A wired bimodal imaging capsule endoscopy system

Abstract

This invention discloses a wired dual-modal imaging capsule endoscopy system, belonging to the field of medical device technology. The system includes a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The capsule module is used to achieve 360° circumferential scanning imaging of the esophageal mucosa. The transmission and control module ensures stable transmission of optical and electrical signals and precise control of capsule movement. The dual-modal imaging module integrates an optical coherence tomography submodule and a photoacoustic imaging submodule to acquire tissue morphology information and microvascular distribution information, respectively. The signal analysis module processes the dual-modal signals. This invention achieves three-dimensional high-resolution integrated imaging of the esophageal mucosa without the need for exogenous labeling agents, significantly improving the detection accuracy of early esophageal cancer and precancerous lesions.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more specifically, to a wired dual-modal imaging capsule endoscopy system, which is particularly suitable for label-free assessment of early esophageal cancer and Barrett's esophagus-related precancerous lesions, and can be applied to clinical diagnosis and cancer screening in gastroenterology. Background Technology

[0002] Esophageal cancer is a prevalent malignant tumor worldwide, affecting a large number of people each year. Esophageal adenocarcinoma accounts for the highest proportion in Western countries, and its incidence has increased significantly in recent decades. Barrett's esophagus, as a known precancerous lesion of esophageal adenocarcinoma, has associated risk factors in a large population globally. However, the mortality rate of esophageal cancer remains high, primarily due to the difficulty in early diagnosis. Current diagnostic methods mainly rely on white light endoscopy and random biopsies. Early precancerous lesions are difficult to distinguish under white light endoscopy, and even with systematic biopsy protocols, many early lesions are still missed. Furthermore, the biopsy process is time-consuming, costly, and poorly tolerated by patients.

[0003] To improve the diagnostic performance of endoscopy, existing technologies include chromoendoscopy, narrow-band imaging, and confocal laser endoscopy. However, chromoendoscopy requires dye, prolongs the examination time, and its detection benefit is controversial; narrow-band imaging has no significant advantage in detecting precancerous lesions; and confocal laser endoscopy has a small field of view, making it difficult to cover a large area of ​​mucosa. More importantly, these technologies can only obtain surface information and cannot assess structural and functional abnormalities of the entire esophageal mucosa.

[0004] Optical coherence tomography (OCT) and photoacoustic imaging (PAI) offer complementary advantages: OCT can display tissue morphology at high resolution, while PAI can identify microvascular distribution without markers. However, current technologies primarily use separate devices for both, lacking a miniaturized, integrated system suitable for esophageal examination. Wireless capsule endoscopy suffers from unstable signal transmission, low resolution, and a lack of dedicated signal analysis software, making it impossible to extract lesion features in real time and thus failing to meet the needs of early esophageal cancer assessment. Therefore, developing a wired dual-modal capsule endoscopy system integrating OCT, PAI, and dedicated signal analysis software is crucial for solving the challenge of early esophageal cancer diagnosis. Summary of the Invention

[0005] This invention aims to provide a wired dual-modal imaging capsule endoscopy system that integrates optical coherence tomography (OCT) and photoacoustic imaging technologies, and combines them with computer software for signal analysis. This addresses the problems of low detection rates and limited imaging information in existing endoscopes for early esophageal cancer and precancerous lesions. The system achieves integrated imaging and quantitative analysis of the esophageal mucosa's "structure-function," improving diagnostic accuracy and reducing reliance on invasive biopsies.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a wired dual-modal imaging capsule endoscopy system, comprising: a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module; wherein, the capsule module is used to achieve 360° circumferential scanning imaging of the esophageal mucosa; the transmission and control module is used to ensure stable transmission of optical and electrical signals, and to adjust the rotation and longitudinal retraction of the capsule module to form a spiral scanning trajectory; the dual-modal imaging module is used to acquire tissue morphology signals and microvascular distribution signals respectively; the signal analysis module is used to process the dual-modal signals, reconstruct images, and quantize features to assist in lesion diagnosis; the transmission and control module is connected to the capsule module at one end and to the light source and receiver of the dual-modal imaging module at the other end through an internal flexible sheath, double-clad optical fiber, and electrical wire; the electrical and optical signal output terminals of the dual-modal imaging module are connected to the computer where the signal analysis module is located through a data acquisition card; the signal analysis module connects and controls the transmission and control module and the dual-modal imaging module to work together by outputting a synchronous trigger signal.

[0007] The present invention has the following beneficial effects:

[0008] 1. Dual-modal fusion improves diagnostic accuracy: Optical coherence tomography provides information on tissue microstructure, photoacoustic imaging provides information on label-free microvascular function, and combined with the quantification of key features by the software analysis module, it significantly improves the detection capability of early esophageal cancer and precancerous lesions.

[0009] 2. Wired design ensures stability: Stable transmission of optical, electrical, and control signals is achieved through flexible sheaths, double-clad optical fibers, and electrical conductors, avoiding signal attenuation and interference in wireless transmission, resulting in better imaging resolution and synchronization.

[0010] 3. Flexible and efficient software analysis: The computer software module can optimize signal processing accuracy through algorithm iteration, support real-time imaging and offline analysis, adapt to clinical diagnosis and scientific research needs, and reduce hardware upgrade costs.

[0011] 4. Strong clinical applicability: The capsule size is adapted to the esophageal lumen diameter, the operation does not require sedation, and patients tolerate it well; the imaging time is short, making it suitable for large-scale screening and follow-up. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the capsule module provided in an embodiment of the present invention;

[0013] Figure 2 A schematic diagram of the overall structure of the wired dual-modal imaging capsule endoscopy system provided in an embodiment of the present invention;

[0014] The following are the symbols and their meanings: 1. Transparent shell; 2. Ultra-wideband ultrasonic transducer; 3. Mirror; 4. Gradient refractive index lens; 5. Hollow shaft motor; 6. Coupling medium. Detailed Implementation

[0015] The present invention will be further described below with reference to the embodiments.

[0016] This invention provides a wired dual-modal imaging capsule endoscopy system, including a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The modules work together to achieve high-resolution imaging and lesion analysis of the esophageal mucosa.

[0017] The capsule module, serving as the core of in vivo imaging, includes a transparent shell 1, an ultra-wideband ultrasonic transducer 2, optical components, a hollow shaft motor 5, and a coupling medium 6. The transparent shell 1 has a diameter of 10 mm. 30 The surface is marked with carbon fiber for image registration; the ultra-wideband ultrasonic transducer 2 is made of lithium niobate and has a center frequency of 80 Hz. 110 bandwidth The center has 1 Aperture; the optical components include a 45° reflecting mirror 3 and a gradient refractive index lens 4, used to guide and focus dual-mode light signals; the hollow shaft motor 5 is used to drive the ultra-wideband ultrasonic transducer 2 at 20 Frequency rotation is used to achieve circular scanning; the coupling medium 6 is preferably heavy water, degassed water or silicone oil, etc., to ensure efficient transmission of ultrasonic signals.

[0018] The transmission and control module includes a flexible sheath, a double-clad optical fiber, electrical conductors, a motor control system, and a signal amplifier. The flexible sheath has a diameter of 2. The double-clad optical fiber is used to provide mechanical support and protection for the capsule module; the double-clad optical fiber is used for synchronous transmission of 1300 Optical coherence tomography (OCT) light and 532 The photoacoustic imaging light; the electrical conductor is used to transmit the electrical signals for photoacoustic imaging and the motor control signals; the motor control system is used to adjust the rotation and longitudinal retraction of the capsule module to form a spiral scanning trajectory; the signal amplifier is used to amplify the photoacoustic electrical signals to reduce transmission loss.

[0019] The dual-modal imaging module includes an optical coherence tomography (OCT) submodule and a photoacoustic imaging submodule. The OCT submodule uses a center wavelength of 1300 nm. 100 bandwidth Broadband laser source, interferometer and balanced photodetector acquire tissue morphological signals, axial resolution 5 Horizontal resolution 8 The photoacoustic imaging submodule uses 532 A pulsed laser source excites the photoacoustic effect, and combined with an ultra-wideband ultrasonic transducer 2, the microvascular distribution signal is acquired, with an axial resolution of 15. Horizontal resolution 25 The two achieve spatiotemporal registration of signals through synchronous control.

[0020] The signal analysis module is a computer-run software module, including a signal preprocessing module, an image reconstruction module, and a feature quantization module. The signal preprocessing module performs filtering and noise reduction and Fourier transform on the optical coherence tomography (OCT) signal, and frequency band separation and Hilbert transform on the photoacoustic imaging signal. The image reconstruction module stitches the original signals into a three-dimensional OCT structural image and a depth-coded photoacoustic vascular image. The feature quantization module calculates key indicators such as glandular transparency, vessel density, vessel depth, and epithelial heterogeneity to aid in lesion diagnosis.

[0021] More specifically, the present invention provides a wired dual-modal imaging capsule endoscopy system, such as Figure 1 , Figure 2 As shown, the system includes a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The capsule module enables 360° circumferential scanning imaging of the esophageal mucosa. The transmission and control module ensures stable transmission of optical and electrical signals and adjusts the capsule module's rotation and longitudinal retraction to form a helical scanning trajectory. The dual-modal imaging module acquires tissue morphology signals (via an optical coherence tomography submodule) and microvascular distribution signals (via a photoacoustic imaging submodule). The signal analysis module processes the dual-modal signals, performs image reconstruction, and quantifies features to aid in lesion diagnosis. The transmission and control module, via an internal flexible sheath, double-clad optical fiber, and electrical conductors, is connected at one end to the capsule module and at the other end to the light source and receiver of the dual-modal imaging module. The electrical and optical signal outputs of the dual-modal imaging module are connected to the computer containing the signal analysis module via a data acquisition card. The signal analysis module outputs a synchronous trigger signal to connect and control the transmission and control module and the dual-modal imaging module for coordinated operation.

[0022] The capsule module includes a transparent shell 1, an ultra-wideband ultrasonic transducer 2, a reflector 3, a gradient refractive index lens 4, a hollow shaft motor 5, and a coupling medium 6. The transparent shell 1 provides mechanical support and protection for the internal components, and its surface is marked with carbon fiber for image registration. The ultra-wideband ultrasonic transducer 2 receives ultrasonic signals generated by the photoacoustic effect. It has a central opening for the light signal to pass through, and an externally welded gold slip ring connects to the electrical wire for signal output. One side is fixed to the reflector 3, and the entire module is rigidly connected to the hollow shaft motor 5 via a coupling. The reflector 3 guides the light signal to the tissue surface and receives backscattered light; it is fixed to one side of the ultra-wideband ultrasonic transducer 2 with epoxy resin. The gradient refractive index lens 4 guides and focuses the dual-mode light signal and is coaxially fixed to the distal end of a double-clad optical fiber via a fiber optic adapter. The hollow shaft motor 5 drives the transducer assembly to rotate for circular scanning and is rigidly connected to the ultra-wideband ultrasonic transducer 2 assembly via a coupling; its interface is connected to the electrical wire. The coupling medium 6 is used to ensure efficient transmission of ultrasonic signals. It is filled inside the transparent shell 1 and sealed by a sealing ring.

[0023] The transparent outer shell 1 is injection molded from polymethyl methacrylate and has a diameter of 10 mm. 30 Its surface is covered with carbon fiber markings for image registration; the tail of the outer shell is integrated with a medical-grade buckle for rigid connection with the flexible sheath.

[0024] The ultra-wideband ultrasonic transducer 2 is made of lithium niobate and has a center frequency of 80 Hz. 6 Bandwidth 110 The center has 1 The aperture is used for optical signal transmission; the ultra-wideband ultrasonic transducer 2 has a gold slip ring welded to the outside as an ultrasonic signal output interface.

[0025] The reflector 3 is made of aluminum-coated optical glass and is fixed to one side of the ultra-wideband ultrasonic transducer 2 by epoxy resin.

[0026] The gradient refractive index lens 4 is coaxially fixed to the far end of the double-clad fiber via an optical fiber adapter to ensure that the optical signal is guided to the tissue surface via the reflector 3.

[0027] The hollow shaft motor 5 is rigidly connected to the ultra-wideband ultrasonic transducer 2 assembly via a coupling. Electrical wires are welded to the motor's power supply and control interface. The rotation frequency is 20 rpm. The hollow shaft motor 5 includes a base, and the bottom structure is used to fix the motor and connect the cables.

[0028] The coupling medium 6 is heavy water, degassed water, or silicone oil, etc., filled inside the transparent shell 1, and sealed by a sealing ring to ensure the coupling efficiency of the ultrasonic signal.

[0029] The transmission and control module includes an optical signal transmission link, an electrical signal transmission link, and a mechanical linkage structure.

[0030] In the optical signal transmission link, the double-clad optical fiber adopts a coaxial design of multimode and single-mode fiber cores. Its distal end is inserted into the tail end of the gradient refractive index lens 4 through an optical fiber adapter, and its proximal end splits into two branches after passing through the flexible sheath: the multimode end is connected to the 532 of the photoacoustic imaging submodule through an optical fiber coupler. The pulsed laser source, with its single-mode end connected to the 1300nm optical coherence tomography submodule via another coupler, is... A broadband laser source. The optical fiber runs entirely through the flexible sheath.

[0031] In the electrical signal transmission link, one end of the first set of electrical wires is welded to the gold slip ring of the ultra-wideband ultrasonic transducer 2, and the other end passes through the flexible sheath and is connected to the input end of the signal amplifier of the transmission and control module; one end of the second set of electrical wires is welded to the interface of the hollow shaft motor 5, and the other end is connected to the internal rotary motor controller to realize closed-loop control of the motor speed.

[0032] In the aforementioned mechanical linkage structure, the distal end of the flexible sheath is locked to the tail of the capsule shell via a snap-fit, while the proximal end is wound and fixed to the transmission wheel of an external retraction motor. The transmission wheel drives the sheath at a 1-2 degree angle via a lead screw structure. The speed moves longitudinally, coordinating with the rotation of the hollow shaft motor 5 to form a spiral scanning trajectory.

[0033] The dual-modal imaging module includes a photoacoustic imaging submodule and an optical coherence tomography submodule.

[0034] In the photoacoustic imaging submodule, the output terminal of the signal amplifier is connected to the signal input terminal of the photoacoustic imaging submodule via a shielded coaxial cable; the pulsed laser source of the photoacoustic imaging submodule is connected to the laser synchronization trigger interface of the transmission and control module via a control line.

[0035] In the optical coherence tomography submodule, the near end of the single-mode fiber core of the double-clad fiber is connected to an interferometer via an optical fiber circulator, the reference arm of the interferometer is connected to an adjustable delay line, and the signal arm is connected to a balanced photodetector; the broadband laser source of the optical coherence tomography submodule is connected to the master clock interface of the transmission and control module via a trigger line.

[0036] The balanced photodetector output of the optical coherence tomography (OCT) submodule is connected to a channel of the high-speed data acquisition card via a differential signal line; the signal output of the photoacoustic imaging submodule is connected to another channel of the acquisition card via a coaxial cable. The acquisition card is connected to the computer of the signal analysis module via an interface.

[0037] The computer is connected to the master clock circuit of the transmission and control module through a converter, and outputs a synchronous trigger signal to control the laser frequency sweep trigger of optical coherence tomography, the laser pulse trigger of photoacoustic imaging, the internal rotary motor and the external retraction motor respectively.

[0038] The working process of a wired dual-modal imaging capsule endoscopy system is as follows:

[0039] The capsule module and the flexible sheath are placed together in a high-temperature, high-pressure sterilizer for sterilization to ensure compliance with medical sterility standards. After sterilization, they are removed, and the distal end of the double-clad optical fiber is connected to the gradient refractive index lens 4 of the capsule module via an optical fiber adapter. Electrical wires are connected to the gold slip ring of the ultra-wideband ultrasonic transducer 2 and the interface of the hollow shaft motor 5, respectively. The proximal end of the flexible sheath is fixed to the external retraction motor drive wheel of the transmission and control module. The signal analysis software on the computer is opened, and scanning parameters, including laser power, pulse energy, rotation frequency, retraction speed, and imaging frame rate, are entered in the parameter setting interface. After parameter confirmation, the software automatically synchronizes with the dual-modal imaging module and the motor control system.

[0040] The patient assumes an appropriate position with their head slightly tilted back to widen the esophageal passage, and holds a medical mouthguard to prevent biting the flexible sheath. The medical staff holds the sheath control end of the transmission and control module and gently places the capsule module in the patient's oral vestibule. Under the auxiliary field of vision, the flexible sheath is slowly pushed until the capsule module reaches the target area of ​​the esophagus. After confirming the capsule position, the outer end of the sheath is fixed to prevent the capsule from shifting during the scanning process.

[0041] Clicking the "Start Scan" button in the software triggers end-to-end synchronous operation: the internal rotating motor of the transmission and control module drives the capsule module at 20... The external retraction motor drives the flexible sheath to rotate at a frequency of 1-2. The speed retracts at a constant rate, forming a spiral scanning trajectory; the dual-modal imaging module starts synchronously: 1300 Broadband laser light is transmitted to the capsule module via the single-mode core of the double-clad optical fiber. It is focused by the gradient refractive index lens 4 and guided to the esophageal mucosa by the reflector 3. The backscattered light returns along the original optical path to the optical coherence tomography submodule, where it forms an interference signal via an interferometer and is converted into an electrical signal by a balanced photodetector. Simultaneously, 532... A pulsed laser is transmitted to the mucosal tissue via a multimode fiber core, exciting an ultrasonic signal generated by the photoacoustic effect. This signal is received by the ultra-wideband ultrasonic transducer 2, amplified by a signal amplifier, and then transmitted to the photoacoustic imaging submodule. A high-speed data acquisition card simultaneously acquires optical coherence tomography (OCT) and photoacoustic imaging electrical signals and transmits them to the computer in real time.

[0042] After receiving the data, the signal analysis software automatically processes it according to a preset procedure: the signal preprocessing module filters and reduces noise in the optical coherence tomography (OCT) signal and converts it into a depth signal using Fourier transform; it performs frequency band separation and envelope extraction on the photoacoustic imaging signal; the image reconstruction module stitches the processed data into a three-dimensional OCT structural image and a photoacoustic imaging depth-coded vascular image, and achieves dual-mode image registration, displaying the single-mode image and the fused image in a split-screen manner on the software interface; the feature quantization module automatically calculates key indicators such as gland transparency, vascular density, and vascular depth, and automatically marks areas that meet the suspected lesion threshold; doctors can adjust the marking position through interface operation or manually select potential lesion areas not identified by the software, and the marking information is linked to the scanning position in real time.

[0043] When the capsule module retracts to the esophageal inlet, the software automatically stops scanning, and the external retraction motor rotates in the opposite direction to retract the capsule module and the flexible sheath. Clicking the "Generate Report" button automatically summarizes the scan data, including examination time, scan range of each esophageal segment, number and location of suspected lesions, key quantitative indicators, and includes single-modal and fused images of typical lesion areas. The report can be exported in a standard format, and the data is automatically stored in the computer. Finally, the capsule module and the double-clad optical fiber are disassembled, sorted, and stored for future sterilization and reuse. The surface of the transmission and control module is cleaned, completing the examination.

[0044] The content disclosed above is only a preferred and feasible embodiment of the present invention, and is not intended to limit the scope of protection of the present invention. Therefore, all equivalent technical changes made based on the content of the present invention specification and drawings are included within the scope of protection of the present invention. Furthermore, the elements therein can be updated as technology develops.

[0045] The technologies, shapes, and structures not described in detail in this invention are all known technologies.

Claims

1. A wired dual-modal imaging capsule endoscopy system, characterized in that, include: The system comprises a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The capsule module enables 360° circumferential scanning imaging of the esophageal mucosa. The transmission and control module ensures stable transmission of optical and electrical signals and adjusts the capsule module's rotation and longitudinal retraction to form a helical scanning trajectory. The dual-modal imaging module acquires tissue morphology signals and microvascular distribution signals separately. The signal analysis module processes the dual-modal signals, performs image reconstruction, and quantifies features to aid in lesion diagnosis. The transmission and control module, via an internal flexible sheath, double-clad optical fiber, and electrical conductors, is connected at one end to the capsule module and at the other end to the light source and receiver of the dual-modal imaging module. The electrical and optical signal outputs of the dual-modal imaging module are connected to the computer containing the signal analysis module via a data acquisition card. The signal analysis module outputs a synchronous trigger signal to connect and control the transmission and control module and the dual-modal imaging module for coordinated operation.

2. The wired dual-modal imaging capsule endoscopy system according to claim 1, characterized in that, The capsule module includes a transparent shell, an ultra-wideband ultrasonic transducer, optical components, a hollow shaft motor, and a coupling medium. The optical components include a reflector and a gradient refractive index lens. The transparent shell provides mechanical support and protection for the internal components, and its surface is marked with carbon fiber for image registration. The ultra-wideband ultrasonic transducer receives ultrasonic signals generated by the photoacoustic effect. It has a central opening for the light signal to pass through, and an externally welded gold slip ring connects to the electrical wire for signal output. One side is fixed to the reflector, and the entire unit is rigidly connected to the hollow shaft motor via a coupling. The reflector guides the light signal to the tissue surface and receives backscattered light; it is fixed to one side of the ultra-wideband ultrasonic transducer with epoxy resin. The gradient refractive index lens guides and focuses the dual-mode light signal and is coaxially fixed to the distal end of a double-clad optical fiber via a fiber optic adapter. The hollow shaft motor drives the ultra-wideband ultrasonic transducer to rotate for circular scanning and is rigidly connected to the ultra-wideband ultrasonic transducer assembly via a coupling. Its interface is connected to the electrical wire. The coupling medium ensures efficient transmission of the ultrasonic signal, fills the interior of the transparent shell, and is sealed with a sealing ring.

3. The wired dual-modal imaging capsule endoscopy system according to claim 1, characterized in that, The transmission and control module includes a flexible sheath, a double-clad optical fiber, electrical conductors, a motor control system, and a signal amplifier; wherein the flexible sheath has a diameter of 2. The double-clad optical fiber is used to provide mechanical support and protection for the capsule module; the double-clad optical fiber is used for synchronous transmission of 1300 Optical coherence tomography (OCT) light and 532 The photoacoustic imaging light; the electrical conductor is used to transmit the electrical signals for photoacoustic imaging and the motor control signals; the motor control system is used to adjust the rotation and longitudinal retraction of the capsule module to form a spiral scanning trajectory; the signal amplifier is used to amplify the photoacoustic electrical signals to reduce transmission loss.

4. The wired dual-modal imaging capsule endoscopy system according to claim 1, characterized in that, The dual-modal imaging module includes an optical coherence tomography (OCT) submodule and a photoacoustic imaging submodule; wherein, the OCT submodule includes a center wavelength of 1300 nm. Bandwidth is 100 The system includes a broadband laser source, an interferometer, and a balanced photodetector; the photoacoustic imaging submodule includes a wavelength of 532 nm. A pulsed laser source.

5. A wired dual-modal imaging capsule endoscopy system according to claim 2, characterized in that, The transparent outer shell of the capsule module has a diameter of 10. 30 The ultra-wideband ultrasonic transducer is made of lithium niobate and has a center frequency of 80 Hz. 6 Bandwidth is 110 The center has 1 The aperture allows light signals to pass through; the coupling medium is heavy water, degassed water, or silicone oil.

6. A wired dual-modal imaging capsule endoscopy system according to claim 4, characterized in that, The axial resolution of the optical coherence tomography submodule is 5. The horizontal resolution is 8 ; The axial resolution of the photoacoustic imaging submodule is 15. The horizontal resolution is 25. The pulse energy of the photoacoustic imaging submodule is 10-20. The pulse width is 2 .

7. A wired dual-modal imaging capsule endoscopy system according to claim 5, characterized in that, The capsule module contains a hollow shaft motor that drives the transducer at 20... Frequency rotation; the transmission and control module includes an external retraction motor, controlling the capsule at 1-2... The speed is retracted longitudinally to achieve helical scanning.

8. A wired dual-modal imaging capsule endoscopy system according to claim 4, characterized in that, The photoacoustic imaging submodule supports multi-band reconstruction, including full-band, low-band, and high-band; the high-band is 80-120. It is used to highlight capillary structures.

9. A wired dual-modal imaging capsule endoscopy system according to claim 1, characterized in that, The double-clad optical fiber is used for synchronous transmission of 1300. Optical coherence tomography (OCT) light and 532 Photoacoustic imaging light; the optical fiber is connected to the optical components inside the capsule module via a double-clad fiber coupler.

10. A wired dual-modal imaging capsule endoscopy system according to claim 1, characterized in that, The system also includes a synchronous triggering circuit for coordinating optical coherence tomography laser frequency sweeping, photoacoustic imaging laser pulses, motor rotation, and data acquisition to achieve synchronous acquisition of dual-mode signals.

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