Use of mulberry polysaccharide in treatment of type 2 diabetes mellitus by regulating intestinal flora

By regulating gut microbiota and increasing the secretion of short-chain fatty acids through mulberry polysaccharides, and targeting the gut microbiota-SCFAs axis, various oral drug formulations have been prepared, solving the problems of large side effects of existing chemical hypoglycemic drugs and unclear active mechanisms of natural mulberries, thus achieving safe and effective treatment for type 2 diabetes.

CN122398847APending Publication Date: 2026-07-17CHANGCHUN UNIV OF CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGCHUN UNIV OF CHINESE MEDICINE
Filing Date
2026-05-22
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing chemical hypoglycemic drugs have significant side effects, and the mechanism of action of the active ingredients in natural mulberries is unclear, making it difficult to provide a safe and effective treatment plan for type 2 diabetes.

Method used

Using mulberry polysaccharide as the sole active ingredient, this drug can regulate gut microbiota, enhance the secretion of short-chain fatty acids, and target the gut microbiota-SCFAs axis to be formulated into various oral drug formulations for the treatment of type 2 diabetes.

Benefits of technology

It significantly improves body weight, food intake, and water intake in type 2 diabetic rats, repairs liver tissue damage, regulates glucose and lipid metabolism, enhances antioxidant capacity, and avoids the side effects of chemical drugs.

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Abstract

The application discloses a new application of mulberry polysaccharide in preparation of a medicine for treating type 2 diabetes by regulating intestinal flora, and belongs to the technical field of medicinal and edible plant polysaccharides. In the application, a type 2 diabetes rat model is constructed by using high-sugar and high-fat feed in combination with streptozotocin, biochemical index detection, liver HE staining and oil red O staining, intestinal flora 16S rRNA high-throughput sequencing, and GC-MS detection of short-chain fatty acid content are carried out, so as to confirm that the mulberry polysaccharide can regulate the intestinal flora structure of T2DM rats, improve the secretion level of short-chain fatty acids, improve insulin resistance and glycolipid metabolism disorder, enhance the antioxidant capacity of the body, and repair the pathological damage of the liver. The application clearly defines the anti-type 2 diabetes mechanism of the mulberry polysaccharide, which takes the intestinal flora-short-chain fatty acid axis as the core. The mulberry polysaccharide is a natural low-toxicity medicinal and edible active ingredient, has no side effects of chemical hypoglycemic drugs, can be prepared into various oral medicine dosage forms, and is used for the prevention and clinical treatment of type 2 diabetes, so the application prospect is wide.
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