Pharmaceutical monomers, compositions and uses for the treatment of inflammatory bowel disease

The combination of succinate saponin C, capsicum alkaloid, 4-O-methylpinepic acid and methyl dihydroxydimethylbenzoate provides synergistic treatment for inflammatory bowel disease, overcoming the limitations of existing drug treatments and achieving more effective symptom improvement and enhanced safety.

CN122398832APending Publication Date: 2026-07-17HEILONGJIANG UNIV OF CHINESE MEDICINE

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEILONGJIANG UNIV OF CHINESE MEDICINE
Filing Date
2026-04-30
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing drugs for treating inflammatory bowel disease lack a radical cure, and commonly used drug treatments are expensive and have significant side effects. Traditional Chinese medicine treatments have limitations, and there are currently no reports on the application of bitter perilla saponin C, succinate, 4-O-methylpinene acid, or methyl dihydroxydimethylbenzoate.

Method used

A combination of perilla saponin C, scutellarin, 4-O-methylpinepic acid and methyl dihydroxydimethylbenzoate is used to synergistically treat inflammatory bowel disease by administration via the gastrointestinal tract or non-gastrointestinal route, thereby regulating the intestinal flora, repairing the intestinal barrier, and inhibiting the inflammatory response.

Benefits of technology

It significantly improves symptoms of inflammatory bowel disease, including weight loss, loose stools, shortened colon, and impaired intestinal barrier; reduces serum levels of pro-inflammatory factors; increases levels of anti-inflammatory factors; and provides a safer and more effective treatment option.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明涉及用于治疗炎症性肠病的药物单体、组合物及用途,属于制药领域。本发明提供了四种可用于治疗炎症性肠病的化合物,以及包含这四种化合物的药物组合物。相较于四种化合物单独给药,其组合使用能够发挥协同作用,更有效地改善炎症性肠病,改善体重下降、大便不成形、便血、结肠缩短、肠道屏障受损等情况,降低血清中TNF‑α、IL‑1β、IL‑6、LPS、Lcn2的水平,上调IL‑10的水平,从而为炎症性肠病的治疗提供了新的、更加有效的治疗方案。
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