A stomach-nourishing honeyed pill comprising a volatile oil inclusion technique and a preparation method thereof

Abstract

This invention relates to the preparation of stomach-nourishing honey pills, specifically to a stomach-nourishing honey pill incorporating volatile oil technology and its preparation method, comprising the following components by weight: 2-6 parts refined honey, 0.5-1.5 parts dried tangerine peel, 0.2-1.0 parts lily bulb, 0.2-1.0 parts Japanese raisin tree fruit, 0.2-1.0 parts peppermint, 0.3-1.0 parts yam, 0.1-0.8 parts poria cocos, 0.2-1.0 parts citronella, 0.2-1.0 parts jujube, and 0.2-1.0 parts chicken gizzard lining. This invention addresses the problem of volatile oils being easily lost during the pill-making and storage processes, resulting in a short shelf life and expiration date for the honey pills.

Description

Technical Field

[0001] This invention relates to the preparation of stomach-nourishing honey pills, specifically to a stomach-nourishing honey pill incorporating volatile oil technology and its preparation method. Background Technology

[0002] Stomach-nourishing honey pills are a common type of traditional Chinese medicine honey pills, which have the effects of strengthening the spleen and replenishing qi, nourishing the stomach and harmonizing the stomach.

[0003] Traditional formulas often involve directly grinding stomach-nourishing ingredients into powder for consumption. The resulting fibrous texture is difficult to swallow. Furthermore, the volatile oils in the formulas, such as peppermint, dried tangerine peel, and bergamot, are key components for regulating qi and the stomach. However, these oils are easily lost during the traditional grinding process and storage, leading to a short shelf life and effective shelf life for the honey pills. Summary of the Invention

[0004] The purpose of this invention is to provide a stomach-nourishing honey pill containing volatile oil encapsulation technology and its preparation method, which solves the problem that volatile oil is easily lost during the pill-making and storage process, resulting in a short storage period and shelf life of the honey pill.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0006] A stomach-nourishing honey pill incorporating volatile oils comprises the following ingredients in parts by weight: 2-6 parts refined honey, 0.5-1.5 parts dried tangerine peel, 0.2-1.0 parts lily bulb, 0.2-1.0 parts Japanese raisin tree fruit, 0.2-1.0 parts peppermint, 0.3-1.0 parts Chinese yam, 0.1-0.8 parts Poria cocos, 0.2-1.0 parts Buddha's hand, 0.2-1.0 parts jujube, and 0.2-1.0 parts chicken gizzard lining.

[0007] A further technical solution includes the following ingredients in parts by weight: 4 parts refined honey, 1 part dried tangerine peel, 0.5 parts lily bulb, 0.5 parts Japanese raisin tree fruit, 0.5 parts peppermint, 0.6 parts yam, 0.4 parts poria cocos, 0.5 parts citron, 0.5 parts jujube, and 0.5 parts chicken gizzard lining.

[0008] A method for preparing a stomach-nourishing honey pill incorporating volatile oil encapsulation technology includes the following steps:

[0009] S1. Extraction of volatile oils from peppermint, dried tangerine peel, and bergamot;

[0010] S2. The extracted volatile oil is then encapsulated.

[0011] S3. The volatile oil after the encapsulation treatment is allowed to stand and dry to obtain volatile oil-β-CD inclusion complex powder.

[0012] S4. The peppermint, dried tangerine peel, Buddha's hand, yam, poria, jujube, chicken gizzard lining, lily and Japanese raisin tree fruit that have had their volatile oils extracted are dried. After drying, the above medicinal materials are pulverized to 200 mesh using a cell wall pulverizer to obtain pulverized medicinal powder.

[0013] S5. Mix the obtained volatile oil-β-CD inclusion complex powder with the pulverized medicinal powder and refined honey evenly to make honey pills;

[0014] S6. The prepared honey pills are placed into honey pill shells, sealed with food-grade paraffin wax, and packaged in boxes. The finished product.

[0015] A further technical solution is that the volatile oil extraction in step S2 involves taking peppermint, dried tangerine peel, and bergamot, crushing them through a 10-mesh sieve, and then performing low-temperature critical extraction at 25-30 MPa and 50-55℃ for 2-2.5 hours with a CO2 flow rate of 20 L / h to obtain a clear, yellow-brown volatile oil, which is then sealed and bottled.

[0016] A further technical solution is that, in step S2, the encapsulation treatment uses β-cyclodextrin (β-CD) as the encapsulating agent, with an oil-to-solid ratio of β-CD:volatile oil = 8:1-10:1 (g:mL). β-CD is added to purified water at a ratio of β-CD:water = 1:10-1:15 (g:mL), heated to 45-55℃ to dissolve it, and a saturated solution is prepared. A high-shear dispersing emulsifier is then turned on at a speed of 9000 to 10000 r / min, and the volatile oil is slowly dripped into the saturated β-CD solution. The mixture is then sheared and stirred at 40-55℃ for 1.5 to 3 hours.

[0017] A further technical solution is that, in step S3, the volatile oil after the encapsulation treatment is allowed to stand and dry by cooling to room temperature after stirring, and then standing overnight in a freezer at 2 to 8°C for 12 to 24 hours to allow the inclusion complex to precipitate. The inclusion complex suspension is then freeze-dried to obtain volatile oil-β-CD inclusion complex powder.

[0018] Compared with the prior art, the beneficial effects of the present invention are:

[0019] 1. The stomach-nourishing ingredients are made into honey pills, which avoids the problem of directly taking powdered medicinal materials, which are coarse and difficult to swallow. This makes the pills more palatable for patients.

[0020] 2. The extracted volatile oil in the prepared honey pills is encapsulated with β-cyclodextrin, which ensures the stable presence of the active ingredients, making the stomach-protecting effect more lasting and avoiding the slight irritation of the stomach by the volatile oil. Attached Figure Description

[0021] Figure 1This is a schematic flowchart of a method for preparing a stomach-nourishing honey pill containing volatile oil encapsulation technology according to the present invention. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0023] Example 1:

[0024] Figure 1 This invention illustrates a preferred embodiment of a stomach-nourishing honey pill containing volatile oil encapsulation technology and its preparation method. Specifically, the stomach-nourishing honey pill in this embodiment comprises the following components by weight: 2-6 parts refined honey, 0.5-1.5 parts dried tangerine peel, 0.2-1.0 parts lily bulb, 0.2-1.0 parts Japanese raisin tree fruit, 0.2-1.0 parts peppermint, 0.3-1.0 parts yam, 0.1-0.8 parts poria cocos, 0.2-1.0 parts citron, 0.2-1.0 parts jujube, and 0.2-1.0 parts chicken gizzard lining.

[0025] Specifically, the ingredients by weight can be 4 parts refined honey, 1 part dried tangerine peel, 0.5 parts lily bulb, 0.5 parts Japanese raisin tree fruit, 0.5 parts mint, 0.6 parts yam, 0.4 parts poria cocos, 0.5 parts citron, 0.5 parts jujube, and 0.5 parts chicken gizzard lining.

[0026] A method for preparing a stomach-nourishing honey pill incorporating volatile oil encapsulation technology includes the following steps:

[0027] S1. Extraction of volatile oils from peppermint, dried tangerine peel, and bergamot;

[0028] S2. The extracted volatile oil is then encapsulated.

[0029] S3. The volatile oil after the encapsulation treatment is allowed to stand and dry to obtain volatile oil-β-CD inclusion complex powder.

[0030] S4. The peppermint, dried tangerine peel, Buddha's hand, yam, poria, jujube, chicken gizzard lining, lily and Japanese raisin tree fruit that have had their volatile oils extracted are dried. After drying, the above medicinal materials are pulverized to 200 mesh using a cell wall pulverizer to obtain pulverized medicinal powder.

[0031] S5. Mix the obtained volatile oil-β-CD inclusion complex powder with the pulverized medicinal powder and refined honey evenly to make honey pills;

[0032] S6. The prepared honey pills are placed into honey pill shells, sealed with food-grade paraffin wax, and packaged in boxes. The finished product.

[0033] Specifically, in step S2, the volatile oil extraction involves taking peppermint, dried tangerine peel, and bergamot, crushing them through a 10-mesh sieve, and then performing low-temperature critical extraction at 25-30 MPa and 50-55℃ for 2-2.5 hours with a CO2 flow rate of 20 L / h to obtain a clear, yellow-brown volatile oil, which is then sealed and bottled.

[0034] In step S2, the encapsulation process uses β-cyclodextrin (β-CD) as the encapsulating agent, with an oil-to-solid ratio of β-CD:volatile oil = 8:1-10:1 (g:mL). β-CD is added to purified water at a ratio of β-CD:water = 1:10-1:15 (g:mL), and heated to 45-55℃ to dissolve it, forming a saturated solution. A high-shear dispersing emulsifier is then turned on at a speed of 9000 to 10000 r / min, and the volatile oil is slowly dripped into the saturated β-CD solution. The mixture is then sheared and stirred at 40-55℃ for 1.5 to 3 hours.

[0035] In step S3, the volatile oil after encapsulation treatment is allowed to stand and dry. After stirring, it is cooled to room temperature and left to stand overnight in a freezer at 2 to 8°C for 12 to 24 hours to allow the inclusion complex to precipitate. The inclusion complex suspension is then freeze-dried to obtain volatile oil-β-CD inclusion complex powder.

[0036] The ingredients used in this invention are yam, poria cocos, tangerine peel, and bergamot to invigorate the spleen and regulate qi; chicken gizzard to aid digestion; and jujube to relieve hangovers and protect the stomach. Combined with honey and jujube, this combination has the effects of invigorating the spleen, regulating qi, aiding digestion, and protecting the stomach.

[0037] Implement Column 2:

[0038] The prepared stomach-nourishing honey pills were used in a human trial. Specifically, the subjects were individuals aged 18-65 years with functional dyspepsia (symptoms such as loss of appetite, early satiety, and abdominal distension), excluding those with organic diseases. The sample size was at least 50 cases per group, with at least 50 cases in each of the experimental and control groups. The subjects were randomly assigned to either the stomach-nourishing honey pill group or the placebo group. Data were collected using a clinical symptom scoring method, as shown in Table 1.

[0039] Table 1:

[0040] Before treatment, there were no significant differences in symptom scores between the two groups (P>0.05). After treatment, the scores for epigastric pain in the honey pill group decreased from 2.15=0.62 to 0.85+0.43, loss of appetite from 2.32+0.58 to 0.92+0.51, and abdominal distension from 2.08=0.55 to 0.78=0.42, all significantly lower than those in the placebo group (P<0.01). The proportion of patients with a ≥50% decrease in total clinical symptom score in the stomach-nourishing honey pill group was 76.0%, significantly higher than the 22.0% in the placebo group (P<0.01).

[0041] The clinical efficacy rate of the Yangwei Miwan group was 94.0% (47 / 50), which was significantly higher than that of the placebo group (22.0% (11 / 50) (P<0.01).

[0042] Excellent human trial results: In a clinical observation of 60 subjects with functional dyspepsia, the total effective rate of the honey pills of this invention reached 94.0%, which can significantly improve symptoms such as stomach pain, loss of appetite, and abdominal distension (P<0.01), increase gastric emptying rate by 22.5%, decrease GSRS score by 53.6%, and have no adverse reactions.

[0043] To examine the effect of volatile oil encapsulation, the same formula was used to directly pulverize the medicinal materials, add refined honey, and make them into pills. These pills were then placed in an accelerated stability chamber for comparative accelerated stability testing (conditions: temperature 37.5℃, relative humidity 75%), as shown in Table 2.

[0044] Table 2: .

[0045] Conclusion: After three months of accelerated stabilization using β-cyclodextrin inclusion technology, the volatile oil retention rate was 60%, while that of the control was 0%, thus proving that the process significantly improved the product stability.

[0046] Although the invention has been described herein with reference to several illustrative embodiments, it should be understood that many other modifications and implementations can be devised by those skilled in the art, which will fall within the scope and spirit of the principles disclosed herein. More specifically, various variations and modifications can be made to the components and / or layout of the subject matter arrangement within the scope of the disclosure, drawings, and claims. Besides variations and modifications to the components and / or layout, other uses will be apparent to those skilled in the art.

Claims

1. A stomach-friendly honey pill comprising a volatile oil inclusion technology, characterized by, It includes the following ingredients by weight: 2-6 parts refined honey, 0.5-1.5 parts dried tangerine peel, 0.2-1.0 parts lily bulb, 0.2-1.0 parts Japanese raisin tree fruit, 0.2-1.0 parts peppermint, 0.3-1.0 parts yam, 0.1-0.8 parts poria cocos, 0.2-1.0 parts citron, 0.2-1.0 parts jujube, and 0.2-1.0 parts chicken gizzard lining.

2. The method for preparing a stomach-nourishing honey pill incorporating volatile oil according to claim 1, characterized in that, The ingredients include the following components by weight: 4 parts refined honey, 1 part dried tangerine peel, 0.5 parts lily bulb, 0.5 parts Japanese raisin tree fruit, 0.5 parts peppermint, 0.6 parts yam, 0.4 parts poria cocos, 0.5 parts citron, 0.5 parts jujube, and 0.5 parts chicken gizzard lining.

3. A stomach-nourishing honey pill comprising volatile oil encapsulation technology as described in claim 1, characterized in that, Includes the following steps: S1. Extract volatile oils from peppermint, dried tangerine peel, and bergamot; S2. Encapsulate the extracted volatile oils; S3. Allow the encapsulated volatile oils to stand and dry to obtain volatile oil-β-CD inclusion complex powder; S4. Dry the peppermint, dried tangerine peel, bergamot, yam, poria cocos, jujube, chicken gizzard lining, lily bulb, and Japanese raisin tree fruit after volatile oil extraction, and then pulverize the above medicinal materials to 200 mesh using a cell-wall breaking pulverizer to obtain pulverized medicinal powder; S5. Mix the obtained volatile oil-β-CD inclusion complex powder, pulverized medicinal powder, and refined honey evenly to make honey pills; S6. Fill the prepared honey pills into honey pill shells, seal them with food-grade white wax, and pack them into packaging boxes to obtain the finished product.

4. The method for preparing a stomach-nourishing honey pill incorporating volatile oil according to claim 3, characterized in that: In step S2, the volatile oil is extracted by taking peppermint, dried tangerine peel, and bergamot, crushing them through a 10-mesh sieve, and then performing low-temperature critical extraction at 25-30 MPa and 50-55℃ for 2-2.5 hours with a CO2 flow rate of 20 L / h to obtain a clear, yellow-brown volatile oil, which is then sealed and bottled.

5. The method for preparing a stomach-nourishing honey pill incorporating volatile oil according to claim 4, characterized in that: In step S2, the encapsulation process uses β-cyclodextrin (β-CD) as the encapsulating agent, with an oil-to-solid ratio of β-CD:volatile oil = 8:1-10:1 (g:mL). β-CD is added to purified water at a ratio of β-CD:water = 1:10-1:15 (g:mL), and heated to 45-55℃ to dissolve it, forming a saturated solution. A high-shear dispersing emulsifier is then turned on at a speed of 9000 to 10000 r / min, and the volatile oil is slowly dripped into the saturated β-CD solution. The mixture is then sheared and stirred at 40-55℃ for 1.5 to 3 hours.

6. The method for preparing a stomach-nourishing honey pill incorporating volatile oil encapsulation technology according to claim 5, characterized in that: In step S3, the volatile oil after encapsulation treatment is allowed to stand and dry. After stirring, it is cooled to room temperature and left to stand overnight in a freezer at 2 to 8°C for 12 to 24 hours to allow the inclusion complex to precipitate. The inclusion complex suspension is then freeze-dried to obtain volatile oil-β-CD inclusion complex powder.

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