An active safety pathological sampling knife handle, sampling knife and sampling method

Abstract

This invention discloses a pathological sampling knife handle, sampling knife, and sampling method with active safety protection, belonging to the technical field of pathological testing instruments. The knife handle includes a handle, a controller, and a power supply. A first driving component is located within the handle, with its actuator connected to a knife clamp. A pressure sensor is mounted on the surface of the handle. The controller controls the first driving component to retract the knife clamp based on the pressure sensor signal. An inertial measurement unit is also included; the controller controls the knife clamp retraction based on its detection signal, achieving dual active protection against cutting obstruction and equipment drop. The knife clamp offers three individually usable blade fixing methods: a blade-locking groove, a clamping component driven by a second driving component, and a locking bolt. A protective cover is fitted to the front end of the handle to prevent contaminant contact; a charging connector with a protective cover is located at the end of the handle. The sampling knife includes the aforementioned handle and a detachable blade. The sampling method covers system startup, blade installation, real-time detection, protection triggering, and reset steps.

Description

Technical Field

[0001] This invention relates to the field of pathological testing instruments, specifically to a pathological sampling knife handle with active safety protection, a sampling knife, and a sampling method. Background Technology

[0002] The pathology scalpel is a core tool used in pathology departments for cutting and obtaining tissue samples. Current pathology scalpels generally employ a structure where the blade is fixedly connected to a clip, and the clip is fixed to the handle. The blade remains exposed at all times, and existing equipment lacks an active retraction mechanism based on changes in grip force or movement.

[0003] In practice, when the blade accidentally cuts into hard tissue (such as calcifications or bone fragments), the cutting resistance increases dramatically, causing the operator to grip the blade in response to the stress. At this point, the equipment cannot actively control the blade position based on the change in grip strength, and the exposed blade is prone to shaking and shifting due to the reaction force, easily injuring personnel operating nearby. This problem has become the most significant safety hazard in pathological tissue sampling, but currently, no effective active protection solution has been provided by similar products both domestically and internationally.

[0004] In addition to the aforementioned core safety issues, existing equipment also has varying degrees of shortcomings in blade fixing methods and equipment status detection, which are minor technical issues in this field. Summary of the Invention

[0005] The purpose of this invention is to address the problems existing in the prior art by providing an active safety protection pathological sampling knife handle, sampling knife, and sampling method. First, it solves the main technical problem of the existing active safety protection structure of sampling knives that lacks pressure detection and knife clip retraction linkage.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is: an active safety protection pathological tissue sampling knife handle, including a handle, a controller, and a power supply. The handle has a mounting cavity, and a first driving member is fixed in the mounting cavity. The actuating end of the first driving member is drivenly connected to a knife clip, and a knife groove is formed in the knife clip. A pressure sensor is installed on the surface of the handle. The pressure sensor and the first driving member are both electrically connected to the controller. The controller is configured to control the action of the first driving member according to the signal from the pressure sensor to realize the retraction of the knife clip.

[0007] Preferably, it further includes an inertial measurement device mounted on the handle, the inertial measurement device being electrically connected to the controller, and the controller being configured to control the first drive element to move according to the signal detected by the inertial measurement device, so as to realize the retraction of the tool holder.

[0008] Preferably, the controller is configured to trigger the first actuator when the rate of change of the pressure value detected by the pressure sensor exceeds a sudden change threshold.

[0009] Preferably, the power source is a storage battery installed in the mounting cavity, and the end of the handle away from the blade holder is provided with a charging connector with a protective cover.

[0010] Preferably, the inner wall of the blade groove is provided with an elastic locking protrusion and / or an interference fit structure to achieve the locking and fixing of the blade with the blade groove.

[0011] Preferably, the side wall of the blade holder is threaded with a locking bolt, which is used to lock the blade in the blade groove.

[0012] Preferably, the blade holder has a clearance groove that communicates with at least one of the blade slots, and a second driving member is installed on the blade holder. The actuating end of the second driving member passes through the clearance groove and is connected to a clamping member, which is used to clamp the blade.

[0013] Preferably, the handle is provided with a protective cover, which is fitted onto the end of the handle near the knife clip; the protective cover is used to reduce the contact of contaminants with the handle, keep the handle dry and clean, and reduce the risk of slippage.

[0014] The present invention also provides a pathological sampling knife with active safety protection, characterized in that it includes a pathological sampling knife handle with active safety protection as described above, and a blade detachably installed in a knife clip.

[0015] This invention also provides a pathological tissue sampling method with active safety protection, applied to the sampling knife described in the above scheme, characterized by comprising the following steps:

[0016] Powering on the controller and all detection and drive components puts them into working condition.

[0017] Install the blade into the blade holder and secure it;

[0018] The operator holds the handle to pick up materials, and the pressure sensor and inertial measurement device detect signals in real time and transmit them to the controller;

[0019] When the controller analyzes the signal and the rate of change of the pressure value detected by the pressure sensor exceeds the sudden change threshold or the motion parameters detected by the inertial measurement device change abruptly, it controls the first driving component to drive the tool holder to retract to achieve safety protection.

[0020] After the protection is completed, the controller controls the first drive component to reset the tool holder so that it can be used for the next material handling.

[0021] Compared with the prior art, the beneficial effects of the present invention are:

[0022] 1. This pathological sampling knife with active safety protection achieves active retraction protection of the knife clip based on changes in grip force through the linkage control of the pressure sensor and the first driving component. The controller can trigger protection immediately when the rate of change of pressure value exceeds the sudden change threshold. At the same time, it works with the inertial measurement device to protect against abnormal equipment movement. The dual active safety protection structure covers two common dangerous scenarios: cutting hard tissue and accidental equipment drop. It effectively constrains the position of the blade and reduces the risk of operators being cut by the blade.

[0023] 2. This pathological sampling knife with active safety protection features three blade fixing schemes that can be used independently: a blade locking groove, a clamping element, and a locking bolt. This provides a variety of blade fixing options to meet the needs of cutting tissues of different hardness and different operating habits in pathological testing. All three schemes can achieve a firm connection between the blade and the blade clamp, preventing the blade from loosening or shifting during cutting, thus improving the structural adaptability and operational stability of the equipment.

[0024] 3. This active safety protection pathological sampling knife uses a clamp to fix the blade. The blade does not need to be interference-fitted with the blade groove during installation, avoiding the risk of the blade slipping off due to forceful pressing, thus effectively reducing the possibility of operators being cut during installation.

[0025] 4. This pathological sampling knife with active safety protection has a protective cover at the end of the handle near the blade holder. This effectively prevents contaminants such as blood and tissue contents from coming into contact with the handle grip, keeping the handle surface dry and clean, reducing the probability of the handle slipping due to wetness, and reducing the contact area between contaminants and the handle, thus reducing the frequency of cleaning the handle by the operator and lightening the workload.

[0026] 5. This pathological sampling knife with active safety protection uses a rechargeable battery as its power source. With the charging connector at the end of the handle equipped with a protective cover, the power source can be repeatedly charged and reused without frequently opening the mounting cavity to replace the power supply, thus improving the ease of operation. The protective cover can effectively prevent contaminants from entering the charging connector, ensuring the stability of charging and power supply, and is suitable for continuous sampling work scenarios in pathological testing. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the external structure of the present invention.

[0028] Figure 2 This is a schematic diagram of the structure of the present invention after part of the handle has been removed.

[0029] Figure 3 This is a schematic diagram of the structure of the present invention after the outer shell is removed.

[0030] Figure 4 This is a schematic diagram of the structure of the clamping button and reset button of the present invention installed on the controller.

[0031] Figure 5 This is a side view of the second driving component of the present invention mounted on the tool holder.

[0032] In the diagram: 1. Handle; 11. Mounting cavity; 12. Clamping button; 13. Reset button; 2. First drive component; 3. Tool holder; 31. Tool groove; 32. Clearance groove; 33. Scale line; 4. Pressure sensor; 5. Controller; 6. Power supply; 61. Charging connector; 62. Protective cover; 7. Inertial measurement device; 8. Second drive component; 81. Clamping component; 9. Locking bolt; 10. Protective cover; 20. Blade. Detailed Implementation

[0033] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] like Figures 1 to 5 As shown in the figure, this embodiment provides a pathological tissue sampling knife with active safety protection, including a sampling knife handle and a blade 20 detachably mounted on the sampling knife handle. The sampling knife handle provides the mounting base, power drive, and safety protection for the blade 20, and is the core structure of the device; the blade 20 is a reusable blade commonly used in pathological testing, used for cutting and sampling pathological tissue.

[0035] Please see Figure 1 , Figure 2 and Figure 5 The material handling tool includes a handle 1, a controller 5, and a power supply 6. The handle 1 provides a grip for the operator and has an axially oriented mounting cavity 11 inside. The mounting cavity 11 is a closed cavity used to house and secure various functional components. The controller 5 integrates signal reception, signal analysis, and command transmission functions, serving as the control core of the entire device. The power supply 6 is a battery, fixedly installed within the mounting cavity 11, and electrically connected to all electrical components such as the controller 5, the first drive component 2, the pressure sensor 4, the inertial measurement device 7, and the second drive component 8, providing a continuous and stable operating voltage. A charging connector 61 is located at the end of the handle 1 furthest from the tool holder 3. This charging connector 61 is electrically connected to the charging terminal of the power supply 6, used to connect an external charging device to replenish the battery's power. A protective cover 62 is movably connected to the charging connector 61; when the protective cover 62 is fastened, it forms a sealed protection, effectively preventing contaminants from entering the charging interface.

[0036] Please see Figure 2 and Figure 3The mounting cavity 11 houses a first driving component 2, which can be a micro linear motor, electromagnetic push rod, or lead screw slide module, or other drive mechanism capable of outputting linear reciprocating motion. The power supply end of the first driving component 2 is electrically connected to the power supply 6, and the control end is electrically connected to the controller 5. Its execution end extends out of the mounting cavity 11 and is connected to the blade holder 3 via a transmission connection. The blade holder 3 serves as the mounting carrier for the blade 20, and is elongated and flat, with a groove 31 inside to accommodate the mounting end of the blade 20. The first driving component 2 can drive the blade holder 3 to reciprocate linearly along the length of the handle 1, switching the blade holder 3 between a working position and a retracted position. In the working position, the blade 20 is fully exposed for cutting; in the retracted position, the blade 20 retracts with the blade holder 3 to a position close to the handle 1, and the cutting edge of the blade 20 is concealed by the blade holder 3 for protection.

[0037] The surface of the handle 1, specifically the area that contacts the operator's palm, is fitted with a pressure sensor 4. The detection surface of the pressure sensor 4 is flush with or slightly protruding from the surface of the handle 1, without affecting normal gripping. Its signal output terminal is electrically connected to the controller 5. The pressure sensor 4 is used to collect the pressure value when the operator grips the handle 1 in real time and transmit the pressure signal to the controller 5 in the form of an electrical signal in real time. The controller 5 has a preset mutation threshold, which is calibrated according to the range of grip force changes when cutting normal tissue in pathological sampling. It only triggers a protective action when there is a sudden and rapid increase in grip force, thereby avoiding accidental triggering during normal operation. For example, the mutation threshold is set to more than twice the normal grip force change rate. When the blade 20 accidentally cuts into hard tissue (such as calcifications, bone fragments, or foreign objects), the cutting resistance increases instantly, and the operator will have an instinctive stress gripping reaction. At this time, the pressure value change rate detected by the pressure sensor 4 will quickly exceed the preset sudden change threshold. After receiving the abnormal pressure signal, the controller 5 immediately sends a retraction command to the first drive component 2, driving the first drive component 2 to quickly retract the blade holder 3 and the blade 20 to the hidden position, thereby constraining the position of the blade 20 from the source and preventing it from shaking or shifting due to the reaction force of hard tissue, which could scratch the personnel operating at close range.

[0038] Please see Figure 2To further enhance the safety of the equipment in non-operational states, this embodiment also includes an inertial measurement unit (IMU) 7 fixed within the mounting cavity 11 of the handle 1. The IMU 7 can be a three-axis accelerometer, a six-axis gyroscope, or an inertial measurement unit (IMU). Its power supply terminal is electrically connected to the power supply 6, and its signal output terminal is electrically connected to the controller 5. The IMU 7 is used to detect the overall motion state of the cutting blade in real time, including motion parameters such as acceleration and angular velocity, and transmits the motion state signal to the controller 5 in real time. When the cutting blade accidentally slips from the hand, the equipment enters a state of weightlessness or accelerated fall. The IMU 7 detects a sudden abnormal change in acceleration or angular velocity. Upon receiving this abnormal motion signal, the controller 5 immediately triggers the retraction of the first drive component 2, causing the blade 20 to be concealed before landing. This structure complements the protection triggered by the pressure sensor 4, covering two typical dangerous scenarios: "cutting obstruction" and "equipment falling," respectively, achieving dual active safety protection.

[0039] like Figures 2 to 4 As shown, the blade holder 3 is equipped with a variety of blade fixing schemes that can be used independently. Operators can flexibly choose according to material requirements, tissue hardness and personal operating habits. Each scheme can achieve a firm and detachable connection between the blade 20 and the blade holder 3.

[0040] As a basic fixing solution (not shown in the figure), the blade holder 3 has a blade groove 31 that matches the shape of the mounting end of the blade 20. The inner wall of the blade groove 31 is provided with an elastic locking protrusion and / or an interference fit structure. The mounting end of the blade 20 can be directly pushed into the blade groove 31 and locked in place. This solution has a simple structure, requires no additional drive or manual locking components, and the installation and removal of the blade 20 are extremely fast. It is suitable for routine tissue sampling scenarios that require frequent replacement of the blade 20.

[0041] As another reliable purely mechanical fixing solution (not shown in the figure), the side wall of the blade holder 3 has a threaded through hole that communicates with the blade groove 31. A locking bolt 9 is fitted into this threaded through hole. The end of the locking bolt 9 is a flat head or a tapered head. After the blade 20 is installed into the blade groove 31, the operator can manually rotate the locking bolt 9 so that its end abuts against the side of the blade 20, thereby fixing the blade 20 through tightening force. This solution is completely independent of electrical drive, unaffected by power supply, and the tightening force can be flexibly adjusted according to actual needs, exhibiting extremely high reliability and suitable for emergency material retrieval or environments where the use of electrical equipment is limited.

[0042] Please see Figure 1 and Figure 5As another preferred fixing method, the blade holder 3 has a blade groove 31 and at least one clearance groove 32 communicating with the blade groove 31. A second drive member 8 is fixedly installed on the outer wall of the blade holder 3. The second drive member 8 can be a miniature electromagnet, a miniature linear motor, or a piezoelectric ceramic actuator. Its actuating end passes through the clearance groove 32 and is connected to a clamping member 81. The end of the clamping member 81 has a pressure block or toothed surface adapted to the surface shape of the blade 20. When the blade 20 is embedded in the blade groove 31, the operator can send a clamping command through the clamping button 12 on the handle 1. The controller 5 controls the second drive member 8 to drive the clamping member 81 to move towards the blade 20, and the blade 20 is pressed and fixed in the blade groove 31 by the compressive force. This solution uses a mechanical clamping method, which provides uniform, stable and controllable clamping force. It is especially suitable for cutting hard tissues or scenarios that require large stroke and high frequency cutting, and can effectively prevent the blade 20 from loosening or shifting. At the same time, the blade 20 does not need to be interference-fitted with the blade groove 31 during installation, avoiding the risk of the blade 20 slipping off due to forceful pressing, thereby effectively reducing the possibility of operators being cut during the installation process.

[0043] The blade holder 3 is also equipped with a scale line 33, which is used to measure the size of the tissue sample. This allows the user to quickly measure the size of the tissue sample on the spot, thereby improving work efficiency. The length of the scale line 33 is generally 5cm.

[0044] Please see Figure 2 and Figure 3 A protective cover 10 is fitted onto the end of the handle 1 near the blade clamp 3. The protective cover 10 is made of elastic rubber or soft plastic and fits tightly against the outer wall of the handle 1, preventing displacement due to equipment shaking or the extension / retraction of the blade clamp 3 after installation. The protective cover 10 is funnel-shaped or cylindrical, with its open end extending towards the blade clamp 3, covering the connection area between the blade clamp 3 and the handle 1. During pathological tissue cutting, blood, tissue fluid, fat, and other contents are prone to splashing or dripping from the working end of the blade clamp 3. The protective cover 10 effectively blocks these contaminants, significantly reducing the contact area between contaminants and the gripping area of ​​the handle 1, thereby keeping the surface of the handle 1 dry and clean, preventing slippage and unstable grip. Simultaneously, the protective cover 10 reduces the frequency of cleaning the handle 1 by the operator, helping to improve the efficiency of continuous material handling operations. It should be noted that the structural design of the protective cover 10 does not interfere with the normal extension / retraction movement of the blade clamp 3, nor does it obstruct the operator's view, ensuring the accuracy and safety of the material handling operation.

[0045] Please see Figures 1 to 5Based on the aforementioned scalpel handle, this invention also provides a pathological scalpel comprising the handle and a blade. This scalpel has a compact overall structure and high integration. The blade 20 is detachably mounted in the blade holder 3 using any of the aforementioned fixing methods. When the blade 20 becomes dull or needs to be replaced with a different blade size, the operator can quickly disassemble and assemble it without the need for special tools.

[0046] Based on the structure of the aforementioned sampling knife, this invention further provides a method for pathological sampling applied to this sampling knife. This method is adapted to the equipment structure, fully utilizes the functions of each component, and achieves safe, efficient, and intelligent pathological sampling operations. Specifically, it includes the following steps:

[0047] The first step is system startup and self-test. The operator turns on the power switch of power supply 6, and all electrical components, including controller 5, pressure sensor 4, inertial measurement unit 7, first drive component 2, and second drive component 8, are powered on and enter working state. Controller 5 executes the power-on self-test program to verify the communication status of each component and preset parameters (such as sudden change thresholds). After confirming that there are no abnormalities, it enters standby mode. At this time, the first drive component 2 remains in its initial extended state, the tool holder 3 is in the working position, and the equipment is ready.

[0048] The second step is blade installation and fixing. The operator holds the non-working end of the blade 20, aligns the mounting end of the blade 20 with the groove 31 of the blade holder 3, and pushes it in. Depending on the actual material requirements and operating habits, one of the following three fixing methods can be used to complete the locking: 1. Quick fixing is achieved by directly using the snap-fit ​​structure of the groove 31; 2. A clamping command is sent through the clamping button 12 on the handle 1, and the controller 5 drives the second drive component 8 to drive the clamping component 81 to clamp the blade 20; 3. The locking bolt 9 is manually tightened so that its end is pressed against the side of the blade 20.

[0049] The third step is real-time detection and signal acquisition. The operator holds the handle 1, ensuring their palm naturally contacts the detection surface of the pressure sensor 4, and then pushes the blade 20 to cut the pathological tissue. During the cutting process, the pressure sensor 4 collects the grip pressure value in real time at a sampling frequency of no less than 100Hz and continuously sends the pressure signal to the controller 5; simultaneously, the inertial measurement device 7 collects the acceleration, angular velocity, and other motion parameters of the cutting blade in real time and transmits the motion status signal synchronously to the controller 5. The controller 5 performs differential calculations on the received pressure signal, extracts the rate of change of pressure value in real time, and performs abrupt change analysis on the motion status signal.

[0050] The fourth step is the active safety protection trigger. Controller 5 continuously compares the real-time pressure change rate with the preset abrupt change threshold and compares the real-time motion state parameters with the motion baseline under normal operation. Controller 5 determines that the protection trigger condition is met when any of the following conditions occur: first, the pressure change rate exceeds the abrupt change threshold, indicating that hard tissue has been cut, causing a sudden increase in grip force; second, the instantaneous change in acceleration or angular velocity exceeds the drop judgment threshold, indicating that the equipment is in an accidental drop state. After the condition is met, controller 5 sends a retraction command to the first drive component 2 within milliseconds. The first drive component 2 quickly drives the blade holder 3 and the blade 20 to retract to the hidden protective position. The entire triggering and execution process is completed before the blade 20 undergoes significant displacement or the equipment hits the ground, effectively preventing operator cuts and damage to the blade 20 from impact.

[0051] Step 5: Reset and Continuous Operation. After the abnormal state is resolved, the operator can send a reset command by pressing the reset button 13 on the handle 1. Upon receiving the reset signal, the controller 5 sends an extension command to the first drive component 2, driving the blade holder 3 to smoothly reset to its initial working position, and the equipment returns to its normal ready-to-cut state. If the blade 20 needs to be replaced, the operator can first reset the blade holder 3 to the extended position, and then disassemble it according to the fixing method used: blades 20 fixed by snap-fit ​​can be pulled out directly; blades 20 fixed by clamping component 81 can be released by sending a release command through clamping button 12; blades 20 fixed by locking bolt 9 can be removed by unscrewing the bolt in the opposite direction. After replacing the blade, repeat step 2 to continue the material handling operation.

[0052] The material sourcing method in this embodiment achieves closed-loop control from blade installation, cutting operation, abnormal protection to rapid reset through the intelligent scheduling of the entire process by the controller 5. The dual-source detection mechanism of the pressure sensor 4 and the inertial measurement device 7 covers two types of risks: operational abnormalities and environmental abnormalities. The high-speed response of the first drive component 2 ensures the timeliness of protective actions. The design of multiple blade 20 fixing schemes and the protective cover 10 further improves the ease of use and safety of the equipment from the perspective of supporting structure.

[0053] It should be further noted that the present invention is not limited to the specific structural forms described in the above embodiments. For example, the first driving component 2 can also use a rotary motor in conjunction with a gear and rack mechanism to realize the extension and retraction of the blade holder 3; the inertial measurement device 7 can be integrated on the same circuit board as the controller 5 to save space; the protective cover 10 can be designed to be detachable for easy cleaning and replacement; the charging connector 61 can also be replaced by a wireless charging module to further improve the protection level. These simple modifications or equivalent substitutions based on the technical concept of the present invention should all be considered to fall within the protection scope of the present invention.

[0054] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pathological tissue sampling knife handle with active safety protection, comprising a handle (1), a controller (5), and a power supply (6), characterized in that, The handle (1) has an installation cavity (11) inside, and a first drive member (2) is fixed inside the installation cavity (11). The execution end of the first drive member (2) is connected to a blade holder (3). A blade groove (31) is opened inside the blade holder (3). A pressure sensor (4) is installed on the surface of the handle (1). The pressure sensor (4) and the first drive member (2) are both electrically connected to a controller (5). The controller (5) is configured to control the first drive member (2) to move according to the signal of the pressure sensor (4) so ​​as to realize the retraction of the blade holder (3).

2. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, It also includes an inertial measurement unit (7) mounted on the handle, the inertial measurement unit (7) being electrically connected to the controller (5), the controller (5) being configured to control the first drive (2) to move according to the signal detected by the inertial measurement unit (7) to achieve the retraction of the tool holder (3).

3. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, The controller (5) is configured to trigger the first actuator (2) when the rate of change of pressure value detected by the pressure sensor (4) exceeds the mutation threshold.

4. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, The power source (6) is a storage battery installed in the mounting cavity (11), and the end of the handle (1) away from the blade clip (3) is provided with a charging connector (61) with a protective cover (62).

5. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, The inner wall of the cutting groove (31) is provided with an elastic locking protrusion and / or an interference fit structure to realize the locking and fixing of the blade (20) and the cutting groove (31).

6. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, The side wall of the blade holder (3) is threaded with a locking bolt (9), which is used to lock the blade (20) in the blade groove (31).

7. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, The blade holder (3) has an clearance groove (32) that communicates with at least one blade groove (31). A second drive member (8) is installed on the blade holder (3). The execution end of the second drive member (8) passes through the clearance groove (32) and is connected to a clamping member (81). The clamping member (81) is used to clamp the blade (20).

8. The pathological tissue sampling knife handle with active safety protection according to claim 1, characterized in that, The handle (1) is provided with a protective cover (10), which is fitted onto the end of the handle (1) near the knife clip (3).

9. A pathological sampling knife with active safety protection, characterized in that, The pathology sampling knife handle with active safety protection as described in any one of claims 1-8, and the blade (20) detachably mounted in the knife clip (3).

10. A method for pathological tissue sampling with active safety protection, applied to the sampling knife as described in claim 9, characterized in that, Includes the following steps: Turn on the power supply (6) to put the controller (5), pressure sensor (4), inertial measurement device (7), first drive unit (2) and second drive unit (8) into working state; Install the blade (20) into the blade holder (3) and secure it; The operator holds the handle (1) to collect materials, and the pressure sensor (4) and the inertial measurement device (7) detect the signal in real time and transmit it to the controller (5). When the controller (5) analyzes the signal and the rate of change of the pressure value detected by the pressure sensor (4) exceeds the sudden change threshold or the motion parameter detected by the inertial measurement device (7) changes suddenly, it controls the first driving component (2) to drive the blade holder (3) to retract to achieve safety protection. After the protection is completed, the controller (5) controls the first drive unit (2) to drive the knife clamp (3) to reset so that it can be used for the next material taking.

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