Compounds with broad-spectrum antifungal activity and plant-induced resistance and methods of use

By developing compounds 2,4-dibromo-6-nitrophenol and 7-denitr-2'-deoxy-7-iodoadenosine, which have broad-spectrum antifungal activity, the problem of traditional plant inducers needing to be applied in advance before the onset of disease has been solved, achieving full-cycle control and treatment of rice blast.

CN122355834APending Publication Date: 2026-07-10SHANDONG ACADEMY OF AGRICULTURAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG ACADEMY OF AGRICULTURAL SCIENCES
Filing Date
2026-04-23
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Traditional plant antagonists need to be applied in advance before the onset of disease, which makes it difficult to meet the needs of disease control throughout the entire life cycle in the field. They also lack direct antibacterial or bactericidal effects, resulting in limited control effectiveness.

Method used

The compounds 2,4-dibromo-6-nitrophenol and 7-denitr-2'-deoxy-7-iodoadenosine, which possess both broad-spectrum antifungal activity and plant-induced resistance, were developed for foliar application in rice at the four-leaf stage to prevent and treat rice blast after the disease develops, directly inhibiting pathogen growth and enhancing plant resistance.

Benefits of technology

It achieves full-cycle control of rice blast, with both preventive and curative effects, and is not limited by the speed of plant immune response, providing immediate chemical protection.

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Abstract

This invention provides compounds and methods of application that possess both broad-spectrum antifungal activity and plant-induced resistance, belonging to the field of agricultural technology. It addresses the problem that "traditional pure immune inducers must be applied before disease onset, making it difficult to meet the full-cycle control needs of disease prevention and treatment in the field." Compared to the previously developed PC1 and PC20, the two compounds of this invention, 2,4-dibromo-6-nitrophenol and 7-deazon-2'-deoxy-7-iodoadenosine, can both inhibit the growth of rice blast fungus and significantly improve rice resistance to rice blast through foliar spraying, meeting the full-cycle control needs of disease prevention and treatment in the field. Furthermore, these two compounds can directly inhibit the growth of various fungal pathogens such as peanut white mold, tomato gray mold, wheat scab, rice bakanae disease, rice false smut, mango malformation, and banana wilt.
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