Technetium-99m production system and methods of use and applications thereof

Abstract

This invention provides a technetium-99m preparation system, its usage method, and its applications. The system includes a reaction module and a purification module. The reaction module includes an electron beam channel, a shell, and a gamma photon fabrication unit inside the shell, forming a Mo-containing solution region between the shell and the gamma photon fabrication unit. The gamma photon fabrication unit is used to produce gamma photons, and the Mo-containing solution region is used to contain the Mo-containing solution and carry out the reaction. The gamma photon fabrication unit includes a metal outer layer and at least one target plate disposed inside the metal outer layer. The electron beam channel penetrates the shell and connects to the metal outer layer of the gamma photon fabrication unit. The Mo-containing solution region and the purification module also include a circulation loop. The mixture generated in the Mo-containing solution region is passed through the circulation loop into the purification module for purification to form a technetium-99m separation solution and a Mo separation solution. The Mo separation solution is returned to the Mo-containing solution region through the circulation loop. By using the technetium-99m preparation system provided by this invention, low-cost and high-efficiency production of technetium-99m can be achieved.

Description

Technical Field

[0001] This invention relates to a preparation system for technetium-99m, its method of use, and its application. Background Technology

[0002] Technetium-99m is one of the most widely used radioactive isotopes in nuclear medicine diagnostics. Its ideal physical and chemical properties make it irreplaceable in single-photon emission computed tomography (SPECT). With a half-life of only 6.02 hours, Technetium-99m decays rapidly, releasing gamma rays with an energy of 140 keV. These gamma rays can be detected by SPECT scanners, generating high-resolution images of internal organs.

[0003] High-energy electron accelerator irradiation of molybdenum-100 is one of the effective ways to obtain technetium-99m. The combination of enriched target material and high-energy electron accelerator provides an innovative path for technetium-99m supply that avoids reactorization and high-enrichment. A high-energy electron beam (energy ≥30 MeV) bombards a primary target of high atomic number materials (such as tungsten, tantalum, etc.), generating bremsstrahlung and producing high-energy gamma photons with energies ranging from several MeV to tens of MeV. These high-energy gamma photons react with enriched molybdenum-100, undergoing a (γ,n) reaction to generate molybdenum-99, with a reaction threshold energy of approximately 8 MeV. The reaction cross-section σ is maximized (approximately 150 mb) when the gamma ray energy reaches 14.5 MeV. Molybdenum-99 then undergoes its own β-reaction... - The decay produces technetium-99m, and molybdenum-99 has a half-life of 66 hours.

[0004] The production of technetium-99m using electron accelerator irradiation of molybdenum-100 also faces the following challenges: (1) The irradiation target sheet is usually thin, and high-energy gamma rays can easily penetrate the molybdenum target, causing ineffective gamma ray loss, which is not conducive to increasing the yield of technetium-99m; the specific activity of molybdenum-99 produced by single-batch irradiation of molybdenum-100 is low, which is not suitable for existing molybdenum-technetium generators, and a large amount of molybdenum-100 is lost during the recovery-target preparation process, which in turn increases the cost of technetium-99m. Therefore, how to ensure a stable supply of technetium-99m is a major problem for medical diagnosis and treatment using medical radionuclides. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to overcome the defects of high cost and low yield in the preparation of technetium-99m in the prior art, and to provide a system for preparing technetium-99m and its application.

[0006] The present invention solves the above-mentioned technical problems through the following technical solution: In a first aspect, the present invention provides a preparation system for technetium-99m, which includes a reaction module and a purification module; The reaction module includes an electron beam channel, a housing, and a gamma photon manufacturing unit disposed inside the housing. A Mo-containing solution region is formed between the housing and the gamma photon manufacturing unit. The gamma photon manufacturing unit is used to manufacture gamma photons, and the Mo-containing solution region is used to contain the Mo-containing solution and carry out the reaction. The gamma photonic manufacturing unit includes a metal outer layer and at least one target sheet disposed inside the metal outer layer. The electron beam channel passes through the outer shell and is connected to the metal outer layer of the gamma photonic manufacturing unit. The Mo-containing solution zone is connected to the purification module via a circulation loop. The outlet of the Mo-containing solution zone is connected to the inlet of the purification module via the circulation loop, and the outlet of the purification module is connected to the inlet of the Mo-containing solution zone via the circulation loop. The mixture generated in the Mo-containing solution zone is passed through the circulation loop into the purification module for purification to form Technetium-99m separation liquid and Mo separation liquid. The Mo separation liquid is returned to the Mo-containing solution zone via the circulation loop. The thickness of the Mo-containing solution region is 200 mm or more; An electron accelerator is connected to the electron beam channel, and the electron accelerator is used to generate an electron beam.

[0007] In this invention, the Mo-containing solution refers to an aqueous solution prepared with a molybdenum-soluble compound as the solute and water as the solvent, wherein Mo is uniformly dispersed in the solution in the form of ions.

[0008] In this invention, the thickness refers to the path length traversed by a gamma photon along its emission direction after being emitted from the gamma photon manufacturing unit. For example, the thickness of the Mo-containing solution region refers to the path length of a gamma photon passing through the Mo-containing solution region along its emission direction after being emitted from the gamma photon manufacturing unit.

[0009] In this invention, the target sheet can be made of one or more of tungsten, tantalum and molybdenum, preferably tungsten or tungsten plated with tantalum.

[0010] In this invention, each target sheet may be disposed perpendicularly to the direction in which the electron beam channel extends.

[0011] In this invention, the number of target pieces can be 1 to 10, for example, 4.

[0012] Preferably, the plurality of target sheets are arranged in a direction extending along the electron beam channel.

[0013] Preferably, the vertical distance between adjacent target pieces is equal.

[0014] Preferably, the vertical distance between adjacent target pieces is 0.5 to 2 mm, for example, 1 mm.

[0015] In this invention, the thickness of the target sheet can be 0.5~5 mm, for example, 1 mm.

[0016] In this invention, the target sheet may be circular in shape.

[0017] In this invention, the diameter of the target sheet is preferably 10-200 mm, for example 50 mm.

[0018] In this invention, in the gamma photonic manufacturing unit, a cooling zone can be formed between the outer metal layer and the target sheet. The cooling zone has a built-in circulation pipeline, which consists of a cooling water circuit and a water circuit shell.

[0019] The cooling water in the cooling water circuit can be deionized water.

[0020] The temperature at the inlet of the cooling water into the cooling water circuit can be 20~50℃, for example, 30℃.

[0021] The temperature of the cooling water at the outlet of the cooling water circuit can be 50~99℃, for example, 85℃.

[0022] In this invention, the outer shell material of the water circuit can be selected from one or more of aluminum, copper, and aluminum alloys, for example, copper.

[0023] In this invention, the thickness of the outer shell material of the water circuit can be 0.5~2 mm, for example, 1 mm.

[0024] In this invention, the material of the outer shell can be a conventional corrosion-resistant metal and / or corrosion-resistant alloy in the art, preferably selected from one or more of copper, stainless steel and aluminum alloy, such as stainless steel.

[0025] The thickness of the outer shell can be 80-150 mm, for example, 100 mm.

[0026] In this invention, the reaction module may further include a neutron shielding layer, a gamma shielding layer, and a metal inner layer, wherein the outer shell, the neutron shielding layer, the gamma shielding layer, and the metal inner layer are arranged sequentially from the outside to the inside, and the Mo-containing solution region is formed between the metal inner layer and the metal outer layer.

[0027] Preferably, the material of the neutron shielding layer is boron-containing polyethylene neutron shielding material or boron-containing lead brick neutron shielding material, and more preferably boron-containing polyethylene neutron shielding material, for example, boron-containing polyethylene neutron shielding material with boron content accounting for 20% of the total mass.

[0028] Preferably, the thickness of the neutron shielding layer is 80-150 mm, for example, 100 mm.

[0029] Preferably, the material of the gamma shielding layer is selected from one or more of tungsten, lead, and lead-containing concrete, for example, lead.

[0030] Preferably, the thickness of the gamma shielding layer is 150~300 mm, for example 200 mm.

[0031] Preferably, the material of the inner metal layer is selected from one or more of copper, stainless steel and aluminum alloy, for example, copper.

[0032] In this invention, the container containing the Mo solution is cylindrical, and the diameter of the cylinder can be 200~1500 mm, for example, 1000 mm.

[0033] In this invention, the height of the cylinder can be 200~1500 mm, for example, 1000 mm.

[0034] In this invention, the volume of the cylinder can be 0.0314~2.649 m³. 3 For example, 0.785 m 3 .

[0035] In this invention, the Mo-containing solution zone can accommodate a Mo-containing solution.

[0036] Preferably, the abundance of Mo-100 in the Mo-containing solution is 9.8% to 99.9%.

[0037] Preferably, the solute in the Mo-containing solution is sodium molybdate, and more preferably, the solubility of the sodium molybdate is 20% to 60%, for example, 40%.

[0038] In this invention, the density of the Mo-containing solution is 3.78 g / cm³. 3 .

[0039] In some embodiments of the present invention, the molybdenum material is natural molybdenum, and the isotopes and their proportions are 14.5% molybdenum-92, 9.2% molybdenum-94, 15.8% molybdenum-95, 16.7% molybdenum-96, 9.6% molybdenum-97, 24.4% molybdenum-98, and 9.8% molybdenum-100.

[0040] In some preferred embodiments of the present invention, the molybdenum material is natural molybdenum, and the isotopes and their proportions are 0.1%molybdenum-92, 0.1%molybdenum-94, 0.2%molybdenum-95, 0.2%molybdenum-96, 0.1%molybdenum-97, 0.3%molybdenum-98, and 99.0%molybdenum-100, respectively.

[0041] Preferably, the solvent of the Mo-containing solution is high-purity water; more preferably, the high-purity water is high-purity water with an impurity concentration of less than 0.01 mg / L.

[0042] In this invention, the high-purity water refers to water that meets the requirements of GB / T 33087-2016, with a resistivity (25°C) of not less than 10 MΩ·cm, total organic carbon (TOC) of less than 50 μg / L, and meets specific absorbance and ion limits.

[0043] In this invention, the purification module may sequentially include a first purification unit, a second purification unit, and a third purification unit.

[0044] The first purification unit may be equipped with PEG resin for the first purification.

[0045] In this invention, the PEG resin is a three-dimensional network polymer carrier composed of cross-linked polyethylene glycol, such as PEGMatrix (R1) type PEG resin.

[0046] The second purification unit may be equipped with a cation exchange resin for a second purification process.

[0047] In this invention, the cationic resin has a cross-linked polystyrene backbone and acidic active groups bonded thereto, wherein the acidic active groups are preferably sulfonic acid groups or carboxyl groups, such as Eichrom AG 50W×8 type cationic resin.

[0048] The third purification unit may be equipped with alumina resin for a third purification.

[0049] In this invention, the alumina resin contains activated alumina as the main component, such as Waters Sep-Pak acidic alumina columns.

[0050] Preferably, the PEG resin has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; for example, the adsorption efficiency for technetium-99m is 99% and the adsorption efficiency for Mo is 1%.

[0051] Preferably, the cation exchange resin has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; Preferably, the alumina resin has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; Preferably, the Mo-containing solution zone and the first purification unit are provided with the circulation loop.

[0052] In some particularly preferred embodiments of the present invention, the technetium-99m preparation system comprises the following parts: A reaction module includes an electron beam channel, a housing, and a gamma photon fabrication unit disposed inside the housing. A Mo-containing solution region is formed between the housing and the gamma photon fabrication unit. The gamma photon fabrication unit is used to fabricate gamma photons, and the Mo-containing solution region is used to contain the Mo-containing solution and carry out the reaction. An electron accelerator is externally connected to the electron beam channel. The electron accelerator is used to generate an electron beam with an energy of 30~50 MeV, a beam current intensity of 1 mA~3.5 mA, and an electron beam spot diameter of 10~100 mm. The gamma photonic manufacturing unit includes a metal outer layer and 1 to 10 target sheets disposed inside the metal outer layer. The electron beam channel passes through the outer shell and is connected to the metal outer layer of the gamma photonic manufacturing unit. The target sheets are arranged along the direction of the electron beam channel, and the vertical distance between adjacent target sheets is equal. In the gamma photonics manufacturing unit, a cooling zone is formed between the outer metal layer and the target sheet. The cooling zone has a built-in circulation pipeline, which consists of a cooling water circuit and a water circuit shell. The cooling water in the cooling water circuit is deionized water. The shell material of the water circuit is selected from one or more of aluminum, copper, and aluminum alloys. The thickness of the shell material of the water circuit is 0.5~2 mm. The Mo-containing solution zone is connected to the purification module through the circulation loop, the outlet of the Mo-containing solution zone is connected to the inlet of the purification module through the circulation loop, and the outlet of the purification module is connected to the inlet of the Mo-containing solution zone through the circulation loop. The mixture generated in the Mo-containing solution zone is purified by passing it through the circulation loop into the purification module to form technetium-99m separation solution and Mo separation solution. The Mo separation solution is then returned to the Mo-containing solution zone through the circulation loop. The circulation loop also includes a pump for driving the flow of the mixture, the technetium-99m separation liquid, and the Mo separation liquid in the circulation loop.

[0053] Secondly, the present invention also provides a method for using the technetium-99m preparation system as described above, comprising the following steps: An electron accelerator is used to generate an electron beam, which is then passed through the electron beam channel to bombard the target sheet, continuously generating gamma photons. These gamma photons irradiate the Mo-containing solution in the Mo-containing solution region to obtain a mixed solution. The mixed solution is then passed through the circulation loop into the purification module for purification to form a technetium-99m separation solution and a Mo separation solution. The Mo separation solution is then returned to the Mo-containing solution region through the circulation loop for further irradiation.

[0054] In this invention, the electron kinetic energy of the electron beam can be 30~50 MeV, for example, 40 MeV.

[0055] In this invention, the beam current intensity of the electron beam can be 0.2~3.5 mA, for example, 1 mA.

[0056] In this invention, the diameter of the electron beam spot can be 10~100 mm, for example, 50 mm.

[0057] In this invention, the irradiation time can be more than 3 days, for example, 300 days.

[0058] In this invention, the flow rate of the mixture into the purification module via the circulation loop can be 10~500 mL / min, for example, 100 mL / min.

[0059] In this invention, the purification module sequentially includes a first purification unit, a second purification unit, and a third purification unit; the first purification unit is provided with PEG resin; the second purification unit is provided with cationic resin; the third purification unit is provided with alumina resin; the purification includes a first purification, a second purification, and a third purification performed sequentially by the first purification unit, the second purification unit, and the third purification unit.

[0060] Preferably, the first purification includes rinsing with a first eluent.

[0061] Preferably, the first rinsing solution is an alkaline solution.

[0062] The alkaline solution can be a conventional alkaline solution in the art, preferably a potassium hydroxide solution, such as a 5 M potassium hydroxide solution.

[0063] Preferably, the second purification includes rinsing with a second eluent; preferably, the second eluent is ultrapure water.

[0064] In this invention, the ultrapure water refers to water that meets the requirements of GB / T 33087-2016, with a resistivity (25°C) of not less than 18.2 MΩ·cm, a total organic carbon (TOC) of less than 10 μg / L, and meets specific absorbance and ion limits.

[0065] Preferably, the third purification includes rinsing with a third rinsing solution; preferably, the third rinsing solution is physiological saline.

[0066] Preferably, the saline solution is an aqueous sodium chloride solution, such as a 0.9% aqueous sodium chloride solution.

[0067] In this invention, the technetium-99m separation solution can be Na 99m TcO4 solution, preferably, the Na 99m TcO4 solution 99m The purity of Tc is over 99%.

[0068] Thirdly, the present invention also provides the application of the technetium-99m preparation system as described above in the preparation of medical isotopes.

[0069] The positive and progressive effects of this invention are as follows: The technetium-99m preparation system provided by this invention can produce technetium-99m in an online, efficient, convenient, and cost-effective manner based on electron accelerator irradiation of molybdenum-100 solution, effectively solving the supply and demand problem of technetium-99m and ultimately achieving low-cost and high-efficiency production of technetium-99m. Attached Figure Description

[0070] Figure 1 This is the preparation system for technetium-99m in Example 1.

[0071] Figure 2 This is a partially enlarged view of the preparation system of technetium-99m in Example 1.

[0072] The attached figures are labeled as follows: 1-Electron beam channel; 2-Gamma photonic manufacturing unit; 3-Electron Accelerator; 4-Mo-containing solution region; 5-Circular loop; 6-Pump; 7-First purification unit; 8-Alkaline solution storage tank; 9-Ultrapure water storage tank; 10 - Second purification unit; 11-Third purification unit; 12-Saline storage tank; 13-Na 99m TcO4 solution storage tank; 14-Metallic inner layer; 15- Gamma shielding layer composed of lead material; 16- Neutron shielding layer composed of boron-containing polyethylene; 17-Casing made of stainless steel.

[0073] 18-Metallic outer layer. Detailed Implementation

[0074] The present invention will be further illustrated by way of embodiments below, but the present invention is not limited to the scope of the embodiments described herein.

[0075] Example 1

[0076] This embodiment provides a preparation system for technetium-99m, which includes a reaction module and a purification module. Its specific structure is as follows: Figure 1 As shown, the reaction module is as follows Figure 2 As shown. The reaction module is connected to the purification module via circulation loop 5. The outlet of the Mo-containing solution zone 4 is connected to the inlet of the purification module via circulation loop 5, and the outlet of the purification module is connected to the inlet of the Mo-containing solution zone 4 via circulation loop 5. The molybdenum-100 aqueous solution in the Mo-containing solution zone 4 is continuously irradiated with gamma photons in the reaction module to generate a mixed solution. The mixed solution enters the purification module for purification via circulation loop 5. The purified Mo separation solution is returned to the reaction module via circulation loop 5 to continue participating in the reaction. The technetium-99m separation solution is output to the Na 99m TcO4 solution storage tank 13.

[0077] The reaction module consists of, from the outside in, a stainless steel outer shell 17, a boron-containing polyethylene neutron shielding layer 16, a lead gamma shielding layer 15, and a metal inner layer 14. The stainless steel outer shell 17 is 100 mm thick; the boron-containing polyethylene neutron shielding layer 16 has boron comprising 20% ​​of its total mass and is 100 mm thick; the lead gamma shielding layer 15 is 200 mm thick; and the metal inner layer 14 is made of copper. A Mo-containing solution region 4 is formed between the metal inner layer 14 and the metal outer layer 18 to contain a molybdenum-100 aqueous solution for the reaction. The Mo-containing solution region 4 is cylindrical with a diameter of 1000 mm, a height of 1000 mm, and a volume of 0.785 m³. The thickness of the Mo-containing solution is equal to the diameter of the cylinder (1000 mm). The density of the aqueous solution containing molybdenum-100 is 3.78 g / cm³; the solute is sodium molybdate with a solubility of 40 wt%; the solvent is high-purity water with an impurity concentration of less than 0.01 mg / L. The isotopes and their proportions in the molybdenum material are as follows: 0.1% molybdenum-92, 0.1% molybdenum-94, 0.2% molybdenum-95, 0.2% molybdenum-96, 0.1% molybdenum-97, 0.3% molybdenum-98, and 99.0% molybdenum-100.

[0078] The gamma photonics fabrication unit 2 includes a metal outer layer 18 and target sheets disposed inside the metal outer layer 18. The target sheet material is tungsten, and there are 4 target sheets, each of which is perpendicular to the extension direction of the electron beam channel. The multiple target sheets are arranged along the extension direction of the electron beam channel, and the vertical distance between adjacent target sheets is equal, with a spacing of 1 mm. Each target sheet is 1 mm thick, circular in shape, and has a diameter of 50 mm.

[0079] A cooling zone is formed between the outer metal layer 18 and the target plate. The cooling zone has a built-in circulation pipe, which consists of a cooling water circuit and a copper water circuit shell (1 mm thick). The cooling water is deionized water, with a temperature of 30°C at the inlet of the cooling water circuit and a temperature of 85°C at the outlet of the cooling water circuit.

[0080] The electron beam channel 1 passes through the stainless steel outer shell 17 and connects to the metal outer layer 18 of the gamma photonics manufacturing unit 2. An electron accelerator 3 is connected to the electron beam channel 1, and the electron beam generated by the electron accelerator 3 is injected into the gamma photonics manufacturing unit 2 along the electron beam channel 1. The electron kinetic energy of the electron beam is 40 MeV, the beam current intensity is 1 mA, and the beam spot diameter is 50 mm.

[0081] A circulation loop 5 is provided between the Mo-containing solution zone 4 and the first purification unit 7 of the purification module. A pump 6 is provided on the circulation loop 5 to drive the molybdenum-100 aqueous solution to circulate in the system. The mixture is driven by the pump 6 and enters the purification module through the circulation loop 5 at a flow rate of 100 mL / min. The purified Mo separation liquid is returned to the Mo-containing solution zone 4 through the same circulation loop 5 to continue to participate in the reaction.

[0082] The purification module sequentially includes a first purification unit 7, a second purification unit 10, and a third purification unit 11. The first purification unit 7 is equipped with PEGMatrix(R1) PEG resin, which has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; the second purification unit 10 is equipped with Eichrom AG 50W×8 (100-200 mesh) cationic resin, which has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; the third purification unit 11 is equipped with Waters Sep-Pak acidic alumina column alumina resin.

[0083] The technetium-99m preparation system provided in this embodiment is used in the following manner: Electron accelerator 3 is activated, generating an electron beam with an electron kinetic energy of 40 MeV, a beam current of 1 mA, and a beam spot diameter of 50 mm. The electron beam is injected into gamma photon fabrication unit 2 through electron beam channel 1, where it interacts with the tungsten target to continuously generate high-energy gamma photons. During the reaction, cooling water continuously circulates within the cooling zone to remove the heat generated by the target, maintaining the inlet temperature at 30°C and the outlet temperature at 85°C.

[0084] High-energy gamma photons continuously irradiated the molybdenum-100 aqueous solution in Mo-containing solution region 4 for 300 days, thereby continuously accumulating a mixture containing technetium-99m in Mo-containing solution region 4.

[0085] The mixture is pumped to the purification module by pump 6 at a flow rate of 100 mL / min through circulation loop 5, and undergoes three-step purification in sequence through the first purification unit 7, the second purification unit 10, and the third purification unit 11: First purification: The mixture passes through the first purification unit 7, where technetium-99m is selectively adsorbed by the PEG resin, and Mo is refluxed to the Mo-containing solution zone 4 via the circulation loop 5. Subsequently, the PEG resin is rinsed with an alkaline solution storage tank 8 (containing a 5 M potassium hydroxide solution) to remove trace amounts of Mo. Then, the technetium-99m in the PEG resin is eluted with an ultrapure water storage tank 9 to obtain a technetium-99m aqueous solution.

[0086] Second purification: Technetium-99m aqueous solution enters the second purification unit 10 to remove cationic impurities in the solution with a removal efficiency of 80%~99%; ultrapure water storage tank 9 is used for elution to obtain a further purified Technetium-99m solution.

[0087] Third purification: The technetium-99m solution purified in the second purification enters the third purification unit 11, where technetium-99m is adsorbed by alumina resin to further remove residual impurities; then the alumina resin is eluted in physiological saline tank 12 (0.9% sodium chloride aqueous solution) to obtain the final product.

[0088] After three purification steps, a medical-grade Na99mTcO4 solution was obtained and collected in Na99mTcO4 solution storage tank 13. In this embodiment, "medical-grade" represents the solution contained therein. 99m The purity of Tc is over 99%; the Mo separation solution is enriched with undecayed molybdenum-100 and molybdenum-99 components, and is recycled back to the Mo-containing solution zone 4 through the circulation loop 5.

[0089] Driven by pump 6, the Mo separation solution is refluxed through circulation loop 5 to the Mo-containing solution zone 4, where it mixes with the Mo-100 aqueous solution and continues to be irradiated with high-energy gamma photons to participate in the next round of reaction cycle. Through the above continuous online circulation mode, the efficient and continuous preparation of technetium-99m is achieved, with a total separation and extraction efficiency of 85%, and technetium-99m 150 Ci can be produced per day.

[0090] Example 2

[0091] The only difference between Example 2 and Example 1 is that the molybdenum material in Example 2 is natural molybdenum, and the isotopes and their proportions are 14.5% molybdenum-92, 9.2% molybdenum-94, 15.8% molybdenum-95, 16.7% molybdenum-96, 9.6% molybdenum-97, 24.4% molybdenum-98, and 9.8% molybdenum-100.

[0092] In Example 2, the separation and extraction efficiency of technetium-99m was 85%, and technetium-99m 15 Ci could be produced daily.

[0093] While specific embodiments of the present invention have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of the present invention is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, but all such changes and modifications fall within the scope of protection of the present invention.

Claims

1. A system for preparing technetium-99m, characterized in that, It includes a reaction module and a purification module; The reaction module includes an electron beam channel, a housing, and a gamma photon manufacturing unit disposed inside the housing. A Mo-containing solution region is formed between the housing and the gamma photon manufacturing unit. The gamma photon manufacturing unit is used to manufacture gamma photons, and the Mo-containing solution region is used to contain the Mo-containing solution and carry out the reaction. The gamma photonic manufacturing unit includes a metal outer layer and at least one target sheet disposed inside the metal outer layer. The electron beam channel passes through the outer shell and is connected to the metal outer layer of the gamma photonic manufacturing unit. The Mo-containing solution zone is connected to the purification module via a circulation loop. The outlet of the Mo-containing solution zone is connected to the inlet of the purification module via the circulation loop, and the outlet of the purification module is connected to the inlet of the Mo-containing solution zone via the circulation loop. The mixture generated in the Mo-containing solution zone is passed through the circulation loop into the purification module for purification to form Technetium-99m separation liquid and Mo separation liquid. The Mo separation liquid is returned to the Mo-containing solution zone via the circulation loop. The thickness of the Mo-containing solution region is 200 mm or more; An electron accelerator is connected to the electron beam channel, and the electron accelerator is used to generate an electron beam.

2. The preparation system for technetium-99m according to claim 1, characterized in that, It satisfies one or more of the following conditions (1) to (5): (1) The material of the target sheet is selected from one or more of tungsten, tantalum and molybdenum, preferably tungsten or tungsten plated with tantalum; (2) Each of the target pieces is disposed perpendicular to the direction in which the electron beam channel extends; (3) The number of target pieces is 1 to 10, for example, 4; Preferably, the plurality of target sheets are arranged in a direction extending along the electron beam channel; Preferably, the vertical distance between adjacent target pieces is equal; preferably, the vertical distance between adjacent target pieces is 0.5~2 mm, for example, 1 mm. (4) The thickness of the target sheet is 0.5~5 mm, for example, 1 mm; (5) The target is circular in shape; the diameter of the target is preferably 10 to 200 mm, for example 50 mm.

3. The preparation system for technetium-99m according to claim 1, characterized in that, In the gamma photonics manufacturing unit, a cooling zone is formed between the outer metal layer and the target sheet. The cooling zone has a built-in circulation pipeline, which consists of a cooling water circuit and a water circuit shell. Preferably, it also satisfies one or more of the following conditions (1) to (3): (1) The cooling water in the cooling water circuit is deionized water; The temperature of the cooling water at the inlet of the cooling water circuit is 20~50℃, for example, 30℃; The temperature of the cooling water at the outlet of the cooling water circuit is 50~99℃, for example, 85℃; (2) The outer shell material of the water circuit is selected from one or more of aluminum, copper and aluminum alloy, for example, copper; (3) The thickness of the outer shell material of the water circuit is 0.5~2 mm, for example, 1 mm.

4. The preparation system for technetium-99m according to claim 1, characterized in that, It satisfies one or more of the following conditions (1) to (4): (1) The material of the outer shell is selected from one or more of copper, stainless steel and aluminum alloy, such as stainless steel; wherein the thickness of the outer shell is 80~150 mm, for example 100 mm; (2) The reaction module further includes a neutron shielding layer, a gamma shielding layer and a metal inner layer. The outer shell, the neutron shielding layer, the gamma shielding layer and the metal inner layer are arranged sequentially from the outside to the inside. The metal inner layer and the metal outer layer form the Mo-containing solution region. Preferably, the material of the neutron shielding layer is boron-containing polyethylene neutron shielding material or boron-containing lead brick neutron shielding material, preferably boron-containing polyethylene neutron shielding material, for example, boron-containing polyethylene neutron shielding material with boron content accounting for 20% of the total mass; preferably, the thickness of the neutron shielding layer is 80~150 mm, for example, 100 mm. Preferably, the material of the gamma shielding layer is selected from one or more of tungsten, lead, and lead-containing concrete, for example, lead; Preferably, the material of the inner metal layer is selected from one or more of copper, stainless steel and aluminum alloy, for example, copper; (3) The container containing the Mo solution is cylindrical in shape, and the diameter of the cylinder is 200~1500 mm, for example, 1000 mm; The height of the cylinder is 200~1500 mm, for example, 1000 mm; (4) The Mo-containing solution zone contains a Mo-containing solution; Preferably, the abundance of Mo-100 in the Mo-containing solution is 9.8% to 99.9%. Preferably, the solute in the Mo-containing solution is sodium molybdate; more preferably, the solubility of the sodium molybdate is 20% to 60%, for example, 40%. Preferably, the solvent of the Mo-containing solution is high-purity water; more preferably, the high-purity water is high-purity water with an impurity concentration of less than 0.01 mg / L.

5. The preparation system for technetium-99m according to claim 1, characterized in that, The purification module includes a first purification unit, a second purification unit, and a third purification unit in sequence; the first purification unit is equipped with PEG resin for first purification; the second purification unit is equipped with cationic resin for second purification; and the third purification unit is equipped with alumina resin for third purification. Preferably, the PEG resin has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; Preferably, the cation exchange resin has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; Preferably, the alumina resin has an adsorption efficiency of greater than 90% for technetium-99m and an adsorption efficiency of less than 1% for Mo; Preferably, the Mo-containing solution zone and the first purification unit are equipped with the circulation loop.

6. The technetium-99m preparation system according to claim 1, characterized in that, It consists of the following parts: A reaction module includes an electron beam channel, a housing, and a gamma photon fabrication unit disposed inside the housing. A Mo-containing solution region is formed between the housing and the gamma photon fabrication unit. The gamma photon fabrication unit is used to fabricate gamma photons, and the Mo-containing solution region is used to contain the Mo-containing solution and carry out the reaction. An electron accelerator is externally connected to the electron beam channel. The electron accelerator is used to generate an electron beam with an energy of 30~50 MeV, a beam current intensity of 1 mA~3.5 mA, and an electron beam spot diameter of 10~100 mm. The gamma photonic manufacturing unit includes a metal outer layer and 1 to 10 target sheets disposed inside the metal outer layer. The electron beam channel passes through the outer shell and is connected to the metal outer layer of the gamma photonic manufacturing unit. The target sheets are arranged along the direction of the electron beam channel, and the vertical distance between adjacent target sheets is equal. In the gamma photonics manufacturing unit, a cooling zone is formed between the outer metal layer and the target sheet. The cooling zone has a built-in circulation pipeline, which consists of a cooling water circuit and a water circuit shell. The cooling water in the cooling water circuit is deionized water. The shell material of the water circuit is selected from one or more of aluminum, copper, and aluminum alloys. The thickness of the shell material of the water circuit is 0.5~2 mm. The Mo-containing solution zone is connected to the purification module through the circulation loop, the outlet of the Mo-containing solution zone is connected to the inlet of the purification module through the circulation loop, and the outlet of the purification module is connected to the inlet of the Mo-containing solution zone through the circulation loop. The mixture generated in the Mo-containing solution zone is purified by passing it through the circulation loop into the purification module to form technetium-99m separation solution and Mo separation solution. The Mo separation solution is then returned to the Mo-containing solution zone through the circulation loop. The circulation loop also includes a pump for driving the flow of the mixture, the technetium-99m separation liquid, and the Mo separation liquid in the circulation loop.

7. The method of using the technetium-99m preparation system according to any one of claims 1 to 6, characterized in that, It includes the following steps: An electron accelerator is used to generate an electron beam, which is then passed through the electron beam channel to bombard the target sheet, continuously generating gamma photons. These gamma photons irradiate the Mo-containing solution in the Mo-containing solution region to obtain a mixed solution. The mixed solution is then passed through the circulation loop into the purification module for purification to form a technetium-99m separation solution and a Mo separation solution. The Mo separation solution is then returned to the Mo-containing solution region through the circulation loop for further irradiation.

8. The method of using the technetium-99m preparation system according to claim 7, characterized in that, It satisfies one or more of the following conditions (1) to (3): (1) The electron kinetic energy of the electron beam is 30~50 MeV, for example 40 MeV; (2) The beam current intensity of the electron beam is 0.2~3.5 mA, for example, 1 mA; (3) The diameter of the electron beam spot is 10~100 mm, for example 50 mm.

9. The method of using the technetium-99m preparation system according to claim 7, characterized in that, It satisfies one or more of the following conditions (1) to (4): (1) The irradiation time is more than 3 days, for example, 300 days; (2) The flow rate of the mixture into the purification module through the circulation loop is 10~500 mL / min; (3) The purification module includes a first purification unit, a second purification unit and a third purification unit in sequence; the first purification unit is provided with PEG resin; the second purification unit is provided with cationic resin; the third purification unit is provided with alumina resin; the purification includes first purification, second purification and third purification in sequence through the first purification unit, the second purification unit and the third purification unit; Preferably, the first purification includes rinsing with a first eluent; preferably, the first eluent is an alkaline solution. The alkaline solution is preferably a potassium hydroxide solution, such as a 5 M potassium hydroxide solution. Preferably, the second purification includes rinsing with a second eluent; preferably, the second eluent is ultrapure water. Preferably, the third purification includes rinsing with a third rinsing solution; preferably, the third rinsing solution is physiological saline. Preferably, the saline solution is an aqueous sodium chloride solution, such as a 0.9% aqueous sodium chloride solution. (4) The technetium-99m separation solution is Na 99m TcO4 solution, preferably, the Na 99m TcO4 solution 99m The purity of Tc is over 99%.

10. The application of the technetium-99m preparation system according to any one of claims 1 to 6 in the preparation of medical isotopes.

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