Non-aqueous oral compositions

Abstract

The present application relates to a non-aqueous oral composition which, when applied to the oral cavity, provides a pleasant foaming sensation while suppressing a sense of stickiness, and which, after storage, effectively prevents the generation of carbon dioxide. That is, the present application provides a non-aqueous oral composition comprising the following components (A) to (E): (A) a non-aqueous solvent having a relative dielectric constant of less than 10 at 25°C and a melting point of 0°C or lower; (B) an acid which is solid at 25°C; (C) a carbonate; (D) an oily gelation agent; and (E) a sugar alcohol which is solid at 25°C.

Description

Technical Field

[0001] This invention relates to a non-aqueous oral composition. Background Technology

[0002] Non-aqueous oral compositions containing organic acids and carbonates as carbon dioxide generators can produce carbon dioxide and create a unique foaming sensation when applied to the oral cavity. Therefore, various non-aqueous oral compositions have been developed.

[0003] For example, Patent Document 1 discloses an oral composition containing a non-aqueous oral composition base, sodium bicarbonate, and an acidic component that is solid at room temperature, which attempts to mitigate bitterness and astringency and improve foaming properties. Additionally, Patent Document 2 discloses a paste-like toothpaste containing an organic acid coated with a coating agent, sodium bicarbonate coated with a coating material, and polyacrylic acid, which attempts to suppress carbon dioxide generation during long-term storage.

[0004] (Patent Document 1) Japanese Patent Application Publication No. 2002-302429

[0005] (Patent Document 2) Japanese Patent Application Publication No. 2022-81908 Summary of the Invention

[0006] This invention provides a non-aqueous oral composition comprising the following components (A) to (E):

[0007] (A) Non-aqueous solvents with a relative permittivity of less than 10 at 25°C and a melting point below 0°C;

[0008] (B) An acid that is a solid at 25°C;

[0009] (C) Carbonates;

[0010] (D) Oily gelling agents;

[0011] (E) Sugar alcohols that are solid at 25°C.

[0012] Even with the technology described in any of the aforementioned patent documents, there is still room for improvement in providing a pleasant foaming sensation in the oral cavity and ensuring a good user experience that suppresses greasiness, and further in preventing the generation of carbon dioxide after storage.

[0013] Therefore, the present invention relates to a non-aqueous oral composition that, when applied to the oral cavity, provides a pleasant foaming sensation while suppressing greasiness, and effectively prevents carbon dioxide generation even after storage.

[0014] The inventors have conducted various studies and discovered that a non-aqueous oral composition can be obtained by using a non-aqueous solvent with a specific relative permittivity, an acid that is solid at 25°C, a carbonate, an oily gelling agent, and a sugar alcohol that is solid at 25°C. This composition not only maintains good manufacturing stability and provides a good foaming and user experience, but also effectively prevents the generation of carbon dioxide even after storage due to its excellent storage stability.

[0015] According to the non-aqueous oral composition of the present invention, when applied to the oral cavity, carbon dioxide forms bubbles with a characteristic, pleasant foaming sensation. These bubbles burst pleasantly in the mouth and suppress unpleasant greasy feeling, providing a refreshing sensation even after use. Furthermore, the non-aqueous oral composition of the present invention exhibits good shape retention, manufacturing stability, and excellent storage stability. It effectively prevents carbon dioxide generation even after storage and avoids unnecessary container expansion during storage in filled containers. Attached Figure Description

[0016] Figure 1 The photograph shown is taken from the side, with the preserved container upright, in the evaluation of preservation stability. Figure 1 (a) is a photograph of Example 1. Figure 1 (b) is a photograph of Comparative Example 1. Figure 1 (c) is a photograph of Comparative Example 2. Detailed Implementation

[0017] The present invention will now be described in detail.

[0018] In this invention, a "non-aqueous oral composition" is a composition that does not contain water as a component, meaning that it is an oral composition that substantially does not contain water except in cases of unavoidable mixing. Furthermore, substantially not containing water means that the water content in the oral composition is preferably less than 2% by mass, more preferably less than 1% by mass.

[0019] In addition, "good foaming sensation" means the following: when applied in the oral cavity, the acid and carbonate contained in the non-aqueous oral composition of the present invention, which are solid at 25°C as carbon dioxide producers, begin to react with the moisture in saliva to produce carbon dioxide. This carbon dioxide diffuses in the oral cavity as bubbles with a unique and pleasant foaming sensation, and when they burst, they bring a pleasant and refreshing feeling.

[0020] Furthermore, "good usability" means that when applied to the mouth, it not only suppresses unpleasant greasiness but also does not ruin the flavor.

[0021] Therefore, the "refreshing sensation" brought about by the non-aqueous oral composition of the present invention has the meaning of a general term for excellent sensation in the oral cavity, which includes not only the good "foaming sensation" or "use sensation" when applied to the oral cavity, but also the "refreshing sensation" that is actually felt after application.

[0022] The non-aqueous oral composition of the present invention contains a non-aqueous solvent as component (A) with a relative permittivity of less than 10 at 25°C and a melting point of 0°C or less. In the non-aqueous oral composition of the present invention, an acid that is solid at 25°C (component (B)) and a carbonate (component (C)) are present as carbon dioxide generators. The presence of component (A) effectively prevents the generation of unwanted carbon dioxide during manufacturing, storage, or before use, thereby greatly contributing to maintaining good manufacturing stability and ensuring storage stability. Furthermore, when the non-aqueous oral composition of the present invention is applied to the oral cavity, components (B) and (C) react upon contact with saliva or the like, generating carbon dioxide bubbles that provide a unique and pleasant foaming sensation in the oral cavity. These bubbles diffuse within the oral cavity and burst, providing a pleasant and refreshing feeling.

[0023] Furthermore, in this invention, "non-aqueous solvent" refers to a solvent other than water, meaning a solvent that is substantially free of water. Additionally, "melting point" refers to a value at 1 atmosphere.

[0024] The relative permittivity of component (A) at 25°C is less than 10, preferably 5 or less, and more preferably 3 or less. Furthermore, the melting point of component (A) is 0°C or less, preferably -10°C or less.

[0025] Specifically, the component (A) may be selected from one or more of hydrocarbon oils, volatile silicone oils and ester oils.

[0026] As a hydrocarbon oil, it can be selected from one or more of liquid paraffin, squalane, petrolatum and turpentine.

[0027] Examples of volatile silicone oils include one or more selected from octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecylcyclohexasiloxane, methylcyclopolysiloxane, octamethyltrisiloxane, tetradecylhexasiloxane, and low-viscosity methylpolysiloxane.

[0028] As an ester oil, examples include one or more of jojoba oil, argan oil, olive oil, and coconut oil.

[0029] Of these components (A), from the viewpoint of effectively preventing the generation of unwanted carbon dioxide during manufacturing, storage or before use, and ensuring excellent storage stability, hydrocarbon oil is preferred, more preferably one or two selected from liquid paraffin and squalane, and even more preferably liquid paraffin.

[0030] As liquid paraffin, a mixture of colorless and odorless liquid alkanes with 20 or more carbon atoms can be used. Commercially available and known products can be used, and there are no particular limitations. In this invention, it is preferred to use a product that conforms to the specifications specified in the quasi-pharmaceutical raw material specifications, etc.

[0031] More specifically, the liquid paraffin used as component (A) preferably has a density of 0.800–0.900 g / cm³ at 15°C. 3 More preferably, it is 0.820–0.890 g / cm³. 3 Furthermore, the preferred value is 0.845–0.885 g / cm³. 3 More preferably, it is 0.850–0.880 g / cm³. 3 Furthermore, the liquid paraffin used as component (A) preferably has a viscosity of 1 to 120 mm at 37.8°C. 2 / s, more preferably 10 to 100 mm 2 / s, and more preferably 37–95 mm 2 / s, and more preferably 40–90 mm 2 / s, and more preferably 74–88 mm 2 / s.

[0032] Furthermore, the viscosity of the liquid paraffin was measured according to JIS K-2283 using a glass capillary viscometer.

[0033] From the viewpoint of effectively improving preservation stability and suppressing the unpleasant greasy feeling when applied to the oral cavity, the content of component (A) in the non-aqueous oral composition of the present invention is preferably 15% by mass or more, more preferably 20% by mass or more, even more preferably 25% by mass or more, even more preferably 30% by mass or more, preferably 50% by mass or less, even more preferably 45% by mass or less, even more preferably 41% by mass or less, even more preferably 38% by mass or less. Furthermore, the content of component (A) in the non-aqueous oral composition of the present invention is preferably 15 to 50% by mass, more preferably 20 to 45% by mass, even more preferably 25 to 41% by mass, even more preferably 30 to 38% by mass.

[0034] The non-aqueous oral composition of the present invention contains an acid that is solid at 25°C as component (B). When the non-aqueous oral composition of the present invention is applied to the oral cavity, the component (B) reacts with a carbonate as component (C) in the presence of saliva or the like, thereby generating carbon dioxide bubbles that provide a unique and pleasant foaming sensation that brings a refreshing feeling.

[0035] As component (B), examples include organic acids or amino acids with 4 to 6 carbon atoms having 1 to 3 carboxyl groups within their molecules. More specifically, examples include one or more selected from malic acid, citric acid, succinic acid, fumaric acid, tartaric acid, adipic acid, aspartic acid, glutamic acid, and pyroglutamic acid. From the viewpoint of ensuring good foaming properties, it is preferable to select one or more selected from malic acid, citric acid, tartaric acid, and succinic acid, more preferably one or two selected from malic acid and tartaric acid, and even more preferably malic acid.

[0036] The content of malic acid in component (B) is preferably 20% by mass or more, preferably 40% by mass or more, more preferably 60% by mass or more, more preferably 80% by mass, and more preferably 100% by mass.

[0037] Furthermore, the component (B) contained in the non-aqueous oral composition of the present invention may have a coating layer formed by a coating material or may not have a coating layer, but from the viewpoint of generating a pleasant carbon dioxide bubble that bursts in the oral cavity and thus exhibiting a good foaming sensation, it is preferable that component (B) does not have a coating layer.

[0038] The absence of a coating layer in component (B) means that part or all of the surface of component (B) is not covered by a coating material, i.e., no coating layer is formed on part or all of the surface of component (B). A coating material is a material used to pre-coat part or all of the surface of component (B) to inhibit unwanted reactions in non-aqueous oral compositions during manufacturing, storage, or prior to use, thereby preventing the generation of carbon dioxide. As a coating material, it is sufficient to cover part or all of the surface of component (B).

[0039] Regarding the content of component (B), from the viewpoint of ensuring a good foaming sensation by generating pleasant carbon dioxide bubbles that burst in the oral cavity, it is preferably 6% by mass or more in the non-aqueous oral composition of the present invention, more preferably 8% by mass or more, even more preferably 10% by mass or more, preferably 25% by mass or less, even more preferably 22% by mass or less, and even more preferably 18% by mass or less. Furthermore, regarding the content of component (B), it is preferably 6 to 25% by mass, more preferably 8 to 22% by mass, and even more preferably 10 to 18% by mass in the non-aqueous oral composition of the present invention.

[0040] The non-aqueous oral composition of the present invention contains carbonate as a component (C).

[0041] Specifically, as the component (C), examples may be one or more selected from sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate and magnesium carbonate.

[0042] From the viewpoint of improving storage stability, it is preferable to select one or two of sodium bicarbonate and sodium carbonate, and more preferably to select both containing sodium bicarbonate and sodium carbonate.

[0043] Furthermore, from the viewpoint of improving the foaming sensation, sodium carbonate is preferred.

[0044] When sodium bicarbonate and sodium carbonate are included as component (C), from the viewpoint of ensuring a good foaming sensation by generating pleasant carbon dioxide bubbles that burst, the content of sodium carbonate in 100% by mass of component (C) is preferably 10% by mass or more, more preferably 15% by mass or more, more preferably 35% by mass or less, and more preferably 30% by mass or less.

[0045] Furthermore, as a component (C) contained in the non-aqueous oral composition of the present invention, in terms of having good manufacturing stability and excellent storage stability, it may or may not have a coating layer, just like component (B). However, from the viewpoint of generating pleasant carbon dioxide bubbles that burst in the oral cavity and thus exhibiting a good foaming sensation, it is preferable that component (C) does not have a coating layer.

[0046] The absence of a coating layer in component (C) means that part or all of the surface of component (C) is not covered by a coating material. A coating material is a material used to pre-coat part or all of the surface of component (C) to inhibit unwanted reactions in non-aqueous oral compositions during manufacturing, storage, or prior to use, thereby preventing the generation of carbon dioxide.

[0047] Regarding the content of component (C), from the viewpoint of ensuring a good foaming sensation by generating pleasant carbon dioxide bubbles that burst in the oral cavity, it is preferably 6% by mass or more in the non-aqueous oral composition of the present invention, more preferably 8% by mass or more, even more preferably 10% by mass or more, preferably 35% by mass or less, even more preferably 32% by mass or less, and even more preferably 30% by mass or less. Furthermore, regarding the content of component (C), it is preferably 6 to 35% by mass, more preferably 8 to 32% by mass, and even more preferably 10 to 30% by mass in the non-aqueous oral composition of the present invention.

[0048] The mass ratio ((B) / (C)) of component (B) to component (C) is preferably 0.3 or more, more preferably 0.4 or more, more preferably 0.5 or more, more preferably 1.1 or less, more preferably 1 or less, and more preferably 0.9 or less, from the viewpoint of generating a moderate amount of carbon dioxide to form a pleasant bubble that bursts in the mouth. Furthermore, the mass ratio ((B) / (C)) of component (B) to component (C) is preferably 0.3 to 1.1, more preferably 0.4 to 1, and more preferably 0.5 to 0.9.

[0049] From the viewpoint of promoting the diffusion of carbon dioxide bubbles in the oral cavity and ensuring excellent storage stability, the total content of components (B) and (C) in the non-aqueous oral composition of the present invention is preferably 12% by mass or more, more preferably 15% by mass or more, more preferably 18% by mass or more, more preferably 55% by mass or less, more preferably 53% by mass or less, and more preferably 50% by mass or less. Furthermore, the total content of components (B) and (C) in the non-aqueous oral composition of the present invention is preferably 12 to 55% by mass, more preferably 15 to 53% by mass, and more preferably 18 to 50% by mass.

[0050] The mass ratio ({(B)+(C)} / (A)) of the total content of components (B) and (C) to the content of component (A) is preferably 0.2 or more, more preferably 0.3 or more, more preferably 0.5 or more, more preferably 3.5 or less, more preferably 2.5 or less, and more preferably 2 or less. Furthermore, the mass ratio ({(B)+(C)} / (A)) of the total content of components (B) and (C) to the content of component (A) is preferably 0.2 to 3.5, more preferably 0.3 to 2.5, and more preferably 0.5 to 2.

[0051] The non-aqueous oral composition of the present invention contains an oily gelling agent as component (D). The oily gelling agent of component (D) is a component that enables component (A) to solidify or gel, and is also a component that helps to exhibit moderate shape retention and ensure good manufacturing stability.

[0052] As this component (D), examples include fatty acids, fatty acid esters or fatty acid condensates selected from dextrin fatty acid esters, 12-hydroxystearic acid, oligomers obtained by condensing glycerol with a mixture of fatty acids composed of behenic acid and eicosanoidic acid.

[0053] Microcrystalline wax, polyethylene wax, paraffin wax, Fischer-Tropsch wax, carnauba wax, candelilla wax, natural ozokerite, and refined ceresin wax are petroleum waxes or natural waxes with a melting point (value at 1 atmosphere) of 50°C or higher.

[0054] Polyethylene powder and other resin powders;

[0055] Metal soaps such as zinc stearate, calcium stearate, calcium palmitate, lithium 2-ethylhexanoate, and aluminum 12-hydroxystearate;

[0056] N-acyl amino acid amides such as lauroyl glutamate dibutylamide, lauroyl glutamate stearylamide, dihexanoyl lysine lauroyl phenylalanine lauroylamide;

[0057] N-acyl amino acid amine salts such as dihexanoyl lysine laurylamine salt;

[0058] N-acyl amino acid esters such as dihexanoyl lysine lauryl ester;

[0059] One or more of the following clay minerals: bentonite, organically modified bentonite, and synthetic lithium saponite.

[0060] Of these components (D), from the viewpoint of effectively promoting the curing or gelation of component (A) and effectively inhibiting unwanted reactions caused by components (B) and (C), one or more are preferably selected from fatty acids, fatty acid esters or fatty acid condensates, and more preferably dextrin fatty acid esters.

[0061] Regarding the content of component (D), from the viewpoint of ensuring proper curing or gelation of component (A) and preventing the generation of carbon dioxide, in the non-aqueous oral composition of the present invention, it is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, and even more preferably 1% by mass or more, preferably 5% by mass or less, more preferably 4% by mass or less, even more preferably 3% by mass or less, even more preferably 2.3% by mass or less, and even more preferably 1.8% by mass or less. Furthermore, in the non-aqueous oral composition of the present invention, the content of component (D) is preferably 0.5 to 5% by mass, more preferably 0.7 to 4% by mass, even more preferably 1 to 3% by mass, even more preferably 1 to 2.3% by mass, and even more preferably 1 to 1.8% by mass.

[0062] The mass ratio (A) / (D) of component (A) to component (D) is preferably 10 or more, more preferably 12 or more, more preferably 15 or more, more preferably 18 or more, more preferably 20.5 or more, more preferably 30 or less, more preferably 27 or less, and more preferably 25 or less, from the viewpoint that the content of component (A) to component (D) is preferably 10 to 30, more preferably 12 to 27, more preferably 15 to 25, more preferably 18 to 25, and more preferably 20.5 to 25.

[0063] The non-aqueous oral composition of the present invention contains a sugar alcohol as a component (E) that is solid at 25°C. The solubility of component (E) in water at 25°C (the amount dissolved in 100% by mass of a saturated aqueous solution at 25°C) is preferably 5% by mass or more, more preferably 8% by mass or more, more preferably 12% by mass or more, more preferably 20% by mass or more, preferably 75% by mass or less, more preferably 65% ​​by mass or less, and more preferably 55% by mass or less. Furthermore, the solubility of component (E) in water at 25°C is preferably 5 to 75% by mass, more preferably 8 to 65% by mass, more preferably 12 to 55% by mass, and more preferably 20 to 55% by mass.

[0064] Specifically, the ingredient (E) may be one or more selected from erythritol, mannitol, sorbitol, xylitol and isomaltitol (a mixture of α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol).

[0065] From the viewpoint of ensuring a good user experience by suppressing greasiness, it is preferable to select one or more of erythritol, xylitol and mannitol, more preferably one or two of erythritol and xylitol, and even more preferably erythritol.

[0066] Regarding the content of component (E), from the viewpoint of ensuring a pleasant user experience and good foaming sensation when applied to the oral cavity, ensuring the suppression of unpleasant greasiness, the content in the non-aqueous oral composition of the present invention is preferably 2% by mass or more, more preferably 5% by mass or more, even more preferably 8% by mass or more, even more preferably 15% by mass or more, preferably 45% by mass or less, even more preferably 40% by mass or less, even more preferably 35% by mass or less. Furthermore, regarding the content of component (E), in the non-aqueous oral composition of the present invention, it is preferably 2 to 45% by mass, more preferably 5 to 45% by mass, even more preferably 8 to 40% by mass, even more preferably 15 to 35% by mass.

[0067] The mass ratio ((A) / (E)) of component (A) to component (E) is preferably 0.4 or more, more preferably 0.6 or more, more preferably 0.8 or more, and even more preferably 1 or more, preferably 15 or less, more preferably 8 or less, even more preferably 4 or less, and even more preferably 3.5 or less, from the perspective of ensuring both a pleasant user experience and a foaming sensation when applied to the oral cavity. Furthermore, the mass ratio ((A) / (E)) of component (A) to component (E) is preferably 0.4 to 15, more preferably 0.6 to 8, even more preferably 0.8 to 4, and even more preferably 1 to 3.5.

[0068] The mass ratio ((B) / (E)) of component (B) to component (E) is preferably 0.1 or more, more preferably 0.2 or more, more preferably 0.3 or more, more preferably 0.5 or more, preferably 5 or less, more preferably 2 or less, more preferably 1.5 or less, and more preferably 1 or less, from the viewpoint of ensuring both a pleasant user experience and a foaming sensation when applied to the oral cavity. Furthermore, the mass ratio ((B) / (E)) of component (B) to component (E) is preferably 0.1 to 5, more preferably 0.2 to 2, more preferably 0.3 to 1.5, and more preferably 0.5 to 1.

[0069] The mass ratio ((C) / (E)) of component (C) to component (E) is preferably 0.1 or more, more preferably 0.2 or more, more preferably 0.3 or more, more preferably 0.35 or more, preferably 8 or less, more preferably 3 or less, more preferably 2.5 or less, and more preferably 1.5 or less, from the perspective of ensuring both a pleasant user experience and a foaming sensation when applied to the oral cavity. Furthermore, the mass ratio ((C) / (E)) of component (C) to component (E) is preferably 0.1 to 8, more preferably 0.2 to 3, more preferably 0.3 to 2.5, and more preferably 0.35 to 1.5.

[0070] As the non-aqueous oral composition of the present invention, from the viewpoint of effectively suppressing unwanted reactions between components (B) and (C) in the non-aqueous oral composition during manufacturing, storage, or before use, and preventing the generation of carbon dioxide in advance, thereby ensuring good manufacturing stability and excellent storage stability, it is preferable to further contain one or more metal compounds (F) selected from zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, titanium oxide, sodium sulfate, magnesium sulfate, calcium sulfate, calcium chloride, magnesium chloride, zinc chloride, magnesium silicate, and calcium silicate.

[0071] From the viewpoint of effectively preventing the generation of carbon dioxide, it is preferable to select one or more of zinc oxide, magnesium oxide and magnesium sulfate, and more preferably one or two of zinc oxide and magnesium oxide.

[0072] From the viewpoint of effectively preventing the generation of carbon dioxide in the non-aqueous oral composition during storage or before use, the content of component (F) in the non-aqueous oral composition of the present invention is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, and even more preferably 0.8% by mass or more, preferably 7% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. Furthermore, the content of component (F) in the non-aqueous oral composition of the present invention is preferably 0.5 to 7% by mass, more preferably 0.7 to 5% by mass, and even more preferably 0.8 to 3% by mass.

[0073] The mass ratio ((F) / (A)) of the content of component (F) to the content of component (A) is preferably 0.005 or more, more preferably 0.008 or more, and even more preferably 0.01 or more, preferably 0.1 or less, more preferably 0.08 or less, and even more preferably 0.05 or less, from the viewpoint of effectively preventing the generation of carbon dioxide in the non-aqueous oral composition during storage or before use. Furthermore, the mass ratio ((F) / (A)) of the content of component (F) to the content of component (A) is preferably 0.005 to 0.1, more preferably 0.008 to 0.08, and even more preferably 0.01 to 0.05.

[0074] The mass ratio ((F) / (B)) of the content of component (F) to the content of component (B) is preferably 0.01 or more, more preferably 0.03 or more, and even more preferably 0.05 or more, preferably 0.7 or less, more preferably 0.6 or less, and even more preferably 0.5 or less, from the viewpoint of effectively preventing the generation of carbon dioxide in the non-aqueous oral composition during storage or before use. Furthermore, the mass ratio ((F) / (B)) of the content of component (F) to the content of component (B) is preferably 0.01 to 0.7, more preferably 0.03 to 0.6, and even more preferably 0.05 to 0.5.

[0075] The mass ratio ((F) / (C)) of the content of component (F) to the content of component (C) is preferably 0.005 or more, more preferably 0.008 or more, and even more preferably 0.01 or more, preferably 0.3 or less, more preferably 0.2 or less, and even more preferably 0.1 or less, from the viewpoint of effectively preventing the generation of carbon dioxide in the non-aqueous oral composition during storage or before use. Furthermore, the mass ratio ((F) / (C)) of the content of component (F) to the content of component (C) is preferably 0.005 to 0.3, more preferably 0.008 to 0.2, and even more preferably 0.01 to 0.1.

[0076] From the viewpoint of improving abrasiveness, the non-aqueous oral composition of the present invention preferably contains anhydrous silica. Specifically, examples of anhydrous silica include abrasive silica such as smoky, porous, non-porous, or spherical abrasive silica and thickening silica, or anhydrous silica that has undergone hydrophobic treatment.

[0077] From the viewpoint of effectively improving abrasiveness and effectively preventing the generation of carbon dioxide in the non-aqueous oral composition during storage or before use, the content of anhydrous silica in the non-aqueous oral composition of the present invention is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, preferably 6.9% by mass or less, more preferably 6.5% by mass or less, and even more preferably 6% by mass or less. Furthermore, the content of anhydrous silica in the non-aqueous oral composition of the present invention is preferably 0.1 to 6.9% by mass, more preferably 0.5 to 6.5% by mass, and even more preferably 1 to 6% by mass.

[0078] On the other hand, from the viewpoint of effectively suppressing unwanted reactions between components (B) and (C) in the non-aqueous oral composition of the present invention during manufacturing, storage or before use, and preventing the generation of carbon dioxide in advance, thereby ensuring good manufacturing stability and excellent storage stability, it is preferable to limit the content of anhydrous silica.

[0079] Regarding the content of anhydrous silicic acid in the non-aqueous oral composition of the present invention, it is preferably less than 10% by mass, more preferably less than 7% by mass, even more preferably less than 5% by mass, even more preferably less than 4% by mass, even more preferably less than 1% by mass, or preferably the non-aqueous oral composition of the present invention substantially does not contain anhydrous silicic acid. Furthermore, "substantially does not contain anhydrous silicic acid" means that the content of anhydrous silicic acid in the oral composition is less than 0.1% by mass.

[0080] As the non-aqueous oral composition of the present invention, from the viewpoint of effectively suppressing unwanted reactions between components (B) and (C) in the non-aqueous oral composition during manufacturing, storage, or before use, and preventing the generation of carbon dioxide in advance, thereby ensuring good manufacturing stability and excellent storage stability and ensuring good foaming sensation, it is preferable to limit the content of non-aqueous solvents with a relative permittivity of 10 or more at 25°C.

[0081] Examples of non-aqueous solvents with a relative permittivity of 10 or higher at 25°C include glycerol, polyethylene glycol, 1,3-butanediol, propylene glycol, dipropylene glycol, and diglycerol.

[0082] The content of the non-aqueous solvent with a relative permittivity of 10 or more at 25°C is preferably less than 18% by mass, more preferably less than 10% by mass, even more preferably less than 6% by mass, even more preferably less than 3% by mass, or preferably the non-aqueous oral composition of the present invention substantially does not contain a non-aqueous solvent with a relative permittivity of 10 or more at 25°C. Furthermore, "substantially does not contain a non-aqueous solvent with a relative permittivity of 10 or more at 25°C" means that the content of the non-aqueous solvent with a relative permittivity of 10 or more at 25°C in the oral composition is less than 1% by mass.

[0083] The non-aqueous oral composition of the present invention may contain antibacterial agents or bactericides, pharmaceutical ingredients, fragrances, colorants, etc., as other ingredients besides those mentioned above, without impairing the effects of the present invention.

[0084] The non-aqueous oral composition of the present invention is filled into a deformable container, and the non-aqueous oral composition as the contents is discharged from the discharge port provided by the container by applying external force to the container.

[0085] The container only needs to have a discharge outlet, and its shape is not particularly limited. Examples of container shapes include a tubular container with a main body and a lid with a discharge outlet, a spouted container with a bag-shaped main body, and a squeeze-type container with a deformable container body. Furthermore, there are no particular limitations on the material of the container. For example, in the case of a tubular container with a multi-layered body, in addition to the innermost layer made of polyethylene such as low-density polyethylene, the multi-layered structure may also include metallic layers such as aluminum, or synthetic resin layers such as polypropylene or polyethylene terephthalate.

[0086] If it is a non-aqueous oral composition of the present invention, it can effectively prevent excessive container expansion during storage, even when filled into any container, due to its excellent storage stability.

[0087] Regarding the above embodiments, the present invention further discloses the following non-aqueous oral composition.

[0088] [1] A non-aqueous oral composition comprising the following components (A) to (E):

[0089] (A) Non-aqueous solvents with a relative permittivity of less than 10 at 25°C and a melting point below 0°C;

[0090] (B) An acid that is a solid at 25°C;

[0091] (C) Carbonates;

[0092] (D) Oily gelling agents;

[0093] (E) Sugar alcohols that are solid at 25°C.

[0094] [2] The non-aqueous oral composition as described in [1] above, wherein the relative permittivity of component (A) at 25°C is preferably 5 or less, more preferably 3 or less, and the melting point of component (A) is preferably -10°C or less.

[0095] [3] The non-aqueous oral composition as described in [1] or [2] above, wherein component (A) is one or more selected from hydrocarbon oils, volatile silicone oils and ester oils, preferably hydrocarbon oils, more preferably one or two selected from liquid paraffin and squalane, and even more preferably liquid paraffin.

[0096] [4] In the non-aqueous oral composition as described in [3] above, the density of the liquid paraffin at 15°C is preferably 0.800 to 0.900 g / cm³. 3 More preferably, it is 0.820–0.890 g / cm³. 3 Furthermore, the preferred value is 0.845–0.885 g / cm³. 3 More preferably, it is 0.860–0.880 g / cm³. 3 The viscosity at 37.8℃ is preferably 1–120 mm. 2 / s, more preferably 10 to 100 mm 2 / s, and more preferably 37–95 mm 2 / s, and more preferably 40–90 mm 2 / s, and more preferably 74–88 mm 2 / s.

[0097] [5] The non-aqueous oral composition of any one of [1] to [4] above, wherein the content of component (A) is preferably 15% by mass or more, more preferably 20% by mass or more, more preferably 25% by mass or more, more preferably 30% by mass or more, preferably 50% by mass or less, more preferably 45% by mass or less, more preferably 41% by mass or less, and more preferably 38% by mass or less.

[0098] [6] The non-aqueous oral composition of any one of [1] to [5] above, wherein component (B) is preferably an organic acid or amino acid having 4 to 6 carbon atoms having 1 to 3 carboxyl groups in the molecule, more preferably one or more selected from malic acid, citric acid, succinic acid, fumaric acid, tartaric acid, adipic acid, aspartic acid, glutamic acid and pyroglutamic acid, further preferably one or more selected from malic acid, citric acid, tartaric acid and succinic acid, further more preferably one or two selected from malic acid and tartaric acid, further more preferably malic acid.

[0099] [7] The non-aqueous oral composition of any one of [1] to [6] above, wherein the content of component (B) is preferably 6% by mass or more, more preferably 8% by mass or more, more preferably 10% by mass or more, more preferably 25% by mass or less, more preferably 22% by mass or less, and more preferably 18% by mass or less.

[0100] [8] The non-aqueous oral composition of any one of [1] to [7] above, wherein component (C) is preferably selected from one or more of sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate and magnesium carbonate, more preferably selected from one or two of sodium bicarbonate and sodium carbonate, and even more preferably both of sodium bicarbonate and sodium carbonate.

[0101] [9] In the non-aqueous oral composition as described in [8] above, the content of sodium carbonate in component (C) 100% by mass is preferably 10% by mass or more, more preferably 15% by mass or more, more preferably 35% by mass or less, and more preferably 30% by mass or less.

[0102]

[10] The non-aqueous oral composition of any one of [1] to [9] above, wherein the content of component (C) is preferably 6% by mass or more, more preferably 8% by mass or more, more preferably 10% by mass or more, more preferably 35% by mass or less, more preferably 32% by mass or less, and more preferably 30% by mass or less.

[0103]

[11] The non-aqueous oral composition of any one of [1] to

[10] above, wherein the mass ratio of the content of component (B) to the content of component (C) ((B) / (C)) is preferably 0.3 or more, more preferably 0.4 or more, more preferably 0.5 or more, more preferably 1.1 or less, more preferably 1 or less, and more preferably 0.9 or less.

[0104]

[12] The non-aqueous oral composition of any one of [1] to

[11] above, wherein the mass ratio of the total content of component (B) and component (C) to the content of component (A) ({(B)+(C)} / (A)) is preferably 0.2 or more, more preferably 0.3 or more, more preferably 0.5 or more, more preferably 3.5 or less, more preferably 2.5 or less, and more preferably 2 or less.

[0105]

[13] The non-aqueous oral composition of any one of [1] to

[12] above, wherein component (D) is preferably one or more selected from fatty acids, fatty acid esters or fatty acid condensates, more preferably dextrin fatty acid esters.

[0106]

[14] The non-aqueous oral composition of any one of [1] to

[13] above, wherein the content of component (D) is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, more preferably 1% by mass or more, preferably 5% by mass or less, more preferably 4% by mass or less, more preferably 3% by mass or less, more preferably 2.3% by mass or less, and more preferably 1.8% by mass or less.

[0107]

[15] The non-aqueous oral composition of any one of [1] to

[14] above, wherein the mass ratio ((A) / (D)) of the content of component (A) to the content of component (D) is preferably 10 or more, more preferably 12 or more, more preferably 15 or more, more preferably 18 or more, more preferably 20.5 or more, preferably 30 or less, more preferably 27 or less, and more preferably 25 or less.

[0108]

[16] The non-aqueous oral composition of any one of [1] to

[15] above, wherein the solubility of component (E) in water at 25°C (the amount dissolved in 100% by mass of a saturated aqueous solution at 25°C) is preferably 5% by mass or more, more preferably 8% by mass or more, more preferably 12% by mass or more, more preferably 20% by mass or more, preferably 75% by mass or less, more preferably 65% ​​by mass or less, and more preferably 55% by mass or less.

[0109]

[17] The non-aqueous oral composition of any one of [1] to

[16] above, wherein component (E) is preferably one or more selected from erythritol, mannitol, sorbitol, xylitol and isomaltitol (a mixture of α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol), more preferably one or more selected from erythritol, xylitol and mannitol, and even more preferably one or two selected from erythritol and xylitol, and even more preferably erythritol.

[0110]

[18] The non-aqueous oral composition of any one of [1] to

[17] above, wherein the content of component (E) is preferably 2% by mass or more, more preferably 5% by mass or more, more preferably 8% by mass or more, more preferably 15% by mass or more, preferably 45% by mass or less, more preferably 40% by mass or less, and more preferably 35% by mass or less.

[0111]

[19] The non-aqueous oral composition of any one of [1] to

[18] above, wherein the mass ratio ((A) / (E)) of the content of component (A) to the content of component (E) is preferably 0.4 or more, more preferably 0.6 or more, more preferably 0.8 or more, and even more preferably 1 or more, preferably 15 or less, more preferably 8 or less, even more preferably 4 or less, and even more preferably 3.5 or less.

[0112]

[20] The non-aqueous oral composition of any one of [1] to

[19] above, wherein the mass ratio ((B) / (E)) of the content of component (B) to the content of component (E) is preferably 0.1 or more, more preferably 0.2 or more, more preferably 0.3 or more, more preferably 0.5 or more, preferably 5 or less, more preferably 2 or less, more preferably 1.5 or less, more preferably 1 or less.

[0113]

[21] The non-aqueous oral composition of any one of [1] to

[20] above, wherein the mass ratio ((C) / (E)) of the content of component (C) to the content of component (E) is preferably 0.1 or more, more preferably 0.2 or more, more preferably 0.3 or more, more preferably 0.35 or more, preferably 8 or less, more preferably 3 or less, more preferably 2.5 or less, more preferably 1.5 or less.

[0114]

[22] The non-aqueous oral composition of any one of [1] to

[21] above, wherein it further contains one or more metal compounds (F) selected from zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, titanium oxide, sodium sulfate, magnesium sulfate, calcium sulfate, calcium chloride, magnesium chloride, zinc chloride, magnesium silicate and calcium silicate.

[0115]

[23] The non-aqueous oral composition as described in

[22] above, wherein component (F) is preferably selected from one or more of zinc oxide, magnesium oxide and magnesium sulfate, more preferably selected from one or two of zinc oxide and magnesium oxide.

[0116]

[24] In the non-aqueous oral composition as described in

[22] or

[23] above, the content of component (F) is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, and even more preferably 0.8% by mass or more, preferably 7% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less.

[0117]

[25] The non-aqueous oral composition of any one of

[22] to

[24] above, wherein the mass ratio of the content of component (F) to the content of component (A) ((F) / (A)) is preferably 0.005 or more, more preferably 0.008 or more, and even more preferably 0.01 or more, preferably 0.1 or less, more preferably 0.08 or less, and even more preferably 0.05 or less.

[0118]

[26] The non-aqueous oral composition of any one of

[22] to

[25] above, wherein the mass ratio of the content of component (F) to the content of component (B) ((F) / (B)) is preferably 0.01 or more, more preferably 0.03 or more, and even more preferably 0.05 or more, preferably 0.7 or less, more preferably 0.6 or less, and even more preferably 0.5 or less.

[0119]

[27] The non-aqueous oral composition of any one of

[22] to

[26] above, wherein the mass ratio of the content of component (F) to the content of component (C) ((F) / (C)) is preferably 0.005 or more, more preferably 0.008 or more, and even more preferably 0.01 or more, preferably 0.3 or less, more preferably 0.2 or less, and even more preferably 0.1 or less.

[0120]

[28] The non-aqueous oral composition of any one of [1] to

[27] above, wherein the content of anhydrous silica is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, preferably 6.9% by mass or less, more preferably 6.5% by mass or less, and even more preferably 6% by mass or less, or preferably less than 10% by mass, more preferably less than 7% by mass, even more preferably less than 5% by mass, even more preferably less than 4% by mass, even more preferably less than 1% by mass, or the non-aqueous oral composition of the present invention is preferably substantially free of anhydrous silica.

[0121]

[29] The non-aqueous oral composition of any one of [1] to

[28] above, wherein the content of the non-aqueous solvent having a relative permittivity of 10 or more at 25°C is preferably less than 18% by mass, more preferably 10% by mass or less, more preferably 6% by mass or less, more preferably 3% by mass or less, or the non-aqueous oral composition of the present invention preferably does not substantially contain a non-aqueous solvent having a relative permittivity of 10 or more at 25°C.

[0122]

[30] A non-aqueous oral composition as described in any of [1] to

[29] above, wherein component (B) and / or component (C) preferably does not have a coating layer.

[0123] [Example]

[0124] The present invention will now be specifically described based on embodiments. Furthermore, unless otherwise stated, the content of each component in the table represents a percentage by mass.

[0125] [Examples 1-11, Comparative Examples 1-5]

[0126] According to the formulations shown in Table 1, each non-aqueous oral composition was manufactured using conventional methods. First, the manufacturing stability was evaluated according to the methods described below. Furthermore, for the evaluation results of Z1 to Z3, no further appropriate evaluations were conducted due to problems with the products.

[0127] Then, the obtained non-aqueous oral compositions were filled into tubular containers (manufactured by Kyodo Printing Co., Ltd., 32φ aluminum / polyethylene tube, 100 g capacity container), and each was evaluated according to the following method.

[0128] The results are shown in Table 1.

[0129] <<Evaluation of Manufacturing Stability>>

[0130] When manufacturing non-aqueous oral compositions, the following criteria are used for evaluation.

[0131] X: Able to manufacture without problems

[0132] Z1: Contains components with poor dispersibility and no shape retention.

[0133] Z2: Bubbles are generated during the manufacturing process involving a reaction of components.

[0134] Z3: Partially liquefied, liquid separation occurs.

[0135] <<Evaluation of the foamy texture>>

[0136] Squeeze 1 g of each non-aqueous oral composition from the tubular container and place it on a toothbrush, then brush your teeth for 2 minutes. Evaluate the foaming sensation during brushing according to the following criteria.

[0137] 5: The popping of bubbles is very pleasant.

[0138] 4: The popping of bubbles is delightful.

[0139] 3: The bubbles popped slightly.

[0140] 2: Although the bubbles can be sensed, the popping or crackling sound cannot be felt.

[0141] 1: No bubbles can be detected

[0142] <<Evaluation of the greasiness>>

[0143] Squeeze 1 g of each non-aqueous oral composition from the tubular container and place it on a toothbrush, then brush your teeth for 2 minutes. Evaluate the greasy feeling during brushing according to the following criteria.

[0144] 5: Not greasy at all

[0145] 4: Not too oily

[0146] 3: Slightly oily, but within acceptable limits.

[0147] 2: Oily, but within acceptable limits.

[0148] 1: Very greasy

[0149] <<Evaluation of the feeling of exhilaration>>

[0150] Squeeze 1 g of each non-aqueous oral composition from the tubular container and place it on a toothbrush, then brush your teeth for 2 minutes. Evaluate the feeling of freshness in the mouth after brushing according to the following criteria, using the degree of freshness as an indicator.

[0151] 5: Very refreshing in the mouth

[0152] 4: Leaves a refreshing feeling in the mouth

[0153] 3: Slightly refreshing in the mouth

[0154] 2: The mouth feels a little dry, but it's within an acceptable range.

[0155] 1: Unpleasant feeling in the mouth

[0156] <<Evaluation of Preservation Stability>>

[0157] According to the following criteria, after filling each non-aqueous oral composition into a tubular container at room temperature (25°C), the container is stored in a constant temperature bath at 50°C until the specified time below, and the degree of expansion of the container is visually evaluated.

[0158] Furthermore, photographs taken of the preserved containers from Example 1, Comparative Example 1 (expansion confirmed at a time point 10 minutes after self-filling), and Comparative Example 2 (expansion confirmed at a time point 1 hour after self-filling) are shown below. Figure 1 middle.

[0159] 5: No swelling was detected after a one-month storage period.

[0160] 4: No swelling was detected after a 2-week storage period.

[0161] 3: No swelling was detected within the one-week storage period.

[0162] 2: Swelling was confirmed within a 1-week storage period.

[0163] 1. There is no need to store it in a constant temperature bath; expansion can be confirmed on the day it is filled into the tubular container.

[0164] [Table 1]

[0165]

[0166] ※1: HICALL K-350, manufactured by KANEDA, density at 15°C: 0.867 g / cm³ 3 Viscosity at 37.8℃: 81.2 mm 2 / s

[0167] ※2: HICALL K-160, manufactured by KANEDA, density at 15°C: 0.839 g / cm³ 3 Viscosity at 37.8℃: 7.35 mm 2 / s

Claims

1. A non-aqueous oral composition, wherein, It contains the following ingredients (A) to (E): (A) Non-aqueous solvents with a relative permittivity of less than 10 at 25°C and a melting point below 0°C; (B) An acid that is a solid at 25°C; (C) Carbonates; (D) Oily gelling agents; (E) Sugar alcohols that are solid at 25°C.

2. The non-aqueous oral composition of claim 1, wherein, The solubility of component (E) in water at 25°C is more than 5% by mass and less than 75% by mass.

3. The non-aqueous oral composition as described in claim 1 or 2, wherein, The mass ratio of component (A) to component (E) is 0.4 to 5.

4. The non-aqueous oral composition according to any one of claims 1 to 3, wherein, The mass ratio of component (A) to component (D) is between 10 and 30.

5. The non-aqueous oral composition according to any one of claims 1 to 4, wherein, The mass ratio of the total content of components (B) and (C) to the content of component (A), {(B)+(C)} / (A), is between 0.2 and 3.

5.

6. The non-aqueous oral composition according to any one of claims 1 to 5, wherein, Ingredient (C) contains sodium bicarbonate and sodium carbonate.

7. The non-aqueous oral composition according to any one of claims 1 to 6, wherein, The content of component (B) is more than 6% by mass and less than 25% by mass.

8. The non-aqueous oral composition according to any one of claims 1 to 7, wherein, The content of anhydrous silicic acid is less than 7% by mass.

9. The non-aqueous oral composition according to any one of claims 1 to 8, wherein, The content of non-aqueous solvents with a relative permittivity of 10 or higher at 25°C is less than 18% by mass.

10. The non-aqueous oral composition according to any one of claims 1 to 9, wherein, It further contains one or more metal compounds (F) selected from zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, titanium oxide, sodium sulfate, magnesium sulfate, calcium sulfate, calcium chloride, magnesium chloride, zinc chloride, magnesium silicate, and calcium silicate.

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