 parts ginger powder, and 1 part eucommia male flower pollen.

[0042] Prepare according to the following method: (1) Mix ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, add water at 20 times the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, decoct for 2 hours, and filter; add Aspergillus oryzae at 1.5% of the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder to the filtrate, with a viable count of 1×10⁻⁶. 11 CFU / g, fermented at 37℃ for 24h, then inactivated at 120℃ for 10min, to obtain filtrate A; (2) Mix maca powder and Eucommia ulmoides male pollen, add water at a ratio of 5 times the total weight of the maca powder and Eucommia ulmoides male pollen, decoct for 1 hour, and filter; add Bacillus subtilis at a ratio of 0.2% of the total weight of the maca powder and Eucommia ulmoides male pollen to the filtrate, with a viable count of 1×10⁻⁶. 11 CFU / g, fermented at 37℃ for 24h, then inactivated at 120℃ for 10min, to obtain filtrate B; (3) Mix filtrate A and filtrate B, concentrate under reduced pressure until the solid content is 80%, and spray dry for 12 hours to obtain the composition.

[0043] Example 3: A composition for relieving physical fatigue By weight, it consists of the following raw materials: 25 parts ginseng powder, 20 parts maca powder, 1 part polygonatum powder, 8 parts wolfberry powder, 5 parts ginger powder, and 10 parts eucommia male flower powder.

[0044] Prepare according to the following method: (1) Mix ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, add water at 10 times the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, decoct for 1 hour, and filter; add Aspergillus oryzae at 0.5% of the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder to the filtrate, with a viable count of 1×10⁻⁶. 11 CFU / g, fermented at 30℃ for 40h, then inactivated at 100℃ for 20min, to obtain filtrate A; (2) Mix maca powder and Eucommia ulmoides male pollen, add water at a weight of 10 times the total weight of the maca powder and Eucommia ulmoides male pollen, decoct for 3 hours, and filter; add Bacillus subtilis at a weight of 0.5% of the total weight of the maca powder and Eucommia ulmoides male pollen to the filtrate, with a viable count of 1×10⁻⁶. 11 CFU / g, fermented at 30℃ for 40h, then inactivated at 100℃ for 20min, to obtain filtrate B; (3) Mix filtrate A and filtrate B, concentrate under reduced pressure until the solid content is 70%, and spray dry for 18 hours to obtain the composition.

[0045] Comparative Example 1 The difference from Example 1 is that Aspergillus oryzae in step (1) of the preparation method is replaced with Forgites indigo.

[0046] (1) Mix ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, add water at 15 times the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder, decoct for 1.5 hours, and filter; add 1% of indigofera oryzae (1% of the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder) to the filtrate, with a viable count of 1×10⁻⁶. 11 CFU / g, fermented at 35℃ for 48h, then inactivated at 110℃ for 15min, to obtain filtrate A; The remaining dosages and steps are the same as in Example 1.

[0047] Comparative Example 2 The difference from Example 1 is that 15 parts of Eucommia ulmoides male pollen are replaced with 15 parts of oyster shell powder, specifically: (2) Mix maca powder and oyster powder, add water at 8 times the total weight of maca powder and oyster powder, decoct for 2 hours, and filter; add Bacillus subtilis at 0.3% of the weight of maca powder and oyster powder to the filtrate, ferment at 35℃ for 48 hours, and inactivate at 110℃ for 15 minutes to obtain filtrate B. The remaining dosages and steps are the same as in Example 1.

[0048] Comparative Example 3 The difference from Example 1 is that the proportions of each group are not within the scope of protection of this invention, namely: 10 parts ginseng powder, 30 parts maca powder, 30 parts polygonatum powder, 1 part wolfberry powder, 12 parts ginger powder and 16 parts eucommia male flower pollen, and the preparation method is the same as that of Example 1.

[0049] Comparative Example 4 The difference from Example 1 lies in the preparation method, which is as follows: (1) Mix ginseng powder, polygonatum powder, wolfberry powder, ginger powder, maca powder and eucommia male pollen, add water at 10 times the total weight of ginseng powder, polygonatum powder, wolfberry powder, ginger powder, maca powder and eucommia male pollen, decoct for 1.5 hours, and filter; add 1% Aspergillus oryzae and 0.3% Bacillus subtilis at the total weight of ginseng powder, polygonatum powder, wolfberry powder, ginger powder, maca powder and eucommia male pollen to the filtrate, with the viable count of Aspergillus oryzae being 1×10⁻⁶. 11 CFU / g, viable count of Bacillus subtilis is 1×10⁻⁶. 11 CFU / g, fermented at 35℃ for 48h, then inactivated at 110℃ for 15min, to obtain filtrate; (2) The filtrate is concentrated under reduced pressure until the solid content is 75%, and then spray-dried for 24 hours to obtain the composition.

[0050] Comparative Example 5 A tonic product consisting of deer antler, ginseng, oyster, eucommia male flower, and eucommia was prepared according to Example 1 of patent CN110934999A.

[0051] Effect Experiment (a) Fatigue resistance test 1. Experimental Methods (1) Experimental animals and their grouping: SPF-grade male Kunming mice weighing 18-22g were selected and acclimatized for 7 days. The mice were then randomly divided into groups of 8 mice each: control group, Example 1-Example 3 group and Comparative Example 1-Comparative Example 5 group.

[0052] (2) Fatigue resistance test: (2.1) Measurement of swimming time at exhaustion in mice: Groups 1-3 and Comparative Examples 1-5 were administered the prepared composition at 1.2 g / kg via gavage, while the control group was administered an equal volume of physiological saline via gavage. The administration was repeated for 14 days, once daily. One hour after the last administration, a lead wire equal to 5% of the mouse's body weight was tied to the base of the mouse's tail. The mice were then placed in glass tanks with a water depth of 20 cm and a water temperature maintained at 25 ± 0.5 °C. Swimming time was recorded. A mouse was considered exhausted when its head remained submerged for 10 seconds, and this was recorded as its swimming time. The results are shown in Table 2.

[0053] (2.2) Determination of liver glycogen content: The intact livers of mice in each group were removed, rinsed with physiological saline, and the surface moisture was absorbed with filter paper. The liver weight was measured and the data was recorded. The livers were then wrapped in aluminum foil and stored in an ultra-low temperature freezer at -70℃ for later use. The determination of liver glycogen content was performed according to the method provided by the kit (Nanjing Jiancheng).

[0054] 2. Experimental Results As can be seen from the data in Table 2, compared with the control group, the weight-bearing swimming time of mice in Examples 1 to 3 of the present invention was significantly prolonged. Although the weight-bearing swimming time of mice in Comparative Examples 1 to 5 was higher than that of the control group, the effect was not as good as that of the Example group. Therefore, it can be concluded that the composition prepared by the present invention can effectively prolong the exercise time of mice, relieve fatigue, and thus improve the body's exercise endurance and explosive power.

[0055] It is known that liver glycogen in mice is one of the substances that provides energy for bodily movement. When liver glycogen stores are low, it leads to insufficient energy supply, making the body prone to fatigue. Compared with the control group, the liver glycogen levels of mice in Examples 1-3 and Comparative Examples 1-5 were significantly increased. Moreover, compared with Comparative Examples 1-5, the liver glycogen levels of mice in Example 1 were significantly higher, showing a statistically significant difference. This indicates that the composition particles prepared in Examples 1-3 of this invention have the effect of reducing fatigue in mice, helping to restore physical strength and promote fatigue elimination.

[0056] Table 2 Results of mouse swimming time and liver glycogen content determination

[0057] Note: Compared with the control group, p < 0.05 p < 0.01; compared with Example 1 group, # p < 0.05 ## p < 0.05.

[0058] (II) Testing of rat testosterone and testosterone index 1. Experimental Methods Male SD Kunming rats, weighing 200±10g, were selected and acclimatized for 7 days. They were then randomly divided into groups of 8 rats each: blank group, model group, Example 1-Example 3 groups, and Comparative Examples 1-Comparative Examples 5 groups.

[0059] A kidney-yang deficiency model was established: The model group, Examples 1-3, and Comparative Examples 1-5 were subcutaneously injected with hydrocortisone 25 mg / kg once daily; the blank group was subcutaneously injected with an equal volume of physiological saline daily. Seven days after modeling, drug administration began. Examples 1-3 and Comparative Examples 1-5 were administered the corresponding prepared composition by gavage at 4.5 g / kg, while the blank group and model group were administered an equal volume of physiological saline by gavage once daily for 7 consecutive days. Simultaneously with sample administration, modeling was not initiated (i.e., hydrocortisone was not injected). After the last administration, blood was collected from the abdominal aorta of the rats, and serum was separated. Serum testosterone (T) levels were detected using an ELISA kit. After euthanasia, the testes were dissected, and the testicular index (the ratio of testicular weight to body weight) was measured. All kits were purchased from Shanghai Enzyme-Linked Biotechnology Co., Ltd. The results are shown in Table 3.

[0060] 2. Experimental Results As can be seen from the data in Table 3, the composition particles prepared in the embodiments of the present invention can promote an increase in testosterone levels, while the recovery of testosterone levels in Comparative Examples 1-5 is lower than that in the Example groups. The composition prepared in the embodiments of the present invention helps to restore the testicular index decreased due to hydrocortisone. Therefore, the composition prepared in the embodiments of the present invention can promote testosterone secretion, thereby promoting the body to improve testicular damage.

[0061] Table 3. Results of Testosterone (T) Level and Testosterone Index Measurement

[0062] Note: Compared to the model group p < 0.05 p < 0.01; compared with Example 1 group, # p < 0.05 ## p < 0.01.

[0063] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A medicinal and edible composition for relieving fatigue, characterized in that, By weight, it includes the following ingredients: 15-25 parts ginseng powder, 10-20 parts maca powder, 1-10 parts polygonatum powder, 5-10 parts goji berry powder, 5-10 parts ginger powder, and 1-10 parts eucommia male flower powder.

2. The medicinal and edible composition according to claim 1, characterized in that, By weight, it includes the following ingredients: 20 parts ginseng powder, 15 parts maca powder, 5 parts polygonatum powder, 5 parts wolfberry powder, 8 parts ginger powder, and 5 parts eucommia male flower powder.

3. The method for preparing the medicinal and edible homologous composition according to any one of claims 1-2, characterized in that, Includes the following steps: (1) Mix ginseng powder, polygonatum powder, wolfberry powder and ginger powder, add water, decoct and filter; add Aspergillus oryzae to the filtrate, ferment and inactivate to obtain filtrate A; (2) Add water to maca powder and Eucommia ulmoides male pollen, decoct and filter; add Bacillus subtilis to the filtrate, ferment and inactivate to obtain filtrate B; (3) Mix filtrate A and filtrate B, concentrate and dry to obtain the final product.

4. The preparation method according to claim 3, characterized in that, The amount of water added in step (1) is 10-20 times the total weight of ginseng powder, polygonatum powder, wolfberry powder, and ginger powder; the decoction time is 1-2 hours.

5. The preparation method according to claim 3, characterized in that, The amount of Aspergillus oryzae added in step (1) is 0.5-1.5% of the total weight of ginseng powder, polygonatum powder, wolfberry powder and ginger powder.

6. The preparation method according to claim 3, characterized in that, The amount of water added in step (2) is 5-10 times the weight of the maca powder and eucommia male pollen; the decoction time is 1-3 hours.

7. The preparation method according to claim 3, characterized in that, The amount of Bacillus subtilis added in step (2) is 0.2-0.5% of the weight of maca powder and Eucommia ulmoides male pollen.

8. The preparation method according to claim 3, characterized in that, The concentration described in step (3) is vacuum concentration, which is concentrated to a solid content of 70-80%.

9. The preparation method according to claim 3, characterized in that, The drying process described in step (3) is spray drying, and the drying time is 12-24 hours.

10. The use of the food-medicine composition according to any one of claims 1-2 or the food-medicine composition prepared by the preparation method according to any one of claims 3-9 in the preparation of food for relieving fatigue.

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