An anhydrous soothing and repairing spray based on small molecule transdermal technology and its preparation method

Abstract

This invention discloses an anhydrous soothing and repairing spray based on small molecule transdermal technology and its preparation method, relating to the field of skincare sprays. The invention constructs a bioactive system centered on yeast fermentation product filtrate, lactobacillus fermentation product, and lactobacillus / ginseng root fermentation product filtrate, and synergizes with small molecule polyols to form a transdermal delivery network. This achieves efficient and stable dispersion and deep delivery of multiple active ingredients under anhydrous conditions, significantly reducing the system's water activity and improving the overall stability and activity retention rate of the product. By introducing functional ingredients such as acetyl hexapeptide-8, sodium hyaluronate, niacinamide, 3-o-ethyl ascorbic acid, and tranexamic acid, a synergistic effect of soothing repair, anti-inflammatory calming, antioxidant, and anti-wrinkle firming is achieved.

Description

Technical Field

[0001] This invention relates to the field of skin care sprays, and in particular to an anhydrous soothing and repairing spray based on small molecule transdermal technology and its preparation method. Background Technology

[0002] With the rapid development of functional skincare products and dermatological aesthetics, consumers have placed higher demands on the safety, stability, and efficacy of skin-soothing, repairing, anti-inflammatory, and anti-aging products. This is especially true for sensitive skin, post-operative repair, and skin barrier damage care. Products not only need to provide good immediate soothing effects but also need to ensure skin tolerance and the stability of active ingredients over long-term use. Most commercially available spray skincare products use a water-based system with deionized water as the main component. Although this type of system has a mature manufacturing process and a refreshing feel, its high water activity makes it prone to microbial growth. It usually requires a high concentration or high-efficiency preservative system to ensure product safety, thus increasing the potential risk of irritation or sensitization to sensitive skin. Summary of the Invention

[0003] Therefore, in order to overcome the above-mentioned shortcomings, the present invention provides an anhydrous soothing and repairing spray based on small molecule transdermal technology and its preparation method.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: an anhydrous soothing and repairing spray based on small molecule transdermal technology, comprising the following components by mass percentage: 28-38% yeast fermentation product filtrate, 12-22% lactobacillus fermentation product, 0.5-1.5% lactobacillus / ginseng root fermentation product filtrate, 8-18% rose water, 6-12% propylene glycol, 6-10% butylene glycol, 0.5-2% dipropylene glycol, 1-3% hydroxypropyl tetrahydropyrantriol, 1-3% nicotinamide, 0.5-2% tranexamic acid, 0.5-2% 3-o-ethyl ascorbic acid, and acetyl hexapeptide-8. 0.2-0.8%, Acetyl hexapeptide 0.1-0.5%, Sodium hyaluronate 0.2-1%, Allantoin 0.1-0.3%, Dipotassium glycyrrhizate 0.1-0.3%, Ergothioneine 0.05-0.3%, Ectoin 0.1-0.5%, Retinol 0.01-0.1%, p-hydroxyacetophenone 0.3-0.7%, Chlorphenesin 0.1-0.2%, 1,2-Hexanediol 0.3-1%, Centella asiatica extract 0.1-0.5%, Calendula officinalis extract 0.1-0.5%.

[0005] Preferably, by weight percentage, it comprises the following components: 32.0% yeast fermentation product filtrate, 17.0% Lactobacillus fermentation product, 1.0% Lactobacillus / ginseng root fermentation product filtrate, 14.0% rose water, 10.0% propylene glycol, 8.0% butylene glycol, 1.0% dipropylene glycol, 2.0% hydroxypropyl tetrahydropyrantriol, 2.0% nicotinamide, 1.0% tranexamic acid, 1.0% 3-o-ethyl ascorbic acid, 0.5% acetyl hexapeptide-8, 0.3% acetyl hexapeptide, 0.5% sodium hyaluronate, 0.2% allantoin, 0.15% dipotassium glycyrrhizate, 0.15% ergothioneine, 0.3% ectoine, 0.05% retinol, 0.5% p-hydroxyacetophenone, 0.15% chlorphenesin, 0.5% 1,2-hexanediol, 0.3% Centella asiatica extract, and 0.25% calendula extract.

[0006] Preferably, the preparation method includes the following steps:

[0007] S1 Dissolution and Premixing: Under anhydrous conditions, propylene glycol, butylene glycol, dipropylene glycol and hydroxypropyl tetrahydropyrantriol are mixed and stirred to form a humectant mixture;

[0008] S2 active component addition: Add nicotinamide, tranexamic acid, 3-o-ethyl ascorbic acid, ergothioneine, ectoine, acetyl hexapeptide-8, acetyl hexapeptide, sodium hyaluronate, allantoin and dipotassium glycyrrhizate in sequence, and stir until completely dissolved.

[0009] S3 Fermentation Product Mixing: Before adding the fermentation products, retinol is pre-dissolved in a portion of dipropylene glycol or propylene glycol to form a mother liquor, which is then slowly added to the system to improve its dispersion stability and avoid photothermal degradation. Yeast fermentation product filtrate, lactobacillus fermentation product and lactobacillus / ginseng root fermentation product filtrate are added to the system and slowly stirred until homogeneous.

[0010] S4 Plant Extract Addition: Continue to add Centella Asiatica extract and Calendula extract, ensuring they are fully dispersed in the system;

[0011] S5 stabilization system establishment: p-hydroxyacetophenone, chlorophenoxyacetophenone and 1,2-hexanediol were added as preservatives and system stabilizers;

[0012] S6 Homogenization and Ultrasonic Dispersion: A clear and transparent spray liquid is obtained through high-speed homogenization and ultrasonic dispersion.

[0013] S7 Filling and Packaging: The obtained liquid is poured into a sealed spray bottle and stored away from light to obtain the finished product.

[0014] Preferably, in step S2, the order of addition of the active components is: nicotinamide → tranexamic acid → 3-o-ethyl ascorbic acid → ergothioneine → ectoine → acetyl hexapeptide-8 → acetyl hexapeptide → sodium hyaluronate → allantoin → dipotassium glycyrrhizate.

[0015] Preferably, in step S6, the homogenization speed is 8000-12000 rpm and the time is 10-20 minutes; the ultrasonic dispersion time is 5-15 minutes.

[0016] Preferably, the ambient temperature is kept not higher than 25°C and the relative humidity is kept below 50% during the preparation process.

[0017] The beneficial effects of this invention are:

[0018] This invention constructs a bioactive system centered on yeast fermentation product filtrate, lactobacillus fermentation product, and lactobacillus / ginseng root fermentation product filtrate, and synergizes with small molecule polyols to form a transdermal delivery network. This achieves efficient and stable dispersion and deep delivery of multiple active ingredients under anhydrous conditions, significantly reducing the system's water activity and improving overall product stability and activity retention. By introducing functional ingredients such as acetyl hexapeptide-8, sodium hyaluronate, niacinamide, 3-o-ethyl ascorbic acid, and tranexamic acid, it achieves synergistic effects of soothing repair, anti-inflammatory calming, antioxidant, and anti-wrinkle firming. Comparative test results show that this invention significantly outperforms the comparative product in key indicators such as stratum corneum hydration improvement rate, skin elasticity improvement rate, fine line improvement rate, and erythema index reduction rate, with zero skin irritation incidence, demonstrating excellent safety and efficacy. Furthermore, the anhydrous system of this invention avoids the reliance on high-strength preservative systems found in traditional aqueous products, maintaining good appearance and active ingredient stability even under long-term storage conditions, while also offering a pleasant skin feel, rapid absorption, and significant efficacy. Detailed Implementation

[0019] To further explain the technical solution of the present invention, a detailed description is provided below through specific embodiments.

[0020] Example 1

[0021] This invention provides an anhydrous soothing and repairing spray based on small molecule transdermal technology. The formula, by weight percentage, is as follows: 32.0% yeast fermentation product filtrate, 17.0% Lactobacillus fermentation product, 1.0% Lactobacillus / ginseng root fermentation product filtrate, 14.0% rose water, 10.0% propylene glycol, 8.0% butylene glycol, 1.0% dipropylene glycol, 2.0% hydroxypropyl tetrahydropyrantriol, 2.0% nicotinamide, 1.0% tranexamic acid, 1.0% 3-o-ethyl ascorbic acid, 0.5% acetyl hexapeptide-8, 0.3% acetyl hexapeptide, 0.5% sodium hyaluronate, 0.2% allantoin, 0.15% dipotassium glycyrrhizate, 0.15% ergothioneine, 0.3% ectoine, 0.05% retinol, 0.5% p-hydroxyacetophenone, 0.15% chlorphenesin, 0.5% 1,2-hexanediol, 0.3% Centella asiatica extract, and 0.25% calendula extract.

[0022] Among them, yeast fermentation product filtrate, lactobacillus fermentation product and lactobacillus / ginseng root fermentation product filtrate constitute the main bioactive system, which, together with rose water and centella asiatica and calendula extracts, achieve skin soothing, barrier repair and anti-inflammatory and calming effects; multiple moisturizers and antioxidants work together to build a stable anhydrous system.

[0023] The preparation method is as follows:

[0024] Environmental and equipment pretreatment: The relative humidity of the production environment is controlled below 45% and the temperature is controlled below 25℃. The mixing tank, pipelines and spray filling equipment are dried and dehumidified to avoid the introduction of free moisture into the system.

[0025] Construction of moisturizing and penetrating system: Add propylene glycol, butylene glycol, dipropylene glycol and hydroxypropyl tetrahydropyrantriol to a clean mixing tank, and stir at 600-800 rpm for 10-15 min to form a homogeneous and transparent small molecule penetrating moisturizing system.

[0026] Anti-wrinkle activity pre-dissolution treatment: Take a portion of dipropylene glycol or propylene glycol as a solvent to dissolve retinol to form a mother liquor, and slowly add it to the moisturizing penetration system under light-protected conditions, and stir continuously for 5 minutes to fully disperse the retinol.

[0027] Add the water-soluble functional ingredients in sequence: Add nicotinamide, tranexamic acid, 3-o-ethyl ascorbic acid, ergothioneine, ectoine, acetyl hexapeptide-8, acetyl hexapeptide, sodium hyaluronate, allantoin and dipotassium glycyrrhizate in that order. Stir for 3-5 minutes after each addition until completely dissolved.

[0028] Construction of fermentation active system: Add yeast fermentation product filtrate, lactobacillus fermentation product and lactobacillus / ginseng root fermentation product filtrate to the above system, and stir slowly at 400-600 rpm for 10 min to ensure that the bioactive components are fully and evenly dispersed.

[0029] Soothing plant ingredient dispersion: Centella asiatica extract and calendula extract are added and homogenized at high speed (8000-12000 rpm) for 10-15 minutes to form a stable dispersion system of plant active ingredients.

[0030] Establishment of stabilization and preservation system: Add p-hydroxyacetophenone, chlorphenesin and 1,2-hexanediol, and continue stirring for 5 minutes to form a complex antibacterial and stabilizing system;

[0031] Ultrasonic degassing and fine filtration: The obtained system is ultrasonically treated for 5-10 minutes to eliminate microbubbles and aggregated particles, and then filtered through a 0.22μm filter membrane to obtain a clear and transparent spray liquid;

[0032] Filling and sealing: Under light-protected conditions, the spray liquid is filled into an anhydrous spray bottle and sealed to obtain an anhydrous spray product with soothing, repairing, antioxidant, and anti-wrinkle firming effects.

[0033] Example 2

[0034] The traditional water-based soothing spray has the following formula by weight percentage: deionized water 65.0%, glycerin 8.0%, butylene glycol 5.0%, propylene glycol 4.0%, yeast ferment filtrate 5.0%, lactobacillus ferment filtrate 3.0%, rose water 5.0%, centella asiatica extract 1.0%, calendula extract 1.0%, nicotinamide 1.0%, 3-o-ethyl ascorbic acid 0.5%, p-hydroxyacetophenone 0.4%, phenoxyethanol 1.1%;

[0035] The preparation method is as follows: after mixing and dissolving the aqueous raw materials, the active ingredients and the preservative system are added in sequence, and after stirring evenly, the mixture is directly filled into a spray product.

[0036] Because it contains a large amount of aqueous components, the system has high water activity, and the active substances are prone to degradation, making it a highly susceptible preservative system to microbial contamination. At the same time, most of the active ingredients have poor stability in the aqueous phase, and their antioxidant capacity and soothing effect decrease significantly after a period of storage. Furthermore, its transdermal absorption efficiency is lower than that of the waterless spray of this invention.

[0037] Example 3

[0038] Anhydrous spray, but without a small molecule transdermal synergistic system, its formula by mass percentage is: silicone oil (cyclopentamethoxysiloxane) 40.0%, isododecane 25.0%, vegetable oil esters 20.0%, yeast fermentation product oil dispersion 5.0%, fat-soluble vitamin E 1.0%, fragrance 0.5%, antioxidant 0.3%, the remainder being additives;

[0039] The preparation method is as follows: mix and stir the various oil phase raw materials, homogenize them, and then directly fill them into a spray product;

[0040] Although it is an anhydrous system, it is mainly composed of an oil phase and lacks a transdermal delivery system composed of small molecule polyols. This makes it difficult for fermentation products and functional ingredients to effectively penetrate into the deep stratum corneum. After use, the skin feels greasy, absorption is slow, and the soothing, repairing and antioxidant effects are significantly weaker than the product of this invention.

[0041] Example 1: Complete formula (containing fermentation products + nicotinamide + 3-o-ethyl ascorbic acid + tranexamic acid + acetyl hexapeptide-8 + sodium hyaluronate + soothing ingredients) waterless spray;

[0042] Example 2: Acetyl hexapeptide-8 and sodium hyaluronate were removed, while the remaining components remained unchanged;

[0043] Example 3: The fermentation product system (yeast fermentation product filtrate, lactobacillus fermentation product, lactobacillus / ginseng root fermentation product filtrate) was removed, while the remaining components remained unchanged;

[0044] The comparative tests are as follows:

[0045] Test Project Example 1 Example 2 Example 3 Test Project Increase in stratum corneum moisture content (%) 38.6 24.3 21.7 Increase in stratum corneum moisture content (%) Skin elasticity improvement rate (%) 26.9 12.8 15.3 Skin elasticity improvement rate (%) Fine line improvement rate (%) 23.4 9.6 11.2 Fine line improvement rate (%) The rate of decrease in the erythema index (%) 31.5 18.4 13.9 The rate of decrease in the erythema index (%) Incidence of skin irritation (%) 0 3.3 6.7 Incidence of skin irritation (%)

[0046] Comparing the test results of Example 1 with Examples 2 and 3, it can be seen that Example 1 is significantly better than the two comparative examples in key skin care indicators such as the improvement rate of stratum corneum moisture content, the improvement rate of skin elasticity, the improvement rate of fine lines, and the reduction rate of erythema index. This indicates that the introduction of acetyl hexapeptide-8 and sodium hyaluronate can significantly improve skin firmness and anti-wrinkle effect. The fermentation product system plays an important role in promoting skin soothing repair and barrier stability. Example 2, due to the lack of anti-wrinkle and firming ingredients, shows a significant decrease in its effects on improving elasticity and fine lines. Example 3, due to the lack of the fermentation product active system, is weaker in terms of soothing repair and overall stability, and the incidence of irritation is increased. Further stability tests show that Example 1 still maintains a good appearance and a high retention rate of active ingredients under high temperature storage conditions, demonstrating the advantages of the anhydrous system combined with the polyol synergistic stabilization system. Therefore, the anhydrous spray of the present invention has a significant synergistic effect in soothing repair, anti-oxidation, and anti-wrinkle firming, and is suitable for the industrial application of functional skin spray products.

[0047] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A waterless soothing and repairing spray based on small molecule transdermal technology, characterized in that: By weight percentage, it comprises the following components: 28-38% yeast fermentation product filtrate, 12-22% Lactobacillus fermentation product, 0.5-1.5% Lactobacillus / ginseng root fermentation product filtrate, 8-18% rose water, 6-12% propylene glycol, 6-10% butylene glycol, 0.5-2% dipropylene glycol, 1-3% hydroxypropyl tetrahydropyrantriol, 1-3% nicotinamide, 0.5-2% tranexamic acid, 0.5-2% 3-o-ethyl ascorbic acid, and acetyl hexapeptide-8. 0.2-0.8%, Acetyl hexapeptide 0.1-0.5%, Sodium hyaluronate 0.2-1%, Allantoin 0.1-0.3%, Dipotassium glycyrrhizate 0.1-0.3%, Ergothioneine 0.05-0.3%, Ectoin 0.1-0.5%, Retinol 0.01-0.1%, p-hydroxyacetophenone 0.3-0.7%, Chlorphenesin 0.1-0.2%, 1,2-Hexanediol 0.3-1%, Centella asiatica extract 0.1-0.5%, Calendula officinalis extract 0.1-0.5%.

2. The waterless soothing and repairing spray based on small molecule transdermal technology according to claim 1, characterized in that: By weight percentage, it comprises the following components: 32.0% yeast fermentation product filtrate, 17.0% Lactobacillus fermentation product, 1.0% Lactobacillus / ginseng root fermentation product filtrate, 14.0% rose water, 10.0% propylene glycol, 8.0% butylene glycol, 1.0% dipropylene glycol, 2.0% hydroxypropyl tetrahydropyrantriol, 2.0% nicotinamide, 1.0% tranexamic acid, 1.0% 3-o-ethyl ascorbic acid, 0.5% acetyl hexapeptide-8, 0.3% acetyl hexapeptide, 0.5% sodium hyaluronate, 0.2% allantoin, 0.15% dipotassium glycyrrhizate, 0.15% ergothioneine, 0.3% ectoine, 0.05% retinol, 0.5% p-hydroxyacetophenone, 0.15% chlorphenesin, 0.5% 1,2-hexanediol, 0.3% Centella asiatica extract, and 0.25% calendula extract.

3. A method for preparing an anhydrous soothing and repairing spray based on small molecule transdermal technology as described in claim 1, characterized in that: Includes the following steps: S1 Dissolution and Premixing: Under anhydrous conditions, propylene glycol, butylene glycol, dipropylene glycol and hydroxypropyl tetrahydropyrantriol are mixed and stirred to form a humectant mixture; S2 active component addition: Add nicotinamide, tranexamic acid, 3-o-ethyl ascorbic acid, ergothioneine, ectoine, acetyl hexapeptide-8, acetyl hexapeptide, sodium hyaluronate, allantoin and dipotassium glycyrrhizate in sequence, and stir until completely dissolved. S3 Fermentation Product Mixing: Before adding the fermentation products, retinol is pre-dissolved in a portion of dipropylene glycol or propylene glycol to form a mother liquor, which is then slowly added to the system to improve its dispersion stability and avoid photothermal degradation. Yeast fermentation product filtrate, lactobacillus fermentation product and lactobacillus / ginseng root fermentation product filtrate are added to the system and slowly stirred until homogeneous. S4 Plant Extract Addition: Continue to add Centella Asiatica extract and Calendula extract, ensuring they are fully dispersed in the system; S5 stabilization system establishment: p-hydroxyacetophenone, chlorophenoxyacetophenone and 1,2-hexanediol were added as preservatives and system stabilizers; S6 Homogenization and Ultrasonic Dispersion: A clear and transparent spray liquid is obtained through high-speed homogenization and ultrasonic dispersion. S7 Filling and Packaging: The obtained liquid is poured into a sealed spray bottle and stored away from light to obtain the finished product.

4. The method for preparing the waterless spray with soothing, repairing, and antioxidant effects according to claim 3, characterized in that: In S2, the preferred order of addition of the active components is: nicotinamide → tranexamic acid → 3-o-ethyl ascorbic acid → ergothioneine → ectoine → acetyl hexapeptide-8 → acetyl hexapeptide → sodium hyaluronate → allantoin → dipotassium glycyrrhizate.

5. The preparation method of the anhydrous soothing and repairing spray based on small molecule transdermal technology according to claim 3, characterized in that: In S6, the homogenization process is carried out at a speed of 8000–12000 rpm for 10–20 minutes; the ultrasonic dispersion time is 5–15 minutes.

6. The preparation method of the anhydrous soothing and repairing spray based on small molecule transdermal technology according to claim 3, characterized in that: During the preparation process, the ambient temperature is kept no higher than 25°C and the relative humidity is kept below 50%.