A dual-network crosslinked hydrogel against streptococcus mutans, its preparation method and application in pet oral care

By designing a dual-network cross-linked hydrogel, utilizing a carbomer-sodium alginate interpenetrating network and ferrous ion cross-linking, combined with multiple active ingredients, the antibacterial and anti-inflammatory issues of pet oral care products are solved, achieving highly effective inhibition of Streptococcus mutans and relief of gingival inflammation.

CN122398705APending Publication Date: 2026-07-17SHAANXI UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHAANXI UNIV OF SCI & TECH
Filing Date
2026-05-29
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing pet oral care products have difficulty maintaining antibacterial effects, poor palatability, and asynchronous release and coverage, making them unable to effectively control dental plaque and gingivitis caused by Streptococcus mutans.

Method used

The product employs a dual-network cross-linked hydrogel, which forms an interpenetrating network structure through carbomer and sodium alginate, combined with electrostatic composite cross-linking of ferrous ions and polyhexamethylene biguanide, along with ingredients such as dipotassium glycyrrhizate and green-lipped mussel extract, to achieve targeted antibacterial and anti-inflammatory effects against Streptococcus mutans.

Benefits of technology

It achieves a high inhibition rate of Streptococcus mutans (≥99.9%), while reducing gingival redness and pain, improving the product's palatability and multiple care effects, and possessing good stability and biocompatibility.

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Abstract

本发明公开了一种抗变形链球菌的双网络交联水凝胶及其制备方法和在宠物口腔护理中的应用，属于宠物护理用品技术领域。以质量百分比计，双网络交联水凝胶中含有：0.4%～0.8%卡波姆、0.2%～0.5%海藻酸钠、0.02%～0.1%聚六亚甲基双胍、0.01%～0.02%抗氧化剂、3%～5%保湿剂、0.2%～0.5%烟酰胺、0.01%～0.05%生物素、0.1%～0.2%甘草酸二钾、0.2%～1%甜味剂、0.5%～1%绿唇贻贝提取物、0.1%～0.5% pH调节剂和0.05%～0.15%亚铁盐，余量为水。该双网络交联水凝胶中，亚铁盐、海藻酸钠和聚六亚甲基双胍共同构成离子交联‑静电复合协同增强的网络结构，延长水凝胶在口腔内的停留时间并赋予按需释放特性，甘草酸二钾与绿唇贻贝提取物协同抗炎，保湿剂与甜味剂结合提升宠物接受度。
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