A method for screening the spore biomarker pyridine dicarboxylic acid and the Eu used therein 3+ -GQDs@MXene ratio fluorescence sensing material

By using Eu3+-GQDs@MXene ratiometric fluorescent sensing material, combined with electrostatic adsorption and coordination, the problems of complexity and instrument dependence in existing DPA detection technologies have been solved, achieving highly sensitive and selective DPA detection suitable for on-site screening.

CN122278477APending Publication Date: 2026-06-26HEFEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEFEI UNIV OF TECH
Filing Date
2026-05-20
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing DPA detection technologies are labor-intensive, time-consuming, and require cumbersome sample pretreatment and complex instruments, which limits their widespread application in on-site diagnosis. Furthermore, traditional fluorescence analysis methods rely on the fact that lanthanide ion luminescent probes do not emit light in aqueous media.

Method used

Using Eu3+-GQDs@MXene ratio fluorescence sensing material, graphene quantum dots (GQDs) are loaded onto Ti3C2Tx MXene nanosheets through electrostatic adsorption and coordination, and combined with Eu3+. The detection is performed using the ratio of dual emission signals at 420 nm and 615 nm, and visualization analysis is achieved by combining paper-based carriers and mobile terminals.

Benefits of technology

It reduces the impact of background signal and probe dosage variations on detection results, provides a simple DPA detection method, is suitable for on-site screening, has high sensitivity and selectivity, and is suitable for rapid detection in complex environments.

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Abstract

This invention belongs to the field of fluorescence detection and discloses a method for screening the spore biomarker pyridine dicarboxylic acid and the Eu used therein. 3+ -GQDs@MXene ratiometric fluorescent sensing material, which uses Ti3C2T x MXene nanosheets were used as a substrate to load graphene quantum dots and coordinate Eu. 3+ A composite material is formed. GQDs and MXene are prepared separately, then compounded and Eu is introduced. 3+ During detection, the sample to be tested is brought into contact with the sensing material, and 2,6-pyridine dicarboxylic acid is qualitatively or quantitatively detected based on the change in fluorescence intensity ratio at 420 nm and 615 nm. This method can be used for spore biomarker screening.
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