A method for detecting starch content in sucrose ferric hydroxide and its application

By combining reversed-phase high-performance liquid chromatography (RP-HPLC) with a specific mobile phase, the accuracy problem in detecting starch content in sucrose ferric hydroxide was solved, achieving efficient and stable detection of starch content, which is suitable for quality control of sucrose ferric hydroxide.

CN122306965APending Publication Date: 2026-06-30上海药坦药物研究开发有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海药坦药物研究开发有限公司
Filing Date
2024-12-27
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing methods for detecting starch content in sucrose ferric hydroxide have problems such as large errors, complex operation and poor sensitivity, especially the iodine titration method and colorimetric method, which are difficult to accurately determine starch content.

Method used

The starch content in sucrose ferric hydroxide was calculated using reversed-phase high-performance liquid chromatography (RP-HPLC) with an amino column and a mobile phase of a specific ratio (ammonia-acetonitrile-water) combined with the external standard method. Sucrose was removed by hydrolysis and filtration, and glucose was used as an internal standard for detection.

Benefits of technology

It achieves accurate quantification of starch content, and the detection results show good symmetry of glucose peak shape and baseline stability. The detection method is stable and reliable, and is suitable for the quality control of sucrose ferric hydroxide.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention discloses a method and application for detecting starch content in sucrose ferric hydroxide. The method provides a way to detect starch in sucrose ferric hydroxide. This method can indirectly quantify starch by accurately quantifying glucose, eliminating interference from the sample solution matrix on glucose peaks. Furthermore, the glucose peaks obtained by this method exhibit good symmetry, baseline stability, accuracy, and stability.
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