Flexible electrode array, system and method of manufacturing for closed-loop neuromodulation

By designing high-density matrix recording sites and coplanar stimulation sites on a flexible biocompatible substrate, combined with an external control unit, the problems of low recording resolution and spatiotemporal lag in existing technologies are solved, achieving efficient and stable closed-loop neural modulation.

CN122321341APending Publication Date: 2026-07-03SHANGHAI JINNAO MEDICAL TECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI JINNAO MEDICAL TECHNOLOGY CO LTD
Filing Date
2026-06-02
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing flexible electrode arrays suffer from problems such as low recording resolution, spatiotemporal lag between stimulus and recording sites, and poor biocompatibility in neural modulation, making it difficult to achieve efficient closed-loop neural modulation.

Method used

A flexible biocompatible substrate is used to design high-density matrix recording sites and coplanar stimulation sites. Combined with an external control unit, dynamic stimulation parameters can be adjusted, and the electrode array is fabricated using micro-nano fabrication technology.

Benefits of technology

It improves the spatial resolution of neurophysiological signals, shortens the spatiotemporal distance between stimulation and monitoring, enhances biocompatibility and stability, and realizes real-time and precise closed-loop neural modulation.

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Abstract

This invention discloses a flexible electrode array, system, and manufacturing method for closed-loop neural modulation, relating to the fields of neural engineering, medical devices, and biosensor technologies. The flexible electrode array includes a flexible biocompatible substrate, a recording electrode array, and a stimulating electrode array. The recording sites are arranged in a matrix, and the stimulating sites are coplanar with the recording sites, located between or within rows of the recording electrode array, achieving a spatially co-located layout of recording and stimulation. The system also includes an external control unit for receiving neural signals acquired by the recording electrode array and dynamically adjusting the stimulation parameters applied to the stimulating electrode array based on the neural signals. This application improves biocompatibility, achieves high-resolution signal mapping, and enables efficient closed-loop neural modulation by shortening the spatiotemporal distance between stimulation and monitoring.
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