Preparation of albumin-based gold cluster compounds and use for the treatment of inflammatory bowel disease

Abstract

This invention relates to the preparation of albumin-based gold clusters and their application in the treatment of inflammatory bowel disease (IBD), belonging to the pharmaceutical field. The method uses thiol-containing albumin as a template, mixes it with a trivalent gold salt compound under alkaline conditions, and irradiates it in a microwave reactor at 40–70°C for 1–5 cycles, each cycle lasting 1–10 minutes. This allows for the rapid synthesis of hydrated gold clusters with a particle size less than 20 nm and excellent fluorescence properties without the need for an external reducing agent. This method offers advantages such as rapid reaction speed, high yield, and good batch stability, overcoming the problems of long reaction time, low efficiency, and non-uniform products associated with traditional hydrothermal methods. The obtained albumin-gold clusters exhibit good biocompatibility and targeting properties, effectively accumulating at sites of intestinal inflammation after oral or injectable administration, achieving targeted therapy for IBD and providing a novel drug solution for the clinical treatment of IBD.

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