Method and system for adjusting optimization of ct contrast scan parameters

Abstract

This invention discloses a method and system for adjusting and optimizing CT contrast-enhanced scanning parameters, comprising: acquiring the patient's physiological characteristic parameters and injection parameters, and calculating the contrast agent concentration at the target site at different times based on the physiological characteristic parameters and injection parameters, generating a time-density curve. The enhancement coefficient corresponding to the current peak voltage of the X-ray tube is determined using the CT contrast-enhanced curve, and the time-enhanced value curve of the current target site is determined by combining the time-density curve. The peak enhancement value is determined based on the scanning time window and the time-enhanced value curve, and the peak enhancement value is compared with the enhancement target. If the peak enhancement value does not meet the enhancement target, the injection parameters or scanning parameters are adjusted, and the peak enhancement value is recalculated and compared with the enhancement target. This process continues until the peak enhancement value meets the enhancement target. This method can automatically search and decide on the optimal CT contrast-enhanced scanning scheme in reverse, solving the problem of unsatisfactory CT scan results.

Description

Technical Field

[0001] This invention relates to the field of medical imaging information technology, and in particular to a method and system for individualized parameter optimization in CT contrast-enhanced scanning. This technical solution integrates knowledge from multiple disciplines such as mathematical modeling, physiology, physics, and clinical medicine, and achieves precision and individualization in CT contrast-enhanced scanning by establishing a pharmacokinetic model of iodine contrast agents. It mainly relates to the field of computed tomography (CT) scanning technology, specifically to a method and system for adjusting and optimizing CT contrast-enhanced scanning parameters. Background Technology

[0002] CT operators typically use default CT scan configuration parameters without adjusting them. This is partly because they lack a thorough understanding of the flow of iodine contrast agents within the body, especially when scanning less common blood vessels or organs. Furthermore, the flow of iodine contrast agents varies from patient to patient, making fixed, default scan parameters unsuitable for all. Moreover, since the flow pattern of iodine contrast agents within the body is not readily observable, injecting more than the patient's actual need increases the likelihood of iodine extravasation or adverse reactions. Even with overdose, inappropriate scan parameters may prevent the detection of the contrast agent peak plateau, resulting in suboptimal CT scan results. Summary of the Invention

[0003] To address the shortcomings of existing technologies, this invention proposes a method and system for adjusting and optimizing CT contrast-enhanced scanning parameters, capable of automatically searching and determining the optimal CT contrast-enhanced scanning scheme. The specific technical solution is as follows: In a first aspect, a method for adjusting and optimizing CT contrast-enhanced scan parameters is provided, wherein in a first implementable manner of the first aspect, the method includes: Obtain the patient's physiological characteristics and the currently selected injection parameters, and calculate the time-density curve of the iodine contrast agent at the target site based on the physiological characteristics and injection parameters; The enhancement coefficient of the iodine contrast agent is determined based on the peak voltage of the tube in the set scanning parameters, and the time-enhancement value curve of the iodine contrast agent at the target site is determined in combination with the time-density curve. The peak enhancement value is determined by combining the time-enhancement curve and the scanning time window in the scanning parameters, and this peak enhancement value is compared with the enhancement target of the target area; In response to the enhancement value peak not meeting the enhancement target, the injection parameters and / or scanning parameters are adjusted, and the time-enhancement value curve is re-determined and compared with the enhancement target; This process is repeated until the peak enhancement value meets the enhancement target.

[0004] In conjunction with the first feasible method of the first aspect, in the second feasible method of the first aspect, the time-density curve of the iodine contrast agent at the target site is calculated, including: The flow of the iodine contrast agent from the injection site to the target site, passing through various organ sites, was determined. Using a density model matched to the organ site, the density of iodine contrast agent in each organ site is calculated step by step, and finally the time-density curve of the target site is obtained.

[0005] In conjunction with the first feasible method of the first aspect, in the third feasible method of the first aspect, the enhancement coefficient of the iodine contrast agent is determined according to the set scanning parameters, including: Obtain the CT enhancement curve corresponding to the CT scanning equipment. The CT enhancement curve includes the contrast enhancement value corresponding to the unit iodine concentration under different tube peak voltages. Based on the CT enhancement curve, the enhancement coefficient is determined according to the peak voltage of the X-ray tube in the scanning parameters. The enhancement coefficient is the contrast enhancement value corresponding to a unit iodine concentration.

[0006] In a fourth implementation of the first aspect, in conjunction with the first possible implementation of the first aspect, determining the peak enhancement value by combining the time-enhancement curve and the scan time window includes: Calculate the average enhancement value of the time-enhancement curve and the overlapping region of each scanning time window; The average enhancement values ​​corresponding to each scanning time window are compared, and the maximum average enhancement value is selected as the peak enhancement value.

[0007] In conjunction with the first possible implementation of the first aspect, in the fifth possible implementation of the first aspect, adjusting the injection parameters and / or scanning parameters includes: Adjust the injection flow rate, injection duration, and / or iodine contrast agent concentration in the injection parameters, and / or adjust the tube peak voltage in the scanning parameters.

[0008] Secondly, a system for adjusting and optimizing CT contrast-enhanced scan parameters is provided, and in a first possible implementation of the second aspect, it includes: The time-density module is configured to acquire the patient's physiological characteristic parameters and the currently selected injection parameters, and calculate the time-density curve of the iodine contrast agent at the target site based on the physiological characteristic parameters and injection parameters; The time-enhancement value module is configured to determine the enhancement coefficient of the iodine contrast agent based on the peak voltage of the tube in the set scanning parameters, and to determine the time-enhancement value curve of the iodine contrast agent at the target site in combination with the time-density curve; The optimization and adjustment module is configured to determine the peak enhancement value by combining the time-enhancement value curve and the scanning time window in the scanning parameters, and compare the peak enhancement value with the enhancement target of the target area; In response to the enhancement value peak not meeting the enhancement target, the injection parameters and / or scanning parameters are adjusted, and the time-enhancement value curve is re-determined and compared with the enhancement target; This process is repeated until the peak enhancement value meets the enhancement target.

[0009] In conjunction with the first possible implementation of the second aspect, in the second possible implementation of the second aspect, the time-density module includes: The flow path unit is configured to determine the flow of the iodine contrast agent from the injection site to the target site through various organ sites; The density calculation unit is configured to use a density model that matches the organ site to calculate the iodine contrast agent density of each organ site step by step, and finally obtain the time-density curve of the target site.

[0010] In conjunction with the first possible implementation of the second aspect, in the third possible implementation of the second aspect, the time-enhanced value module includes: The acquisition unit is configured to acquire the CT enhancement curve corresponding to the CT scanning device, which includes the contrast enhancement value corresponding to the unit iodine concentration under different tube peak voltages; The determination unit is configured to determine the enhancement coefficient based on the CT enhancement curve and the peak voltage of the X-ray tube in the scanning parameters. The enhancement coefficient is the contrast enhancement value corresponding to a unit iodine concentration.

[0011] In conjunction with the first possible implementation of the second aspect, in the fourth possible implementation of the second aspect, the optimization adjustment module includes: The curve calculation unit is configured to calculate the average enhancement value within the overlapping area of ​​the time-enhancement curve and each scan time window, respectively. The peak comparison unit is configured to compare the average enhancement values ​​corresponding to each scanning time window and select the maximum average enhancement value as the peak enhancement value.

[0012] In conjunction with the first possible implementation of the second aspect, in the fifth possible implementation of the second aspect, the optimization and adjustment module includes: The adjustment unit is configured to adjust the injection flow rate, injection duration, and / or iodine contrast agent concentration in the injection parameters, and / or adjust the tube peak voltage and / or trigger delay time in the scanning parameters.

[0013] Beneficial Effects: The method and system for adjusting and optimizing CT contrast-enhanced scanning parameters of this invention can calculate the time-density curve of the iodine contrast agent at the target site using the patient's physiological characteristic parameters and the currently set injection parameters. By using the peak voltage of the X-ray tube in the currently set scanning parameters, the enhancement coefficient of the iodine contrast agent can be determined. Combining the time-density curve and the enhancement coefficient, the time-enhance value curve of the iodine contrast agent at the target site can be determined, quantifying the scanning enhancement effect at different time points and determining the degree of enhancement in each scanning time window. Guided by the clinically desired enhancement target, the system automatically searches and decides on injection parameters, scanning parameters, etc., to ensure that the degree of enhancement in the scanning time window reaches the clinically desired enhancement target. In this way, it can automatically search and decide on the optimal CT contrast-enhanced scanning scheme, solving the problem of unsatisfactory CT scan results. Attached Figure Description

[0014] To more clearly illustrate the specific embodiments of the present invention, the accompanying drawings used in the specific embodiments will be briefly described below. In all the drawings, the elements or parts are not necessarily drawn to scale.

[0015] Figure 1 A flowchart illustrating a method for adjusting and optimizing CT contrast-enhanced scanning parameters according to an embodiment of the present invention; Figure 2 This is a system block diagram of a system for adjusting and optimizing CT contrast-enhanced scan parameters according to an embodiment of the present invention; Figure 3 CT enhancement curves for two different models of CT scanners; Figure 4 This refers to the overlapping area between the scanning time window and the time-enhancement curve. Detailed Implementation

[0016] The embodiments of the technical solution of the present invention will now be described in detail with reference to the accompanying drawings. These embodiments are merely illustrative of the technical solution of the present invention and are therefore intended to limit the scope of protection of the present invention.

[0017] like Figure 1 The flowchart shown illustrates a method for adjusting and optimizing CT contrast-enhanced scan parameters, which includes: Step 1: Obtain the patient's physiological characteristics and the currently selected injection parameters, and calculate the time-density curve of the iodine contrast agent at the target site based on the physiological characteristics and injection parameters; Step 2: Determine the enhancement coefficient of the iodine contrast agent based on the peak voltage of the X-ray tube in the set scanning parameters, and determine the time-enhancement value curve of the iodine contrast agent at the target site in combination with the time-density curve. Step 3: Determine the peak enhancement value by combining the time-enhancement curve and the scanning time window in the scanning parameters, and compare the peak enhancement value with the enhanced target of the target area; Step 4: In response to the fact that the peak enhancement value does not meet the enhancement target, adjust the injection parameters and / or scanning parameters, and redetermine the time-enhancement value curve for comparison with the enhancement target; This process is repeated until the peak enhancement value meets the enhancement target.

[0018] Specifically, firstly, the system can acquire manually input physiological parameters of the patient, such as height, weight, age, and the target site to be scanned, as well as currently selected injection parameters, such as injection site, iodine contrast agent concentration, injection flow rate, and injection duration. Based on the acquired physiological and injection parameters, the contrast agent concentration at the target site at different times after iodine contrast agent injection can be calculated, generating a time-density curve corresponding to the target site.

[0019] Then, the enhancement coefficient corresponding to the peak tube voltage in the currently set scanning parameters can be determined using the CT enhancement curve preset by the CT scanner. The CT enhancement curve includes the enhancement coefficient per unit iodine contrast agent concentration at different tube peak voltages. Combined with the previously calculated time-density curve, the scanning enhancement value of the target area at different times can be determined under the currently set tube peak voltage, generating the time-enhancement curve corresponding to the target area.

[0020] Subsequently, based on the scan time windows set in the scan parameters, enhancement value data segments corresponding to each scan time window can be extracted from the time-enhancement curve, and the average enhancement value corresponding to each scan time window can be statistically analyzed. The average enhancement values ​​corresponding to all scan time windows are compared, and the maximum average enhancement value is selected as the peak enhancement value. This peak enhancement value is then compared with the clinically desired enhancement target.

[0021] If the peak enhancement value reaches or exceeds the enhancement target, the injection can be performed at the injection site according to the currently set injection flow rate, injection duration, and iodine contrast agent. At the same time, the scanning time window corresponding to the peak enhancement value can be used as the trigger delay time for CT scanning. The CT machine will be triggered to scan the target area after the scanning time window is reached.

[0022] If the peak enhancement value does not reach the enhancement target, the injection flow rate, injection duration, iodine contrast agent concentration, injection site, and / or the CT scanner's peak tube voltage can be adjusted, and the peak enhancement value can be recalculated and compared with the enhancement target. This process is repeated until the peak enhancement value reaches or exceeds the enhancement target. In this way, the optimal CT contrast-enhanced scanning scheme can be automatically searched and determined in reverse, solving the problem of unsatisfactory CT scan results.

[0023] In this embodiment, optionally, calculating the time-density curve of the iodine contrast agent at the target site includes: The flow of the iodine contrast agent from the injection site to the target site, passing through various organ sites, was determined. Using a density model matched to the organ site, the density of iodine contrast agent in each organ site is calculated step by step, and finally the time-density curve of the target site is obtained.

[0024] Specifically, when calculating the time-density curve corresponding to the target site, the path of the iodine contrast agent from the injection site to the target site can be determined based on the target site and the injection site. For example, if the injection site is the vein of the right upper limb and the target site is the lung, then the iodine contrast agent passes through the injection site, right heart, pulmonary artery, pulmonary capillaries, and lung in sequence from the injection site to the target site.

[0025] Then, based on the set product concentration and injection flow rate of the iodine contrast agent, the concentration of the iodine contrast agent at the injection site can be calculated using a density model corresponding to the injection site. In this embodiment, a density model matching the injection site can be constructed by combining the injection flow rate, product concentration, and equivalent volume of the injection point. The specific expression of the density model corresponding to the injection site is as follows: ; in, This refers to the injection flow rate of the iodine contrast agent. This refers to the product concentration of the iodine contrast agent. This represents the equivalent flow rate of the iodine contrast agent at the injection site. The iodine concentration at the injection site. This is the equivalent volume of the injection point.

[0026] Then, based on the iodine contrast agent concentration at the injection site, the iodine contrast agent concentration of the right heart can be calculated using the density model corresponding to the right heart. In this embodiment, a density model adapted to the current organ site can be constructed based on the blood flow of the organ site, combined with the iodine contrast agent concentration and blood flow of the adjacent previous organ site. In this embodiment, the specific expression of the density model corresponding to the right heart is as follows: ; , These represent the equivalent flow rate at the injection point and the iodine concentration at the injection point, respectively. , These represent the venous blood flow and venous iodine contrast agent concentration in the right upper limb, respectively. , The values ​​represent venous blood flow and venous iodine contrast agent concentration in the left upper limb, respectively. , These are coronary blood flow and coronary iodine contrast agent concentration, respectively. This represents the penetration rate of iodine contrast agent from the coronary arteries into the myocardial intercellular matrix.

[0027] This refers to the concentration of iodine contrast agent in the interstitial tissue of cardiomyocytes. , These represent bronchial artery blood flow and bronchial artery iodine contrast agent concentration, respectively. This refers to the penetration rate of iodine contrast agent from bronchial arteries to the intercellular matrix. This refers to the concentration of iodine contrast agent in the bronchial intercellular matrix. , These represent the blood flow in the inferior vena cava of the upper segment of the liver and the iodine concentration within the inferior vena cava of the upper segment of the liver, respectively. , These represent the blood flow in the head and jugular veins and the concentration of iodine contrast agent in the head and jugular veins, respectively. , These represent right ventricular blood flow and right ventricular iodine contrast agent concentration, respectively. This refers to the volume of the right heart.

[0028] Based on the iodine contrast agent concentration corresponding to the right heart, the iodine contrast agent concentration corresponding to the pulmonary artery is calculated using a density model. The specific expression of the density model matched to the pulmonary artery is as follows: ; in, This refers to the blood flow in the pulmonary artery. This refers to the concentration of iodine contrast agent in the pulmonary artery. This refers to the volume of the pulmonary artery.

[0029] Then, based on the iodine contrast agent concentration corresponding to the pulmonary artery, the iodine contrast agent concentration corresponding to the pulmonary capillary can be calculated using a density model matched to the pulmonary capillary. The specific expression of the density model matched to the pulmonary capillary is as follows: ; in, This refers to the blood flow in the pulmonary capillaries. This refers to the concentration of iodine contrast agent in pulmonary capillaries. This refers to the volume of the pulmonary artery.

[0030] Finally, based on the iodine contrast agent concentration corresponding to the pulmonary capillaries, the iodine contrast agent concentration corresponding to the pulmonary interstitial space can be calculated using a density model that matches the pulmonary interstitial space. The specific expression for the density model that matches the pulmonary interstitial space is as follows: ; in, This refers to the penetration rate of iodine contrast agent from pulmonary capillaries to the intercellular matrix of lung cells. This refers to the concentration of iodine contrast agent in the interstitium of lung cells. It refers to the volume of the interstitial tissue of lung cells.

[0031] By combining the iodine contrast agent concentrations corresponding to the lung intercellular matrix and lung capillaries, the iodine contrast agent concentration corresponding to the lung veins can be calculated using a density model matched to the lung veins. The specific expression of the density model matched to the lung veins is as follows: ; in, This refers to the volume of the pulmonary veins.

[0032] Finally, by integrating, the concentration of iodine contrast agent in the pulmonary vein at different times can be obtained, generating the time-density curve corresponding to the target site.

[0033] In this embodiment, optionally, determining the enhancement coefficient of the iodine contrast agent based on the set scanning parameters includes: Obtain the CT enhancement curve corresponding to the CT scanning equipment. The CT enhancement curve includes the contrast enhancement value corresponding to the unit iodine concentration under different tube peak voltages. Based on the CT enhancement curve, the enhancement coefficient is determined according to the peak voltage of the X-ray tube in the scanning parameters. The enhancement coefficient is the contrast enhancement value corresponding to a unit iodine concentration.

[0034] Specifically, such as Figure 3 As shown, different models of CT scanners have different CT enhancement curves. When determining the enhancement effect of a target area under a currently set peak tube voltage, the appropriate CT enhancement curve can be selected based on the model of the CT scanner. Then, the set peak tube voltage can be input into the CT enhancement curve to determine the contrast enhancement value, i.e., the enhancement coefficient, corresponding to a unit iodine concentration under the current peak tube voltage.

[0035] In this embodiment, optionally, determining the peak enhancement value by combining the time-enhancement curve and the scan time window includes: Calculate the average enhancement value within the overlapping area of ​​the time-enhancement curve and each scanning time window; The average enhancement values ​​corresponding to each scanning time window are compared, and the maximum average enhancement value is selected as the peak enhancement value.

[0036] Specifically, such as Figure 4As shown, by multiplying the iodine contrast agent concentration in the time-density curve corresponding to the target area by the enhancement factor, the CT enhancement values ​​of the target area at different times can be obtained, generating a time-enhancement curve. Then, according to the set scanning time window, the enhancement value data segment overlapping with the scanning time window is extracted from the time-enhancement curve, and the average enhancement value corresponding to each scanning time window is calculated. Finally, the average enhancement values ​​corresponding to all scanning time windows are compared, and the maximum average enhancement value is selected as the peak enhancement value.

[0037] In this embodiment, optionally, adjusting the injection parameters and / or scanning parameters includes: Adjust the injection flow rate, injection duration, and / or iodine contrast agent concentration in the injection parameters, and / or adjust the tube peak voltage in the scanning parameters.

[0038] Specifically, when determining the optimal scanning scheme, various adjustments can be made. For example, increasing the injection flow rate of the iodine contrast agent can increase the iodine contrast dose injected into the body per unit time, thereby increasing the iodine contrast agent concentration at the target site and improving the peak enhancement value. Similarly, extending the injection time can also increase the iodine contrast dose injected into the body, thus increasing the iodine contrast agent concentration at the target site and improving the peak enhancement value. Increasing the concentration of the injected iodine contrast agent product can also increase the iodine contrast dose injected into the body per unit time. In addition, reducing the peak voltage of the CT scanner tube can increase the enhancement coefficient, thereby improving the peak enhancement value.

[0039] In this embodiment, the above-described adjustment methods can be used individually to search for the optimal injection parameters or scanning parameters. However, in practical applications, both injection and scanning parameters have certain limitations; the peak voltage of the X-ray tube can only be adjusted within the range specified by the CT scanning equipment, and the concentration of the iodine contrast agent cannot exceed the concentration threshold that the patient can tolerate. If a single adjustment method cannot achieve the desired enhancement peak, multiple adjustment methods can be combined to search for the optimal injection or scanning parameters.

[0040] For example, when adjusting the concentration of the iodine contrast agent cannot meet the enhancement target, the method of reducing the peak voltage of the X-ray tube can be combined to search for the iodine contrast agent concentration and the peak voltage of the X-ray tube that can make the peak enhancement value meet the enhancement target, thus obtaining the optimal scanning scheme.

[0041] like Figure 2 The system block diagram shown is for a system that adjusts and optimizes CT contrast-enhanced scan parameters. The system includes: The time-density module is configured to acquire the patient's physiological characteristic parameters and the currently selected injection parameters, and calculate the time-density curve of the iodine contrast agent at the target site based on the physiological characteristic parameters and injection parameters; The time-enhancement value module is configured to determine the enhancement coefficient of the iodine contrast agent based on the peak voltage of the tube in the set scanning parameters, and to determine the time-enhancement value curve of the iodine contrast agent at the target site in combination with the time-density curve; The optimization and adjustment module is configured to determine the peak enhancement value by combining the time-enhancement value curve and the scanning time window in the scanning parameters, and compare the peak enhancement value with the enhancement target of the target area; In response to the enhancement value peak not meeting the enhancement target, the injection parameters and / or scanning parameters are adjusted, and the time-enhancement value curve is re-determined and compared with the enhancement target; This process is repeated until the peak enhancement value meets the enhancement target.

[0042] Specifically, the system includes a time-density module, a time-enhancement value module, and an optimization adjustment module. The time-density module can acquire manually input physiological characteristic parameters of the patient, as well as the currently selected injection parameters. Based on the acquired physiological characteristic parameters and injection parameters, the time-density module calculates the contrast agent concentration at the target site at different times after iodine contrast agent injection, generating a time-density curve corresponding to the target site.

[0043] The time-enhancement module can determine the enhancement coefficient corresponding to the peak voltage of the X-ray tube in the currently set scanning parameters by using the CT enhancement curve preset by the CT machine. Combined with the previously calculated time-density curve, it determines the scanning enhancement value of the target area at different times under the currently set peak voltage of the X-ray tube, and generates the time-enhancement curve corresponding to the target area.

[0044] The optimization and adjustment module can extract enhancement value data segments corresponding to each scanning time window from the time-enhancement curve based on the scanning time windows set in the scanning parameters, and statistically analyze the average enhancement value corresponding to each scanning time window. The average enhancement values ​​corresponding to all scanning time windows are compared, and the maximum average enhancement value is selected as the peak enhancement value. This peak enhancement value is then compared with the clinically desired enhancement target.

[0045] If the peak enhancement value does not reach the enhancement target, the injection flow rate, injection duration, iodine contrast agent concentration, injection site, and / or the CT scanner's peak tube voltage can be adjusted, and the peak enhancement value can be recalculated and compared with the enhancement target. This process is repeated until the peak enhancement value reaches or exceeds the enhancement target. In this way, the optimal CT contrast-enhanced scanning scheme can be automatically searched and determined in reverse, solving the problem of unsatisfactory CT scan results.

[0046] In this embodiment, optionally, the time-density module includes: The flow path unit is configured to determine the flow of the iodine contrast agent from the injection site to the target site through various organ sites; The density calculation unit is configured to use a density model that matches the organ site to calculate the iodine contrast agent density of each organ site step by step, and finally obtain the time-density curve of the target site.

[0047] Specifically, the time-density module includes a flow path unit and a density calculation unit. The flow path unit determines the various organ sites the iodine contrast agent must pass through from the injection site to the target site based on the target site and the injection volume. The density calculation unit, based on the set iodine contrast agent product concentration and injection flow rate, uses density models corresponding to the organ sites to sequentially calculate the iodine contrast agent concentration at each organ site along the flow path from the injection site to the target site at different times. This ultimately yields the iodine contrast agent concentration at the target site at different times, generating the desired time-density curve.

[0048] In this embodiment, optionally, the time-enhanced value module includes: The acquisition unit is configured to acquire the CT enhancement curve corresponding to the CT scanning device, which includes the contrast enhancement value corresponding to the unit iodine concentration under different tube peak voltages; The determination unit is configured to determine the enhancement coefficient based on the CT enhancement curve and the peak voltage of the X-ray tube in the scanning parameters. The enhancement coefficient is the contrast enhancement value corresponding to a unit iodine concentration.

[0049] Specifically, the time-enhancement value module includes an acquisition unit and a determination unit. The acquisition unit can obtain a CT enhancement curve representing the contrast enhancement value corresponding to a unit iodine concentration at different tube peak voltages, based on the model of the CT scanning equipment. The determination unit can determine the enhancement coefficient corresponding to the CT scanning equipment at the currently set tube peak voltage, i.e., the contrast enhancement value corresponding to a unit iodine concentration, based on the CT enhancement curve. The time-enhancement value module multiplies the enhancement coefficient by the iodine contrast agent concentration in the time-density curve to obtain the scanning enhancement value representing the target area at different times, generating the corresponding time-enhancement value curve.

[0050] In this embodiment, optionally, the optimization adjustment module includes: The curve calculation unit is configured to calculate the average enhancement value within the overlapping area of ​​the time-enhancement curve and each scan time window, respectively. The peak comparison unit is configured to compare the average enhancement values ​​corresponding to each scanning time window and select the maximum average enhancement value as the peak enhancement value.

[0051] Specifically, the optimization and adjustment module includes a curve calculation unit and a peak comparison unit. The curve calculation unit can extract corresponding enhancement value data segments from the time-enhancement value curve according to a set scan time window and calculate the average enhancement value corresponding to that scan time window. The peak comparison unit can compare the calculated average enhancement values ​​corresponding to all scan time windows and select the largest average enhancement value as the enhancement value peak for comparison with the enhancement target.

[0052] If the peak enhancement value does not meet the enhancement target, the optimization and adjustment module will optimize and adjust the injection parameters or scanning parameters, or optimize and adjust the injection parameters and scanning parameters, under the set constraints, such as the iodine contrast agent not exceeding the patient's tolerance limit and the peak voltage range of the X-ray tube. It will then recalculate the peak enhancement value through the time-density module and the time-enhancement value module and compare it with the enhancement target until the peak enhancement value meets the enhancement target. The optimization and adjustment module can then provide the operator with the current injection parameters and scanning parameters as the optimal injection plan.

[0053] In this embodiment, optionally, the optimization adjustment module includes: The adjustment unit is configured to adjust the injection flow rate, injection duration, and / or iodine contrast agent concentration in the injection parameters, and / or adjust the tube peak voltage in the scanning parameters.

[0054] Specifically, when searching for the optimal scanning scheme, the optimization and adjustment module can increase the injection flow rate of the iodine contrast agent, increase the concentration of the iodine contrast agent at the target site, prolong the injection time, or reduce the peak voltage of the CT scanner tube, and increase the enhancement coefficient, among other adjustments. If a single adjustment method cannot achieve the desired enhancement peak value, multiple adjustment methods can be combined to search for the optimal injection or scanning parameters.

[0055] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered within the scope of the claims and specification of the present invention.

Claims

1. A method for adjusting and optimizing CT contrast-enhanced scan parameters, characterized in that, include: Obtain the patient's physiological characteristics and the currently selected injection parameters, and calculate the time-density curve of the iodine contrast agent at the target site based on the physiological characteristics and injection parameters; The enhancement coefficient of the iodine contrast agent is determined based on the peak voltage of the tube in the set scanning parameters, and the time-enhancement value curve of the iodine contrast agent at the target site is determined in combination with the time-density curve. The peak enhancement value is determined by combining the time-enhancement curve and the scanning time window in the scanning parameters, and this peak enhancement value is compared with the enhancement target of the target area; In response to the enhancement value peak not meeting the enhancement target, the injection parameters and / or scanning parameters are adjusted, and the time-enhancement value curve is re-determined and compared with the enhancement target; This process is repeated until the peak enhancement value meets the enhancement target.

2. The method for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 1, characterized in that, Calculate the time-density curve of the iodine contrast agent at the target site, including: The flow of the iodine contrast agent from the injection site to the target site, passing through various organ sites, was determined. Using a density model matched to the organ site, the density of iodine contrast agent in each organ site is calculated step by step, and finally the time-density curve of the target site is obtained.

3. The method for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 1, characterized in that, The enhancement factor of the iodine contrast agent is determined based on the set scanning parameters, including: Obtain the CT enhancement curve corresponding to the CT scanning equipment. The CT enhancement curve includes the contrast enhancement value corresponding to the unit iodine concentration under different tube peak voltages. Based on the CT enhancement curve, the enhancement coefficient is determined according to the peak voltage of the X-ray tube in the scanning parameters. The enhancement coefficient is the contrast enhancement value corresponding to a unit iodine concentration.

4. The method for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 1, characterized in that, Determining the peak enhancement value by combining the time-enhancement curve and the scan time window includes: Calculate the average enhancement value within the overlapping area of ​​the time-enhancement curve and each scanning time window; The average enhancement values ​​corresponding to each scanning time window are compared, and the maximum average enhancement value is selected as the peak enhancement value.

5. The method for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 1, characterized in that, Adjusting the injection parameters and / or scanning parameters includes: Adjust the injection flow rate, injection duration, and / or iodine contrast agent concentration in the injection parameters, and / or adjust the tube peak voltage in the scanning parameters.

6. A system for adjusting and optimizing CT contrast-enhanced scan parameters, characterized in that, include: The time-density module is configured to acquire the patient's physiological characteristic parameters and the currently selected injection parameters, and calculate the time-density curve of the iodine contrast agent at the target site based on the physiological characteristic parameters and injection parameters; The time-enhancement value module is configured to determine the enhancement coefficient of the iodine contrast agent based on the peak voltage of the tube in the set scanning parameters, and to determine the time-enhancement value curve of the iodine contrast agent at the target site in combination with the time-density curve; The optimization and adjustment module is configured to determine the peak enhancement value by combining the time-enhancement value curve and the scanning time window in the scanning parameters, and compare the peak enhancement value with the enhancement target of the target area; In response to the enhancement value peak not meeting the enhancement target, the injection parameters and / or scanning parameters are adjusted, and the time-enhancement value curve is re-determined and compared with the enhancement target; This process is repeated until the peak enhancement value meets the enhancement target.

7. The system for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 6, characterized in that, The time-density module includes: The flow path unit is configured to determine the flow of the iodine contrast agent from the injection site to the target site through various organ sites; The density calculation unit is configured to use a density model that matches the organ site to calculate the iodine contrast agent density of each organ site step by step, and finally obtain the time-density curve of the target site.

8. The system for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 6, characterized in that, The time-enhanced value module includes: The acquisition unit is configured to acquire the CT enhancement curve corresponding to the CT scanning device, which includes the contrast enhancement value corresponding to the unit iodine concentration under different tube peak voltages; The determination unit is configured to determine the enhancement coefficient based on the CT enhancement curve and the peak voltage of the X-ray tube in the scanning parameters. The enhancement coefficient is the contrast enhancement value corresponding to a unit iodine concentration.

9. The system for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 6, characterized in that, The optimization and adjustment module includes: The curve calculation unit is configured to calculate the average enhancement value within the overlapping area of ​​the time-enhancement curve and each scan time window, respectively. The peak comparison unit is configured to compare the average enhancement values ​​corresponding to each scanning time window and select the maximum average enhancement value as the peak enhancement value.

10. The system for adjusting and optimizing CT contrast-enhanced scanning parameters according to claim 6, characterized in that, The optimization and adjustment module includes: The adjustment unit is configured to adjust the injection flow rate, injection duration, and / or iodine contrast agent concentration in the injection parameters, and / or adjust the tube peak voltage in the scanning parameters.

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