Multi-sensor array for customizing photobiomodulation dosing

Abstract

A sensor array for monitoring and customizing photobiologically modulated doses is disclosed. The sensor array includes a temperature sensor for monitoring the surface temperature at the target treatment site when photons are emitted from a photobiologically modulated device onto the target treatment site.

Description

[0001] Cross-references to related applications This application claims priority to U.S. Provisional Patent Application No. 63 / 578610, filed August 24, 2023, the entire contents of which are hereby incorporated by reference. Technical Field

[0002] This disclosure generally relates to photobiological regulation. More specifically, this disclosure relates to systems and methods for adjusting parameters of photobiological regulation to improve efficacy. Background Technology

[0003] The use of low doses of light energy capable of stimulating or inhibiting biological responses is known as photobiological modulation (PBM) therapy. A major drawback of mainstream PBM therapy has been inconsistent and unreproducible clinical benefits. Therefore, it is desirable to provide systems and methods that use sensor arrays to assess biological responses in real time in order to tailor PBM dosages for optimal therapeutic benefit. Summary of the Invention

[0004] The exemplary embodiments disclosed herein are intended to provide systems and methods that meet the aforementioned needs. These embodiments may be systems and methods for evaluating and adjusting photobiologically modulated doses to improve clinical benefit.

[0005] The disclosed technology includes a sensor array for customizing photobiologically modulated dosing. The sensor array may include a distance sensor for measuring the distance from the photobiologically modulated device to the target treatment site / region. The sensor array may also include an optical sensor for acquiring skin color at the target treatment site and a thermal sensor for measuring the temperature of the target treatment site.

[0006] The distance sensor can be an ultrasonic distance sensor, an infrared distance sensor, or a laser distance sensor. The optical sensor can be a digital camera. The thermal sensor can be a thermal camera.

[0007] The disclosed technology includes a system for delivering a customized photobiomodulated dose to a target treatment site. The system may include a photobiomodulation device for delivering photons to the target treatment site. The system may also include a sensor array for analyzing the target treatment site. The sensor array may include a distance sensor for measuring the distance from the photobiomodulation device to the target treatment site, an optical sensor for measuring the skin color of the target treatment site, and a thermal sensor for measuring the temperature of the target treatment site. The system may also include a controller for adjusting one or more parameters of the photobiomodulation device. The system may include a memory for storing processor-executable instructions and a processor for executing the processor-executable instructions. The executable instructions may cause the processor to receive the distance from the photobiomodulation device to the target treatment site measured by the distance sensor, the skin color of the target treatment site measured by the optical sensor, and the temperature of the target treatment site measured by the thermal sensor. The processor may further analyze the distance from the photobiomodulation device to the target treatment site, the skin color of the target treatment site, and the temperature of the target treatment site. The processor may then send one or more signals to the controller to adjust one or more parameters of the photobiomodulation device based on information collected by the sensor array.

[0008] When the temperature of the target treatment site exceeds a predetermined maximum temperature, the processor can send a signal to power off the photobiomodulation device. The predetermined maximum temperature can be 42 degrees Celsius. When the temperature of the target treatment site drops below a predetermined minimum temperature, the processor can send a signal to power on the photobiomodulation device. The predetermined minimum temperature can be 37 degrees Celsius. The sensor array and photobiomodulation device can be mounted on a mobile platform. The mobile platform can be automated to adjust the distance from the photobiomodulation device to the target treatment site. One or more parameters of the photobiomodulation device can include the wavelength of the emitted light, the power of the emitted light, the duration of the emitted light, and the distance from the photobiomodulation device to the target treatment site. The wavelength of the light emitted from the photobiomodulation device is approximately 400 nanometers to 1200 nanometers. The photobiomodulation device can include a laser or light array, such as a light-emitting diode (LED) array.

[0009] This document discloses a method for tailoring photobiologically modulated dosing to a target treatment site. One method may include emitting photons from a photobiological modulation device onto the target treatment site. The method may further include monitoring the temperature of the target treatment site and adjusting one or more parameters of the photobiological modulation device to maintain the temperature of the target treatment site below a predetermined temperature threshold.

[0010] The method may further include a step of measuring the skin color of the target treatment site. Measuring the skin color of the target treatment site can be performed before photons are emitted from the photobiomodulation device onto the target treatment site. Adjusting one or more parameters of the photobiomodulation device based on the measured skin color can be done before photons are emitted from the photobiomodulation device onto the target treatment site.

[0011] The method may also include measuring the biological response to the photobiologically regulated dose and adjusting one or more parameters of the photobiologically regulated device prior to a second photobiological regulation. The parameters of the photobiologically regulated device can be adjusted to prevent phototoxicity.

[0012] Other aspects of this disclosure will become clear when viewed in conjunction with the accompanying drawings in the following detailed description. Additional features or manufacturing and use steps may be included, as will be appreciated and understood by one of ordinary skill in the art. Attached Figure Description

[0013] The foregoing and other aspects of the invention will be further discussed in conjunction with the accompanying drawings and the following description, wherein similar numerals in the figures indicate similar structural elements and features. The drawings are not necessarily to scale; instead, the focus is on illustrating the principles of the invention. The figures depict one or more embodiments of the device of the invention and are by way of example only, not as limitation. It is anticipated that those skilled in the art will conceive of and combine elements from the multiple figures to better meet the needs of the user.

[0014] Figure 1 This is a schematic diagram of a system for monitoring and adjusting the output of a photobiological regulation device according to various aspects of the present invention.

[0015] Figure 2A This is a flowchart illustrating a method for adjusting the output of a photobiological regulation device according to various aspects of the present invention.

[0016] Figure 2B This is a table depicting exemplary sensors in a sensor array and their functions for adjusting parameters of a photobiological modulation device according to various aspects of the present invention.

[0017] Figure 3A It is a representation of a thermal image of a target therapeutic site undergoing photobiomodulation according to various aspects of the present invention.

[0018] Figure 3B It is a graphical representation of the average temperature measured at the target treatment site according to various aspects of the present invention.

[0019] Figure 4 This is a graphical representation of the effect of photobiomodulation devices according to various aspects of the present invention on temperature at the target treatment site.

[0020] Figure 5A This is a description of a wound assessed over a seven-day period according to various aspects of the present invention.

[0021] Figure 5B This is a graphical representation of wound closure after a seven-day period according to various aspects of the present invention.

[0022] Figure 5C This is a description of a wound assessed over a seven-day period according to various aspects of the present invention.

[0023] Figure 5D This is a graphical representation of wound closure after a seven-day period according to various aspects of the present invention.

[0024] Figure 6 This is a description of a scoring system for assessing skin color at a target treatment site according to various aspects of the present invention.

[0025] Figure 7 These are Western blots and bar graphs of ATF-4 expression evaluated after photobiological regulation treatment according to various aspects of the present invention. Detailed Implementation

[0026] Specific examples of the invention will now be described in detail with reference to the accompanying drawings, wherein like reference numerals indicate functionally similar or identical elements. These examples provide solutions for monitoring and adjusting parameters of photobiomodulation (PBM) devices. Sensor arrays can be used to monitor the target treatment site during photobiomodulation doses or events. Information collected by the sensor arrays can be used to adjust the parameters of the photobiomodulation device that emits photons onto the target treatment site. The target treatment site can be the tissue or skin surface of a subject.

[0027] This invention is not necessarily limited to the described examples, and may vary in construction and details. As used herein, the terms “about” or “approximately” for any numerical value or range indicate suitable dimensional tolerances that allow a set of parts or components to be used for their intended purpose as described herein. More specifically, “about” or “approximately” may refer to a value range of ±20%, for example, “about 90%” may refer to a value range from 71% to 99%.

[0028] refer to Figure 1According to some examples, a system 100 for providing a customized photobiomodulated dose to a target treatment site 150 is depicted. In some examples, system 100 includes a photobiomodulation device 135 for delivering photons 140 to the target treatment site 150. The system also includes a sensor array 105 for analyzing the target treatment site 150. Sensor array 105 may include a distance sensor 110 for measuring the distance (d) from photobiomodulation device 135 to the target treatment site 150. Sensor array 105 may also include an optical sensor 115 for measuring the skin color of the target treatment site 150. Sensor array 105 may further include a thermal sensor 120 for measuring the temperature of the target treatment site 150.

[0029] In some examples, the system includes a processor 125 operatively coupled to a sensor array 105 to receive a distance (d) from the photobiomodulation device 135 to the target treatment site 150, measured by a distance sensor 110. The processor 125 may further receive skin color of the target treatment site 150, measured by an optical sensor 115. The processor 125 may further receive temperature of the target treatment site 150, measured by a thermal sensor 120. In some examples, the processor 125 analyzes the distance (d) from the photobiomodulation device 135 to the target treatment site 150, the skin color of the target treatment site 150, and / or the temperature of the target treatment site 150. After analyzing the information received from the sensors of the sensor array 105, the processor may send one or more signals to a controller 130 to adjust one or more parameters of the photobiomodulation device 135 based on the data acquired by the sensor array. In some examples, one or more parameters of the photobiomodulation device 135 include the wavelength of the emitted light, the power of the emitted light, the duration of the emitted light, and the distance (d) from the photobiomodulation device 135 to the target treatment site.

[0030] System 100 may include a memory 126 operatively coupled to a processor 125 for storing processor-executable instructions. Processor 126 may analyze, based on the processor-executable instructions stored in memory 126, the distance (d) from photobiomodulation device 135 to target treatment site 150, the skin color of target treatment site 150, and the temperature of target treatment site 150. Processor 125 may then derive signals based on the processor-executable instructions to send to controller 130, thereby adjusting one or more parameters of photobiomodulation device 135 based on information collected by sensor array 105. Memory 126 may include a non-transitory computer-readable medium.

[0031] As disclosed herein, photobiomodulation device 135 is configured to emit photons 140 toward a target treatment site 150 to provide a photobiomodulated dose. In some examples, photobiomodulation device 135 includes a laser or light array. In some examples, the light array may include an array of light-emitting diodes (LEDs). In some examples, the wavelength of the light emitted from photobiomodulation device 135 is approximately 400 nanometers to 1200 nanometers.

[0032] Parameters for photobiologically modulated dose or events may include the wavelength, irradiance, and flux of emitted photons incident on the target treatment site 150. Irradiance is defined as the incident laser power per unit surface area and expressed in watts per centimeter. 2 (E) indicates flux. Flux is due to irradiance E (W / cm²). 2 And reach “A”cm 2 The energy Q (J) of the surface area. If maintained for a specific duration "t" seconds, the flux can be expressed as J / cm². 2 Treatments using varying powers but equal flux have shown that infrared wavelengths can induce higher cell proliferation than visible light wavelengths. Light sources with equivalent power output may show similar effects on fibroblast proliferation, regardless of their wavelength. However, neither irradiance nor flux can accurately predict phototoxicity. The assimilation of transferred energy (as measured by an increase in temperature) is likely crucial for phototoxic responses. This transfer is determined by the rate (irradiance mW / cm²). 2 The total energy (flux) is determined by the time and the total energy, but it must be "constrained" within the system (determined by thermal relaxation time, diffusion, and anisotropy) to elicit a biological response.

[0033] As disclosed herein, an increase in surface temperature can be an accurate predictor of the phototoxicity and efficacy of photobiologically modulated doses. In some examples, a thermal sensor 120 of the sensor array 105 is used to monitor the temperature at the treatment site during photobiologically modulated doses. The thermal sensor 120 may include a thermal camera (e.g., an infrared camera), a temperature probe, a thermometer, or a combination thereof. By monitoring the temperature at the target treatment site, the system can generate an effective PBM dose, independent of the wavelength of the light emitted by the PBM device.

[0034] In some examples, processor 125 is operatively coupled to thermal sensor 120 and sends a signal to de-energize photobiomodulation device 135 when the temperature of the target treatment site 150, as measured by thermal sensor 120, exceeds a predetermined maximum temperature. In some examples, the predetermined maximum temperature is 42 degrees Celsius.

[0035] In some examples, the photobiomodulation device 135 can be powered on and off to maintain the surface temperature at the treatment site between 37 degrees Celsius and 42 degrees Celsius. Figure 3A An exemplary image obtained by a thermal camera is depicted, showing the temperature rise at the treatment site 150 caused by photobiologically regulated dosage. Figure 3B This is a graph depicting the surface temperature 310 of the control without photobiological regulation versus the surface temperature 315 during a photobiological regulation (PBM) event.

[0036] Figure 4 This is a graph 400 depicting a surface temperature measurement 415 during exemplary operation of the system described herein, relative to the surface temperature 410 of a control in which no photobiological modulation is applied. In some examples, the PBM device is turned off when the surface temperature reaches a maximum threshold. In some examples, the PBM device is turned on when the surface temperature reaches a minimum threshold. In some examples, the PBM device is turned on and off to maintain the surface temperature 415 during the application of a photobiologically modulated dose, thereby maintaining an elevated surface temperature at the target treatment site for the duration of the dose. In some examples, the maximum threshold temperature is 43 degrees Celsius. In some examples, the minimum threshold temperature is 37 degrees Celsius. In some examples, the temperature should be maintained at no higher than 45 degrees Celsius to prevent phototoxicity, charring, or other damage to tissue.

[0037] Return to reference Figure 1 According to some examples, a distance sensor 110 is provided to measure the distance (d) from the PBM device to the target treatment area 150. In some examples, the distance (d) is adjustable. In some examples, the sensor array 105 and the photobiomodulation device 135 are physically coupled such that the distance between the distance sensor 110 and the PBM device 135 is fixed. In some examples, the photobiomodulation device 135 is mounted on a movable platform. In some examples, the movement of this platform is automated to adjust the distance (d) from the photobiomodulation device 135 to the target treatment site 150. The distance (d) can be adjusted such that the flux of photons 140 emitted to the target treatment site 150 is increased or decreased during the application of the photobiomodulated dose. In some examples, the photobiomodulation device 135 can be handheld or manually operated, allowing a user to manually adjust the distance (d) between the PBM device 135 and the target treatment site 150. In this case, the power of the PBM device and / or the duration of the emitted photons 140 can be adjusted to account for changes in the distance (d) measured by the distance sensor 110. The distance sensor 110 can be an ultrasonic distance sensor, an infrared distance sensor, or a laser distance sensor.

[0038] In some examples, sensor array 105 includes optical sensor 115. Optical sensor 115 can be used to measure skin color (i.e., the color, hue, or complexion of tissue) at the target treatment site. In some examples, optical sensor 115 is a color digital camera. In some examples, optical sensor 115 is a three-dimensional (3D) profilometry camera. Using such a 3D camera can help to more accurately measure the distance (d) between PBM device 135 and target treatment area 150. In some examples, the 3D camera will allow for minute adjustments to the parameters of PBM device 135 to account for the three-dimensional topography in target treatment area 150. Images acquired by optical sensor 115 can also be used to track progress at the target treatment site (e.g., wound healing). For example, Figure 5A and Figure 5C It depicts a series of images taken over seven days to track the closure of the wound. Figure 5A The study depicted wound closure progression over seven days in a control group (i.e., no PBM applied) relative to PBM-treated sites for darker skin tones. Results were plotted in... Figure 5B In the bar chart. Figure 5C The progress of wound closure over seven days was depicted for lighter skin tones, in control (i.e., no PBM applied) compared to PBM-treated sites. Results were plotted in... Figure 5D In the bar chart.

[0039] In some examples, skin color of tissue at the target treatment site 150 is measured before photons are emitted from the photobiological modulation device 135. In some examples, the processor 125 receives an image of the target treatment site 150 from the optical sensor 115 and assigns a score based on skin color. (See reference...) Figure 6 In some examples, skin color at the target treatment site is categorized into one of six different types based on a score, with Type I being the lightest and Type VI the darkest. One or more parameters of the photobiological modulation device 135 can be adjusted based on the skin color score. For example, in some examples, because darker skin types are more resistant to burns, the power and / or duration of the PBM dose can be increased for darker skin types to result in a more effective PBM dose.

[0040] In some examples, the parameters of the PBM device take into account specific biological responses, which can be broadly categorized into five protocols. These are pain or inflammation relief, modulation of immune responses, and promotion of tissue healing and regeneration. It has been noted that these therapeutic categories require a discrete set of PBM parameters. This can be selectively achieved through reprogramming cellular bioenergetics and metabolism via specific PBM-induced signaling pathways.

[0041] In some examples, the biological response to a photobiologically regulated dose is measured, and one or more parameters of the photobiologically regulated device 135 can be adjusted prior to subsequent photobiologically regulated doses to prevent phototoxicity and / or verify the efficacy of the dose. Discrete biomarkers and their expression levels can determine the optimal PBM dose. Biomarkers can be classified into three groups. The first group includes molecular-cellular damage threshold markers, including ATF-4, KEAP1, Nrf2, NFkB, and the like. The second group of biomarkers may be involved in the PBM treatment response, including TGF-β1, cytochrome C oxidase, nitric oxide, purinergic receptors, a range of non-visual opsins, and the like. The third group of biomarkers can be specific to disease or health pathophysiology, such as cardiovascular health, aging, respiration, neurocognition, muscle performance, and the like.

[0042] In some examples, the sensor array 105 also includes a resonance Raman spectrometer 122 for real-time measurement of redox levels. In some examples, reducing or neutralizing redox levels reduces phototoxicity at the target treatment site 150. In some examples, the resonance Raman spectrometer 122 monitors minute changes in the redox levels at the target treatment site 150, which can indicate a therapeutic response to photobiologically modulated doses.

[0043] Figure 7 It was administered at doses of 0, 0.1, 0.3, and 0.5 W (0 to 10 mW / cm²). 2 Western blots and corresponding bar graphs of ATF-4 expression were obtained after PBM treatment at four different doses. Increased ATF-4 expression may correspond to increased PBM dose efficacy.

[0044] In some examples, the system is configured to normalize the delivery of PBM doses over a region of the target treatment site. In some examples, an optical diffuser is used to normalize the PBM dose over the target treatment area. In some examples, single or multiple probes and a programmable robotic system are used to perform PBM dose delivery via automated movement (grating, circular, and punching). The robotic system can be a six-axis robotic system. Furthermore, delivery within precise anatomical planes or internal sites can be achieved through spatial and temporal triangulation. Precise drug delivery can be accomplished using artificial intelligence and iterative machine learning algorithms utilizing quantum computing.

[0045] Figure 2AMethods for customizing PBM dosages are described according to several examples. In some examples, at step 225, data acquired from sensors 210, 215, and 220 are analyzed (e.g., by a processor). At step 230, based on the analysis, signals are derived and sent to the controller of the PBM device to adjust parameters (e.g., the power of emitted light, the duration of emitted light, and the distance from the photobiomodulation device to the target treatment site). At step 235, it can be determined whether there are any problems within the information acquired by the sensors. As disclosed herein, additional information (e.g., biomarkers and their expression levels) can be considered, and the parameters of the PBM device can be further adjusted.

[0046] Figure 2B Examples of sensors to be used in the system, their functions, and the resulting actions are described. In some examples, a distance sensor measures the real-time distance from the PBM device to the target treatment area. Based on the measured distance, the output of the PBM device or the treatment duration can be adjusted. In some examples, an optical sensor (e.g., a digital color camera) measures the skin color of the target treatment area. Based on the measured skin color, the output of the PBM device or the wavelength of photons emitted by the PBM device is adjusted. In some examples, a thermal sensor (e.g., a thermal camera) measures the surface temperature of the target treatment area. Based on the measured surface temperature, the output (on / off) of the PBM device can be adjusted. In some examples, machine learning can be used to account for historical data or data acquired externally to improve the efficacy of the PBM dose by analyzing input parameters and the resulting effects on the target treatment site. In some examples, the system also includes a fourth sensor, which may be a resonance Raman spectrometer that measures redox levels in real time.

[0047] It should be recognized that the systems and methods described herein have a wide range of practical applications. The systems and methods disclosed herein can be used to promote wound healing by utilizing photobiomodulation and the sites of injury, surgery, and the like. Photobiomodulation can be applied to skin tissue, organ tissue, oral mucosa, etc. The systems and methods disclosed herein can be used to monitor surgical incisions using lasers. The systems and methods disclosed herein can be used for other applications such as monitoring photons incident on a surface, including the curing of photosensitive polymers.

[0048] The examples disclosed herein may be implemented by any of the following numbered clauses.

[0049] Clause 1: A sensor array (105) for customizing photobiologically modulated doses, comprising: a distance sensor (110) for measuring the distance (d) from the photobiologically modulated device (135) to the target treatment site (150); an optical sensor (115) for acquiring the skin color of the target treatment site (150); and a thermal sensor (120) for measuring the temperature of the target treatment site.

[0050] Clause 2: The sensor array (105) according to Clause 1, wherein the distance sensor is an ultrasonic distance sensor, an infrared distance sensor or a laser distance sensor.

[0051] Clause 3: The sensor array (105) as described in Clause 2, wherein the distance sensor is an ultrasonic distance sensor.

[0052] Clause 4: A sensor array (105) according to any one of Clauses 1 to 3, wherein the optical sensor (115) is a digital camera.

[0053] Clause 5: A sensor array (105) according to any one of Clauses 1 to 4, wherein the thermal sensor (120) is a thermal camera.

[0054] Clause 6: The sensor array (105) according to any one of Clauses 1 to 4 further includes a resonance Raman spectrometer (122).

[0055] Clause 7: A system (100) for delivering a customized photobiomodulated dose to a target treatment site (150), comprising: a photobiomodulation device (135) for delivering photons (140) to the target treatment site (150); and a sensor array (105) for analyzing the target treatment site (150), the sensor array (105) comprising: a distance sensor (110) for measuring a distance (d) from the photobiomodulation device (135) to the target treatment site (150); an optical sensor (115) for measuring the skin color of the target treatment site (150); and a thermal sensor (120) for measuring the temperature of the target treatment site (150).

[0056] Clause 8: The system (100) according to Clause 7 further includes: a memory (126) storing processor-executable instructions; a controller (130) for adjusting one or more parameters of the photobiomodulation device (135); and a processor (125) for executing processor-executable instructions to perform the following steps: receiving a distance (d) from the photobiomodulation device (135) to a target treatment site (150) measured by a distance sensor (110), receiving a skin color of the target treatment site (150) measured by an optical sensor (115), receiving a temperature of the target treatment site (150) measured by a thermal sensor (120), analyzing the distance (d) from the photobiomodulation device (135) to the target treatment site (150), the skin color of the target treatment site (150), the temperature of the target treatment site (150), and sending one or more signals to the controller to adjust one or more parameters of the photobiomodulation device (135).

[0057] Clause 9: In the system (100) described in Clause 8, when the temperature of the target treatment site (150) exceeds a predetermined maximum temperature, the processor (125) sends a signal to de-energize the photobiomodulation device (135).

[0058] Clause 10: The system (100) as described in Clause 9, wherein the predetermined maximum temperature is 42 degrees Celsius.

[0059] Clause 11: The system (100) according to any one of Clauses 8-10, wherein when the temperature of the target treatment site (150) drops below a predetermined minimum temperature, the processor (125) sends a signal to power on the photobiomodulation device (135).

[0060] Clause 12: The system (100) according to Clause 11, wherein the predetermined minimum temperature is 37 degrees Celsius.

[0061] Clause 13: The system (100) according to any one of Clauses 6 to 12, wherein the sensor array (105) and the photobiological modulation device (135) are mounted on a mobile platform.

[0062] Clause 14: The system (100) according to Clause 13, wherein the mobile platform is automated to adjust the distance (d) from the photobiomodulation device (135) to the target treatment site (150).

[0063] Clause 15: The system (100) according to any one of Clauses 7 to 14, wherein one or more parameters of the photobiomodulation device (135) include the wavelength of the emitted light, the power of the emitted light, the duration of the emitted light, and the distance (d) from the photobiomodulation device (135) to the target treatment site.

[0064] Clause 16: The system (100) according to Clause 15, wherein the wavelength of light emitted from the photobiological modulation device (135) is approximately 400 nanometers to 1200 nanometers.

[0065] Clause 17: The system (100) according to any one of Clauses 6 to 16, wherein the photobiological modulation device (135) includes a laser or an array of light.

[0066] Clause 18: The system (100) according to Clause 17, wherein the light array comprises an array of light-emitting diodes (LEDs).

[0067] Clause 19: A method for customizing photobiologically modulated doses for a target treatment site (150), comprising: emitting photons from a photobiological modulation device (135) onto the target treatment site (150); monitoring the temperature of the target treatment site (150); and adjusting one or more parameters of the photobiological modulation device (135) to maintain the temperature of the target treatment site below a predetermined temperature threshold.

[0068] Clause 20: The method according to Clause 19, wherein one or more parameters of the photobiomodulation device (135) include the power state of the photobiomodulation device (135), the power of the light emitted from the photobiomodulation device (135), and the distance (d) from the photobiomodulation device (135) to the target treatment site (150).

[0069] Clause 21: The method described in Clause 20 further includes a step of measuring the skin color of the target treatment site (150).

[0070] Clause 22: The method according to Clause 21, wherein before emitting photons from the photobiomodulation device (135) onto the target treatment site (150), a step of measuring the skin color of the target treatment site (150) is performed, and before emitting photons from the photobiomodulation device (135) onto the target treatment site (150), a step of adjusting one or more parameters of the photobiomodulation device (135) based on the measured skin color is performed.

[0071] Clause 23: The method according to any one of Clauses 19 to 22 further includes the steps of: measuring the biological response to the photobiologically regulated dose and adjusting one or more parameters of the photobiologically regulated device (135) before the second photobiologically regulated dose to prevent phototoxicity.

[0072] In describing the exemplary embodiments, terminology has been used for clarity. As a result, not all possible combinations are listed, and such variations are generally apparent to those skilled in the art and are intended to fall within the scope of the appended claims. It is intended that each term be interpreted in its broadest sense, as understood by those skilled in the art, and to include all technical equivalents that operate in a similar manner to achieve a similar purpose without departing from the scope and spirit of the invention. It should also be understood that reference to one or more steps of the method does not preclude the existence of additional method steps or the insertion of method steps between those expressly indicated. Similarly, some steps of the method may be performed in a different order than that described herein without departing from the scope of the disclosed technology.

Claims

1. A sensor array (105) for customized photobiological dose regulation, comprising: Distance sensor (110) for measuring distance (d) from photobiomodulation device (135) to target treatment site (150). An optical sensor (115) for acquiring skin color at the target treatment site (150); and A thermal sensor (120) is used to measure the temperature of the target treatment site.

2. The sensor array (105) according to claim 1, wherein the distance sensor is an ultrasonic distance sensor, an infrared distance sensor or a laser distance sensor.

3. The sensor array (105) according to claim 2, wherein the distance sensor is an ultrasonic distance sensor.

4. The sensor array (105) according to claim 1, wherein the optical sensor (115) is a digital camera.

5. The sensor array (105) according to claim 1, wherein the thermal sensor (120) is a thermal camera.

6. The sensor array (105) according to claim 1 further includes a resonance Raman spectrometer (122).

7. A system (100) for delivering a customized photobiologically modulated dose to a target treatment site (150), comprising: Photobiomodulation device (135) for delivering photons (140) to a target treatment site (150); as well as A sensor array (105) for analyzing the target treatment site (150), the sensor array (105) comprising: Distance sensor (110) for measuring the distance (d) from the photobiological modulation device (135) to the target treatment site (150). An optical sensor (115) for measuring skin color at the target treatment site (150), and A thermal sensor (120) is used to measure the temperature of the target treatment site (150).

8. The system (100) according to claim 7, further comprising: Memory (126) that stores processor-executable instructions. A controller (130) is used to adjust one or more parameters of the photobiological regulation device (135); as well as Processor (125) for executing processor-executable instructions to perform the following steps: The distance (d) from the photobiomodulation device (135) to the target treatment site (150) is received by the distance sensor (110). Receives skin color at the target treatment site (150) measured by an optical sensor (115). Receives the temperature of the target treatment site (150) measured by the thermal sensor (120). The analysis included the distance (d) from the photobiological modulation device (135) to the target treatment site (150), the skin color of the target treatment site (150), the temperature of the target treatment site (150), and... Send one or more signals to the controller to adjust one or more parameters of the photobiological regulation device (135).

9. The system (100) according to claim 8, wherein when the temperature of the target treatment site (150) exceeds a predetermined maximum temperature, the processor (125) sends a signal to de-energize the photobiomodulation device (135).

10. The system (100) according to claim 9, wherein the predetermined maximum temperature is 42 degrees Celsius.

11. The system (100) according to claim 9, wherein when the temperature of the target treatment site (150) drops below a predetermined minimum temperature, the processor (125) sends a signal to power on the photobiomodulation device (135).

12. The system (100) according to claim 11, wherein the predetermined minimum temperature is 37 degrees Celsius.

13. The system (100) according to claim 9, wherein the sensor array (105) and the photobiological modulation device (135) are disposed on a mobile platform.

14. The system (100) of claim 13, wherein the mobile platform is automated to adjust the distance (d) from the photobiomodulation device (135) to the target treatment site (150).

15. The system (100) of claim 9, wherein one or more parameters of the photobiomodulation device (135) include the wavelength of the emitted light, the power of the emitted light, the duration of the emitted light, and the distance (d) from the photobiomodulation device (135) to the target treatment site.

16. The system (100) of claim 15, wherein the wavelength of the light emitted from the photobiological modulation device (135) is approximately 400 nanometers to 1200 nanometers.

17. The system (100) of claim 15, wherein the photobiological modulation device (135) comprises a laser or an optical array.

18. The system (100) of claim 17, wherein the light array comprises an array of light-emitting diodes (LEDs).

19. A method for tailoring photobiologically modulated dosing according to a target treatment site (150), comprising: Photons are emitted from the photobiological modulation device (135) onto the target treatment site (150); Monitor the temperature of the target treatment site (150); and Adjust one or more parameters of the photobiological modulation device (135) to keep the temperature of the target treatment site below a predetermined temperature threshold.

20. The method of claim 19, wherein one or more parameters of the photobiomodulation device (135) include the power state of the photobiomodulation device (135), the power of the light emitted from the photobiomodulation device (135), and the distance (d) from the photobiomodulation device (135) to the target treatment site (150).

21. The method of claim 20, further comprising the step of measuring the skin color of the target treatment site (150).

22. The method of claim 21, wherein before emitting photons from the photobiomodulation device (135) onto the target treatment site (150), a step of measuring the skin color of the target treatment site (150) is performed, and before emitting photons from the photobiomodulation device (135) onto the target treatment site (150), a step of adjusting one or more parameters of the photobiomodulation device (135) based on the measured skin color is performed.

23. The method of claim 19, further comprising the step of: Measure the biological response to the photobiologically regulated dose and adjust one or more parameters of the photobiologically regulated device (135) before the second photobiologically regulated dose to prevent phototoxicity.

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